BRPI0515564A - antibióticos carbo e heterocìclicos e uso dos mesmos - Google Patents

antibióticos carbo e heterocìclicos e uso dos mesmos

Info

Publication number
BRPI0515564A
BRPI0515564A BRPI0515564-9A BRPI0515564A BRPI0515564A BR PI0515564 A BRPI0515564 A BR PI0515564A BR PI0515564 A BRPI0515564 A BR PI0515564A BR PI0515564 A BRPI0515564 A BR PI0515564A
Authority
BR
Brazil
Prior art keywords
carbo
activity
ring
heterocyclic
compounds
Prior art date
Application number
BRPI0515564-9A
Other languages
English (en)
Inventor
Suzanne Chamberland
Francois Malouin
Original Assignee
Ulysses Pharmaceutical Product
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ulysses Pharmaceutical Product filed Critical Ulysses Pharmaceutical Product
Publication of BRPI0515564A publication Critical patent/BRPI0515564A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
    • A01N43/08—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings with oxygen as the ring hetero atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/60—1,4-Diazines; Hydrogenated 1,4-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
    • A01N43/76—1,3-Oxazoles; Hydrogenated 1,3-oxazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
    • A01N43/78—1,3-Thiazoles; Hydrogenated 1,3-thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/16—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using chemical substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"ANTIBIóTICOS CARBO E HETEROCìCLICOS E USO DOS MESMOS". A presente invenção relaciona-se a compostos de fórmula (1.0); e sais farmaceuticamente aceitáveis de tais compostos. A presente invenção relaciona-se a entidades químicas que contêm um nitrofurano ou outro antibiótico ligado a um sistema de anel distal de melhoria de atividade diretamente ou via um grupo imina, grupo vinil, cadeia ou anel carbo ou heterocíclico ou uma combinação de um grupo imina ou um grupo vinil e uma cadeia ou anel carbo ou heterocíclico. A atividade antibiótica é obtida, por exemplo, pela porção nitrofurano, enquanto a estrutura remanescente da molécula contribui para atividade antimicrobiana adicional e/ou estende a o espectro antimicrobiano da atividade, ao facilitar a nitro-redução por microorganismos, retenção em bactérias alvo, e/ou penetração intracelular, enquanto também contribui para propriedades farmacológicas (absorção, distribuição no corpo e outros).
BRPI0515564-9A 2004-09-23 2005-09-22 antibióticos carbo e heterocìclicos e uso dos mesmos BRPI0515564A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61214804P 2004-09-23 2004-09-23
PCT/CA2005/001436 WO2006032138A1 (en) 2004-09-23 2005-09-22 Carbo- and hetero-cyclic antibiotics and use thereof

Publications (1)

Publication Number Publication Date
BRPI0515564A true BRPI0515564A (pt) 2008-07-29

Family

ID=36089809

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0515564-9A BRPI0515564A (pt) 2004-09-23 2005-09-22 antibióticos carbo e heterocìclicos e uso dos mesmos

Country Status (10)

Country Link
US (1) US20080188499A1 (pt)
EP (1) EP1797087A4 (pt)
JP (1) JP2008513522A (pt)
CN (1) CN101027299A (pt)
AU (1) AU2005287825A1 (pt)
BR (1) BRPI0515564A (pt)
CA (1) CA2579907A1 (pt)
IL (1) IL181921A0 (pt)
MX (1) MX2007003374A (pt)
WO (1) WO2006032138A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080146562A1 (en) * 2003-08-08 2008-06-19 Ulysses Pharmaceutical Products Inc., Halogenated quinazolinyl nitrofurans as antibacterial agents
US8093246B2 (en) 2006-12-14 2012-01-10 Lexicon Pharmaceuticals, Inc. O-linked pyrimidin-4-amine-based compounds, compositions comprising them, and methods of their use to treat cancer
CN114812491B (zh) * 2022-01-19 2023-10-20 国网甘肃省电力公司经济技术研究院 基于长时间序列分析的输电线路地表形变预警方法及装置
CN119841781B (zh) * 2024-12-17 2025-10-17 青岛科技大学 一种喹唑啉酮-三氮烯类化合物及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3359262A (en) * 1963-03-16 1967-12-19 Dainippon Pharmaceutical Co 2-[2-(5-nitrofuryl)-vinyl]-pyrimidines
DE1695849A1 (de) * 1967-06-23 1971-05-13 Schering Ag Verfahren zur Herstellung neuer Pyrimidinderivate
US3542784A (en) * 1968-04-05 1970-11-24 Norwich Pharma Co 4-(hydroxyanilino)-2-(5-nitro-2-furyl)quinazolines
BE754935A (fr) * 1969-08-13 1971-02-17 Hoechst Ag 2-(thienyl-3'-amino)-1,3-diazacycloalcenes et leur preparation
DE2140280A1 (de) * 1970-08-12 1972-02-17 Chemische Fabrik von Heyden GmbH, 8000 München 4 Amino 2 eckige Klammer auf 2 (5 Nitro 2 furyl)vinyl eckige Klammer zu chinazolinderivate, Herstellungsver fahren dafür und Arzneimittel daraus
US3974277A (en) * 1974-09-06 1976-08-10 Diamond Shamrock Corporation 2-[2-(5-Nitro-2-furyl)vinyl]-4-(anilino)quinazolines as growth promotants and feed efficiency enhancing agents
US3970648A (en) * 1974-09-06 1976-07-20 Diamond Shamrock Corporation 2-[2-(5-Nitro-2-furyl)vinyl]-4-(anilino)quinazolines
US3973021A (en) * 1974-09-06 1976-08-03 Diamond Shamrock Corporation 2-[2-(5-Nitro-2-furyl)vinyl]-4-(phydroxyanilino)quinazoline as a bactericide
EP1660486A4 (en) * 2003-08-08 2006-12-13 Ulysses Pharmaceutical Product HALOGENATED CHINAZOLINYL NITROFURANES AS ANTIBACTERIAL AGENTS

Also Published As

Publication number Publication date
IL181921A0 (en) 2007-07-04
AU2005287825A1 (en) 2006-03-30
CN101027299A (zh) 2007-08-29
JP2008513522A (ja) 2008-05-01
MX2007003374A (es) 2007-06-05
WO2006032138A1 (en) 2006-03-30
CA2579907A1 (en) 2006-03-30
EP1797087A1 (en) 2007-06-20
US20080188499A1 (en) 2008-08-07
EP1797087A4 (en) 2009-06-03

Similar Documents

Publication Publication Date Title
BRPI0517343A (pt) derivados de betulina, preparação destes e uso dos mesmos
BRPI0413372A (pt) composto e composições de nitrofuranos de quinazolinil halogenados, seus métodos de preparação e usos como agentes antibacterianos
BRPI0512985A (pt) derivados de 3-carbamoil-2-piridona
BRPI0517423A (pt) composto, composição farmacêutica, método para o tratamento ou prevenção de distúrbios neurológicos e psiquiátricos associados com disfunção do glutamato em um animal, e, uso em um composto
BR0014136A (pt) Composto, uso do mesmo, métodos para a preparação de um composto, e para inibir aurora 2 quinase em um animal de sangue quente, e, composição farmacêutica
ATE322264T1 (de) Medizinische zusammensetzungen als begleittherapie gegen krebs
BRPI0509795A (pt) composto ou um sal farmacologicamente aceitável do mesmo, composição farmacêutica, uso do composto ou sal farmacologicamente aceitável do mesmo, e, método para promover osteogênese, supressão de ressorção óssea e/ou melhoramento da densidade óssea
BRPI0418099A (pt) compostos, composição farmacêutica, e uso de um composto
BRPI0414238A (pt) antagonistas de crf e compostos heterobicìclicos
BRPI0417800A (pt) derivados de oxazolidinona, método de preparo dos mesmos e composição farmacêutica
BRPI0418149A (pt) derivados heterocìclicos como agonistas do receptor de gprc
GT200400092A (es) Preparacion y uso de derivados de alquilarilo para el tratamiento de la obesidad
TW200615266A (en) Organic compounds
WO2007023507A3 (en) Oxazolidinones bearing antimicrobial activity composition and methods of preparation
BRPI0511532A (pt) composto, uso do mesmo, composição farmacêutica, e, métodos para a terapia de distúrbios gastrointestinais funcionais e de sìndrome do intestino irritável em um animal de sangue quente, e para a preparação de um composto
IL189017A0 (en) 8-methoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-effective agents
BR0310032A (pt) Derivados de benzoxazina como moduladores de 5-ht6 e usos dos mesmos
BR0313727A (pt) Derivados de isoquinolina como inibidores de metaloproteinase da matriz
BRPI0411534A (pt) derivados de lincomicina com atividade antimicrobiana
TW200630378A (en) Macrolones-amino substituted quinolones
BR0308144A (pt) Composto, composição farmacêutica, uso de um composto, e, processo para a preparação de um composto
ES2340502T3 (es) Compuestos de 1,4,8-triazaespiro(4,5)decan-2-ona sustituidos para el tratamiento de la obesidad.
DE60028357D1 (de) Kombination eines nukleinsäurebindenen mittels und eines antibiotikums für bakteriellen antibiotischen widerstand
BRPI0515564A (pt) antibióticos carbo e heterocìclicos e uso dos mesmos
BR0313725A (pt) derivados de lincomicina que possuem atividade antibacteriana

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]