BRPI0515079A - marcadores imobilizados e métodos de detecção de prions conformacionalmente alterados - Google Patents

marcadores imobilizados e métodos de detecção de prions conformacionalmente alterados

Info

Publication number
BRPI0515079A
BRPI0515079A BRPI0515079-5A BRPI0515079A BRPI0515079A BR PI0515079 A BRPI0515079 A BR PI0515079A BR PI0515079 A BRPI0515079 A BR PI0515079A BR PI0515079 A BRPI0515079 A BR PI0515079A
Authority
BR
Brazil
Prior art keywords
markers
immobilized
detection methods
prion detection
immobilized markers
Prior art date
Application number
BRPI0515079-5A
Other languages
English (en)
Inventor
Cindy S Orser
Tao Pan
Original Assignee
Adlyfe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adlyfe Inc filed Critical Adlyfe Inc
Publication of BRPI0515079A publication Critical patent/BRPI0515079A/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

MARCADORES IMOBILIZADOS E MéTODOS DE DETECçãO DE PRIONS CONFORMACIONALMENTE ALTERADOS A presente invenção proporciona métodos de tornar marcadores imobilizados que são específicos para proteínas prions, métodos de uso de tais marcadores para ligar, detectar, e remover proteínas prions de amostras, e kits para desenvolver a invenção. A invenção divulga marcadores imobilizados que são fechados numa configuração particular, pre-determinada e que retém sua atividade e especificidade mesmo quando exposto a condições que poderiam tipicamente alterar sua atividade e especificidade.
BRPI0515079-5A 2004-09-10 2005-09-09 marcadores imobilizados e métodos de detecção de prions conformacionalmente alterados BRPI0515079A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60854104P 2004-09-10 2004-09-10
US11/030,300 US20060057671A1 (en) 2004-09-10 2005-01-07 Immobilized probes and methods of detecting conformationally altered prion proteins
PCT/US2005/032135 WO2006031644A2 (en) 2004-09-10 2005-09-09 Immobilized probes and methods of detecting conformationally altered prion proteins

Publications (1)

Publication Number Publication Date
BRPI0515079A true BRPI0515079A (pt) 2008-07-08

Family

ID=36034515

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0515079-5A BRPI0515079A (pt) 2004-09-10 2005-09-09 marcadores imobilizados e métodos de detecção de prions conformacionalmente alterados

Country Status (8)

Country Link
US (1) US20060057671A1 (pt)
EP (2) EP1789788A4 (pt)
JP (1) JP2008512483A (pt)
AU (1) AU2005285143A1 (pt)
BR (1) BRPI0515079A (pt)
CA (1) CA2579848A1 (pt)
MX (1) MX2007002908A (pt)
WO (1) WO2006031644A2 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002320045B2 (en) 2001-05-31 2008-05-08 Adlyfe, Inc. Misfolded protein sensor method
US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
US20060035242A1 (en) * 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
NZ545385A (en) * 2003-08-13 2010-12-24 Novartis Vaccines & Diagnostic Prion-specific peptide reagents
EP1848831A4 (en) * 2005-01-13 2008-11-05 Novartis Vaccines & Diagnostic ELISA TESTS USING PRION-SPECIFIC PEPTIDE REAGENT
EP1848830A4 (en) * 2005-01-13 2009-05-06 Novartis Vaccines & Diagnostic Osplation of pathogenic prions
WO2006076683A2 (en) * 2005-01-13 2006-07-20 Novartis Vaccines And Diagnostics Inc. Isolation and detection of pathogenic prions
ATE528649T1 (de) * 2005-02-15 2011-10-15 Adlyfe Inc Verfahren zum nachweis falsch gefalteter proteine und prionen
DK1931695T3 (da) * 2005-09-09 2013-07-01 Novartis Ag Prionspecifikke peptoidreagenser
US8008026B2 (en) * 2006-04-21 2011-08-30 Peoplebio, Inc. Methods for differentially detecting a multimeric form from a monomeric form of a multimer-forming polypeptide through three-dimensional interactions
WO2008008047A1 (en) * 2006-07-12 2008-01-17 Agency For Science, Technology And Research Molecular probe for sphingolipids
US8673579B2 (en) * 2006-07-28 2014-03-18 Adlyfe, Inc. Peptide probes for diagnostics and therapeutics
WO2008029965A1 (en) * 2006-09-08 2008-03-13 Peoplebio, Inc. Simultaneous reaction assay for differentially detecting multimeric form
CA2721982A1 (en) * 2008-04-30 2009-11-05 Novartis Ag Assay for pathogenic conformers
EP2391644B1 (en) 2009-01-30 2016-04-13 System of Systems Analytics, Inc. Conformationally dynamic peptides
JP2014514576A (ja) 2011-04-27 2014-06-19 エイディーライフ インコーポレイティッド アミロイドタンパク質の眼における検出法
BR112019016374A2 (pt) 2017-02-17 2020-04-07 Bristol-Myers Squibb Company anticorpos para alfa-sinucleína e usos dos mesmos

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US5434050A (en) * 1991-08-13 1995-07-18 Regents Of The University Of Minnesota Labelled β-amyloid peptide and methods of screening for Alzheimer's disease
ATE177754T1 (de) * 1991-12-03 1999-04-15 Proteus Molecular Design Fragmente von prion proteinen.
US5955343A (en) * 1992-12-28 1999-09-21 Massachusetts Institute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
US5565186A (en) * 1994-05-13 1996-10-15 The Regents Of The University Of California Method of detecting prions in a sample and transgenic animal used for same
US5972634A (en) * 1994-10-19 1999-10-26 The General Hospital Corporation Diagnostic assay for Alzheimer's disease: assessment of Aβ abnormalities
JPH11514333A (ja) * 1995-03-14 1999-12-07 プレーシス ファーマスーティカルズ インコーポレイテッド アミロイドの凝集の調節剤
CA2231409C (en) * 1995-09-14 2003-02-11 The Regents Of The University Of California Antibodies specific for native prpsc
US5750361A (en) * 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes
WO1998030229A1 (en) * 1997-01-10 1998-07-16 Massachusetts Institute Of Technology TREATMENTS FOR NEUROTOXICITY IN ALZHEIMER'S DISEASE BY β-AMYLOID PEPTIDES
US20060178302A1 (en) * 1997-02-05 2006-08-10 Northwestern University & The University Of Southern California Amyloid beta protein (globular assembly and uses thereof)
US20010001061A1 (en) * 1997-02-21 2001-05-10 Prusiner Stanley B. Assay for disease related conformation of a protein
CA2301142A1 (en) * 1997-08-14 1999-02-25 The Regents Of The University Of California Fluorescent amyloid a.beta. peptides and uses thereof
DE59805338D1 (de) * 1997-09-19 2002-10-02 Evotec Ag Verfahren zur messung der assoziation von teilstrukturen pathologischer proteinablagerungen
US5977324A (en) * 1998-02-20 1999-11-02 The Regents Of The University Of California Process for concentrating protein with disease-related conformation
US6214565B1 (en) * 1998-10-09 2001-04-10 The Regents Of The University Of California Assay for disease related conformation of a protein and isolating same
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US20040052928A1 (en) * 2002-09-06 2004-03-18 Ehud Gazit Peptides and methods using same for diagnosing and treating amyloid-associated diseases
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WO2004018511A2 (en) * 2002-08-23 2004-03-04 Copenhagen Biotech Assets Aps Composite peptide compounds for diagnosis and treatment of diseases caused by prion proteins
US20040072236A1 (en) * 2002-09-27 2004-04-15 Neil Cashman PrPSc -interacting molecules and uses thereof
MXPA05005920A (es) * 2002-12-03 2006-03-17 American Nat Red Cross Ligandos de proteina prion y metodos de uso.
US7510848B2 (en) * 2003-04-04 2009-03-31 North Carolina State University Prion protein binding materials and methods of use
NZ545385A (en) * 2003-08-13 2010-12-24 Novartis Vaccines & Diagnostic Prion-specific peptide reagents
US20060035242A1 (en) * 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
JP3910569B2 (ja) * 2003-08-19 2007-04-25 独立行政法人科学技術振興機構 アミロイドβ蛋白質のアミロイド線維化を増幅するための試薬
US8673579B2 (en) * 2006-07-28 2014-03-18 Adlyfe, Inc. Peptide probes for diagnostics and therapeutics

Also Published As

Publication number Publication date
EP1789788A4 (en) 2008-05-14
JP2008512483A (ja) 2008-04-24
US20060057671A1 (en) 2006-03-16
CA2579848A1 (en) 2006-03-23
WO2006031644A3 (en) 2006-08-31
EP2312313A2 (en) 2011-04-20
WO2006031644A2 (en) 2006-03-23
EP1789788A2 (en) 2007-05-30
AU2005285143A1 (en) 2006-03-23
MX2007002908A (es) 2007-06-15
EP2312313A3 (en) 2011-09-14

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B11T Dismissal of application maintained [chapter 11.20 patent gazette]