CR8563A - Inhibidores de la quimasa novedosos - Google Patents

Inhibidores de la quimasa novedosos

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Publication number
CR8563A
CR8563A CR8563A CR8563A CR8563A CR 8563 A CR8563 A CR 8563A CR 8563 A CR8563 A CR 8563A CR 8563 A CR8563 A CR 8563A CR 8563 A CR8563 A CR 8563A
Authority
CR
Costa Rica
Prior art keywords
novel
chimase
inhibitors
chimase inhibitors
methods
Prior art date
Application number
CR8563A
Other languages
English (en)
Inventor
J Hawkins Michael
N Greco Michael
Powell Eugene
De Garavilla Lawrence
E Maryanoff Bruce
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CR8563A publication Critical patent/CR8563A/es

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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
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    • C07F9/28—Phosphorus compounds with one or more P—C bonds
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Abstract

La presente invencion esta dirigida a un compuesto de la formula (I) metodos para preparar estos compuestos, composiciones, intermediarios y derivados de los mismos, y metodos para tratar trastornos inflamatorios y mediados por serina proteasa.
CR8563A 2004-01-23 2006-08-14 Inhibidores de la quimasa novedosos CR8563A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53866304P 2004-01-23 2004-01-23

Publications (1)

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CR8563A true CR8563A (es) 2009-01-14

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CR8563A CR8563A (es) 2004-01-23 2006-08-14 Inhibidores de la quimasa novedosos

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US (2) US7459444B2 (es)
EP (1) EP1716160B1 (es)
JP (1) JP5022711B2 (es)
KR (1) KR101182143B1 (es)
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CA2636774A1 (en) * 2006-01-12 2007-07-26 Janssen Pharmaceutica N.V. Processing of slpi by chymase
JP5404388B2 (ja) * 2006-05-10 2014-01-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 冷メントール受容体−１拮抗薬
US8629281B2 (en) 2011-01-14 2014-01-14 Janssen Pharmaceutica, Nv Cold menthol receptor-1 antagonists
JP5117382B2 (ja) 2006-05-31 2013-01-16 第一三共株式会社 ７員環化合物の製造方法
JP4986249B2 (ja) * 2006-10-06 2012-07-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング チマーゼ阻害剤
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FR2934267B1 (fr) * 2008-07-23 2010-08-13 Pharmaleads Derives aminophosphiniques utiles dans le traitement de la douleur
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CN106467515B (zh) * 2015-08-18 2019-09-24 宁波洞密生物科技有限公司 一类6-吡啶苯并咪唑吲哚衍生物及其制备方法与医药领域的应用
CN107573263B (zh) * 2017-08-14 2020-04-07 大连理工大学 一种ω-取代缩二脲类化合物的合成方法
CN108383875B (zh) * 2018-03-22 2020-04-28 昆明学院 一种银催化的3-膦酰甲基吲哚啉及制备方法
CN115873037A (zh) * 2022-11-30 2023-03-31 南通大学 一种膦化氮杂吲哚啉的合成方法

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MXPA06008375A (es) 2007-03-21
ZA200607024B (en) 2010-02-24
IL177037A (en) 2013-05-30
AR047448A1 (es) 2006-01-18
DE602005025600D1 (de) 2011-02-10
ECSP066721A (es) 2006-10-31
WO2005073214A3 (en) 2005-10-20
CA2554205C (en) 2013-08-27
ATE493421T1 (de) 2011-01-15
JP2007518807A (ja) 2007-07-12
EA011745B1 (ru) 2009-06-30
SG149880A1 (en) 2009-02-27
US20050176769A1 (en) 2005-08-11
WO2005073214A2 (en) 2005-08-11
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KR20060129401A (ko) 2006-12-15
KR101182143B1 (ko) 2012-09-13
CN1934120A (zh) 2007-03-21
NO20063647L (no) 2006-10-19
HK1148753A1 (en) 2011-09-16
NZ548684A (en) 2009-04-30
BRPI0507052A (pt) 2007-06-12
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EP1716160A2 (en) 2006-11-02
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EA200601358A1 (ru) 2007-02-27
EP1716160B1 (en) 2010-12-29
CA2554205A1 (en) 2005-08-11
CN101863923A (zh) 2010-10-20
AU2005207856A1 (en) 2005-08-11
JP5022711B2 (ja) 2012-09-12
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