BRPI0517343A - derivados de betulina, preparação destes e uso dos mesmos - Google Patents

derivados de betulina, preparação destes e uso dos mesmos

Info

Publication number
BRPI0517343A
BRPI0517343A BRPI0517343-4A BRPI0517343A BRPI0517343A BR PI0517343 A BRPI0517343 A BR PI0517343A BR PI0517343 A BRPI0517343 A BR PI0517343A BR PI0517343 A BRPI0517343 A BR PI0517343A
Authority
BR
Brazil
Prior art keywords
preparation
derivatives
betulin derivatives
betulin
present
Prior art date
Application number
BRPI0517343-4A
Other languages
English (en)
Inventor
Gary N Robinson
Carl T Wild
Mark Ashton
Russel J Thomas
Christian Montalbetti
Thomas Stephen Coulter
Filippo Magaraci
Robert James Townsend
Theodore John Nitz
Original Assignee
Panacos Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Panacos Pharmaceuticals Inc filed Critical Panacos Pharmaceuticals Inc
Publication of BRPI0517343A publication Critical patent/BRPI0517343A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

DERIVADOS DE BETULINA, PREPARAçAO DESTES E USO DOS MESMOS. A presente invenção refere-se a novos derivados sintéticos de betulina e o uso de tais derivados como produtos farmacêuticos. A presente invenção é direcionada a novos compostos de Fórmula (I) ou um sal ou pró-droga farmaceuticamente aceitável destes.
BRPI0517343-4A 2004-11-12 2005-11-14 derivados de betulina, preparação destes e uso dos mesmos BRPI0517343A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62688604P 2004-11-12 2004-11-12
US65308005P 2005-02-16 2005-02-16
PCT/US2005/041043 WO2006053255A2 (en) 2004-11-12 2005-11-14 Novel betulin derivatives, preparation thereof and use thereof

Publications (1)

Publication Number Publication Date
BRPI0517343A true BRPI0517343A (pt) 2008-10-07

Family

ID=36337281

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0517343-4A BRPI0517343A (pt) 2004-11-12 2005-11-14 derivados de betulina, preparação destes e uso dos mesmos

Country Status (14)

Country Link
US (1) US20060205697A1 (pt)
EP (1) EP1828223A4 (pt)
JP (1) JP2008519857A (pt)
KR (1) KR20070101851A (pt)
AR (1) AR051768A1 (pt)
AU (1) AU2005304323A1 (pt)
BR (1) BRPI0517343A (pt)
CA (1) CA2587498A1 (pt)
IL (1) IL183102A0 (pt)
MX (1) MX2007005694A (pt)
NO (1) NO20072978L (pt)
RU (1) RU2007121729A (pt)
TW (1) TW200628161A (pt)
WO (1) WO2006053255A2 (pt)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
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EP1869063A2 (en) * 2005-03-29 2007-12-26 Regents Of The University Of Minnesota Methods of manufacturing bioactive 3-esters of betulinic aldehyde and betulinic acid
EP1868613B1 (en) * 2005-04-12 2012-03-07 Myrexis, Inc. Polymorphs of 3-o-(3',3'-dimethylsuccinyl) betulinic acid di-n-methyl-d-glucamine
EP1893629A4 (en) * 2005-06-22 2008-12-17 Myriad Genetics Inc ANTIVIRAL CONNECTIONS
FI121468B (fi) * 2006-06-07 2010-11-30 Valtion Teknillinen Betuliiniperäiset yhdisteet antimikrobisina aineina
US20080039428A1 (en) * 2006-06-29 2008-02-14 Panacos Pharmaceuticals, Inc. Antiretroviral combination therapy
WO2008097341A2 (en) * 2006-07-26 2008-08-14 Myriad Genetics, Inc. Antiviral compounds and use thereof
CZ300722B6 (cs) * 2006-09-27 2009-07-22 Univerzita Karlova v Praze, Prírodovedecká fakulta Zpusob prípravy inkluzního komplexu pentacyklických a tetracyklických terpenoidu a farmaceutického prostredku obsahujícího tento inkluzní komplex, inkluzní komplex pentacyklického nebo tetracyklického terpenoidu a farmaceutický prostredek obsahující
WO2008127364A2 (en) * 2006-10-13 2008-10-23 Myriad Genetics, Inc. Antiviral compounds and use thereof
WO2008115281A2 (en) * 2006-10-16 2008-09-25 Myriad Genetics, Inc. Compounds for treating viral infections
AR063546A1 (es) 2006-11-03 2009-01-28 Panacos Pharmaceuticals Inc DERIVADOS DE TRITERPENO, METODOS PARA SU PREPARACION, COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN Y SU USO EN LA FABRICACION DE MEDICAMENTOS PARA EL TRATAMIENTO DE INFECCIoN POR EL VIRUS VIH.
US20110152229A1 (en) * 2006-11-22 2011-06-23 Duke University Betulinic acid derivatives as anti-hiv agents
CA2744908A1 (en) * 2007-12-04 2009-06-11 Myrexis, Inc. Compounds and therapeutic use thereof
CN101981047A (zh) * 2008-01-03 2011-02-23 Viro化学制药公司 新的羽扇烷衍生物
CA2714049A1 (en) * 2008-02-14 2009-08-20 Virochem Pharma Inc. Novel 17.beta. lupane derivatives
US8431556B2 (en) * 2008-03-26 2013-04-30 Vertex Pharmaceuticals Incorporated C-21-keto lupane derivatives preparation and use thereof
MD4009C2 (ro) * 2008-07-15 2010-08-31 Институт Химии Академии Наук Молдовы Utilizarea 1-metil-4-(N-metilaminobutil-4)-β-carbolinei în calitate de remediu antituberculos
KR101027217B1 (ko) * 2009-03-11 2011-04-06 주식회사 바이오폴리메드 신규한 수용성 베툴린 유도체, 이의 제조방법 및 이를 포함하는 주름 개선용 화장료 조성물
KR101061911B1 (ko) * 2009-04-01 2011-09-02 주식회사 페라온 페길레이션된 베튤린 유도체 및 그를 포함하는 화장료 조성물
US20120101098A1 (en) * 2009-05-15 2012-04-26 Kuo-Hsiung Lee 3,28-disubstituted betulinic acid derivatives as anti-hiv agents
US8802727B2 (en) * 2009-07-14 2014-08-12 Hetero Research Foundation, Hetero Drugs Limited Pharmaceutically acceptable salts of betulinic acid derivatives
US9067966B2 (en) 2009-07-14 2015-06-30 Hetero Research Foundation, Hetero Drugs Ltd. Lupeol-type triterpene derivatives as antivirals
CN102883608A (zh) * 2010-02-11 2013-01-16 葛兰素史密丝克莱恩有限责任公司 白桦脂醇衍生物
CN103038245B (zh) * 2010-06-04 2015-03-25 百时美施贵宝公司 作为hiv成熟抑制剂的c-3经修饰的桦木酸衍生物
US8802661B2 (en) * 2010-06-04 2014-08-12 Bristol-Myers Squibb Company C-28 amides of modified C-3 betulinic acid derivatives as HIV maturation inhibitors
RU2448115C1 (ru) * 2010-12-20 2012-04-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Новосибирский национальный исследовательский государственный университет" (Новосибирский государственный университет (НГУ) Гидрированная бетулоновая кислота и ее амиды как противоопухолевые средства тритерпеновой природы
KR101886467B1 (ko) * 2011-01-31 2018-08-07 비브 헬스케어 유케이 (넘버4) 리미티드 Hiv 성숙 억제 활성을 갖는 c-17 및 c-3 변형 트리테르페노이드
PL2670764T3 (pl) * 2011-01-31 2016-02-29 Bristol Myers Squibb Co C-28 aminy zmodyfikowanych C-3 pochodnych kwasu betulinowego jako inhibitory dojrzewania HIV
EP2567965B1 (en) * 2011-09-12 2015-09-02 Centre National de la Recherche Scientifique (CNRS) Derivatives of 3-O-(3',3'-dimethylsuccinyl)-betulinic acid
WO2013043778A1 (en) 2011-09-21 2013-03-28 Bristol-Myers Squibb Company Novel betulinic acid derivatives with antiviral activity
EP2791102B1 (en) * 2011-12-14 2016-05-18 Glaxosmithkline LLC Propenoate derivatives of betulin
JO3387B1 (ar) * 2011-12-16 2019-03-13 Glaxosmithkline Llc مشتقات بيتولين
US8906889B2 (en) 2012-02-15 2014-12-09 Bristol-Myers Squibb Company C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity
US8889854B2 (en) 2012-05-07 2014-11-18 Bristol-Myers Squibb Company C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity
KR20150093819A (ko) 2012-12-14 2015-08-18 글락소스미스클라인 엘엘씨 약제 조성물
US9637516B2 (en) 2012-12-31 2017-05-02 Hetero Research Foundation Betulinic acid proline derivatives as HIV inhibitors
SG11201505639SA (en) 2013-02-06 2015-08-28 Bristol Myers Squibb Co C-19 modified triterpenoids with hiv maturation inhibitory activity
SG11201506445PA (en) 2013-02-25 2015-09-29 Bristol Myers Squibb Co C-3 alkyl and alkenyl modified betulinic acid derivatives useful in the treatment of hiv
SI3129392T1 (sl) 2014-04-11 2020-11-30 VIIV Healthcare UK(No.4) Limited Triterpenoidi z inhibitorno aktivnostjo maturacije HIV-a, substituirani na položaju 3 z nearomatskim obročem, ki nosi haloalkilni substituent
WO2015195776A1 (en) 2014-06-19 2015-12-23 Bristol-Myers Squibb Company Betulinic acid derivatives with hiv maturation inhibitory activity
WO2015198263A2 (en) * 2014-06-26 2015-12-30 Hetero Research Foundation Novel betulinic proline substituted derivatives as hiv inhibitors
US20170129916A1 (en) 2014-06-26 2017-05-11 Hetero Research Foundation Novel betulinic proline imidazole derivatives as hiv inhibitors
US10092523B2 (en) 2014-09-26 2018-10-09 Glaxosmithkline Intellectual Property (No. 2) Limited Long acting pharmaceutical compositions
EP3218388A1 (en) 2014-11-14 2017-09-20 VIIV Healthcare UK (No.5) Limited C17-aryl substituted betulinic acid analogs
CN107250153A (zh) 2014-11-14 2017-10-13 Viiv保健英国第五有限公司 氧代羽扇豆烯衍生物
CN107207778B (zh) * 2014-11-24 2019-11-05 巴斯夫欧洲公司 用于光诱导交联聚合物线材的单叠氮化合物
MA40886B1 (fr) 2015-02-09 2020-03-31 Hetero Research Foundation Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih
US10370405B2 (en) 2015-03-16 2019-08-06 Hetero Labs Limited C-3 novel triterpenone with C-28 amide derivatives as HIV inhibitors
WO2017017630A1 (en) * 2015-07-28 2017-02-02 Hetero Research Foundation Novel betulinic substituted amide derivatives as hiv inhibitors
WO2017064628A1 (en) * 2015-10-13 2017-04-20 Hetero Research Foundation C-3 novel triterpenone with c-28 urea derivatives as hiv inhibitors
AR107512A1 (es) 2016-02-04 2018-05-09 VIIV HEALTHCARE UK Nº 5 LTD Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1
SI3924361T1 (sl) 2019-02-11 2024-02-29 Hetero Labs Limited Novi derivati triterpena kot zaviralci virusa hiv

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EP1869063A2 (en) * 2005-03-29 2007-12-26 Regents Of The University Of Minnesota Methods of manufacturing bioactive 3-esters of betulinic aldehyde and betulinic acid

Also Published As

Publication number Publication date
RU2007121729A (ru) 2008-12-20
MX2007005694A (es) 2007-07-09
WO2006053255A3 (en) 2007-01-18
KR20070101851A (ko) 2007-10-17
IL183102A0 (en) 2007-09-20
EP1828223A4 (en) 2009-03-11
NO20072978L (no) 2007-06-27
TW200628161A (en) 2006-08-16
WO2006053255A2 (en) 2006-05-18
AU2005304323A1 (en) 2006-05-18
CA2587498A1 (en) 2006-05-18
JP2008519857A (ja) 2008-06-12
EP1828223A2 (en) 2007-09-05
US20060205697A1 (en) 2006-09-14
AR051768A1 (es) 2007-02-07

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012.