BRPI0507580A - métodos para o isolamento e purificação do composto, e, para a fabricação de escitalopram - Google Patents
métodos para o isolamento e purificação do composto, e, para a fabricação de escitalopramInfo
- Publication number
- BRPI0507580A BRPI0507580A BRPI0507580-7A BRPI0507580A BRPI0507580A BR PI0507580 A BRPI0507580 A BR PI0507580A BR PI0507580 A BRPI0507580 A BR PI0507580A BR PI0507580 A BRPI0507580 A BR PI0507580A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- escitalopram
- manufacture
- methods
- derivative
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- WSEQXVZVJXJVFP-FQEVSTJZSA-N escitalopram Chemical compound C1([C@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-FQEVSTJZSA-N 0.000 title abstract 2
- 229960004341 escitalopram Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000002955 isolation Methods 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- VKWCJKDCPBCVNY-FQEVSTJZSA-N 2-[(1s)-4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile Chemical class C1([C@@](O)(CCCN(C)C)C=2C(=CC=CC=2CO)C#N)=CC=C(F)C=C1 VKWCJKDCPBCVNY-FQEVSTJZSA-N 0.000 abstract 2
- 125000002843 carboxylic acid group Chemical group 0.000 abstract 2
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/32—Separation; Purification; Stabilisation; Use of additives
- C07C253/34—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
Abstract
MéTODOS PARA O ISOLAMENTO E PURIFACAçãO DO COMPOSTO, E, PARA A FABRICAçãO DE ESCITALOPRAM. A invenção refere-se a um método de separação e isolamento de um derivado acilado de 4-¢(S)-4-dimeti-ilamino-1-(4-fluorofeinil)-1-hidroxibutil!-3-hidroximetilbe nzonitrila por reação de uma mistura de 4-¢(S)-4-dimeti-ilamino-1-(4-fluorofenil)-1-hidróxi-butil!-3-hidroximetil-be nzonitrila e um derivado acilado da mesma com um composto que forma um derivado de 4-¢(S)-4-dimetilamino-1-(4-fluorofenil)-1-hidróxi-butil!-3-hidroximetibenz onitrila contendo um grupo de ácido carboxílico. O derivado acilado contendo um grupo de ácido carboxílico precipita uma vez que ele é formado e pode facilmente ser separado da mistura de reação.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54497004P | 2004-02-12 | 2004-02-12 | |
| US60/544,970 | 2004-02-12 | ||
| DKPA200400217 | 2004-02-12 | ||
| DKPA200400217 | 2004-02-12 | ||
| PCT/DK2005/000075 WO2005077891A1 (en) | 2004-02-12 | 2005-02-02 | Method for the separation of intermediates which may be used for the preparation of escitalopram |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0507580A true BRPI0507580A (pt) | 2007-07-31 |
| BRPI0507580B1 BRPI0507580B1 (pt) | 2018-01-09 |
| BRPI0507580B8 BRPI0507580B8 (pt) | 2021-05-25 |
Family
ID=36603240
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0507580A BRPI0507580B8 (pt) | 2004-02-12 | 2005-02-02 | métodos para o isolamento e purificação do composto, e, para a fabricação de escitalopram |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7582780B2 (pt) |
| EP (1) | EP1716108B1 (pt) |
| JP (1) | JP4975450B2 (pt) |
| KR (1) | KR101156495B1 (pt) |
| CN (1) | CN1918112B (pt) |
| AR (1) | AR047522A1 (pt) |
| AT (1) | ATE411278T1 (pt) |
| AU (1) | AU2005212455A1 (pt) |
| BR (1) | BRPI0507580B8 (pt) |
| CA (1) | CA2555980C (pt) |
| DK (1) | DK1716108T3 (pt) |
| EA (1) | EA012503B1 (pt) |
| ES (1) | ES2315832T3 (pt) |
| IL (1) | IL177365A0 (pt) |
| MY (1) | MY144749A (pt) |
| NZ (1) | NZ548441A (pt) |
| PE (1) | PE20051139A1 (pt) |
| PL (1) | PL1716108T3 (pt) |
| PT (1) | PT1716108E (pt) |
| RS (1) | RS50689B (pt) |
| SI (1) | SI1716108T1 (pt) |
| TW (1) | TWI339651B (pt) |
| UA (1) | UA86403C2 (pt) |
| UY (1) | UY28743A1 (pt) |
| WO (1) | WO2005077891A1 (pt) |
| ZA (1) | ZA200606639B (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100548974C (zh) * | 2007-10-11 | 2009-10-14 | 浙江大学 | 西酞普兰中间体的萃取分离方法 |
| CN108640856B (zh) * | 2018-06-11 | 2021-06-25 | 淮阴工学院 | 一种依地普仑中间体的不对称合成方法及其中间体 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1526331A (en) * | 1976-01-14 | 1978-09-27 | Kefalas As | Phthalanes |
| GB8419963D0 (en) * | 1984-08-06 | 1984-09-12 | Lundbeck & Co As H | Intermediate compound and method |
| GB8814057D0 (en) | 1988-06-14 | 1988-07-20 | Lundbeck & Co As H | New enantiomers & their isolation |
| WO2000023431A1 (en) | 1998-10-20 | 2000-04-27 | H. Lundbeck A/S | Method for the preparation of citalopram |
| ITMI991579A1 (it) | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | Metodo per la preparazione di citalopram |
| ITMI991581A1 (it) | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | Metodo per la preparazione di citalopram |
| ITMI991486A1 (it) | 1999-07-06 | 2001-01-06 | Vis Farmaceutici S P A | Processo per la sintesi di citalopram |
| GB2360281B (en) * | 1999-10-25 | 2002-01-16 | Lundbeck & Co As H | Method for the preparation of citalopram |
| NL1017415C1 (nl) | 2000-02-24 | 2001-05-18 | Lundbeck & Co As H | Werkwijze voor de bereiding van Citalopram. |
| IES20010157A2 (en) | 2000-03-03 | 2002-03-06 | Lundbeck & Co As H | Method for the preparation of citalopram |
| SK14602002A3 (sk) | 2000-03-13 | 2003-02-04 | H. Lundbeck A/S | Spôsob výroby citalopramu a medziprodukty |
| BR0109364A (pt) | 2000-03-13 | 2002-12-24 | Lundbeck & Co As H | Métodos para fabricação de citalopram através de alquilação escalonada de 5-substituìda 1- (4-fluorofenil) - 1,3- diidroisobenzofuranos e citalopram |
| IL151488A0 (en) | 2000-03-14 | 2003-04-10 | Lundbeck & Co As H | Method for the preparation of citalopram |
| TR200202168T2 (tr) | 2000-03-16 | 2002-12-23 | H. Lundbeck A/S | 5-Siyano-1-(4-Florofenil)-1,3-Dihidroizobenzofuranların preparasyon metodu |
| AR034612A1 (es) | 2001-06-25 | 2004-03-03 | Lundbeck & Co As H | Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram |
| AR034759A1 (es) * | 2001-07-13 | 2004-03-17 | Lundbeck & Co As H | Metodo para la preparacion de escitalopram |
| ATE352546T1 (de) * | 2001-07-31 | 2007-02-15 | Lundbeck & Co As H | Kristalline zusammensetzung enthaltend escitalopram |
| IS7239A (is) * | 2001-12-14 | 2004-04-29 | H. Lundbeck A/S | Aðferð til framleiðslu á essítalóprami |
| ES2194597B2 (es) * | 2002-01-25 | 2004-08-01 | Esteve Quimica, S.A. | Procedimiento para la obtencion de citalopram. |
| GB0204607D0 (en) * | 2002-02-27 | 2002-04-10 | Matrix Lab Ltd | Process |
| CA2381341A1 (en) * | 2002-04-09 | 2003-10-09 | Torcan Chemical Ltd. | Process and intermediates for preparing escitalopram |
| AR040970A1 (es) * | 2002-08-12 | 2005-04-27 | Lundbeck & Co As H | Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram |
| JP4505335B2 (ja) * | 2002-12-23 | 2010-07-21 | ハー・ルンドベック・アクチエゼルスカベット | ラセミ体シタロプラムジオール（ｒａｃｅｍｉｃｃｉｔａｌｏｐｒａｍｄｉｏｌ）および／またはＳ−もしくはＲ−シタロプラムジオールの製造方法、およびラセミ体シタロプラム、Ｒ−シタロプラムおよび／またはＳ−シタロプラムを製造するために、上記ジオールを使用する方法。 |
-
2005
- 2005-01-24 TW TW094102002A patent/TWI339651B/zh not_active IP Right Cessation
- 2005-01-31 AR ARP050100350A patent/AR047522A1/es active IP Right Grant
- 2005-02-02 CA CA2555980A patent/CA2555980C/en not_active Expired - Fee Related
- 2005-02-02 ZA ZA200606639A patent/ZA200606639B/xx unknown
- 2005-02-02 JP JP2006552461A patent/JP4975450B2/ja not_active Expired - Lifetime
- 2005-02-02 CN CN2005800045942A patent/CN1918112B/zh not_active Expired - Lifetime
- 2005-02-02 BR BRPI0507580A patent/BRPI0507580B8/pt active IP Right Grant
- 2005-02-02 EA EA200601469A patent/EA012503B1/ru unknown
- 2005-02-02 ES ES05700625T patent/ES2315832T3/es not_active Expired - Lifetime
- 2005-02-02 EP EP05700625A patent/EP1716108B1/en not_active Expired - Lifetime
- 2005-02-02 DK DK05700625T patent/DK1716108T3/da active
- 2005-02-02 RS RSP-2008/0564A patent/RS50689B/sr unknown
- 2005-02-02 WO PCT/DK2005/000075 patent/WO2005077891A1/en not_active Ceased
- 2005-02-02 NZ NZ548441A patent/NZ548441A/en unknown
- 2005-02-02 AT AT05700625T patent/ATE411278T1/de active
- 2005-02-02 PL PL05700625T patent/PL1716108T3/pl unknown
- 2005-02-02 KR KR1020067016151A patent/KR101156495B1/ko not_active Expired - Lifetime
- 2005-02-02 PT PT05700625T patent/PT1716108E/pt unknown
- 2005-02-02 UA UAA200609731A patent/UA86403C2/uk unknown
- 2005-02-02 AU AU2005212455A patent/AU2005212455A1/en not_active Abandoned
- 2005-02-02 SI SI200530512T patent/SI1716108T1/sl unknown
- 2005-02-02 US US10/597,836 patent/US7582780B2/en not_active Expired - Lifetime
- 2005-02-03 MY MYPI20050416A patent/MY144749A/en unknown
- 2005-02-10 PE PE2005000157A patent/PE20051139A1/es not_active Application Discontinuation
- 2005-02-10 UY UY28743A patent/UY28743A1/es not_active Application Discontinuation
-
2006
- 2006-08-08 IL IL177365A patent/IL177365A0/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] | ||
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/02/2005 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |