BRPI0510994A - composições farmacêuticas - Google Patents

composições farmacêuticas

Info

Publication number
BRPI0510994A
BRPI0510994A BRPI0510994-9A BRPI0510994A BRPI0510994A BR PI0510994 A BRPI0510994 A BR PI0510994A BR PI0510994 A BRPI0510994 A BR PI0510994A BR PI0510994 A BRPI0510994 A BR PI0510994A
Authority
BR
Brazil
Prior art keywords
compounds
bipyrimidinyl
pharmaceutical compositions
heteroaryl
cycloalkyl
Prior art date
Application number
BRPI0510994-9A
Other languages
English (en)
Inventor
Albert Sun-Chi Chan
Gang Chen
Rongwei Guo
Jing Wu
Original Assignee
Univ Hong Kong Polytechnic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Hong Kong Polytechnic filed Critical Univ Hong Kong Polytechnic
Publication of BRPI0510994A publication Critical patent/BRPI0510994A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
    • B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
    • B01J31/2409—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring with more than one complexing phosphine-P atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/006—Palladium compounds
    • C07F15/0066—Palladium compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/40—Substitution reactions at carbon centres, e.g. C-C or C-X, i.e. carbon-hetero atom, cross-coupling, C-H activation or ring-opening reactions
    • B01J2231/44—Allylic alkylation, amination, alkoxylation or analogues
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/10—Complexes comprising metals of Group I (IA or IB) as the central metal
    • B01J2531/16—Copper
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/821—Ruthenium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/822—Rhodium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/824—Palladium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/827—Iridium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/828—Platinum
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/84—Metals of the iron group
    • B01J2531/847—Nickel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

COMPOSIçõES FARMACêUTICAS. A presente invenção fornece compostos de bipirimidinila difosfina de fórmula (I), onde R é alquila opcionalmente substituída, cicloalquila, arila ou heteroarila; R<39> e R"são independentemente alquila opcionalmente substituída, cicloalquila, arila ou heteroarila; ou um enantiómero deste; ou uma mistura enantiomérica deste. Os compostos de fórmula (I) são compostos de bipirimidinila difosfina atropisométricos e, logo, podem ser empregados como ligantes para gerar catalisadores de metal de transição que podem ser aplicados em uma variedade de reações assimétricas, por exemplo, em reações de substituição alílicas assimétricas catalisadas por paládio. Os compostos da presente invenção são de fácila acesso em alta pureza isométrica de acordo com os métodos divulgados aqui.
BRPI0510994-9A 2004-05-11 2005-05-11 composições farmacêuticas BRPI0510994A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56982604P 2004-05-11 2004-05-11
PCT/CN2005/000654 WO2005108377A1 (en) 2004-05-11 2005-05-11 Pharmaceutical compositions

Publications (1)

Publication Number Publication Date
BRPI0510994A true BRPI0510994A (pt) 2007-12-04

Family

ID=35320174

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0510994-9A BRPI0510994A (pt) 2004-05-11 2005-05-11 composições farmacêuticas

Country Status (10)

Country Link
US (2) US7674900B2 (pt)
EP (1) EP1747205B1 (pt)
JP (1) JP4926043B2 (pt)
KR (1) KR101189935B1 (pt)
CN (1) CN100577650C (pt)
BR (1) BRPI0510994A (pt)
ES (1) ES2390277T3 (pt)
PL (1) PL1747205T3 (pt)
PT (1) PT1747205E (pt)
WO (1) WO2005108377A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009046469A (ja) * 2007-07-26 2009-03-05 Chiba Univ 光学活性アリル化合物類の製造方法
ITMI20121489A1 (it) * 2012-09-06 2014-03-07 Univ Degli Studi Milano Metodo per la riduzione di nitro derivati ad ammine
KR20230113577A (ko) * 2020-11-25 2023-07-31 암젠 인크 알데히드의 거울상이성질체 선택적 알케닐화

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62265293A (ja) * 1986-05-13 1987-11-18 Takasago Corp ルテニウム−ホスフイン錯体
JP3148136B2 (ja) * 1996-12-26 2001-03-19 高砂香料工業株式会社 新規なキラルジホスフィン化合物、その製造中間体、該ジホス フィン化合物を配位子とする遷移金属錯体並びに該錯体を含む 不斉水素化触媒
JP2000044544A (ja) * 1998-07-30 2000-02-15 Daicel Chem Ind Ltd ビピリミジン化合物及びその重合体とその利用法

Also Published As

Publication number Publication date
US20080255356A1 (en) 2008-10-16
EP1747205A4 (en) 2008-02-13
US7674900B2 (en) 2010-03-09
EP1747205A1 (en) 2007-01-31
US20070225497A1 (en) 2007-09-27
KR20070008694A (ko) 2007-01-17
CN100577650C (zh) 2010-01-06
ES2390277T3 (es) 2012-11-08
JP2007537030A (ja) 2007-12-20
WO2005108377A1 (en) 2005-11-17
EP1747205B1 (en) 2012-06-20
CN1950344A (zh) 2007-04-18
PL1747205T3 (pl) 2012-11-30
PT1747205E (pt) 2012-09-20
KR101189935B1 (ko) 2012-10-12
US7713900B2 (en) 2010-05-11
JP4926043B2 (ja) 2012-05-09

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Legal Events

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08E Application fees: payment of additional fee required [chapter 8.5 patent gazette]

Free format text: COMPLEMENTAR A RETRIBUICAO DA(S) 7A., 8A., 9A. E 10A. ANUIDADE(S), DE ACORDO COM TABELA VIGENTE, REFERENTE A(S) GUIA(S) DE RECOLHIMENTO 22110520899-5, 92120366692-5, 92130370338-5 E 92140437092-6, RESPECTIVAMENTE E COMPROVAR O RECOLHIMENTO DA(S) 11A. ANUIDADE(S).

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]