BRPI0515819A - métodos para o fornecimento direcionado de material genético ao fìgado - Google Patents
métodos para o fornecimento direcionado de material genético ao fìgadoInfo
- Publication number
- BRPI0515819A BRPI0515819A BRPI0515819-2A BRPI0515819A BRPI0515819A BR PI0515819 A BRPI0515819 A BR PI0515819A BR PI0515819 A BRPI0515819 A BR PI0515819A BR PI0515819 A BRPI0515819 A BR PI0515819A
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- gene therapy
- liver
- genetic material
- target organ
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 7
- 210000004185 liver Anatomy 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 238000001415 gene therapy Methods 0.000 abstract 4
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 210000000056 organ Anatomy 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 210000005161 hepatic lobe Anatomy 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 238000001890 transfection Methods 0.000 abstract 1
- 210000005166 vasculature Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
MéTODOS PARA O FORNECIMENTO DIRECIONADO DE MATERIAL GENéTICO AO FìGADO. A presente invenção refere-se a métodos para o fornecimento aumentado de vários agentes terapêuticos, tais como agentes de terapia genética, à vasculatura de um órgão alvo em um indivíduo mamífero. São revelados os métodos para a terapia genética direcionada no fígado de mamífero como um todo, ou em um lóbulo hepático único. Os métodos revelados contam com procedimentos baseados em cateter minimamente invasivos em que o órgão alvo é isolado e é tratado localmente com um agente de terapia genética. Os métodos oferecem transfecções mais eficientes e localizados de tecido e são bem adequados para terapia genética em indivíduos humanos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63235904P | 2004-12-01 | 2004-12-01 | |
| PCT/US2005/043590 WO2006060641A2 (en) | 2004-12-01 | 2005-12-01 | Methods for targeted delivery of genetic material to the liver |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0515819A true BRPI0515819A (pt) | 2008-08-05 |
Family
ID=36565758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0515819-2A BRPI0515819A (pt) | 2004-12-01 | 2005-12-01 | métodos para o fornecimento direcionado de material genético ao fìgado |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20080025952A1 (pt) |
| EP (1) | EP1827502A4 (pt) |
| JP (2) | JP2008521575A (pt) |
| CN (1) | CN101068575A (pt) |
| BR (1) | BRPI0515819A (pt) |
| MX (1) | MX2007006524A (pt) |
| WO (1) | WO2006060641A2 (pt) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1759001T3 (pl) | 2004-04-21 | 2011-09-30 | Alexion Pharma Inc | Koniugaty dostarczane do kości i sposób ich zastosowania do nakierowywania białek do kości |
| US20070081984A1 (en) | 2005-10-11 | 2007-04-12 | Shunji Tomatsu | Compositions and methods for treating hypophosphatasia |
| DK2662448T3 (en) | 2007-05-11 | 2017-03-20 | Alexion Pharma Inc | Bone-targeted alkaline phosphatase, kits and methods for its use |
| CN103153344A (zh) | 2010-04-30 | 2013-06-12 | 阿莱克森国际制药有限公司 | 用于治疗基质矿化障碍的方法、组合物、和试剂盒 |
| US8738115B2 (en) * | 2010-05-11 | 2014-05-27 | Siemens Aktiengesellschaft | Method and apparatus for selective internal radiation therapy planning and implementation |
| JP6055779B2 (ja) | 2010-12-27 | 2016-12-27 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | ナトリウム利尿ペプチドを含む組成物およびその使用方法 |
| KR20140084201A (ko) | 2011-10-19 | 2014-07-04 | 알렉시온 파마 홀딩 | 알칼리성 포스파타제 및/또는 나트륨이뇨 펩티드를 포함하는 조성물 및 그의 사용 방법 |
| SG10201604810UA (en) | 2012-02-07 | 2016-08-30 | Global Bio Therapeutics Inc | Compartmentalized method of nucleic acid delivery and compositions and uses thereof |
| US10052366B2 (en) | 2012-05-21 | 2018-08-21 | Alexion Pharmaceuticsl, Inc. | Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof |
| US10806830B2 (en) | 2012-10-26 | 2020-10-20 | Urotronic, Inc. | Drug-coated balloon catheters for body lumens |
| US10881839B2 (en) | 2012-10-26 | 2021-01-05 | Urotronic, Inc. | Drug-coated balloon catheters for body lumens |
| US10898700B2 (en) | 2012-10-26 | 2021-01-26 | Urotronic, Inc. | Balloon catheters for body lumens |
| US10668188B2 (en) | 2012-10-26 | 2020-06-02 | Urotronic, Inc. | Drug coated balloon catheters for nonvascular strictures |
| US11938287B2 (en) | 2012-10-26 | 2024-03-26 | Urotronic, Inc. | Drug-coated balloon catheters for body lumens |
| US10850076B2 (en) | 2012-10-26 | 2020-12-01 | Urotronic, Inc. | Balloon catheters for body lumens |
| US11504450B2 (en) | 2012-10-26 | 2022-11-22 | Urotronic, Inc. | Drug-coated balloon catheters for body lumens |
| RU2664471C2 (ru) * | 2013-07-26 | 2018-08-17 | Юниверсити Оф Айова Рисерч Фаундейшн | Способы и композиции для лечения болезней мозга |
| EP3030171B1 (en) | 2013-08-08 | 2017-11-01 | Global Bio Therapeutics, Inc. | Injection device for minimally invasive procedures |
| CN105813579B (zh) | 2013-08-08 | 2019-05-07 | 全球生物疗法有限公司 | 用于微创手术过程的夹具装置和其应用 |
| WO2016007873A1 (en) | 2014-07-11 | 2016-01-14 | The Regents Of The University Of Michigan | Compositions and methods for treating craniosynostosis |
| JP6787894B2 (ja) | 2014-12-05 | 2020-11-18 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 組換えアルカリホスファターゼを用いた発作の処置 |
| CA2973883A1 (en) | 2015-01-28 | 2016-08-04 | Alexion Pharmaceuticals, Inc. | Methods of treating a subject with an alkaline phosphatase deficiency |
| US11904072B2 (en) | 2015-04-24 | 2024-02-20 | Urotronic, Inc. | Drug coated balloon catheters for nonvascular strictures |
| EP3285820A4 (en) * | 2015-04-24 | 2018-12-12 | Urotronic, Inc. | Drug coated balloon catheters for nonvascular strictures |
| JP6993961B2 (ja) | 2015-08-17 | 2022-01-14 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | アルカリホスファターゼの製造 |
| EP3355904A4 (en) | 2015-09-28 | 2019-06-12 | Alexion Pharmaceuticals, Inc. | IDENTIFICATION OF EFFECTIVE DOSE SHEETS FOR TISSUE-SPECIFIC ALKALINE PHOSPHATASE ENZYMERSAT THERAPY OF HYPOPHOSPHATASIA |
| EP3368062A4 (en) | 2015-10-30 | 2019-07-03 | Alexion Pharmaceuticals, Inc. | METHODS OF TREATING CRANIOSYNOSTOSIS IN A PATIENT |
| US11065306B2 (en) | 2016-03-08 | 2021-07-20 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in children |
| KR20180125979A (ko) | 2016-04-01 | 2018-11-26 | 알렉시온 파마슈티칼스, 인코포레이티드 | 알칼리성 포스파타아제로 근육 약화의 치료 |
| US10898549B2 (en) | 2016-04-01 | 2021-01-26 | Alexion Pharmaceuticals, Inc. | Methods for treating hypophosphatasia in adolescents and adults |
| WO2017214130A1 (en) | 2016-06-06 | 2017-12-14 | Alexion Pharmaceuticals, Inc. | Metal impact on manufacturing of alkaline phosphatases |
| JP7018933B2 (ja) | 2016-08-18 | 2022-02-14 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 気管気管支軟化症の治療方法 |
| US11464892B2 (en) * | 2016-09-22 | 2022-10-11 | All Vascular Pty Limited | Devices and methods for vascular hyperperfusion of extravascular space |
| KR20190129058A (ko) | 2017-03-31 | 2019-11-19 | 알렉시온 파마슈티칼스, 인코포레이티드 | 성인 및 청소년에서 저포스파타제증 (hpp)을 치료하는 방법 |
| WO2019190752A1 (en) | 2018-03-30 | 2019-10-03 | Alexion Pharmaceuticals, Inc. | Manufacturing of glycoproteins |
| WO2020033867A2 (en) | 2018-08-10 | 2020-02-13 | Alexion Pharmaceuticals, Inc. | Methods of treating neurofibromatosis type 1 and related conditions with alkaline phosphatase |
| CN113226352B (zh) * | 2018-08-24 | 2025-08-26 | 星火治疗有限公司 | 最优化启动子序列、无内含子的表达结构及使用方法 |
| CN109504709B (zh) * | 2018-11-28 | 2020-07-24 | 上海安民生物技术有限公司 | 白蛋白启动子驱动的白蛋白表达载体 |
| GB201900741D0 (en) * | 2019-01-18 | 2019-03-06 | Synpromics Ltd | Liver-specifc inducible prometers and methods of use thereof |
| CN118454075A (zh) | 2019-02-22 | 2024-08-09 | 优敦力公司 | 用于体腔的药物涂布的球囊导管 |
| CA3161266A1 (en) | 2019-12-09 | 2021-06-17 | Alexion Pharmaceuticals, Inc. | Alkaline phosphatase polypeptides and methods of use thereof |
| TW202204380A (zh) | 2020-01-31 | 2022-02-01 | 美商詹森藥物公司 | 用於預防及治療冠狀病毒感染之組合物及方法－sars-cov-2疫苗 |
| EP4106828B1 (en) | 2020-02-21 | 2026-03-11 | Tonic Medical, Inc. | Polymer-encapsulated drug particles |
| US12611447B2 (en) | 2020-09-04 | 2026-04-28 | Alexion Pharmaceuticals, Inc. | Methods for treating bone mineralization disorders |
| WO2022100748A1 (en) * | 2020-11-16 | 2022-05-19 | Staidson (Beijing) Biopharmaceuticals Co., Ltd. | Recombinant adeno-associated viruses with enhanced liver tropism and uses thereof |
| AU2022218782B2 (en) | 2021-02-12 | 2026-06-25 | Alexion Pharmaceuticals, Inc. | Alkaline phosphatase polypeptides and methods of use thereof |
| AU2022242921A1 (en) * | 2021-03-25 | 2023-10-19 | The Johns Hopkins University | Hydrodynamic gene delivery |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5328470A (en) * | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| US5674192A (en) * | 1990-12-28 | 1997-10-07 | Boston Scientific Corporation | Drug delivery |
| US6265387B1 (en) * | 1995-10-11 | 2001-07-24 | Mirus, Inc. | Process of delivering naked DNA into a hepatocyte via bile duct |
| US6416510B1 (en) * | 1997-03-13 | 2002-07-09 | Biocardia, Inc. | Drug delivery catheters that attach to tissue and methods for their use |
| US6290689B1 (en) * | 1999-10-22 | 2001-09-18 | Corazón Technologies, Inc. | Catheter devices and methods for their use in the treatment of calcified vascular occlusions |
| US6135976A (en) * | 1998-09-25 | 2000-10-24 | Ekos Corporation | Method, device and kit for performing gene therapy |
| AU1248602A (en) * | 2000-11-03 | 2002-05-15 | Ml Lab Plc | Formulations comprising dextrin polymers in combination with sugars for the delivery of nucleic acids |
| CA2441454A1 (en) * | 2001-03-14 | 2002-09-19 | Avigen, Inc. | Recombinant adeno-associated virus-mediated gene transfer via retroductal infusion of virions |
| US20040009151A1 (en) * | 2002-04-04 | 2004-01-15 | Kay Mark A. | Methods for delivering recombinant adeno-associated virus virions to the liver of a mammal |
| JP2006501177A (ja) * | 2002-06-24 | 2006-01-12 | ジェンザイム・コーポレイション | 遺伝子治療薬を送達する方法 |
-
2005
- 2005-12-01 BR BRPI0515819-2A patent/BRPI0515819A/pt not_active IP Right Cessation
- 2005-12-01 JP JP2007544533A patent/JP2008521575A/ja not_active Withdrawn
- 2005-12-01 EP EP05852728A patent/EP1827502A4/en not_active Ceased
- 2005-12-01 MX MX2007006524A patent/MX2007006524A/es unknown
- 2005-12-01 WO PCT/US2005/043590 patent/WO2006060641A2/en not_active Ceased
- 2005-12-01 CN CNA200580041379XA patent/CN101068575A/zh active Pending
-
2007
- 2007-05-17 US US11/804,291 patent/US20080025952A1/en not_active Abandoned
-
2012
- 2012-06-07 JP JP2012130077A patent/JP2012197297A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CN101068575A (zh) | 2007-11-07 |
| US20080025952A1 (en) | 2008-01-31 |
| JP2012197297A (ja) | 2012-10-18 |
| JP2008521575A (ja) | 2008-06-26 |
| MX2007006524A (es) | 2007-06-22 |
| EP1827502A4 (en) | 2008-01-16 |
| WO2006060641A3 (en) | 2006-08-17 |
| WO2006060641A2 (en) | 2006-06-08 |
| EP1827502A2 (en) | 2007-09-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06H | Technical and formal requirements: requirement cancelled [chapter 6.8 patent gazette] |
Free format text: REF. A RPI NO 2150 DE 20/03/2012. ANULACAO DA EXIGENCIA 6.6 POR TER SIDO INDEVIDA. REQUERENTE NAO APRESENTOU RESPOSTA A EXIGENCIA CONFORME DISPOE A RESOLUCAO 207 DE 24/04/2009, ENTRETANTO, A RESPOSTA CONSTA NO FORMULARIO DE DEPOSITO. |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2282 DE 30/09/2014. |