ECSP088876A - Formas de polimorfos de la (2s)-(4e)-n-metil-5-(3-isopropoxipiridin)il]-4-penten-2-amina para el tratamiento de desórdenes del sistema nervioso central - Google Patents

Formas de polimorfos de la (2s)-(4e)-n-metil-5-(3-isopropoxipiridin)il]-4-penten-2-amina para el tratamiento de desórdenes del sistema nervioso central

Info

Publication number
ECSP088876A
ECSP088876A EC2008008876A ECSP088876A ECSP088876A EC SP088876 A ECSP088876 A EC SP088876A EC 2008008876 A EC2008008876 A EC 2008008876A EC SP088876 A ECSP088876 A EC SP088876A EC SP088876 A ECSP088876 A EC SP088876A
Authority
EC
Ecuador
Prior art keywords
penten
methyl
isopropoxipiridin
polymorphes
amina
Prior art date
Application number
EC2008008876A
Other languages
English (en)
Inventor
Gary Maurice Dull
Julio A Munoz
Original Assignee
Targacept Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Targacept Inc filed Critical Targacept Inc
Publication of ECSP088876A publication Critical patent/ECSP088876A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

La presente invención se relaciona a las formas de polimorfos del (2S)-(4E)-N-metil-5-[3-(5-isopropoxipiridin)il]-4-penten-2-amina p-hidroxibenzoato y métodos para su preparación. También se relaciona con composiciones farmacéuticas que contienen dichos polimorfos.
EC2008008876A 2006-05-09 2008-11-07 Formas de polimorfos de la (2s)-(4e)-n-metil-5-(3-isopropoxipiridin)il]-4-penten-2-amina para el tratamiento de desórdenes del sistema nervioso central ECSP088876A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74682106P 2006-05-09 2006-05-09

Publications (1)

Publication Number Publication Date
ECSP088876A true ECSP088876A (es) 2009-02-27

Family

ID=38441430

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008876A ECSP088876A (es) 2006-05-09 2008-11-07 Formas de polimorfos de la (2s)-(4e)-n-metil-5-(3-isopropoxipiridin)il]-4-penten-2-amina para el tratamiento de desórdenes del sistema nervioso central

Country Status (29)

Country Link
US (3) US8461344B2 (es)
EP (2) EP2418201B1 (es)
JP (1) JP4477097B2 (es)
KR (1) KR20090005369A (es)
CN (1) CN101472893A (es)
AR (1) AR060786A1 (es)
AU (1) AU2007249485B2 (es)
BR (1) BRPI0709781A2 (es)
CA (1) CA2649961A1 (es)
DK (1) DK2418201T3 (es)
EC (1) ECSP088876A (es)
ES (1) ES2460919T3 (es)
HR (1) HRP20140385T1 (es)
IL (1) IL194833A0 (es)
MX (1) MX2008013982A (es)
MY (1) MY144132A (es)
NO (1) NO20084567L (es)
NZ (1) NZ597177A (es)
PL (1) PL2418201T3 (es)
PT (1) PT2418201E (es)
RS (1) RS53286B (es)
RU (1) RU2440984C2 (es)
SA (1) SA07280230B1 (es)
SI (1) SI2418201T1 (es)
TW (1) TWI389889B (es)
UA (1) UA96447C2 (es)
UY (1) UY30330A1 (es)
WO (1) WO2007134034A1 (es)
ZA (1) ZA200809284B (es)

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TWI389889B (zh) 2006-05-09 2013-03-21 Targacept Inc （２ｓ）-（４ｅ）-ｎ-甲基-５-〔３-（５-異丙氧基吡啶）基〕-４-戊烯-２-胺之新穎多晶型
EP2021325A2 (en) * 2006-05-09 2009-02-11 AstraZeneca AB Salt forms of (2s)-(4e)-n-methyl-5-[3-(5-isopropoxypyridin)yl]-4-penten-2-amine
TW200829244A (en) * 2006-09-15 2008-07-16 Astrazeneca Ab Therapeutic combinations 482
EP2112923A1 (en) * 2007-01-22 2009-11-04 Targacept Inc. Intranasal, buccal, and sublingual administration of metanicotine analogs
CN101772343A (zh) * 2007-07-31 2010-07-07 塔格赛普有限公司 (2s)-(4e)-n-甲基-5-(3-(5-异丙氧基吡啶)基)-4-戊烯-2-胺的经皮给药
US20110130428A1 (en) * 2008-06-11 2011-06-02 Astrazeneca Ab Sublingual Compositions Comprising (2S) - (4E) -N-Methyl-5- (3- (5-Isopropoxypyridin) YL)-4-Penten-2-Amine
WO2010080757A2 (en) * 2009-01-07 2010-07-15 Astrazeneca Ab Combinations with an alpha-4beta-2 nicotinic agonist
FR2959107B1 (fr) 2010-04-23 2015-03-27 Oreal Unite d'application d'un produit cosmetique
BR112012029326A2 (pt) * 2010-05-20 2017-08-08 Astrazeneca Ab processo para a preparação de animais olefínicas substituídas por arila
WO2013184732A1 (en) * 2012-06-06 2013-12-12 Targacept, Inc. Crystalline (2s)-(4e)-n-methyl-5-[3-(5-isopropoxypyridin)yl]4-penten-2-amine 1,5-naphthalenedisulfonate
KR101579904B1 (ko) 2014-09-05 2016-01-05 동신대학교산학협력단 마스카라

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Also Published As

Publication number Publication date
US20100048643A1 (en) 2010-02-25
ZA200809284B (en) 2009-08-26
US20070265314A1 (en) 2007-11-15
IL194833A0 (en) 2009-08-03
RU2008148325A (ru) 2010-06-20
JP4477097B2 (ja) 2010-06-09
US20130310425A1 (en) 2013-11-21
WO2007134034A1 (en) 2007-11-22
NO20084567L (no) 2008-12-04
US8461344B2 (en) 2013-06-11
SI2418201T1 (sl) 2014-06-30
CN101472893A (zh) 2009-07-01
MX2008013982A (es) 2009-03-13
SA07280230B1 (ar) 2010-08-20
RS53286B (sr) 2014-08-29
CA2649961A1 (en) 2007-11-22
AU2007249485B2 (en) 2012-11-01
AR060786A1 (es) 2008-07-10
TWI389889B (zh) 2013-03-21
MY144132A (en) 2011-08-15
PL2418201T3 (pl) 2014-07-31
TW200808726A (en) 2008-02-16
RU2440984C2 (ru) 2012-01-27
JP2009531465A (ja) 2009-09-03
EP2021326A1 (en) 2009-02-11
KR20090005369A (ko) 2009-01-13
ES2460919T3 (es) 2014-05-16
DK2418201T3 (da) 2014-05-12
EP2418201A1 (en) 2012-02-15
BRPI0709781A2 (pt) 2011-07-26
UY30330A1 (es) 2008-10-31
AU2007249485A1 (en) 2007-11-22
EP2418201B1 (en) 2014-02-12
HRP20140385T1 (hr) 2014-06-06
UA96447C2 (ru) 2011-11-10
PT2418201E (pt) 2014-04-14
NZ597177A (en) 2013-06-28

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