BRPI0508808A - processo quimio-enzimático para preparar escitalopram - Google Patents

processo quimio-enzimático para preparar escitalopram

Info

Publication number
BRPI0508808A
BRPI0508808A BRPI0508808-9A BRPI0508808A BRPI0508808A BR PI0508808 A BRPI0508808 A BR PI0508808A BR PI0508808 A BRPI0508808 A BR PI0508808A BR PI0508808 A BRPI0508808 A BR PI0508808A
Authority
BR
Brazil
Prior art keywords
chemo
escitalopram
enzymatic process
enzymatic
prepare
Prior art date
Application number
BRPI0508808-9A
Other languages
English (en)
Inventor
Giovanni Cotticelli
Silvia Rocchietti
Marco Terreni
Massimo Pregnolato
Raul Salvetti
Original Assignee
Adorkem Technology Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adorkem Technology Spa filed Critical Adorkem Technology Spa
Publication of BRPI0508808A publication Critical patent/BRPI0508808A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Processo quimio-enzimático para preparar Escitalopram. O presente invento descreve um processo para preparar o intermediário para sintetizar escitalopram e os sais farmaceuticamente aceitáveis a partir de 4-(4-dimetilamino)-1-(4'-fluorofenil)-1-(hidroxibutil)-3-(aciloximetil) benzonitrila que, por meio de resolução enantiomérica enzimática, é sintetizada em um dos seus enantiómeros.
BRPI0508808-9A 2004-04-09 2005-04-07 processo quimio-enzimático para preparar escitalopram BRPI0508808A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000717A ITMI20040717A1 (it) 2004-04-09 2004-04-09 Procedimento chemo-enzimatico per la preparazione dell'escitalopram
PCT/IB2005/001067 WO2005098018A1 (en) 2004-04-09 2005-04-07 Chemo-enzymatic process for preparing escitalopram

Publications (1)

Publication Number Publication Date
BRPI0508808A true BRPI0508808A (pt) 2007-08-07

Family

ID=34967756

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0508808-9A BRPI0508808A (pt) 2004-04-09 2005-04-07 processo quimio-enzimático para preparar escitalopram

Country Status (16)

Country Link
US (1) US7470526B2 (pt)
EP (1) EP1733042B1 (pt)
JP (1) JP2007532106A (pt)
CN (1) CN1946854A (pt)
AT (1) ATE395429T1 (pt)
BR (1) BRPI0508808A (pt)
CA (1) CA2561888A1 (pt)
DE (1) DE602005006770D1 (pt)
DK (1) DK1733042T3 (pt)
ES (1) ES2308465T3 (pt)
IT (1) ITMI20040717A1 (pt)
MX (1) MXPA06011609A (pt)
PL (1) PL1733042T3 (pt)
PT (1) PT1733042E (pt)
SI (1) SI1733042T1 (pt)
WO (1) WO2005098018A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20041872A1 (it) 2004-10-01 2005-01-01 Adorkem Technology Spa Processo per la preparazione di citalopram e di scitalopram
EP1736550A1 (en) * 2005-06-22 2006-12-27 Adorkem Technology SpA Chemoenzymatic process for the synthesis of escitalopram
US11008597B2 (en) * 2014-04-10 2021-05-18 Genomatica, Inc. Chemo-enzymatic process
KR20170029625A (ko) 2014-07-18 2017-03-15 알이지 라이프 사이언시스, 엘엘씨 지방 디올의 미생물 생산

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
JPS62151196A (ja) * 1985-09-26 1987-07-06 Nitto Electric Ind Co Ltd ｌ−プロプラノロ−ルの生化学的分離法
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
JP3097145B2 (ja) * 1991-02-27 2000-10-10 日産化学工業株式会社 コーリーラクトンジオールの光学分割方法
CA2291134C (en) * 1998-10-20 2006-05-23 H. Lundbeck A/S Method for the preparation of citalopram
EA004742B1 (ru) * 1999-12-28 2004-08-26 Х.Лундбекк А/С Способ получения циталопрама
AR034612A1 (es) 2001-06-25 2004-03-03 Lundbeck & Co As H Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
AR034759A1 (es) 2001-07-13 2004-03-17 Lundbeck & Co As H Metodo para la preparacion de escitalopram
IS7239A (is) 2001-12-14 2004-04-29 H. Lundbeck A/S Aðferð til framleiðslu á essítalóprami
AR040970A1 (es) * 2002-08-12 2005-04-27 Lundbeck & Co As H Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram

Also Published As

Publication number Publication date
CN1946854A (zh) 2007-04-11
CA2561888A1 (en) 2005-10-20
DE602005006770D1 (de) 2008-06-26
ES2308465T3 (es) 2008-12-01
EP1733042B1 (en) 2008-05-14
SI1733042T1 (sl) 2008-10-31
ATE395429T1 (de) 2008-05-15
WO2005098018A1 (en) 2005-10-20
JP2007532106A (ja) 2007-11-15
MXPA06011609A (es) 2007-01-23
PL1733042T3 (pl) 2008-10-31
HK1101827A1 (en) 2007-10-26
DK1733042T3 (da) 2008-09-08
US20070238887A1 (en) 2007-10-11
US7470526B2 (en) 2008-12-30
PT1733042E (pt) 2008-07-29
ITMI20040717A1 (it) 2004-07-09
EP1733042A1 (en) 2006-12-20

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A E 6A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE A 8.6 NA RPI 2099 DE 29/03/2011.