BRPI0507233A - processo de produção de polipeptìdeo heterólogo em e.coli - Google Patents
processo de produção de polipeptìdeo heterólogo em e.coliInfo
- Publication number
- BRPI0507233A BRPI0507233A BRPI0507233-6A BRPI0507233A BRPI0507233A BR PI0507233 A BRPI0507233 A BR PI0507233A BR PI0507233 A BRPI0507233 A BR PI0507233A BR PI0507233 A BRPI0507233 A BR PI0507233A
- Authority
- BR
- Brazil
- Prior art keywords
- coli
- production process
- polypeptide
- heterologous polypeptide
- polypeptide production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/32—Processes using, or culture media containing, lower alkanols, i.e. C1 to C6
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
PROCESSO DE PRODUçãO DE POLIPEPTìDEO HETERóLOGO EM E. COLI é descrito um processo de produção de polipeptídeo heterólogo a E. coli, em que as células de E. coli compreendem ácido nucléico codificador do polipeptídeo são cultivadas em meio de cultivo mediante alimentação ao meio de cultivo de organofosfato transportável, de tal forma que o ácido nucléico seja expresso. O polipeptídeo é recuperado das células em seguida.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55267804P | 2004-03-11 | 2004-03-11 | |
| US60/552,678 | 2004-03-11 | ||
| PCT/US2005/007880 WO2005087802A2 (en) | 2004-03-11 | 2005-03-10 | Process for producing polypeptides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0507233A true BRPI0507233A (pt) | 2007-06-26 |
| BRPI0507233B1 BRPI0507233B1 (pt) | 2018-01-23 |
| BRPI0507233B8 BRPI0507233B8 (pt) | 2021-05-25 |
Family
ID=34976293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0507233A BRPI0507233B8 (pt) | 2004-03-11 | 2005-03-10 | processo para a produção de um polipeptídeo heterólogo em e. coli |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US7294483B2 (pt) |
| EP (1) | EP1733037B1 (pt) |
| JP (1) | JP5014116B2 (pt) |
| KR (1) | KR101210083B1 (pt) |
| CN (1) | CN1954074B (pt) |
| AU (1) | AU2005222397A1 (pt) |
| BR (1) | BRPI0507233B8 (pt) |
| CA (2) | CA2946323A1 (pt) |
| DK (1) | DK1733037T3 (pt) |
| ES (1) | ES2527291T3 (pt) |
| HR (1) | HRP20150077T1 (pt) |
| IL (1) | IL177488A0 (pt) |
| ME (1) | ME02058B (pt) |
| NZ (1) | NZ549266A (pt) |
| PL (1) | PL1733037T3 (pt) |
| PT (1) | PT1733037E (pt) |
| RS (1) | RS53774B1 (pt) |
| RU (1) | RU2433185C2 (pt) |
| SI (1) | SI1733037T1 (pt) |
| WO (1) | WO2005087802A2 (pt) |
| ZA (1) | ZA200606913B (pt) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0507233B8 (pt) * | 2004-03-11 | 2021-05-25 | Genentech Inc | processo para a produção de um polipeptídeo heterólogo em e. coli |
| EP1926654B1 (de) * | 2005-09-15 | 2009-12-09 | Continental Teves AG & Co. oHG | Verfahren und vorrichtung zum lenken eines kraftfahrzeugs |
| JP2009095237A (ja) | 2006-02-02 | 2009-05-07 | Ajinomoto Co Inc | Ｌ−アミノ酸の製造法 |
| ES3011307T3 (en) | 2012-02-23 | 2025-04-07 | Juno Therapeutics Gmbh | Chromatographic isolation of cells and other complex biological materials |
| MX389350B (es) | 2014-12-05 | 2025-03-19 | Alexion Pharma Inc | Fosfatasas alcalinas recombinantes y usos de las mismas para el tratamiento de convulsiones. |
| JP6868561B2 (ja) | 2015-01-28 | 2021-05-12 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | アルカリホスファターゼ欠損を有する被験者を治療する方法 |
| CN108350440A (zh) | 2015-08-17 | 2018-07-31 | 阿雷克森制药公司 | 碱性磷酸酯的制造 |
| MX2018004875A (es) | 2015-10-22 | 2018-08-01 | Juno Therapeutics Gmbh | Metodos para cultivar celulas y kits y aparatos para ello. |
| EP3365453A2 (en) | 2015-10-22 | 2018-08-29 | Juno Therapeutics GmbH | Methods, kits, agents and apparatuses for transduction |
| JP2018533571A (ja) | 2015-10-30 | 2018-11-15 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 患者の頭蓋縫合早期癒合症を治療するための方法 |
| JP7613826B2 (ja) | 2016-04-01 | 2025-01-15 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | アルカリホスファターゼによって筋力低下を治療すること |
| EP3600383A4 (en) | 2017-03-31 | 2020-10-28 | Alexion Pharmaceuticals, Inc. | METHODS OF TREATMENT OF HYPOPHOSPHATASIA (HPP) IN ADULTS AND ADOLESCENTS |
| JP7339160B2 (ja) | 2017-04-27 | 2023-09-05 | ジュノ セラピューティクス ゲーエムベーハー | オリゴマー粒子試薬およびその使用方法 |
| US11913039B2 (en) | 2018-03-30 | 2024-02-27 | Alexion Pharmaceuticals, Inc. | Method for producing recombinant alkaline phosphatase |
| US12268733B2 (en) | 2018-08-10 | 2025-04-08 | Alexion Pharmaceuticals, Inc. | Methods of treating neurofibromatosis type 1 and related conditions with alkaline phosphatase |
| SG11202104355SA (en) | 2018-10-31 | 2021-05-28 | Juno Therapeutics Gmbh | Methods for selection and stimulation of cells and apparatus for same |
| CA3161266A1 (en) | 2019-12-09 | 2021-06-17 | Alexion Pharmaceuticals, Inc. | Alkaline phosphatase polypeptides and methods of use thereof |
| AU2021337652B2 (en) | 2020-09-04 | 2025-01-30 | Alexion Pharmaceuticals, Inc. | Methods for treating bone mineralization disorders |
| US12453805B2 (en) | 2020-09-24 | 2025-10-28 | Everest Medical Innovation GmbH | Cryoprotective compositions, surgical kits, and methods for protection of a surgical site during cryosurgery |
| US12426594B2 (en) | 2020-09-24 | 2025-09-30 | Everest Medical Innovation GmbH | Cryoprotective compositions and methods for protection of a surgical site during cryosurgery |
| BR112023016048A2 (pt) | 2021-02-12 | 2023-11-14 | Alexion Pharma Inc | Polipeptídeos de fosfatase alcalina e métodos de uso dos mesmos |
| CN113308393A (zh) * | 2021-04-20 | 2021-08-27 | 上田环境修复有限公司 | 一种降解氨氮和总氮的制剂及其制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5304472A (en) * | 1992-11-20 | 1994-04-19 | Genentech, Inc. | Method of controlling polypeptide production in bacterial cells |
| US5342763A (en) | 1992-11-23 | 1994-08-30 | Genentech, Inc. | Method for producing polypeptide via bacterial fermentation |
| NZ310420A (en) * | 1995-06-07 | 2000-01-28 | Bioteknologisk Inst | Recombinant hexose oxidase, a method of producing the same and use of such enzyme |
| DK1666591T3 (da) | 1995-06-29 | 2011-05-23 | Immunex Corp | Cytokin der inducerer apoptose |
| US6030945A (en) | 1996-01-09 | 2000-02-29 | Genentech, Inc. | Apo-2 ligand |
| WO1999000423A1 (en) | 1997-06-26 | 1999-01-07 | Immunex Corporation | Protein that binds trail |
| RU2139343C1 (ru) * | 1997-10-31 | 1999-10-10 | Государственный научный центр прикладной микробиологии | Питательная среда для выделения возбудителя геморрагического колита с гемолитико-уремическим синдромом, вызываемого кишечной палочкой 0157:н7 (сорбитол e.coli 0157:н7агар) |
| WO2000055353A1 (en) | 1999-03-17 | 2000-09-21 | The Board Of Trustees Of The Leland Stanford Junior University | In vitro macromolecule biosynthesis methods using exogenous amino acids and a novel atp regeneration system |
| US6337191B1 (en) * | 1999-03-22 | 2002-01-08 | The Board Of Trustees Of The Leland Stanford Junior University | Vitro protein synthesis using glycolytic intermediates as an energy source |
| AU763039B2 (en) | 1999-04-08 | 2003-07-10 | Genentech Inc. | Composition based on oppositely-charged polypeptides |
| CN101633692A (zh) | 1999-06-28 | 2010-01-27 | 杰南技术公司 | 利用二价金属离子制备Apo-2配体的方法 |
| RU2165455C1 (ru) * | 1999-11-23 | 2001-04-20 | Государственный научно-исследовательский институт особо чистых биопрепаратов | РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pSS5, КОДИРУЮЩАЯ СИНТЕЗ РЕКОМБИНАНТНОГО ЧЕЛОВЕЧЕСКОГО АЛЬФА-2b ИНТЕРФЕРОНА, ШТАММ ESCHERICHIA COLI SS5 - ПРОДУЦЕНТ РЕКОМБИНАНТНОГО ЧЕЛОВЕЧЕСКОГО АЛЬФА-2b ИНТЕРФЕРОНА И СПОСОБ ПОЛУЧЕНИЯ ИНТЕРФЕРОНА АЛЬФА-2b |
| WO2002040497A1 (en) * | 2000-11-14 | 2002-05-23 | The Board Of Trustees Of The Leland Stanford Junior University | In vitro protein synthesis using glycolytic intermediates as an energy source |
| DE60233417D1 (en) * | 2001-09-13 | 2009-10-01 | Genentech Inc | Aminopeptidase b2324 |
| JP2006506985A (ja) * | 2002-10-30 | 2006-03-02 | ファイザー・プロダクツ・インク | コンパニオンアニマルのガンを診断および治療するための方法および組成物 |
| BRPI0507233B8 (pt) * | 2004-03-11 | 2021-05-25 | Genentech Inc | processo para a produção de um polipeptídeo heterólogo em e. coli |
-
2005
- 2005-03-10 BR BRPI0507233A patent/BRPI0507233B8/pt not_active IP Right Cessation
- 2005-03-10 WO PCT/US2005/007880 patent/WO2005087802A2/en not_active Ceased
- 2005-03-10 JP JP2007502982A patent/JP5014116B2/ja not_active Expired - Fee Related
- 2005-03-10 SI SI200531927T patent/SI1733037T1/sl unknown
- 2005-03-10 ZA ZA200606913A patent/ZA200606913B/en unknown
- 2005-03-10 ES ES05725198.5T patent/ES2527291T3/es not_active Expired - Lifetime
- 2005-03-10 PT PT57251985T patent/PT1733037E/pt unknown
- 2005-03-10 HR HRP20150077TT patent/HRP20150077T1/hr unknown
- 2005-03-10 PL PL05725198T patent/PL1733037T3/pl unknown
- 2005-03-10 CA CA2946323A patent/CA2946323A1/en not_active Abandoned
- 2005-03-10 DK DK05725198.5T patent/DK1733037T3/en active
- 2005-03-10 RU RU2006135933/10A patent/RU2433185C2/ru active
- 2005-03-10 US US11/077,272 patent/US7294483B2/en not_active Expired - Lifetime
- 2005-03-10 AU AU2005222397A patent/AU2005222397A1/en not_active Abandoned
- 2005-03-10 CA CA2558911A patent/CA2558911C/en not_active Expired - Lifetime
- 2005-03-10 EP EP05725198.5A patent/EP1733037B1/en not_active Expired - Lifetime
- 2005-03-10 CN CN2005800153788A patent/CN1954074B/zh not_active Expired - Lifetime
- 2005-03-10 RS RS20150072A patent/RS53774B1/sr unknown
- 2005-03-10 NZ NZ549266A patent/NZ549266A/en not_active IP Right Cessation
- 2005-03-10 ME MEP-2015-13A patent/ME02058B/me unknown
-
2006
- 2006-08-15 IL IL177488A patent/IL177488A0/en unknown
- 2006-09-08 KR KR1020067018372A patent/KR101210083B1/ko not_active Expired - Fee Related
- 2006-09-28 US US11/536,551 patent/US20070026496A1/en not_active Abandoned
-
2009
- 2009-09-16 US US12/586,023 patent/US8389242B2/en not_active Expired - Fee Related
-
2013
- 2013-03-01 US US13/782,973 patent/US20130236930A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] | ||
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 10/03/2005 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
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| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 19A ANUIDADE. |
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| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2765 DE 02-01-2024 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |