BRPI0511186A - composto, pró-droga do composto, composição farmacêutica, uso do composto, e, processo para preparar o composto - Google Patents
composto, pró-droga do composto, composição farmacêutica, uso do composto, e, processo para preparar o compostoInfo
- Publication number
- BRPI0511186A BRPI0511186A BRPI0511186-2A BRPI0511186A BRPI0511186A BR PI0511186 A BRPI0511186 A BR PI0511186A BR PI0511186 A BRPI0511186 A BR PI0511186A BR PI0511186 A BRPI0511186 A BR PI0511186A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- optionally substituted
- bond
- pharmaceutical composition
- preparing
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 9
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000000651 prodrug Substances 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 150000003950 cyclic amides Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
COMPOSTO, PRó-DROGA DO COMPOSTO, COMPOSIçãO FARMACêUTICA, USO DO COMPOSTO, E , PROCESSO PARA PREPARAR O COMPOSTO A presente invenção fornece um derivado de amida cíclica útil como um medicamento para tratar fórmula (I): em que R¬ 1¬ representa um grupo hidrocarboneto cíclico opcionalmente substituído ou um grupo heterocíclico opcionalmente substituído. W representa uma ligação ou um grupo hidrocarboneto de cadeia divalente opcionalmente substituído, a representa 0,1 ou 2, X¬ 1¬ representa um alquileno inferior opcionalmente substituído ou um alquenileno inferior opcionalmente substituído, Y¬ 1¬ representa -C(O)-, -S(O)- ou -S(O)~ 2~-, A representa um anel piperazina que pode ser ainda substituído ou um anel piperidina que pode ser ainda substituído, X¬ 2¬ representa uma ligação ou um alquileno inferior opcionalmente substituído, Y¬ 2¬ representa -C(O)-, -S(O)-, -S(O~ 2~- ou -C(=NR¬ 7¬)-, X¬ 3¬ representa um alquileno C~ 1~-~ 4~ opcionalmente substituído ou um alquenileno C~ 2~-~ 4~ opcionalmente substituído, Z¬ 3¬ representa - N(R¬ 4¬)-, -O- ou uma ligação, Z¬ 1¬ representa -C(R¬ 2¬) (R¬ 2¬)-, -N(R¬ 2¬)-, etc., e Z¬ 2¬ representa -C(R¬ 3¬)(R¬ 3¬)-, -N(R¬ 3¬)-, etc., ou um sal destes.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004152000 | 2004-05-21 | ||
| PCT/JP2005/009711 WO2005113504A1 (en) | 2004-05-21 | 2005-05-20 | Cyclic amide derivatives, and their production and use as antithrombotic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0511186A true BRPI0511186A (pt) | 2007-12-04 |
Family
ID=34968275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0511186-2A BRPI0511186A (pt) | 2004-05-21 | 2005-05-20 | composto, pró-droga do composto, composição farmacêutica, uso do composto, e, processo para preparar o composto |
Country Status (26)
| Country | Link |
|---|---|
| US (4) | US7745623B2 (pt) |
| EP (2) | EP1748985B1 (pt) |
| JP (2) | JP4129047B2 (pt) |
| KR (1) | KR101248637B1 (pt) |
| CN (2) | CN102093285B (pt) |
| AT (1) | ATE513813T1 (pt) |
| AU (1) | AU2005245298B2 (pt) |
| BR (1) | BRPI0511186A (pt) |
| CA (1) | CA2567506C (pt) |
| CY (1) | CY1111850T1 (pt) |
| DK (1) | DK1748985T3 (pt) |
| ES (1) | ES2368155T3 (pt) |
| HR (1) | HRP20110640T1 (pt) |
| IL (1) | IL178896A (pt) |
| MX (1) | MXPA06013243A (pt) |
| MY (1) | MY154461A (pt) |
| NO (1) | NO20065929L (pt) |
| NZ (1) | NZ550985A (pt) |
| PH (1) | PH12012501331A1 (pt) |
| PL (1) | PL1748985T3 (pt) |
| PT (1) | PT1748985E (pt) |
| RS (1) | RS51925B (pt) |
| RU (1) | RU2361861C2 (pt) |
| SI (1) | SI1748985T1 (pt) |
| TW (1) | TWI396686B (pt) |
| WO (1) | WO2005113504A1 (pt) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030187023A1 (en) * | 2000-07-17 | 2003-10-02 | Keiji Kubo | Sulfone derivatives, process for their production and use thereof |
| WO2004048363A1 (ja) * | 2002-11-22 | 2004-06-10 | Takeda Pharmaceutical Company Limited | イミダゾール誘導体、その製造法および用途 |
| TWI396686B (zh) * | 2004-05-21 | 2013-05-21 | Takeda Pharmaceutical | 環狀醯胺衍生物、以及其製品和用法 |
| JP2009517406A (ja) * | 2005-11-28 | 2009-04-30 | ザイモジェネティクス， インコーポレイテッド | Ｉｌ−２１受容体アンタゴニスト |
| US20110045028A1 (en) * | 2006-11-30 | 2011-02-24 | Takeda Pharmaceutical Company Limited | Sustained release preparation |
| AR073380A1 (es) | 2008-09-25 | 2010-11-03 | Takeda Pharmaceutical | Composicion farmaceutica solida. comprimido multicapa |
| JP5535931B2 (ja) | 2008-10-27 | 2014-07-02 | 武田薬品工業株式会社 | 二環性化合物 |
| WO2010076884A1 (ja) | 2008-12-29 | 2010-07-08 | 武田薬品工業株式会社 | 新規縮合環化合物およびその用途 |
| US20100190747A1 (en) | 2009-01-27 | 2010-07-29 | Hideo Suzuki | Fused ring compound and use thereof |
| CA2760073A1 (en) | 2009-04-30 | 2010-11-04 | Takeda Pharmaceutical Company Limited | Solid preparation |
| WO2010143733A1 (en) | 2009-06-09 | 2010-12-16 | Takeda Pharmaceutical Company Limited | Novel fused cyclic compound and use thereof |
| BR112012001959A2 (pt) | 2009-07-28 | 2016-03-15 | Takeda Pharmaceutical | comprimido,e, método para reproduzir um comprimido |
| US8221489B2 (en) * | 2009-08-20 | 2012-07-17 | Stentys | Device and method for treating a body lumen |
| CN103025716B (zh) | 2010-04-27 | 2014-12-24 | 武田药品工业株式会社 | 二环化合物衍生物及其作为acc抑制剂的用途 |
| ES2524896T3 (es) | 2010-06-16 | 2014-12-15 | Takeda Pharmaceutical Company Limited | Cristal de compuesto de amida |
| CA2806258A1 (en) | 2010-07-23 | 2012-01-26 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound and application thereof |
| EP2617726A4 (en) | 2010-09-17 | 2014-05-14 | Takeda Pharmaceutical | DIABETES THERAPEUTIC |
| US8729102B2 (en) | 2010-11-30 | 2014-05-20 | Takeda Pharmaceutical Company Limited | Bicyclic compound |
| WO2012111849A1 (en) | 2011-02-17 | 2012-08-23 | Takeda Pharmaceutical Company Limited | Production method of optically active dihydrobenzofuran derivative |
| CA2853221A1 (en) | 2011-10-24 | 2013-05-02 | Tohru Yamashita | Bicyclic compound |
| WO2013105676A1 (en) | 2012-01-12 | 2013-07-18 | Takeda Pharmaceutical Company Limited | Benzimidazole derivatives as mch receptor antagonists |
| US9382188B2 (en) | 2012-02-13 | 2016-07-05 | Takeda Pharmaceutical Company Limited | Aromatic ring compound |
| EP2816032A4 (en) | 2012-02-13 | 2015-09-30 | Takeda Pharmaceutical | AROMATIC RING CONNECTION |
| WO2013122260A1 (en) | 2012-02-15 | 2013-08-22 | Takeda Pharmaceutical Company Limited | Tablet |
| US9238639B2 (en) | 2012-02-24 | 2016-01-19 | Takeda Pharmaceutical Company Limited | Aromatic ring compound |
| US9073864B2 (en) | 2012-03-29 | 2015-07-07 | Takeda Pharmaceutical Company Limted | Aromatic ring compound |
| US9440987B2 (en) | 2012-05-10 | 2016-09-13 | Takeda Pharmaceutical Company Limited | Aromatic ring compound |
| EP2848622A4 (en) | 2012-05-10 | 2015-11-04 | Takeda Pharmaceutical | Aromatic ring compound |
| JP6122879B2 (ja) | 2012-06-05 | 2017-04-26 | 武田薬品工業株式会社 | 固形製剤 |
| JP2015127299A (ja) | 2012-07-19 | 2015-07-09 | 武田薬品工業株式会社 | 固形製剤 |
| US20150299188A1 (en) | 2012-08-24 | 2015-10-22 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| CN103936763B (zh) * | 2013-01-18 | 2017-10-31 | 中国科学院上海药物研究所 | 噁唑烷酮类化合物及其制备方法和用途 |
| JP6247697B2 (ja) | 2013-03-14 | 2017-12-13 | 武田薬品工業株式会社 | スピロアゼチジンイソキサゾール誘導体及びそのｓｓｔｒ５アンタゴニストとしての使用 |
| US10005720B2 (en) | 2013-04-05 | 2018-06-26 | North Carolina Central University | Compounds useful for the treatment of metabolic disorders and synthesis of the same |
| AR096848A1 (es) | 2013-07-09 | 2016-02-03 | Takeda Pharmaceuticals Co | Derivados de indazol con actividad antagonista del receptor de la hormona concentradora de melanina (mch) |
| JP6397410B2 (ja) | 2013-08-09 | 2018-09-26 | 武田薬品工業株式会社 | 芳香環化合物 |
| JO3442B1 (ar) | 2013-10-07 | 2019-10-20 | Takeda Pharmaceuticals Co | مضادات ذات نوع فرعي من مستقبل سوماتوستاتين 5 (sstr5) |
| US9428470B2 (en) | 2014-02-13 | 2016-08-30 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| US9346776B2 (en) | 2014-02-13 | 2016-05-24 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound |
| WO2016045587A1 (zh) * | 2014-09-26 | 2016-03-31 | 常州寅盛药业有限公司 | 作为ns4b抑制剂的苯并呋喃类似物 |
| EP3237390B1 (en) | 2014-12-23 | 2019-05-08 | Crossing S.r.l. | Method for the industrial production of 2-halo-4,6-dialkoxy-1,3,5-triazine and their use in the presence of amines |
| JOP20190211A1 (ar) | 2017-03-31 | 2019-09-15 | Takeda Pharmaceuticals Co | ببتيد منشط لمستقبل gip |
| AR111199A1 (es) | 2017-03-31 | 2019-06-12 | Takeda Pharmaceuticals Co | Compuesto aromático agonista de gpr40 |
| WO2018181847A1 (ja) | 2017-03-31 | 2018-10-04 | 武田薬品工業株式会社 | 芳香環化合物 |
| EP3654968B1 (en) | 2017-07-17 | 2023-08-16 | Merck Sharp & Dohme LLC | Metallo-beta-lactamase inhibitors and methods of use thereof |
| AU2019237507B2 (en) | 2018-03-23 | 2025-04-03 | Carmot Therapeutics, Inc. | Modulators of G-protein coupled receptors |
| WO2020045326A1 (ja) | 2018-08-27 | 2020-03-05 | 株式会社スコヒアファーマ | 安息香酸エステル化合物 |
| JP2022503793A (ja) | 2018-09-24 | 2022-01-12 | 武田薬品工業株式会社 | Ｇｉｐ受容体アゴニストペプチド化合物及びその使用 |
| WO2020067575A1 (en) | 2018-09-24 | 2020-04-02 | Takeda Pharmaceutical Company Limited | Gip receptor agonist peptide compounds and uses thereof |
| PE20231066A1 (es) | 2020-02-07 | 2023-07-17 | Gasherbrum Bio Inc | Agonistas heterociclicos de glp-1 |
| CA3172241A1 (en) | 2020-03-25 | 2021-09-30 | Antoine Charles Olivier HENNINOT | Qw dosing of gip receptor agonist peptide compounds and uses thereof |
| JP2023519446A (ja) | 2020-03-25 | 2023-05-10 | 武田薬品工業株式会社 | Ｇｉｐ受容体アゴニストペプチド化合物のｑｄ投薬及びその使用 |
| EP4143183B1 (en) | 2020-04-29 | 2025-10-22 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| IL308392A (en) | 2021-05-13 | 2024-01-01 | Carmot Therapeutics Inc | G protein-coupled receptor modulators |
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| WO2025137307A1 (en) | 2023-12-20 | 2025-06-26 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
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- 2005-05-20 AT AT05743594T patent/ATE513813T1/de active
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- 2005-05-20 EP EP05743594A patent/EP1748985B1/en not_active Expired - Lifetime
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