BRPI0518396A2 - mÉtodo para estabilizaÇço de droga anti-demÊncia - Google Patents

mÉtodo para estabilizaÇço de droga anti-demÊncia

Info

Publication number
BRPI0518396A2
BRPI0518396A2 BRPI0518396-0A BRPI0518396A BRPI0518396A2 BR PI0518396 A2 BRPI0518396 A2 BR PI0518396A2 BR PI0518396 A BRPI0518396 A BR PI0518396A BR PI0518396 A2 BRPI0518396 A2 BR PI0518396A2
Authority
BR
Brazil
Prior art keywords
dementia drug
molecular weight
high molecular
pharmaceutical composition
drug
Prior art date
Application number
BRPI0518396-0A
Other languages
English (en)
Inventor
Yasuyuki Suzuki
Yosuke Ueki
Satoshi Fujioka
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36615033&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0518396(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of BRPI0518396A2 publication Critical patent/BRPI0518396A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

METODO PARA ESTABILIZAÇçO DE DROGA ANTI-DEMÊNCIA. A presente invenção proporciona um método para estabilização de uma droga anti-demência em uma composição farmacêutica contendo a droga anti-demência e uma substância básica de elevado peso molecular através da adição da substância ácida de elevado peso molecular à referida composição farmacêutica. Ainda, a presente invenção proporciona uma composição farmacêutica contendo uma droga anti-demência e uma substância básica de elevado peso molecular na qual uma substância ácida de elevado peso molecular está contida para estabilização da droga anti- demência. Além disso, a presente invenção proporciona um método para a fabricação de uma composição farmacêutica o qual compreende etapas em que uma solução ou suspensão contendo a substância ácida de elevado peso molecular é adicionada a uma mistura de uma droga anti-demência e da substância básica de elevado peso molecular para fins de estabilização da droga anti-demência.
BRPI0518396-0A 2004-12-27 2005-12-27 mÉtodo para estabilizaÇço de droga anti-demÊncia BRPI0518396A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2004376770 2004-12-27
JP2005041492 2005-02-18
PCT/JP2005/024254 WO2006070930A1 (en) 2004-12-27 2005-12-27 Method for stabilizing anti-dementia drug

Publications (1)

Publication Number Publication Date
BRPI0518396A2 true BRPI0518396A2 (pt) 2008-11-18

Family

ID=36615033

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0518396-0A BRPI0518396A2 (pt) 2004-12-27 2005-12-27 mÉtodo para estabilizaÇço de droga anti-demÊncia

Country Status (13)

Country Link
US (2) US8481565B2 (pt)
EP (1) EP1830886B1 (pt)
JP (2) JP2008525313A (pt)
KR (1) KR100866720B1 (pt)
AU (1) AU2005320547B2 (pt)
BR (1) BRPI0518396A2 (pt)
CA (1) CA2592605C (pt)
IL (1) IL183650A (pt)
MX (1) MX2007007836A (pt)
NO (1) NO20073482L (pt)
NZ (1) NZ555693A (pt)
RU (1) RU2401125C2 (pt)
WO (1) WO2006070930A1 (pt)

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CN103417490B (zh) * 2012-05-21 2015-06-17 成都康弘药业集团股份有限公司 一种含有盐酸多奈哌齐的颗粒剂及其制备方法
CN105163723A (zh) * 2013-02-28 2015-12-16 鲁平有限公司 具有特定体外溶解曲线或药动学参数的多奈哌齐的药物组合物
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KR101990951B1 (ko) * 2015-04-27 2019-06-20 주식회사 네비팜 리바스티그민 함유 서방출 의약조성물
KR101938872B1 (ko) 2016-09-30 2019-01-16 주식회사 바이오파마티스 도네페질 또는 그의 약학적으로 허용 가능한 염 및 메만틴 또는 그의 약학적으로 허용 가능한 염을 함유하는 치매 및 인지기능 장애 예방 또는 치료용 약학 조성물 및 이의 제조방법
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