BRPI0515079A - marcadores imobilizados e métodos de detecção de prions conformacionalmente alterados - Google Patents

marcadores imobilizados e métodos de detecção de prions conformacionalmente alterados

Info

Publication number
BRPI0515079A
BRPI0515079A BRPI0515079-5A BRPI0515079A BRPI0515079A BR PI0515079 A BRPI0515079 A BR PI0515079A BR PI0515079 A BRPI0515079 A BR PI0515079A BR PI0515079 A BRPI0515079 A BR PI0515079A
Authority
BR
Brazil
Prior art keywords
markers
immobilized
detection methods
prion detection
immobilized markers
Prior art date
Application number
BRPI0515079-5A
Other languages
English (en)
Inventor
Cindy S Orser
Tao Pan
Original Assignee
Adlyfe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adlyfe Inc filed Critical Adlyfe Inc
Publication of BRPI0515079A publication Critical patent/BRPI0515079A/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

MARCADORES IMOBILIZADOS E MéTODOS DE DETECçãO DE PRIONS CONFORMACIONALMENTE ALTERADOS A presente invenção proporciona métodos de tornar marcadores imobilizados que são específicos para proteínas prions, métodos de uso de tais marcadores para ligar, detectar, e remover proteínas prions de amostras, e kits para desenvolver a invenção. A invenção divulga marcadores imobilizados que são fechados numa configuração particular, pre-determinada e que retém sua atividade e especificidade mesmo quando exposto a condições que poderiam tipicamente alterar sua atividade e especificidade.
BRPI0515079-5A 2004-09-10 2005-09-09 marcadores imobilizados e métodos de detecção de prions conformacionalmente alterados BRPI0515079A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60854104P 2004-09-10 2004-09-10
US11/030,300 US20060057671A1 (en) 2004-09-10 2005-01-07 Immobilized probes and methods of detecting conformationally altered prion proteins
PCT/US2005/032135 WO2006031644A2 (en) 2004-09-10 2005-09-09 Immobilized probes and methods of detecting conformationally altered prion proteins

Publications (1)

Publication Number Publication Date
BRPI0515079A true BRPI0515079A (pt) 2008-07-08

Family

ID=36034515

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0515079-5A BRPI0515079A (pt) 2004-09-10 2005-09-09 marcadores imobilizados e métodos de detecção de prions conformacionalmente alterados

Country Status (8)

Country Link
US (1) US20060057671A1 (pt)
EP (2) EP2312313A3 (pt)
JP (1) JP2008512483A (pt)
AU (1) AU2005285143A1 (pt)
BR (1) BRPI0515079A (pt)
CA (1) CA2579848A1 (pt)
MX (1) MX2007002908A (pt)
WO (1) WO2006031644A2 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1395833B1 (en) * 2001-05-31 2013-02-27 Adlyfe, Inc. Misfolded protein sensor method
US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
NZ580256A (en) * 2003-08-13 2011-07-29 Novartis Vaccines & Diagnostic Prion-specific peptide reagents comprising the sequence KKRPKPGG
US20060035242A1 (en) * 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
JP5162250B2 (ja) * 2005-01-13 2013-03-13 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド プリオン特異的ペプチド試薬を使用するｅｌｉｓａアッセイ
US20090099343A1 (en) * 2005-01-13 2009-04-16 David Peretz Isolation of pathogenic prions
WO2006076683A2 (en) * 2005-01-13 2006-07-20 Novartis Vaccines And Diagnostics Inc. Isolation and detection of pathogenic prions
AU2006214463B2 (en) * 2005-02-15 2012-08-30 Presympto, Inc. Method for detecting misfolded proteins and prions
EP1931695B1 (en) * 2005-09-09 2013-04-10 Novartis AG Prion-specific peptoid reagents
JP5164971B2 (ja) * 2006-04-21 2013-03-21 ピープルバイオ，アイ エヌ シー 三次元的相互作用を用いてマルチマー形成ポリペプチドのモノマーからマルチマーを分別検出する方法
EP2046822B1 (en) * 2006-07-12 2012-01-04 Agency for Science, Technology and Research Molecular probe for sphingolipids
EP2156181B1 (en) * 2006-07-28 2015-11-04 Adlyfe, Inc. Peptide probes for diagnostics and therapeutics
WO2008029965A1 (en) * 2006-09-08 2008-03-13 Peoplebio, Inc. Simultaneous reaction assay for differentially detecting multimeric form
BRPI0910550A2 (pt) * 2008-04-30 2015-09-29 Novartis Ag ensaio para confôrmeros patogênicos
MX2011007916A (es) 2009-01-30 2011-11-18 Adlyfe Inc Péptidos conformacionalmente dinámicos.
EP2712425A2 (en) 2011-04-27 2014-04-02 Adlyfe, Inc. Ocular detection of amyloid proteins
EA201991720A1 (ru) 2017-02-17 2020-01-20 Бристол-Маерс Сквибб Компани Антитела к альфа-синуклеину и их применения

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444879A (en) * 1981-01-29 1984-04-24 Science Research Center, Inc. Immunoassay with article having support film and immunological counterpart of analyte
US5434050A (en) * 1991-08-13 1995-07-18 Regents Of The University Of Minnesota Labelled β-amyloid peptide and methods of screening for Alzheimer's disease
NZ246059A (en) * 1991-12-03 1995-08-28 Proteus Molecular Design Synthetic polypeptides with at least one antigenic site of a prion protein, methods of their use and manufacture, antibodies thereto, compositions and kits
US5955343A (en) * 1992-12-28 1999-09-21 Massachusetts Institute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
US5565186A (en) * 1994-05-13 1996-10-15 The Regents Of The University Of California Method of detecting prions in a sample and transgenic animal used for same
US5972634A (en) * 1994-10-19 1999-10-26 The General Hospital Corporation Diagnostic assay for Alzheimer's disease: assessment of Aβ abnormalities
US5854204A (en) * 1995-03-14 1998-12-29 Praecis Pharmaceuticals, Inc. Aβ peptides that modulate β-amyloid aggregation
EP1416280A3 (en) * 1995-09-14 2005-08-10 The Regents of the University of California Antibodies specific for native PrPsc
US5750361A (en) * 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes
US6172043B1 (en) * 1997-01-10 2001-01-09 Massachusetts Institute Of Technology Treatments for neurotoxicity in Alzheimer's disease caused by β amyloid peptides
US20060178302A1 (en) * 1997-02-05 2006-08-10 Northwestern University & The University Of Southern California Amyloid beta protein (globular assembly and uses thereof)
US20010001061A1 (en) * 1997-02-21 2001-05-10 Prusiner Stanley B. Assay for disease related conformation of a protein
EP1003539A4 (en) * 1997-08-14 2002-09-11 Univ California AMYLOID beta-FLUORESCENT PEPTIDES AND USE THEREOF
DE59805338D1 (de) * 1997-09-19 2002-10-02 Evotec Ag Verfahren zur messung der assoziation von teilstrukturen pathologischer proteinablagerungen
US5977324A (en) * 1998-02-20 1999-11-02 The Regents Of The University Of California Process for concentrating protein with disease-related conformation
US6214565B1 (en) * 1998-10-09 2001-04-10 The Regents Of The University Of California Assay for disease related conformation of a protein and isolating same
US6638711B1 (en) * 1999-04-29 2003-10-28 The General Hospital Corporation Methods for identifying an agent that inhibits oxygen-dependent hydrogen peroxide formation activity but does not inhibit superoxide-dependent hydrogen peroxide formation
US6750025B1 (en) * 1998-07-09 2004-06-15 V.I. Technologies, Inc. Method of detecting and isolating prion protein and variants thereof
GB2348203B (en) * 1998-11-04 2002-06-19 Imp College Innovations Ltd Solube beta-forms of prion proteins, methods of preparation and use
US20050112607A1 (en) * 1999-01-23 2005-05-26 Bamdad Cynthia C. Rapid and sensitive detection of protein aggregation
US6166187A (en) * 1999-03-05 2000-12-26 The Regents Of The University Of California Method of concentrating prion proteins in blood samples
US6399314B1 (en) * 1999-12-29 2002-06-04 American Cyanamid Company Methods of detection of amyloidogenic proteins
MXPA03000226A (es) * 2000-07-07 2004-05-21 Applied Research Systems Diagnosticos tempranos de enfermedades conformacionales.
US6495335B2 (en) * 2000-12-07 2002-12-17 Mario Chojkier Compositions and methods for diagnosing alzheimer's disease
WO2002094191A2 (en) * 2001-05-23 2002-11-28 New York University Detection of alzheimer's amyloid by magnetic resonance imaging
US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
EP1395833B1 (en) * 2001-05-31 2013-02-27 Adlyfe, Inc. Misfolded protein sensor method
WO2003050139A2 (en) * 2001-12-10 2003-06-19 Applied Research Systems Ars Holding N.V. Prion inhibiting peptides and derivatives thereof
US20040052928A1 (en) * 2002-09-06 2004-03-18 Ehud Gazit Peptides and methods using same for diagnosing and treating amyloid-associated diseases
JP4550425B2 (ja) * 2002-02-28 2010-09-22 マイクロセンズ バイオファージ リミテッド 異常型プリオンタンパク質の結合
US7939641B2 (en) * 2002-04-09 2011-05-10 The Scripps Research Institute Motif-grafted hybrid polypeptides and uses thereof
US20060057636A1 (en) * 2002-08-21 2006-03-16 Peter Heegaard Composite peptide compounds for diagnosis and treatment of diseases caused by prion proteins
US20040072236A1 (en) * 2002-09-27 2004-04-15 Neil Cashman PrPSc -interacting molecules and uses thereof
CA2836951C (en) * 2002-12-03 2017-01-10 North Carolina State University Prion protein ligands and methods of use
US7510848B2 (en) * 2003-04-04 2009-03-31 North Carolina State University Prion protein binding materials and methods of use
US20060035242A1 (en) * 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
NZ580256A (en) * 2003-08-13 2011-07-29 Novartis Vaccines & Diagnostic Prion-specific peptide reagents comprising the sequence KKRPKPGG
JP3910569B2 (ja) * 2003-08-19 2007-04-25 独立行政法人科学技術振興機構 アミロイドβ蛋白質のアミロイド線維化を増幅するための試薬
EP2156181B1 (en) * 2006-07-28 2015-11-04 Adlyfe, Inc. Peptide probes for diagnostics and therapeutics

Also Published As

Publication number Publication date
EP2312313A3 (en) 2011-09-14
AU2005285143A1 (en) 2006-03-23
EP1789788A4 (en) 2008-05-14
WO2006031644A3 (en) 2006-08-31
MX2007002908A (es) 2007-06-15
EP1789788A2 (en) 2007-05-30
WO2006031644A2 (en) 2006-03-23
EP2312313A2 (en) 2011-04-20
CA2579848A1 (en) 2006-03-23
JP2008512483A (ja) 2008-04-24
US20060057671A1 (en) 2006-03-16

Similar Documents

Publication Publication Date Title
WO2008021484A3 (en) Assay system to identify therapeutic agents
WO2007120699A3 (en) Reagents and methods for using human embryonic stem cells to evaluate toxicity of pharmaceutical compounds & other chemicals
ATE541054T1 (de) Bio-barcode erkennung für zielmoleküle
WO2007106118A3 (en) Aptamer-based colorimetric sensor systems
DE602007013524D1 (de) Erkennung und vorhersage von frühgeburten
BRPI0618713B8 (pt) cardiolipina modificada e seus usos
ATE483825T1 (de) Zusammensetzungen für die identifizierung von adenoviren
MX2007010349A (es) Composiciones y metodos para clasificar muestras biologicas.
EP4357783A3 (en) Highly sensitive system and methods for analysis of troponin
EA200100899A1 (ru) ЦИТОЗОЛЬНАЯ ФОСФОЛИПАЗА A2 (cPLA2) И МОДЕЛЬ ЕЕ СТРУКТУРЫ, КРИСТАЛЛИЧЕСКАЯ КОМПОЗИЦИЯ, КОМПЬЮТЕРНАЯ СИСТЕМА, СПОСОБ ИДЕНТИФИКАЦИИ МОЛЕКУЛЫ И МОЛЕКУЛА, СПОСОБ ИДЕНТИФИКАЦИИ СУБСТАНЦИИ (ВАРИАНТЫ), СПОСОБ ИДЕНТИФИКАЦИИ ИНГИБИТОРОВ (ВАРИАНТЫ), АГОНИСТ ИЛИ АНТАГОНИСТ (ВАРИАНТЫ), СУБСТАНЦИЯ (ВАРИАНТЫ)
ATE431854T1 (de) Auf bio-barcodes beruhender nachweis von zielanalyten
DE602006016589D1 (de) Neue markierungsstrategien für den empfindlichen nachweis von analyten
WO2007111938A3 (en) Inflammation-inhibitory serum factors and uses thereof
DK1989544T3 (da) T-celle-testmetode
MX2007002908A (es) Sondas inmovilizadas y metodos para detectar proteinas prionicas alteradas conformacionalmente.
WO2008060483A3 (en) Protein-protein interaction biosensors and methods of use thereof
DE602006021223D1 (de) Verfahren zur identifizierung von trpv2-modulatoren
ATE500503T1 (de) Cd86- und cd80-rezeptorkonkurrenztests
BRPI0607323A2 (pt) composições e uso de polipeptìdeos e kits para a detecção de anticorpo que se liga especificamente a um polipeptìdeo
EP1643894A4 (en) METHOD, KITS AND ANTIBODIES FOR THE DETECTION OF PARATHYROID
DK2005190T4 (da) Inhibering af GASC1
EP1891108A4 (en) PSP94 DIAGNOSTICS AND ASSAYS
GB2457832A (en) Novel toxicity assay based on human blastocyst-derived stem cells and progenitor cells
EP2102393A4 (en) FOR PLATINATE COORDINATION COMPLEX-INDUCED OTOTOXICITY, PRE-DICTIVE POLYMORPHISMS
CY1112488T1 (el) Μεθοδος για τον ποσοτικο προσδιορισμο των πολοξαμερων

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B11T Dismissal of application maintained [chapter 11.20 patent gazette]