BRPI0511768A - composto, pró-droga, métodos para a produção de um composto, e para a profilaxia ou tratamento de cáncer em um mamìfero, agente farmacêutico, e, uso de um composto - Google Patents

composto, pró-droga, métodos para a produção de um composto, e para a profilaxia ou tratamento de cáncer em um mamìfero, agente farmacêutico, e, uso de um composto

Info

Publication number
BRPI0511768A
BRPI0511768A BRPI0511768-2A BRPI0511768A BRPI0511768A BR PI0511768 A BRPI0511768 A BR PI0511768A BR PI0511768 A BRPI0511768 A BR PI0511768A BR PI0511768 A BRPI0511768 A BR PI0511768A
Authority
BR
Brazil
Prior art keywords
compound
optionally substituted
prodrug
prophylaxis
cancer
Prior art date
Application number
BRPI0511768-2A
Other languages
English (en)
Inventor
Tomoyasu Ishikawa
Takahiko Taniguchi
Hiroshi Banno
Masaki Seto
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of BRPI0511768A publication Critical patent/BRPI0511768A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/16—Peri-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Vascular Medicine (AREA)
  • AIDS & HIV (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

COMPOSTO, PRó-DROGA, MéTODOS PARA A PRODUçãO DE UM COMPOSTO, PARA A PROFILAXIA OU TRATAMENTO DE CáNCER EM UM MAMìFERO, AGENTE FARMACêUTICO, E, USO DE UM COMPOSTO A presente invenção diz respeito a um composto representado pela fórmula: em que W é C(R¬ ¹¬) ou N, cada A é um grupo arila opcionalmente substituído ou um grupo heteroarila, X¬ ¹¬ é -NR¬ ³¬-Y~ ¹¬m-, -O-, -S-, -SO-, -SO~ 2~- ou -CHR¬ ³¬- em que R¬ ³¬ é um átomo de hidrogênio ou um grupo hidrocarboneto alifático opcionalmente substituído, ou R¬ ³¬ é opcionalmente ligado a A para formar uma estrutura de anel opcionalmente substituído, R¬ ¹¬ é um átomo de hidrogênio ou um grupo opcionalmente substituído ligado por intermédio de um átomo de carbono, um átomo de nitrogênio ou um átomo de oxigênio, R¬ ²¬ é um átomo de hidrogênio ou grupo opcionalmente substituído ligado por intermédio de um átomo de carbono ou um átomo de enxofre, ou e R¬ ¹¬ e R¬ ²¬, ou R~ ²¬ e R¬ ³¬ são opcionalmente ligados para formar uma estrutura de anel opcionalmente substituído, ou um sal deste e um inibidor da tirosina quinase ou um agente para a profilaxia ou tratamento de câncer, que contenha este composto ou uma pró-droga deste.
BRPI0511768-2A 2004-06-02 2005-06-01 composto, pró-droga, métodos para a produção de um composto, e para a profilaxia ou tratamento de cáncer em um mamìfero, agente farmacêutico, e, uso de um composto BRPI0511768A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2004165050 2004-06-02
JP2005058231 2005-03-02
PCT/JP2005/010451 WO2005118588A1 (ja) 2004-06-02 2005-06-01 縮合複素環化合物

Publications (1)

Publication Number Publication Date
BRPI0511768A true BRPI0511768A (pt) 2008-01-08

Family

ID=35462874

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0511768-2A BRPI0511768A (pt) 2004-06-02 2005-06-01 composto, pró-droga, métodos para a produção de um composto, e para a profilaxia ou tratamento de cáncer em um mamìfero, agente farmacêutico, e, uso de um composto

Country Status (18)

Country Link
US (4) US7507740B2 (pt)
EP (1) EP1752457B1 (pt)
JP (2) JP4134227B2 (pt)
KR (1) KR101194622B1 (pt)
AU (1) AU2005250285B2 (pt)
BR (1) BRPI0511768A (pt)
CA (1) CA2569016C (pt)
CR (1) CR8827A (pt)
GE (1) GEP20105024B (pt)
IL (1) IL179414A (pt)
MA (1) MA28973B1 (pt)
ME (1) MEP8409A (pt)
MX (1) MXPA06013996A (pt)
NO (1) NO20066015L (pt)
NZ (1) NZ551938A (pt)
RU (1) RU2389731C2 (pt)
TW (1) TWI392679B (pt)
WO (1) WO2005118588A1 (pt)

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Also Published As

Publication number Publication date
IL179414A0 (en) 2007-05-15
JP4134227B2 (ja) 2008-08-20
AU2005250285B2 (en) 2011-08-18
US20070244132A1 (en) 2007-10-18
US20090203717A1 (en) 2009-08-13
WO2005118588A1 (ja) 2005-12-15
MXPA06013996A (es) 2007-02-08
US20090018335A1 (en) 2009-01-15
EP1752457A1 (en) 2007-02-14
JP4937172B2 (ja) 2012-05-23
EP1752457A4 (en) 2010-05-26
AU2005250285A1 (en) 2005-12-15
NZ551938A (en) 2010-07-30
RU2389731C2 (ru) 2010-05-20
GEP20105024B (en) 2010-06-25
CR8827A (es) 2007-04-20
EP1752457B1 (en) 2014-03-19
TWI392679B (zh) 2013-04-11
JPWO2005118588A1 (ja) 2008-04-03
KR101194622B1 (ko) 2012-10-29
JP2008247907A (ja) 2008-10-16
TW200611907A (en) 2006-04-16
CA2569016A1 (en) 2005-12-15
KR20070026695A (ko) 2007-03-08
US20090029973A1 (en) 2009-01-29
US7507740B2 (en) 2009-03-24
US8178543B2 (en) 2012-05-15
NO20066015L (no) 2007-02-13
RU2006147267A (ru) 2008-07-20
IL179414A (en) 2013-11-28
MEP8409A (en) 2011-12-20
MA28973B1 (fr) 2007-11-01
CA2569016C (en) 2012-11-27

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