BRPI0508225A - compostos de tetraidroquinolinonas, composição e seus usos como antagonistas de receptores metabotrópicos de glutamato - Google Patents

compostos de tetraidroquinolinonas, composição e seus usos como antagonistas de receptores metabotrópicos de glutamato

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Publication number
BRPI0508225A
BRPI0508225A BRPI0508225-0A BRPI0508225A BRPI0508225A BR PI0508225 A BRPI0508225 A BR PI0508225A BR PI0508225 A BRPI0508225 A BR PI0508225A BR PI0508225 A BRPI0508225 A BR PI0508225A
Authority
BR
Brazil
Prior art keywords
compounds
composition
receptor antagonists
glutamate receptor
metabotropic glutamate
Prior art date
Application number
BRPI0508225-0A
Other languages
English (en)
Inventor
Christopher Graham Rap Parsons
Aigars Jirgensons
Ieva Jaunzeme
Ivars Kalvinsh
Markus Henrich
Maksims Venejevs
Tanja Weil
Valerjans Kauss
Wojciech Danysz
Original Assignee
Merz Pharma Gmbh & Co Kgaa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merz Pharma Gmbh & Co Kgaa filed Critical Merz Pharma Gmbh & Co Kgaa
Publication of BRPI0508225A publication Critical patent/BRPI0508225A/pt

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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Abstract

COMPOSTOS DE TETRAIDROQUINOLINONAS, COMPOSIçãO E SEUS USOS COMO ANTAGONISTAS DE RECEPTORES METABOTRóPICOS DE GLUTAMATO Essa invenção se refere aos derivados de tetraidroquinolinona, bem como seus sais farmaceuticamente aceitáveis, A invenção se refere, adicionalmente, a um processo para preparação de tais compostos. Os compostos da invenção são antagonistas mGLuR do grupo I e são portanto, úteis para o controle e prevenção de distúrbios neurológicos agudos e/ou crónicos,
BRPI0508225-0A 2004-02-27 2005-02-25 compostos de tetraidroquinolinonas, composição e seus usos como antagonistas de receptores metabotrópicos de glutamato BRPI0508225A (pt)

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CA2556653C (en) 2011-08-16
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