BRPI0514734A - variedade bacteriana geneticamente planejada, método para produzir ácidos carboxìlicos em uma cultura anaeróbica e método para produzir ácido succìnico - Google Patents

variedade bacteriana geneticamente planejada, método para produzir ácidos carboxìlicos em uma cultura anaeróbica e método para produzir ácido succìnico

Info

Publication number
BRPI0514734A
BRPI0514734A BRPI0514734-4A BRPI0514734A BRPI0514734A BR PI0514734 A BRPI0514734 A BR PI0514734A BR PI0514734 A BRPI0514734 A BR PI0514734A BR PI0514734 A BRPI0514734 A BR PI0514734A
Authority
BR
Brazil
Prior art keywords
producing
succinic acid
carboxylic acids
genetically engineered
anaerobic culture
Prior art date
Application number
BRPI0514734-4A
Other languages
English (en)
Inventor
Ka-Yiu San
George N Bennett
Ailen Sanchez
Original Assignee
Rice University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rice University filed Critical Rice University
Publication of BRPI0514734A publication Critical patent/BRPI0514734A/pt
Publication of BRPI0514734B1 publication Critical patent/BRPI0514734B1/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

VARIEDADE BACTERIANA GENETICAMENTE PLANEJADA, MéTODO PARA PRODUZIR áCIDOS CARBOXìLICOS EM UMA CULTURA ANAERóBICA E MéTODO PARA PRODUZIR áCIDO SUCCìNICO A invenção refere-se a uma variedade mutante de bactérias, que são desprovidas ou que contêm genes mutantes para diversas enzimas metabólicas chave, e que produzem grandes quantidades de ácido succínico sob condições anaeróbicas.
BRPI0514734-4A 2004-08-27 2005-08-29 VARIEDADE BACTERIANA DE E. Coli MODIFICADA BRPI0514734B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60492204P 2004-08-27 2004-08-27
US60/604,922 2004-08-27
PCT/US2005/030689 WO2006031424A2 (en) 2004-08-27 2005-08-29 Mutant e. coli strain with increased succinic acid production

Publications (2)

Publication Number Publication Date
BRPI0514734A true BRPI0514734A (pt) 2008-06-24
BRPI0514734B1 BRPI0514734B1 (pt) 2018-02-06

Family

ID=36060505

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514734-4A BRPI0514734B1 (pt) 2004-08-27 2005-08-29 VARIEDADE BACTERIANA DE E. Coli MODIFICADA

Country Status (7)

Country Link
US (2) US7223567B2 (pt)
EP (2) EP1781797B1 (pt)
JP (1) JP4771437B2 (pt)
KR (1) KR101245428B1 (pt)
CN (1) CN101044245B (pt)
BR (1) BRPI0514734B1 (pt)
WO (1) WO2006031424A2 (pt)

Families Citing this family (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4469568B2 (ja) 2003-07-09 2010-05-26 三菱化学株式会社 有機酸の製造方法
US7927859B2 (en) * 2003-08-22 2011-04-19 Rice University High molar succinate yield bacteria by increasing the intracellular NADH availability
EP1672077B1 (en) * 2003-08-28 2015-01-21 Mitsubishi Chemical Corporation Process for producing succinic acid
CN100534972C (zh) * 2003-09-30 2009-09-02 味之素株式会社 从发酵液中纯化琥珀酸的方法
US7244610B2 (en) * 2003-11-14 2007-07-17 Rice University Aerobic succinate production in bacteria
JP5023701B2 (ja) 2004-05-20 2012-09-12 味の素株式会社 コハク酸生産菌及びコハク酸の製造方法
JP5572279B2 (ja) * 2004-05-20 2014-08-13 味の素株式会社 コハク酸生産菌及びコハク酸の製造方法
CN101023178A (zh) * 2004-09-17 2007-08-22 莱斯大学 高琥珀酸产出细菌
US7569380B2 (en) * 2004-12-22 2009-08-04 Rice University Simultaneous anaerobic production of isoamyl acetate and succinic acid
WO2007017710A1 (en) * 2005-08-11 2007-02-15 Metabolic Explorer Process for the preparation of aspartate and derived amino acids like lysine, threonine, isoleucine, methionine, homoserine, or valine employing a microorganism with enhanced isocitrate lyase and/or malate synthase expression
AU2006287257A1 (en) * 2005-09-09 2007-03-15 Genomatica, Inc. Methods and organisms for the growth-coupled production of succinate
US20070249018A1 (en) * 2006-02-23 2007-10-25 Goutham Vemuri Reduced overflow metabolism and methods of use
JP5180060B2 (ja) * 2006-02-24 2013-04-10 三菱化学株式会社 有機酸生産菌及び有機酸の製造法
KR100780324B1 (ko) 2006-07-28 2007-11-29 한국과학기술원 신규 순수 숙신산 생성 변이 미생물 및 이를 이용한 숙신산제조방법
BRPI0622099A2 (pt) * 2006-10-31 2011-12-27 Metabolic Explorer Sa processo para a produÇço biolàgica de 1,3-propanodiol a partir de glicerol com alto rendimento
WO2008052596A1 (en) * 2006-10-31 2008-05-08 Metabolic Explorer Process for the biological production of n-butanol with high yield
CA2675026A1 (en) * 2007-01-12 2008-07-24 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods for enhancing tolerance for the production of organic chemicals produced by microorganisms
WO2008091627A2 (en) * 2007-01-22 2008-07-31 Genomatica, Inc. Methods and organisms for growth-coupled production of 3-hydroxypropionic acid
TWI568847B (zh) 2007-03-16 2017-02-01 奇諾麥提卡公司 用於１，４-丁二醇及其前驅物之生物合成的組合物及方法
KR101631719B1 (ko) * 2007-03-20 2016-06-24 유니버시티 오브 플로리다 리서치 파운데이션, 인크. 유효한 숙시네이트 및 말레이트 제조를 위한 물질 및 방법
EP2149608A4 (en) 2007-04-16 2013-02-20 Ajinomoto Kk PROCESS FOR PREPARING AN ORGANIC ACID
EP2147970B1 (en) 2007-04-17 2014-12-31 Ajinomoto Co., Inc. A method for producing an acidic substance having a carboxyl group
JP2010187542A (ja) * 2007-06-14 2010-09-02 Ajinomoto Co Inc 有機酸の製造方法
WO2009045637A2 (en) 2007-08-10 2009-04-09 Genomatica, Inc. Methods for the synthesis of acrylic acid and derivatives from fumaric acid
US7947483B2 (en) * 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
US8048624B1 (en) 2007-12-04 2011-11-01 Opx Biotechnologies, Inc. Compositions and methods for 3-hydroxypropionate bio-production from biomass
EP2241630B1 (en) 2007-12-06 2016-06-01 Ajinomoto Co., Inc. A method for producing an organic acid
FR2925068B1 (fr) * 2007-12-13 2010-01-08 Roquette Freres Procedes de production d'acide succinique
BRPI0722315A2 (pt) * 2007-12-28 2014-06-10 Roquette Freres Método de cultura microbiana em larga escala
CN107090424A (zh) 2008-01-22 2017-08-25 基因组股份公司 利用合成气或其它气态碳源和甲醇的方法和有机体
EP3450550A1 (en) 2008-03-05 2019-03-06 Genomatica, Inc. Primary alcohol producing organisms
PL2265709T3 (pl) 2008-03-27 2018-05-30 Genomatica, Inc. Mikroorganizmy do produkcji kwasu adypinowego i innych związków
KR101498753B1 (ko) * 2008-04-30 2015-03-09 바스프 에스이 이소시트레이트 데히드로게나제 활성이 감소된 미생물을 사용한 정밀 화학물질의 생산 방법
WO2009135074A2 (en) 2008-05-01 2009-11-05 Genomatica, Inc. Microorganisms for the production of methacrylic acid
WO2009155382A1 (en) * 2008-06-17 2009-12-23 Genomatica, Inc. Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate
US20100021978A1 (en) * 2008-07-23 2010-01-28 Genomatica, Inc. Methods and organisms for production of 3-hydroxypropionic acid
CA2735883C (en) 2008-09-10 2020-05-05 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol
KR101613754B1 (ko) 2008-10-03 2016-04-19 메타볼릭 익스플로러 강하 막, 와이프드 막, 박막 또는 단경로 증발기를 사용한 발효 브로쓰로부터의 알콜의 정제 방법
US20100184173A1 (en) * 2008-11-14 2010-07-22 Genomatica, Inc. Microorganisms for the production of methyl ethyl ketone and 2-butanol
CA2746952A1 (en) * 2008-12-16 2010-06-24 Genomatica, Inc. Microorganisms and methods for conversion of syngas and other carbon sources to useful products
RU2422526C2 (ru) 2009-01-30 2011-06-27 Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов (ФГУП ГосНИИгенетика) СПОСОБ ПОЛУЧЕНИЯ ЯНТАРНОЙ КИСЛОТЫ С ИСПОЛЬЗОВАНИЕМ ДРОЖЖЕЙ, ПРИНАДЛЕЖАЩИХ К РОДУ Yarrowia
FR2941959B1 (fr) * 2009-02-12 2013-06-07 Roquette Freres Procedes de production d'acide succinique
KR101823695B1 (ko) * 2009-02-16 2018-03-14 바스프 에스이 신규 미생물 숙신산 생산자 및 숙신산의 정제
US20120058530A1 (en) 2009-04-02 2012-03-08 University Of Florida Research Foundation Inc. Engineering the pathway for succinate production
BRPI1013505A2 (pt) 2009-04-30 2018-02-14 Genomatica Inc organismos para a produção de isopropanol, n-butanol, e isobutanol
EP3865569B1 (en) 2009-04-30 2023-10-04 Genomatica, Inc. Organisms for the production of 1,3-butanediol
WO2010129936A1 (en) 2009-05-07 2010-11-11 Genomatica, Inc. Microorganisms and methods for the biosynthesis of adipate, hexamethylenediamine and 6-aminocaproic acid
KR20120036851A (ko) * 2009-05-15 2012-04-18 게노마티카 인코포레이티드 사이클로헥사논의 제조를 위한 유기체
PL2438036T3 (pl) * 2009-06-04 2017-09-29 Genomatica, Inc. Sposób oddzielania składników brzeczki fermentacyjnej
BRPI1010581A2 (pt) * 2009-06-04 2016-11-08 Genomatica Inc micro-organismos para a produção de 1,4-butanodiol e métodos relacionados
WO2010144746A2 (en) * 2009-06-10 2010-12-16 Genomatica, Inc. Microorganisms and methods for carbon-efficient biosynthesis of mek and 2-butanol
DK2462221T3 (en) 2009-08-05 2017-05-22 Genomatica Inc SEMISYNTHETIC TEREPHTHALIC ACID BY MICRO-ORGANISMS PRODUCING MUCONIC ACID
US8715971B2 (en) 2009-09-09 2014-05-06 Genomatica, Inc. Microorganisms and methods for the co-production of isopropanol and 1,4-butanediol
US8809027B1 (en) 2009-09-27 2014-08-19 Opx Biotechnologies, Inc. Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase
CA2775390C (en) 2009-09-27 2021-06-29 Opx Biotechnologies, Inc. Method for producing 3-hydroxypropionic acid and other products
AU2010306785B2 (en) * 2009-10-13 2016-01-14 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA, putrescine and related compounds, and methods related thereto
US20110097767A1 (en) * 2009-10-23 2011-04-28 Priti Pharkya Microorganisms for the production of aniline
US8778656B2 (en) 2009-11-18 2014-07-15 Myriant Corporation Organic acid production in microorganisms by combined reductive and oxidative tricaboxylic acid cylce pathways
US10017793B2 (en) 2009-11-18 2018-07-10 Myriant Corporation Metabolic evolution of Escherichia coli strains that produce organic acids
EP2501797A4 (en) 2009-11-18 2013-04-17 Myriant Corp TECHNIQUES OF MICROBES FOR THE EFFECTIVE MANUFACTURE OF CHEMICALS
AU2010349739B2 (en) 2009-11-18 2014-10-16 Ptt Global Chemical Public Company Limited Metabolic evolution of Escherchia coli strains that produce organic acids
CA2781400A1 (en) * 2009-11-20 2011-05-26 Opx Biotechnologies, Inc. Production of an organic acid and/or related chemicals
WO2011064151A1 (en) 2009-11-24 2011-06-03 Dsm Ip Assets B.V. Process for the crystallization of succinic acid
US8530210B2 (en) 2009-11-25 2013-09-10 Genomatica, Inc. Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone
CN102753698A (zh) 2009-12-10 2012-10-24 基因组股份公司 合成气或其他气态碳源和甲醇转化为1,3-丁二醇的方法和有机体
EP2519491A4 (en) 2009-12-31 2014-10-08 Groupe Novasep Sas PURIFICATION OF BERNSTEINIC ACID FROM THE FERMENTATION OF SPROUTS WITH AMMONIUM UCCINATE
WO2011083059A1 (en) * 2010-01-06 2011-07-14 Universiteit Gent Bacterial mutants and uses thereof in protein production
CN102834508A (zh) * 2010-01-29 2012-12-19 基因组股份公司 用于生物合成对甲苯甲酸和对苯二甲酸的微生物和方法
US8048661B2 (en) * 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
US8637286B2 (en) * 2010-02-23 2014-01-28 Genomatica, Inc. Methods for increasing product yields
US8163459B2 (en) * 2010-03-01 2012-04-24 Xerox Corporation Bio-based amorphous polyester resins for emulsion aggregation toners
EP2371802A1 (en) 2010-03-30 2011-10-05 DSM IP Assets B.V. Process for the crystallization of succinic acid
US9023636B2 (en) 2010-04-30 2015-05-05 Genomatica, Inc. Microorganisms and methods for the biosynthesis of propylene
KR20190006103A (ko) 2010-05-05 2019-01-16 게노마티카 인코포레이티드 부타디엔을 생합성하기 위한 미생물 및 방법
US8795991B2 (en) 2010-05-07 2014-08-05 William Marsh Rice University Increasing bacterial succinate productivity
US8962272B2 (en) 2010-06-21 2015-02-24 William Marsh Rice University Engineered bacteria produce succinate from sucrose
WO2012018624A2 (en) 2010-07-26 2012-02-09 Genomatica, Inc. Microorganisms and methods for the biosynthesis of aromatics, 2,4-pentadienoate and 1,3-butadiene
US20130130339A1 (en) 2010-07-31 2013-05-23 Myriant Corporation Fermentation process for the production of organic acids
CN101974458B (zh) * 2010-09-30 2012-05-30 江南大学 一株枯草芽孢杆菌及其应用
CN102174458A (zh) * 2011-03-09 2011-09-07 南京工业大学 一种制备重组大肠杆菌发酵生产丁二酸的方法
US9169486B2 (en) 2011-06-22 2015-10-27 Genomatica, Inc. Microorganisms for producing butadiene and methods related thereto
BR112014001371B1 (pt) 2011-07-22 2021-06-01 Myriant Corporation Bactéria escherichia coli geneticamente modificada e método para produção de ácido succínico
EP2753689B1 (en) * 2011-09-07 2018-02-14 William Marsh Rice University Functionalized carboxylic acids and alcohols by reverse fatty acid oxidation
CN103998616A (zh) 2011-10-17 2014-08-20 威廉马什莱斯大学 用于合成脂肪酸的细菌和方法
AU2012351501B2 (en) * 2011-12-16 2018-06-14 Inbiose N.V. Mutant microorganisms to synthesize colanic acid, mannosylated and/or fucosylated oligosaccharides
FR2987678B1 (fr) 2012-03-02 2016-04-15 Roquette Freres Methode de mesure de la stabilite thermique d'un acide succinique cristallin destine a la fabrication de polymeres
CN111705028A (zh) 2012-06-04 2020-09-25 基因组股份公司 制造4-羟基丁酸酯、1，4-丁二醇和相关化合物的微生物和方法
MX2015004180A (es) * 2012-10-02 2015-07-06 Michigan Biotech Inst Microorganismos recombinantes para producir acidos organicos organicos.
US9932611B2 (en) * 2012-10-22 2018-04-03 Genomatica, Inc. Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing succinate related thereto
WO2014135712A2 (en) 2013-03-08 2014-09-12 Dsm Ip Assets B.V. Polyester
WO2014146026A1 (en) 2013-03-15 2014-09-18 Opx Biotechnologies, Inc. Bioproduction of chemicals
WO2014145096A1 (en) 2013-03-15 2014-09-18 Cindy Hoppe Flash evaporation for production purification and recovery
JP2016165225A (ja) 2013-07-09 2016-09-15 味の素株式会社 有用物質の製造方法
JP6603658B2 (ja) 2013-07-19 2019-11-06 カーギル インコーポレイテッド 脂肪酸及び脂肪酸誘導体の製造のための微生物及び方法
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
WO2015034948A1 (en) 2013-09-03 2015-03-12 Myriant Corporation A process for manufacturing acrylic acid, acrylonitrile and 1,4-butanediol from 1,3-propanediol
US9487804B2 (en) 2014-02-13 2016-11-08 William Marsh Rice University Hydroxy- and dicarboxylic-fat synthsis by microbes
CN104046577A (zh) * 2014-04-01 2014-09-17 南京工业大学 一株产苹果酸基因工程菌及其构建及应用
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
CN105543214B (zh) * 2014-10-30 2019-01-08 华东理工大学 利用乙酸生产丁二酸的代谢工程大肠杆菌菌株构建方法和应用
CN104593405A (zh) * 2014-11-24 2015-05-06 安徽大学 一种高产丙氨酸的枯草杆菌工程菌的构建方法
US10189767B2 (en) 2014-12-02 2019-01-29 Dsm Ip Assets B.V. Process for manufacturing succinic acid from a fermentation broth using nano filtration to purify recycled mother liquor
JP2017216881A (ja) 2014-12-26 2017-12-14 味の素株式会社 ジカルボン酸の製造方法
EP3067378A1 (en) 2015-03-11 2016-09-14 DSM IP Assets B.V. Polyester
TWI673360B (zh) 2015-11-12 2019-10-01 財團法人工業技術研究院 促進琥珀酸或乳酸生產的基因改質菌株及方法
US10858661B2 (en) 2017-01-10 2020-12-08 University-Industry Cooperation Group Of Kyung Hee University Use of Methylomonas sp. DH-1 strain and its transformants
KR102028161B1 (ko) * 2017-01-10 2019-10-02 경희대학교 산학협력단 형질전환 미생물을 이용한 2,3-부탄디올 생산방법
WO2018144701A2 (en) 2017-02-02 2018-08-09 Cargill Incorporated Genetically modified cells that produce c6-c10 fatty acid derivatives
CN107881186B (zh) * 2017-10-18 2021-02-02 华东理工大学 利用乙酸生产羟基丙酸的代谢工程大肠杆菌菌株的构建方法与应用
CN108977386A (zh) * 2018-08-08 2018-12-11 大连大学 一种筛选高产低温苹果酸脱氢酶细菌菌株的方法
CN109251941B (zh) * 2018-09-30 2020-11-06 江南大学 一种高产琥珀酸的大肠杆菌及其应用
CN110951660B (zh) * 2019-12-19 2021-12-03 江南大学 一株固定co2产苹果酸的大肠杆菌工程菌的构建及应用
KR102611978B1 (ko) * 2021-12-21 2023-12-11 이화여자대학교 산학협력단 숙신산 생산성이 향상된 미생물 및 이를 이용한 숙신산 생산 방법

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869301A (en) 1995-11-02 1999-02-09 Lockhead Martin Energy Research Corporation Method for the production of dicarboxylic acids
US5770435A (en) * 1995-11-02 1998-06-23 University Of Chicago Mutant E. coli strain with increased succinic acid production
KR19990013007A (ko) * 1997-07-31 1999-02-25 박원훈 형질전환된 대장균 ｓｓ373(ｋｃｔｃ 8818ｐ)과 이를 이용한숙신산의 생산방법
JP3967812B2 (ja) * 1998-01-16 2007-08-29 三菱化学株式会社 ピルビン酸カルボキシラーゼ遺伝子組み換え菌体による有機酸の製造法
US20030087381A1 (en) * 1998-04-13 2003-05-08 University Of Georgia Research Foundation, Inc. Metabolically engineered organisms for enhanced production of oxaloacetate-derived biochemicals
MY121380A (en) 1998-04-13 2006-01-28 Univ Georgia Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells
US6159738A (en) * 1998-04-28 2000-12-12 University Of Chicago Method for construction of bacterial strains with increased succinic acid production
US6743610B2 (en) * 2001-03-30 2004-06-01 The University Of Chicago Method to produce succinic acid from raw hydrolysates
JP4418793B2 (ja) * 2002-07-10 2010-02-24 ザ ペン ステート リサーチ ファウンデーション 遺伝子ノックアウト戦略を決定する方法
WO2004074495A1 (ja) * 2003-02-24 2004-09-02 Research Institute Of Innovative Technology For The Earth 微生物による高効率水素製造方法
US7927859B2 (en) * 2003-08-22 2011-04-19 Rice University High molar succinate yield bacteria by increasing the intracellular NADH availability
JP2005211041A (ja) * 2004-02-02 2005-08-11 Nippon Shokubai Co Ltd コハク酸の製造方法
US7262046B2 (en) * 2004-08-09 2007-08-28 Rice University Aerobic succinate production in bacteria
CN101023178A (zh) * 2004-09-17 2007-08-22 莱斯大学 高琥珀酸产出细菌
US7569380B2 (en) * 2004-12-22 2009-08-04 Rice University Simultaneous anaerobic production of isoamyl acetate and succinic acid
US8187842B2 (en) 2005-06-20 2012-05-29 Archer Daniels Midland Company Altered glyoxylate shunt for improved production of aspartate-derived amino acids and chemicals

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JP4771437B2 (ja) 2011-09-14
US20070184539A1 (en) 2007-08-09
KR20070053716A (ko) 2007-05-25
JP2008516585A (ja) 2008-05-22
BRPI0514734B1 (pt) 2018-02-06
CN101044245B (zh) 2012-05-02
EP1781797A4 (en) 2011-10-05
CN101044245A (zh) 2007-09-26
US7223567B2 (en) 2007-05-29
EP1781797A2 (en) 2007-05-09
WO2006031424A2 (en) 2006-03-23
US20060046288A1 (en) 2006-03-02
KR101245428B1 (ko) 2013-03-19
WO2006031424A3 (en) 2006-11-30
US7790416B2 (en) 2010-09-07
EP3130676A1 (en) 2017-02-15

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