BRPI0419274A - preparação não aquosa para absorção percutánea contendo analgésico não-esteroidal - Google Patents

preparação não aquosa para absorção percutánea contendo analgésico não-esteroidal

Info

Publication number
BRPI0419274A
BRPI0419274A BRPI0419274-5A BRPI0419274A BRPI0419274A BR PI0419274 A BRPI0419274 A BR PI0419274A BR PI0419274 A BRPI0419274 A BR PI0419274A BR PI0419274 A BRPI0419274 A BR PI0419274A
Authority
BR
Brazil
Prior art keywords
drug
inorganic acid
percutaneous absorption
analgesic
aqueous
Prior art date
Application number
BRPI0419274-5A
Other languages
English (en)
Inventor
Seijirou Yama
Naoki Murai
Original Assignee
Lead Chem Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lead Chem Co Ltd filed Critical Lead Chem Co Ltd
Publication of BRPI0419274A publication Critical patent/BRPI0419274A/pt
Publication of BRPI0419274B1 publication Critical patent/BRPI0419274B1/pt
Publication of BRPI0419274B8 publication Critical patent/BRPI0419274B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Botany (AREA)
  • Inorganic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"PREPARAçãO NãO-AQUOSA PARA ABSORçãO PERCUTáNEA CONTENDO ANALGéSICO NãO-ESTEROIDAL. A presente invenção refere-se a uma preparação não-aquosa para absorção percutânea pela laminação em uma camada aderente compreendendo um analgésico antiinflamatório não-esteroidal em um metal alcalino na forma de sal, e um ácido inorgânico o qual é fortemente ácido comparado com o analgésicoantiinflamatório em uma forma livre, junto com uma base não-aquosa, sobre um suporte. De acordo com a presente invenção, as características de liberação da droga e a penetração da pele em uma preparação não-aquosa para absorção percutânea podem ser melhoradas porque a adução de um ácido inorgânico em uma base não aquosa contendo uma droga em um sal alcalino em forma de sal conduz uma melhora em solubilidade da droga na base, e um bom fracionamento da droga na superfície de pele. Em adição, como ácido inorgânico não possui grupo álcool hidroxílico na estrutura, o ácido inorgânico não reage com a droga na estrutura, o ácido inorgânico não reage com a droga, desta forma faz com que abaixe a estabilidade da droga pela esterilização.
BRPI0419274A 2004-11-05 2004-11-05 preparação não aquosa para absorção percutânea contendo analgésico não-esteroidal BRPI0419274B8 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2004/016431 WO2006048939A1 (ja) 2004-11-05 2004-11-05 非ステロイド消炎鎮痛薬を含有する非水系経皮吸収製剤

Publications (3)

Publication Number Publication Date
BRPI0419274A true BRPI0419274A (pt) 2008-09-16
BRPI0419274B1 BRPI0419274B1 (pt) 2017-02-14
BRPI0419274B8 BRPI0419274B8 (pt) 2021-05-25

Family

ID=36318959

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0419274A BRPI0419274B8 (pt) 2004-11-05 2004-11-05 preparação não aquosa para absorção percutânea contendo analgésico não-esteroidal

Country Status (10)

Country Link
US (1) US8551979B2 (pt)
EP (1) EP1815852B1 (pt)
JP (1) JP4678532B2 (pt)
KR (1) KR101121890B1 (pt)
CN (1) CN101052384B (pt)
AU (1) AU2004324693B2 (pt)
BR (1) BRPI0419274B8 (pt)
CA (1) CA2586871C (pt)
ES (1) ES2622403T3 (pt)
WO (1) WO2006048939A1 (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5181320B2 (ja) * 2006-10-18 2013-04-10 ニチバン株式会社 皮膚刺激の少ない経皮吸収型製剤
CN101553213A (zh) 2006-12-06 2009-10-07 尼普洛外用药品株式会社 外用药物组合物及贴剂
WO2008133272A1 (ja) * 2007-04-23 2008-11-06 Hisamitsu Pharmaceutical Co., Inc. 貼付剤
JP5193674B2 (ja) * 2007-06-01 2013-05-08 日東電工株式会社 貼付剤および貼付製剤
KR101539801B1 (ko) 2007-12-12 2015-07-27 데이고꾸세이약꾸가부시끼가이샤 록소프로펜 함유 수성 첩부제
JP5368168B2 (ja) * 2008-06-16 2013-12-18 日東電工株式会社 貼付剤及び貼付製剤
KR101490708B1 (ko) * 2008-06-20 2015-02-09 (주)아모레퍼시픽 록소프로펜 또는 그의 염을 포함하는 경피 흡수용 조성물및 이를 포함하는 경피 투여 첩부제
JP5581080B2 (ja) * 2009-03-19 2014-08-27 共立薬品工業株式会社 外用貼付剤
JP5421063B2 (ja) * 2009-10-23 2014-02-19 帝國製薬株式会社 ジクロフェナクナトリウム含有水性貼付剤
JP2012031131A (ja) * 2010-01-29 2012-02-16 Kowa Co ロキソプロフェン含有医薬組成物
JP5238857B2 (ja) * 2010-06-30 2013-07-17 興和株式会社 ロキソプロフェン含有医薬組成物
JP6131522B2 (ja) * 2011-03-25 2017-05-24 大正製薬株式会社 ロキソプロフェン含有外用剤
JP6131523B2 (ja) * 2011-03-25 2017-05-24 大正製薬株式会社 ロキソプロフェン含有外用剤
KR20160046138A (ko) 2014-10-20 2016-04-28 민경회 비스테로이드성 항염증제를 함유하는 감염성 질환의 예방 또는 치료용 조성물
WO2017111167A1 (ja) 2015-12-25 2017-06-29 興和株式会社 ロキソプロフェンを含有する医薬製剤
CN120035451A (zh) 2023-01-27 2025-05-23 立德化学株式会社 非水系经皮吸收制剂
CN117159508B (zh) * 2023-09-18 2024-11-15 湖南九典制药股份有限公司 热熔型贴剂及其制备方法
CN120346189B (zh) * 2025-06-23 2025-09-16 杭州百诚医药科技股份有限公司 一种热熔型洛索洛芬钠贴剂及其制备方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993004677A1 (fr) * 1991-08-30 1993-03-18 Hisamitsu Pharmaceutical Co., Inc. Sparadrap analgesique anti-inflammatoire
JPS5936609A (ja) * 1982-08-26 1984-02-28 Nitto Electric Ind Co Ltd 粘着性貼付製剤
JPS59181211A (ja) * 1983-03-30 1984-10-15 Nitto Electric Ind Co Ltd ゴム系膏体組成物
GB8422158D0 (en) * 1984-09-01 1984-10-03 Procter & Gamble Ltd Bleach compositions
JPH0747535B2 (ja) * 1985-11-26 1995-05-24 日東電工株式会社 消炎鎮痛用貼付剤
US5234957A (en) * 1991-02-27 1993-08-10 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5059626A (en) * 1988-07-25 1991-10-22 Applied Analytical Industries, Inc. Liquid oral pharmaceutical compositions of non-steroidal anti-inflammatory drugs
JP3154564B2 (ja) * 1992-09-07 2001-04-09 科学技術振興事業団 モノクローナル抗体の改変方法
US5702720A (en) * 1995-12-22 1997-12-30 Minnesota Mining And Manufacturing Company Transdermal device for the delivery of flurbiprofen
JPH10120560A (ja) 1996-08-26 1998-05-12 Sankyo Co Ltd ロキソプロフェン含有外用製剤
CA2232855C (en) * 1997-04-10 2007-10-09 Roche Consumer Health (Worldwide) Sa Pharmaceutical formulation
US6083996A (en) * 1997-11-05 2000-07-04 Nexmed Holdings, Inc. Topical compositions for NSAI drug delivery
KR100322988B1 (ko) * 1998-10-01 2002-11-01 일양약품주식회사 소염진통첩부제조성물및이를함유한소염진통첩부제
EP1277466B1 (en) * 2000-04-18 2011-07-27 Hisamitsu Pharmaceutical Co., Inc. Patch containing anti-inflammatory agent
US6953772B2 (en) * 2000-07-18 2005-10-11 Lopes John A Concentrated sanitizing compositions for cleaning food and food contact surfaces
CN1180770C (zh) * 2002-06-19 2004-12-22 中国人民解放军第二军医大学 芳基丙酸类非甾体抗炎药透皮贴剂
JP2006090782A (ja) * 2004-09-22 2006-04-06 Fyuuensu:Kk 基板上に固定化した蛋白質の構造変化を検出する方法

Also Published As

Publication number Publication date
JPWO2006048939A1 (ja) 2008-05-22
CA2586871C (en) 2012-03-13
KR20070084152A (ko) 2007-08-24
EP1815852A4 (en) 2010-03-03
CA2586871A1 (en) 2006-05-11
CN101052384B (zh) 2011-07-27
ES2622403T3 (es) 2017-07-06
BRPI0419274B1 (pt) 2017-02-14
JP4678532B2 (ja) 2011-04-27
EP1815852A1 (en) 2007-08-08
AU2004324693B2 (en) 2011-05-26
HK1108374A1 (en) 2008-05-09
US20080113010A1 (en) 2008-05-15
AU2004324693A1 (en) 2006-05-11
US8551979B2 (en) 2013-10-08
EP1815852B1 (en) 2017-01-25
KR101121890B1 (ko) 2012-03-19
CN101052384A (zh) 2007-10-10
BRPI0419274B8 (pt) 2021-05-25
WO2006048939A1 (ja) 2006-05-11

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 05/11/2004 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 21A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2854 DE 16-09-2025 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.