BRPI0511530A - formas de dosagem de bisfosfonatos - Google Patents

formas de dosagem de bisfosfonatos

Info

Publication number
BRPI0511530A
BRPI0511530A BRPI0511530-2A BRPI0511530A BRPI0511530A BR PI0511530 A BRPI0511530 A BR PI0511530A BR PI0511530 A BRPI0511530 A BR PI0511530A BR PI0511530 A BRPI0511530 A BR PI0511530A
Authority
BR
Brazil
Prior art keywords
bisphosphonate
tract
food
dosage forms
chelating agent
Prior art date
Application number
BRPI0511530-2A
Other languages
English (en)
Inventor
Richard John Dansereau
Jr David Ernest Burgio
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35355642&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0511530(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of BRPI0511530A publication Critical patent/BRPI0511530A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/22—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of calcitonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

FORMAS DE DOSAGEM DE BISFOSFONATOS. A presente invenção refere-se as formas de dosagem oral de um bisfosfonato que compreende uma quantidade segura e eficaz de uma composição farmacêutica compreendendo um bisfosfonato, um agente quelante e meios para se obter a liberação retardada do bisfosfonato e do agente quelante do trato GI inferior, proporcionam a liberação da composição farmacêutica no trato GI inferior do mamífero, e a absorção farmaceuticamente eficaz do bisfosfonato, com ou sem alimentos ou bebidas. A presente invenção alivia substancialmente a interação entre bisfosfonatos e alimentos ou bebidas, a qual resulta na indisponibilidade do ingrediente ativo de bisfosfonato para absorção. A forma de dosagem oral resultante pode, portanto, ser tomada com ou sem alimentos. Além disso, a presente invenção obtém a liberação do bisfosfonato e do agente quelante no trato GI inferior, aliviando substancialmente a irritação no trato GI superior associadas às terapias com bisfosfonato. Esses benefícios simplificam os regimes de tratamento anteriormente complexos, e pode levar a uma maior adesão do paciente às terapias com bisfosfonato
BRPI0511530-2A 2004-05-24 2005-04-14 formas de dosagem de bisfosfonatos BRPI0511530A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57388104P 2004-05-24 2004-05-24
PCT/US2005/012537 WO2005115331A2 (en) 2004-05-24 2005-04-14 Enteric solid oral dosage form of bisphosphonate containing a chelating agent

Publications (1)

Publication Number Publication Date
BRPI0511530A true BRPI0511530A (pt) 2008-01-02

Family

ID=35355642

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0511530-2A BRPI0511530A (pt) 2004-05-24 2005-04-14 formas de dosagem de bisfosfonatos

Country Status (31)

Country Link
EP (3) EP1753395B1 (pt)
JP (2) JP4605221B2 (pt)
KR (5) KR20080083068A (pt)
CN (2) CN1956706A (pt)
AR (2) AR049022A1 (pt)
AT (1) ATE475412T1 (pt)
AU (2) AU2005247299B2 (pt)
BR (1) BRPI0511530A (pt)
CA (1) CA2566798A1 (pt)
CY (2) CY1111259T1 (pt)
DE (1) DE602005022578D1 (pt)
DK (2) DK1753395T3 (pt)
ES (3) ES2349584T3 (pt)
HR (1) HRP20100583T1 (pt)
HU (1) HUE059143T2 (pt)
IL (1) IL179090A (pt)
MA (1) MA28657B1 (pt)
MX (1) MXPA06013575A (pt)
MY (1) MY144704A (pt)
NO (1) NO20065969L (pt)
NZ (2) NZ587774A (pt)
PE (1) PE20060256A1 (pt)
PL (2) PL1753395T3 (pt)
PT (3) PT2269584T (pt)
RS (1) RS51562B (pt)
RU (1) RU2359678C2 (pt)
SI (1) SI1753395T1 (pt)
SM (1) SMP200600038B (pt)
TW (2) TWI351285B (pt)
WO (1) WO2005115331A2 (pt)
ZA (1) ZA200609446B (pt)

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