BRPI0512784A - tetrahidroquinolinas - Google Patents

tetrahidroquinolinas

Info

Publication number
BRPI0512784A
BRPI0512784A BRPI0512784-0A BRPI0512784A BRPI0512784A BR PI0512784 A BRPI0512784 A BR PI0512784A BR PI0512784 A BRPI0512784 A BR PI0512784A BR PI0512784 A BRPI0512784 A BR PI0512784A
Authority
BR
Brazil
Prior art keywords
tetrahydroquinolines
tumors
employed
compounds
formula
Prior art date
Application number
BRPI0512784-0A
Other languages
English (en)
Inventor
Kai Schiemann
David Bruge
Hans-Peter Buchstaller
Dirk Finsinger
Wolfgang Staehle
Christiane Amendt
Ulrich Emde
Frank Zenke
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BRPI0512784A publication Critical patent/BRPI0512784A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

3TETRAHIDROQUINOLINAS. A presente invenção refere-se a compostos da fórmula (I), onde W, R, R¬ 1¬, R¬ 2¬, R¬ 3¬, R¬ 4¬, R¬ 5¬, R¬ 6¬ e R¬ 7¬ têm os significados indicados na reivindicação 1, podem ser empregados, entre outros, para o tratamento de tumores.
BRPI0512784-0A 2004-06-30 2005-06-03 tetrahidroquinolinas BRPI0512784A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004031656A DE102004031656A1 (de) 2004-06-30 2004-06-30 Tetrahydrochinoline
PCT/EP2005/005981 WO2006002726A1 (de) 2004-06-30 2005-06-03 Tetrahydrochinoline

Publications (1)

Publication Number Publication Date
BRPI0512784A true BRPI0512784A (pt) 2008-04-08

Family

ID=35063029

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0512784-0A BRPI0512784A (pt) 2004-06-30 2005-06-03 tetrahidroquinolinas

Country Status (14)

Country Link
US (1) US7915416B2 (pt)
EP (1) EP1778694A1 (pt)
JP (1) JP5121450B2 (pt)
KR (1) KR20070037585A (pt)
CN (1) CN1976936A (pt)
AR (1) AR049654A1 (pt)
AU (1) AU2005259676B2 (pt)
BR (1) BRPI0512784A (pt)
CA (1) CA2572350C (pt)
DE (1) DE102004031656A1 (pt)
MX (1) MXPA06014293A (pt)
RU (1) RU2007103300A (pt)
WO (1) WO2006002726A1 (pt)
ZA (1) ZA200700819B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007013854A1 (de) * 2007-03-20 2008-09-25 Merck Patent Gmbh Tetrahydrochinoline
TW200934785A (en) 2007-10-19 2009-08-16 Schering Corp Compounds for inhibiting KSP kinesin activity
EP2647638A1 (en) * 2012-04-02 2013-10-09 Almirall, S.A. Substituted tricyclic compounds with activity towards ep1 receptors
CN109666666B (zh) * 2019-01-21 2021-03-05 天津科技大学 一种基于分子动力学的酶柔性分析提高肝素酶i热稳定性的突变体及其制备方法
CN111233761B (zh) * 2020-03-16 2022-01-14 大连理工大学 一类2-取代四氢喹啉化合物及其衍生物、制备方法和应用
WO2022006365A2 (en) * 2020-07-02 2022-01-06 Purdue Research Foundation Tetrahydro-3h-pyrazolo quinolone and tetrahydro-3h-pyrrolo[3,2-f]quinoline-containing compounds and uses thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3631050A (en) * 1968-11-13 1971-12-28 Parke Davis & Co Hexahydro-9b-methylfuro(3 2-c) quinoline compounds
ES2071143T3 (es) * 1990-03-08 1995-06-16 Lepetit Spa Factores b1, b2, c1, c2, d1, d2, e y t del antibiotico ge 2270.
KR100310939B1 (ko) * 1992-10-01 2002-06-20 추후제출 태그로암호화한복합조합화학라이브러리
US6503759B1 (en) 1992-10-01 2003-01-07 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5428051A (en) * 1992-10-13 1995-06-27 University Of North Carolina Methods of combating pneumocystis carinii pneumonia and compounds useful therefor
US5521189A (en) * 1994-05-06 1996-05-28 The University Of Nc At Ch Methods of treating pneumocystis carinii pneumonia
US5602172A (en) * 1994-05-06 1997-02-11 The University Of North Carolina At Chapel Hill Methods of inhibiting Pneumocystis carinii pneumonia, Giardia lamblia, and Cryptosporidium and compounds useful therefor
US5643935A (en) * 1995-06-07 1997-07-01 The University Of North Carolina At Chapel Hill Method of combatting infectious diseases using dicationic bis-benzimidazoles
US5723495A (en) * 1995-11-16 1998-03-03 The University Of North Carolina At Chapel Hill Benzamidoxime prodrugs as antipneumocystic agents
US5790244A (en) 1996-08-23 1998-08-04 Laser Technology, Inc. Pre-biasing technique for a transistor based avalanche circuit in a laser based distance measurement and ranging instrument
CA2273884A1 (en) * 1996-12-18 1998-06-25 Jose Serafin Mendoza Combinatorial process for preparing hydrofuroquinoline libraries
US6180940B1 (en) * 1998-04-07 2001-01-30 Universite Laval Light-driven molecular rotational motor
US6180640B1 (en) 1998-06-25 2001-01-30 Sepracor, Inc. Di- and tetra-hydroquinoline-indole antimicrobial agents, uses and compositions related thereto
AU758563B2 (en) * 1998-08-20 2003-03-27 University Of North Carolina At Chapel Hill, The Dicationic dibenzofuran and dibenzothiophene compounds and methods of use thereof
ES2275362T3 (es) * 1998-09-17 2007-06-01 The University Of North Carolina At Chapel Hill Actividad antifungica de moleculas dicationicas.
MXPA03009935A (es) * 2001-04-30 2004-01-29 Pfizer Prod Inc Metodos e intermedios para preparar inhibidores 4-aminoquinolina de cetp.
US7250423B2 (en) * 2001-09-24 2007-07-31 Chao-Jun Li Methods for synthesizing heterocycles and therapeutic use of the heterocycles for cancers
WO2005016255A2 (en) 2003-07-16 2005-02-24 Ligand Pharmaceuticals Incorporated Substituted tetrahydroquinolines, phenylacetic acids and benzoic acids as hepatocyte nuclear factor 4 (hnf-4 ) modulator compounds
AR073574A1 (es) * 2008-09-10 2010-11-17 Alcon Res Ltd Inhibidores heterociclicos de los receptores de histamina para el tratamiento de una enfermedad

Also Published As

Publication number Publication date
AR049654A1 (es) 2006-08-23
MXPA06014293A (es) 2007-02-19
JP5121450B2 (ja) 2013-01-16
ZA200700819B (en) 2008-01-30
KR20070037585A (ko) 2007-04-05
RU2007103300A (ru) 2008-08-10
AU2005259676A1 (en) 2006-01-12
CN1976936A (zh) 2007-06-06
DE102004031656A1 (de) 2006-01-19
WO2006002726A1 (de) 2006-01-12
US20090030028A1 (en) 2009-01-29
JP2008505136A (ja) 2008-02-21
EP1778694A1 (de) 2007-05-02
AU2005259676B2 (en) 2011-03-10
CA2572350C (en) 2013-02-19
CA2572350A1 (en) 2006-01-12
US7915416B2 (en) 2011-03-29

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired