BRPI0408767A - inibidores de transcriptase reversa não-nucleosìdeos i para o tratamento de doenças mediadas pelo hiv - Google Patents

inibidores de transcriptase reversa não-nucleosìdeos i para o tratamento de doenças mediadas pelo hiv

Info

Publication number
BRPI0408767A
BRPI0408767A BRPI0408767-4A BRPI0408767A BRPI0408767A BR PI0408767 A BRPI0408767 A BR PI0408767A BR PI0408767 A BRPI0408767 A BR PI0408767A BR PI0408767 A BRPI0408767 A BR PI0408767A
Authority
BR
Brazil
Prior art keywords
hiv
treatment
reverse transcriptase
formula
compounds
Prior art date
Application number
BRPI0408767-4A
Other languages
English (en)
Inventor
James Patrick Dunn
Steven Swallow
Zachary Kevin Sweeney
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to BR122016023941-1A priority Critical patent/BR122016023941B1/pt
Publication of BRPI0408767A publication Critical patent/BRPI0408767A/pt
Publication of BRPI0408767B1 publication Critical patent/BRPI0408767B1/pt
Publication of BRPI0408767B8 publication Critical patent/BRPI0408767B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/13—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)

Abstract

"INIBIDORES DA TRANSCRIPTASE REVERSA NãO-NUCLEOSìDEOS I PARA O TRATAMENTO DE DOENçAS MEDIADAS PELO HIV". A presente invenção refere-se a novos compostos heterocíclicos de fórmula (I), em que R¬ 1¬-R¬ 4¬, X¬ 1¬ e X¬ 2¬ são como definidos no sumário e sais e solvatos farmaceuticamente aceitáveis destes, métodos para inibir ou modular a transcriptase reversa do Vírus da Imunodeficiência Humana (HIV) com compostos de fórmula (I), composições farmacêuticas contendo a fórmula I misturadas com pelo menos um solvente, veículo ou excipiente e processos para se preparar os compostos de fórmula I. O compostos são úteis para o tratamento de distúrbios, em que o HIV e os vírus geneticamente relacionados estão envolvidos.
BRPI0408767A 2003-03-24 2004-03-22 inlbidores da transcriptase reversa não-nucleosídeos para tratamento de doenças mediadas pelo hiv, seu uso, e composição farmacêutica BRPI0408767B8 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122016023941-1A BR122016023941B1 (pt) 2003-03-24 2004-03-22 Inibidores da transcriptase reversa não-nucleosídeos para tratamento de doenças mediadas pelo hiv, seu uso e composição farmacêutica

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45713003P 2003-03-24 2003-03-24
US60/457,130 2003-03-24
PCT/EP2004/002995 WO2004085411A1 (en) 2003-03-24 2004-03-22 Non-nucleoside reverse transcriptase inhibitors i for treating hiv mediated diseases

Publications (3)

Publication Number Publication Date
BRPI0408767A true BRPI0408767A (pt) 2006-03-28
BRPI0408767B1 BRPI0408767B1 (pt) 2017-10-31
BRPI0408767B8 BRPI0408767B8 (pt) 2021-05-25

Family

ID=33098199

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0408767A BRPI0408767B8 (pt) 2003-03-24 2004-03-22 inlbidores da transcriptase reversa não-nucleosídeos para tratamento de doenças mediadas pelo hiv, seu uso, e composição farmacêutica
BR122016023941-1A BR122016023941B1 (pt) 2003-03-24 2004-03-22 Inibidores da transcriptase reversa não-nucleosídeos para tratamento de doenças mediadas pelo hiv, seu uso e composição farmacêutica

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR122016023941-1A BR122016023941B1 (pt) 2003-03-24 2004-03-22 Inibidores da transcriptase reversa não-nucleosídeos para tratamento de doenças mediadas pelo hiv, seu uso e composição farmacêutica

Country Status (20)

Country Link
US (2) US7208509B2 (pt)
EP (1) EP1608633B1 (pt)
JP (1) JP4708329B2 (pt)
KR (1) KR101122456B1 (pt)
CN (1) CN100588650C (pt)
AR (1) AR043673A1 (pt)
AU (1) AU2004224153B2 (pt)
BR (2) BRPI0408767B8 (pt)
CA (1) CA2518437C (pt)
CL (1) CL2004000590A1 (pt)
CO (1) CO5601029A2 (pt)
ES (1) ES2574580T3 (pt)
HR (1) HRP20050830A2 (pt)
IL (1) IL170343A (pt)
MX (1) MXPA05010210A (pt)
NO (1) NO334095B1 (pt)
NZ (1) NZ541829A (pt)
RU (1) RU2342367C2 (pt)
TW (1) TW200505441A (pt)
WO (1) WO2004085411A1 (pt)

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CN100516065C (zh) * 2004-04-01 2009-07-22 安万特药物公司 1,3,4-二唑-2-酮作为PPAR-δ调节剂
US8293778B2 (en) 2004-07-27 2012-10-23 Roche Palo Alto Llc Heterocyclic antiviral compounds
ES2391461T3 (es) * 2004-07-27 2012-11-27 F. Hoffmann-La Roche Ag Compuestos de benciltriazolona utilizados como inhibidores no nucleósidos de transcriptasa inversa
EP1863777A1 (en) * 2005-03-24 2007-12-12 F.Hoffmann-La Roche Ag 1,2,4 -triazole-5-one compounds as heterocyclic reverse transcriptase inhibitors
AR057455A1 (es) 2005-07-22 2007-12-05 Merck & Co Inc Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica
BRPI0617205A2 (pt) * 2005-09-30 2011-07-19 Hoffmann La Roche inibidores de nnrt
EP1940781A1 (en) 2005-10-19 2008-07-09 F.Hoffmann-La Roche Ag Phenyl-acetamide nnrt inhibitors
ES2380683T3 (es) * 2005-12-15 2012-05-17 Astrazeneca Ab Difenil-éteres, -amidas, -sulfuros y - metanos sustituidos para el tratamiento de la enfermedad respiratoria
KR101477822B1 (ko) 2006-07-07 2015-01-02 길리애드 사이언시즈, 인코포레이티드 치료제의 약동학 특성의 모듈레이터
CL2007002105A1 (es) * 2006-07-21 2008-02-22 Hoffmann La Roche Compuestos derivados de 2-[3-(3-cianofenoxi)(fenoxi o fenilsulfanil)]-n-fenil acetamida, inhibidores de la transcriptasa inversa del vih; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar u
DE602007013573D1 (de) * 2006-08-16 2011-05-12 Hoffmann La Roche Nicht-nukleosidische reverse-transkriptase-hemmer
TW200831085A (en) * 2006-12-13 2008-08-01 Merck & Co Inc Non-nucleoside reverse transcriptase inhibitors
PT3150586T (pt) * 2007-02-23 2020-03-31 Gilead Sciences Inc Moduladores de propriedades farmacocinéticas de agentes terapêuticos
EP2134711A2 (en) * 2007-04-09 2009-12-23 F. Hoffmann-Roche AG Non-nucleoside reverse transcriptase inhibitors
CA2687770C (en) * 2007-05-30 2016-03-08 F. Hoffmann-La Roche Ag Process for preparing triazolones
BRPI0811645A2 (pt) 2007-05-30 2014-11-11 Hoffmann La Roche Inibidores de transcriptase reversa de não-nucleosídeo
WO2008157273A1 (en) * 2007-06-14 2008-12-24 Smithkline Beecham Corporation Chemical compounds
WO2008157330A1 (en) * 2007-06-14 2008-12-24 Smithkline Beecham Corporation Chemical compounds
WO2009000663A1 (en) * 2007-06-22 2008-12-31 F. Hoffmann-La Roche Ag Urea and carbamate derivatives as non-nucleoside reverse transcriptase inhibitors
US8492415B2 (en) * 2007-07-03 2013-07-23 Yale University Azoles and related derivatives as non-nucleoside reverse transcriptase inhibitors (NNRTIs) in antiviral therapy (HIV)
AU2008340422B2 (en) * 2007-12-21 2014-06-19 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds
MX2012011379A (es) * 2010-03-30 2012-11-30 Merck Canada Inc Inhibidores no nucleosidicos de la transcriptasa inversa.
CU23896B1 (es) * 2010-04-01 2013-05-31 Ct De Ingeniería Genética Y Biotecnología Método para inhibir la replicación del vih en células de mamíferos
JO3470B1 (ar) 2012-10-08 2020-07-05 Merck Sharp & Dohme مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv
CN104230929B (zh) * 2013-06-19 2015-11-18 华东师范大学 一种非核苷类hiv-1反转录酶抑制剂
SI3125894T1 (sl) 2014-04-01 2020-12-31 Merck Sharp & Dohme Corp. Predzdravila inhibitorjev reverzne transkriptaze HIV
WO2026042788A1 (ja) * 2024-08-20 2026-02-26 塩野義製薬株式会社 複素環誘導体

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Also Published As

Publication number Publication date
NO334095B1 (no) 2013-12-09
HRP20050830A2 (en) 2006-09-30
US7348345B2 (en) 2008-03-25
CN100588650C (zh) 2010-02-10
CA2518437A1 (en) 2004-10-07
IL170343A (en) 2014-03-31
EP1608633B1 (en) 2016-04-20
RU2005132632A (ru) 2006-06-10
TW200505441A (en) 2005-02-16
NO20054264D0 (no) 2005-09-15
KR20050115294A (ko) 2005-12-07
US20070179157A1 (en) 2007-08-02
US20040192704A1 (en) 2004-09-30
WO2004085411A1 (en) 2004-10-07
AU2004224153A1 (en) 2004-10-07
BRPI0408767B8 (pt) 2021-05-25
CN1759104A (zh) 2006-04-12
CA2518437C (en) 2012-07-10
RU2342367C2 (ru) 2008-12-27
KR101122456B1 (ko) 2012-04-26
AU2004224153B2 (en) 2009-04-02
BRPI0408767B1 (pt) 2017-10-31
NZ541829A (en) 2008-11-28
JP4708329B2 (ja) 2011-06-22
MXPA05010210A (es) 2005-11-23
JP2006521319A (ja) 2006-09-21
NO20054264L (no) 2005-10-14
CO5601029A2 (es) 2006-01-31
EP1608633A1 (en) 2005-12-28
BR122016023941B1 (pt) 2021-10-13
US7208509B2 (en) 2007-04-24
CL2004000590A1 (es) 2005-02-04
ES2574580T3 (es) 2016-06-20
AR043673A1 (es) 2005-08-03

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
B16C Correction of notification of the grant [chapter 16.3 patent gazette]

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