BRPI0518776A2 - composiÇço e mÉtodo para o cuidado oral, e, mÉtodos para inibir a inflamaÇço em um tecido oral de um paciente, e para promover a saéde oral em um paciente - Google Patents

composiÇço e mÉtodo para o cuidado oral, e, mÉtodos para inibir a inflamaÇço em um tecido oral de um paciente, e para promover a saéde oral em um paciente

Info

Publication number
BRPI0518776A2
BRPI0518776A2 BRPI0518776-1A BRPI0518776A BRPI0518776A2 BR PI0518776 A2 BRPI0518776 A2 BR PI0518776A2 BR PI0518776 A BRPI0518776 A BR PI0518776A BR PI0518776 A2 BRPI0518776 A2 BR PI0518776A2
Authority
BR
Brazil
Prior art keywords
vitamin
oral
patient
composition
methods
Prior art date
Application number
BRPI0518776-1A
Other languages
English (en)
Inventor
Dale S Scherl
Tao Xu
Kimberlee Panaligan
Linh Fruge
Harsh M Trivedi
Original Assignee
Colgate Palmolive Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Colgate Palmolive Co filed Critical Colgate Palmolive Co
Publication of BRPI0518776A2 publication Critical patent/BRPI0518776A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

COMPOSIÇçO E MÉTODO PARA O CUIDADO ORAL, E, MÉTODOS PARA INIBIR A INFLAMAÇçO EM UM TECIDO ORAL DE UM PACIENTE, E PARA PROMOVER A SAéDE ORAL EM UM PACIENTE. Uma composição para o cuidado oral compreende um composto fenólico antibacteriano e uma vitamina ou componente derivado de vitamina, que compreende um a uma pluralidade de derivados de vitamina ou vitamina antioxidante. Em uma modalidade, a vitamina ou o componente derivado de vitamina compreende a vitamina E, e o acetato de vitamina E, e opcionalmente um ou mais derivados de vitamina ou vitaminas adicionais. Em outra modalidade, o componente de vitamina ou de derivado de vitamina compreende uma vitamina antioxidante ou derivado de vitamina e uma fonte de vitamina B5. Um método para o cuidado oral compreende a aplicação de uma composição, como acima descrito, a uma superficie oral de um individuo.
BRPI0518776-1A 2004-12-02 2005-11-10 composiÇço e mÉtodo para o cuidado oral, e, mÉtodos para inibir a inflamaÇço em um tecido oral de um paciente, e para promover a saéde oral em um paciente BRPI0518776A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63248004P 2004-12-02 2004-12-02
US11/238,522 US20060120975A1 (en) 2004-12-02 2005-09-29 Oral care composition comprising a phenolic compound and antioxidant vitamins and vitamin derivatives
PCT/US2005/041076 WO2006060145A2 (en) 2004-12-02 2005-11-10 Oral care composition comprising a phenolic compound and antioxidant vitamins and vitamin derivatives

Publications (1)

Publication Number Publication Date
BRPI0518776A2 true BRPI0518776A2 (pt) 2008-12-09

Family

ID=36001094

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0518776-1A BRPI0518776A2 (pt) 2004-12-02 2005-11-10 composiÇço e mÉtodo para o cuidado oral, e, mÉtodos para inibir a inflamaÇço em um tecido oral de um paciente, e para promover a saéde oral em um paciente

Country Status (13)

Country Link
US (1) US20060120975A1 (pt)
EP (1) EP1817081A2 (pt)
CN (1) CN103462817A (pt)
AR (1) AR052038A1 (pt)
AU (1) AU2005310186B2 (pt)
BR (1) BRPI0518776A2 (pt)
CA (1) CA2589411A1 (pt)
MX (1) MX2007006445A (pt)
MY (1) MY157829A (pt)
RU (1) RU2007124582A (pt)
SG (2) SG170042A1 (pt)
TW (1) TW200637594A (pt)
WO (1) WO2006060145A2 (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8425881B2 (en) * 2005-03-18 2013-04-23 Colgate-Palmolive Company Antibacterial 3′,5-disubstituted 2,4′-dihydroxybiphenyl compounds, derivatives and related methods
CA2601454C (en) * 2005-03-18 2013-09-24 Colgate-Palmolive Company Antibacterial 5,5'-disubstituted 3,3'-dialkoxy-2,2'-dihydroxy-1,1'-biphenyl compounds and related methods
US20070140990A1 (en) 2005-12-21 2007-06-21 Nataly Fetissova Oral Compositions Comprising Propolis
EP1891984A1 (en) * 2006-08-24 2008-02-27 Graftys Macroporous and highly resorbable apatitic calcium-phosphate cement
US20080241117A1 (en) * 2007-04-02 2008-10-02 Abdul Gaffar Oral Care Compositions Containing a Mixed Tocopherol Component
US20080253976A1 (en) * 2007-04-16 2008-10-16 Douglas Craig Scott Personal Care Compositions Comprising An Antimicrobial Blend of Essential Oils or Constituents Thereof
US20090087461A1 (en) * 2007-10-01 2009-04-02 Thomas James Boyd Anti-bacterial pyrocatechols and related methods
GB0724278D0 (en) * 2007-12-13 2008-01-30 Syntopix Ltd uses for antimicrobial agents
WO2009111685A1 (en) * 2008-03-06 2009-09-11 Sensient Flavors Llc Herbal extracts and flavor systems for oral products and methods of making the same
TWI404544B (zh) 2008-08-11 2013-08-11 美國棕欖公司 含珠粒之口腔保健組成物
US20100292287A1 (en) * 2009-05-14 2010-11-18 Kador Peter F Periodontitis treatment
US8084504B2 (en) * 2009-10-02 2011-12-27 Johnson & Johnson Consumer Companies, Inc. High-clarity aqueous concentrates of 4-hexylresorcinol
US20110081305A1 (en) * 2009-10-02 2011-04-07 Steven Cochran Compositions comprising a skin-lightening resorcinol and a skin darkening agent
IN2012DN02441A (pt) * 2009-10-02 2015-08-21 Johnson & Johnson Consumer
US20110081430A1 (en) 2009-10-02 2011-04-07 Simarna Kaur COMPOSITIONS COMPRISING AN NFkB-INHIBITOR AND A TROPOELASTIN PROMOTER
US8906432B2 (en) * 2009-10-02 2014-12-09 Johnson & Johnson Consumer Companies, Inc. Compositions comprising an NFκB-inhibitor and a non-retinoid collagen promoter
CA2775444C (en) 2009-10-29 2015-04-21 Colgate-Palmolive Company Dentifrice comprising stannous fluoride plus zinc citrate and low levels of water
KR101178939B1 (ko) * 2009-11-06 2012-09-03 이용찬 4?헥실레조르시놀(hexylresorcinol)을 포함하는 치과용 골 이식재 및 이를 이용한 임플란트 코팅
MX348897B (es) * 2011-01-25 2017-07-03 Nestec Sa Analogos de alimento y metodos para hacer analogos de alimento.
US20140086859A1 (en) 2012-09-24 2014-03-27 Johnson & Johnson Consumer Companies, Inc. Low oil compositions comprising a 4-substituted resorcinol and a high carbon chain ester
WO2017081725A1 (ja) * 2015-11-09 2017-05-18 花王株式会社 口腔用組成物
KR102272558B1 (ko) * 2017-04-12 2021-07-02 퍼포먼스 랩스 피티이 리미티드 식이 오메가-3 보충제에서 아스피린의 사용 없이 아스피린-유발된 레졸빈의 생산방법
US12246078B2 (en) 2017-09-14 2025-03-11 Gerald P. Curatola Oral care formulations and methods for use
WO2019191187A2 (en) * 2018-03-27 2019-10-03 Dentsply Sirona Inc. Methods of treatment of the dental pulp and filling root canals using anti inflammatory rinse solution and filling composition
CN109303715A (zh) * 2018-10-10 2019-02-05 云南巴菰生物科技有限公司 一种香烟漱口水及其制备方法
CN110123649A (zh) * 2019-06-05 2019-08-16 广东勉衡生物科技有限公司 一种液体牙膏及其制备方法
WO2021137561A2 (ko) * 2019-12-30 2021-07-08 경북대학교 산학협력단 4-헥실레소르시놀을 유효성분으로 포함하는 골질환 예방 또는 치료용 약학조성물
KR20210086463A (ko) 2019-12-30 2021-07-08 경북대학교 산학협력단 4-헥실레소르시놀을 유효성분으로 포함하는 골질환 예방 또는 치료용 약학조성물

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8411731D0 (en) * 1984-05-09 1984-06-13 Unilever Plc Oral compositions
US5288480A (en) * 1987-01-30 1994-02-22 Colgate-Palmolive Co. Antiplaque antibacterial oral composition
CA1340052C (en) * 1988-03-31 1998-09-22 Narasimhan Raghupathi Chemically treated glass fibers for reinforcing thermosetting polymer matrices
US5298237A (en) * 1992-01-24 1994-03-29 The Trustees Of Columbia University In The City Of New York Gel composition for reduction of gingival inflammation and retardation of dental plaque
JPH06211636A (ja) * 1993-01-13 1994-08-02 Lion Corp 口腔用組成物
US6159459A (en) * 1995-05-01 2000-12-12 Colgate Palmolive Company Oral lubricating composition
US6193958B1 (en) * 1995-07-05 2001-02-27 The Procter & Gamble Company Oral compositions
CA2235655C (en) * 1997-04-24 2008-01-22 Sunstar Inc. Oral compositions comprising porous calcium carbonate
JPH1112142A (ja) * 1997-06-19 1999-01-19 Lion Corp 口腔用組成物
US6228347B1 (en) * 1997-12-01 2001-05-08 Thione International, Inc. Antioxidant gel for gingival conditions
US6248343B1 (en) * 1998-01-20 2001-06-19 Ethicon, Inc. Therapeutic antimicrobial compositions
US5968480A (en) * 1998-07-09 1999-10-19 Colgate Palmolive Company Oral composition exhibiting enhanced antiplaque efficacy
DE19834355A1 (de) * 1998-07-30 2000-02-03 Henkel Kgaa Entzündungshemmende Zahnpflegemittel
JP2000256153A (ja) * 1999-03-05 2000-09-19 Lion Corp 口腔用組成物
DE60013111T2 (de) * 1999-04-19 2005-09-01 Unilever N.V. Mundpflegezusammensetzung
US6117415A (en) * 1999-06-17 2000-09-12 Alpharx Inc. Toothpaste comprising bioadhesive submicron emulsion for improved delivery of antibacterial and anticaries agents
US20030158111A1 (en) * 1999-10-01 2003-08-21 David Bar-Or Methods and products for oral care
FR2826868B1 (fr) * 2001-07-04 2007-10-12 Sanofi Synthelabo Composition pour l'hygiene bucco-dentaire comprenant un vecteur d'ions fluorure et un agent antioxydant, ses utilisations notamment pour l'hygiene bucco-dentaire des sujets diabetiques
ES2186569B1 (es) * 2001-09-28 2004-09-16 Lacer, S.A. Composiciones para el alivio de la xerostomia y el tratamiento de los trastornos asociados con la misma.
AU2003216213B2 (en) * 2002-02-07 2008-10-02 The Trustees Of Columbia University In The City Of New York Zinc salt compositions for the prevention of mucosal irritation from spermicides and microbicides
US8071076B2 (en) * 2002-05-28 2011-12-06 Oral Health Clinical Services Llc Oral lubricating and stain retarding compositions
JP3978605B2 (ja) * 2003-04-30 2007-09-19 ライオン株式会社 口腔用製品及び口腔用製品中におけるビタミンe又はその誘導体の安定配合方法
US7846422B2 (en) * 2003-08-04 2010-12-07 Kao Corporation Method for prevention or treatment of periodontal diseases and composition for an oral cavity
US20050112084A1 (en) * 2003-11-21 2005-05-26 The Gillette Company Topical cosmetic composition

Also Published As

Publication number Publication date
MX2007006445A (es) 2007-07-19
WO2006060145A3 (en) 2006-08-03
US20060120975A1 (en) 2006-06-08
SG149856A1 (en) 2009-02-27
MY157829A (en) 2016-07-29
WO2006060145A2 (en) 2006-06-08
AR052038A1 (es) 2007-02-28
EP1817081A2 (en) 2007-08-15
AU2005310186B2 (en) 2011-06-16
AU2005310186A1 (en) 2006-06-08
RU2007124582A (ru) 2009-01-10
CN103462817A (zh) 2013-12-25
SG170042A1 (en) 2011-04-29
TW200637594A (en) 2006-11-01
CA2589411A1 (en) 2006-06-08

Similar Documents

Publication Publication Date Title
BR112012006692A2 (pt) composição farmacêutica compreendendo ácido graxo de omega-3 e um derivado de hidróxi de uma estatina e métodos de uso das mesmas
BRPI0813311A2 (pt) Composto, métodos para modulara a atividade de uma proteína quinase e para tratar câncer em um indivíduo, e, composição farmacêutica.
BRPI0507198A (pt) derivados de bisariluréia
GT200600028A (es) Compuestos y composiciones como inhibidores de proteina kinasa
CR11731A (es) Composiciones y procedimientos para su preparación y uso
SV2009003299A (es) Derivados de dihidropiridina de utilidad como inhibidores de la proteina quinasa
UY30477A1 (es) Derivados de [4,5']bipirimidinil-6,4´-diamina como inhibidores de cinasa de proteina
BRPI0820568A2 (pt) Composto, composição farmacêutica, uso de um composto ou uma composição farmacêutica, e, método de tratamento de um humano ou animal
BR112012022211A2 (pt) composto. composição farmacêutica, método de tratamento de uma doença meidada por h4r, método de inibição de h4h, método de tratamento da dor ou inflamação resultante de cirurgia de catarata, método para atingir um efeito em um paciente e uso de uma composto
BRPI0519391B1 (pt) composição e uso da mesma para promover a saúde oral em um animal de companhia e kit para administração da composição
BRPI1004899A2 (pt) composto, composição farmacêutica, método para tratar uma doença ou distúrbio relacionado a pi3k em um indivíduo necessitando do mesmo, método para tratar uma doença mediada por mtor, método para tratar ambas as doenças mediadas por pi3k e hdac
BRPI0813450A2 (pt) Composto, composição, combinação, formulação farmacêutica, e, métodos para inibir uma enzima, para exterminar ou prevenir o crescimento de um microorganismo e para tratar e/ou prevenir uma doença em um animal
BR112013015503A2 (pt) formulação localizada tópica, uso de uma formulação, e, método para tratamento ou profilaxia de infestação de parasita de um animal
MY157829A (en) Oral care composition comprising a phenolic compound and antioxidant vitamins and vitamin derivatives
EA202091999A3 (ru) Применение ингибиторов dpp iv
BRPI0918337A2 (pt) composto, composição farmacêutica, método de tratamento, método para tratar uma doença ou condição causada, exacerbada ou resultante de um excesso de plaquetas ou ativação indesejada de plaquetas em um paciente, método para reduzir a contagem de plaquetas circulantes em um paciente e uso
ATE486860T1 (de) Phenothiazin-derivat zur wundheilung
BRPI0920847A2 (pt) composto, formulação farmacêutica, e, método para o tratamento, prevenção ou retardo na progressão de câncer em um paciente
CY1108794T1 (el) Σπειροκυκλικα παραγωγα κυκλοεξανιου
CR11684A (es) Dihidropirazolonas sustituidas de hif-propil-4- como inhibidores hidroxilasa
BRPI0806517A2 (pt) Método para chocar ovos de chocadeira, composição formulada para o tratamento de ovos de chocadeira antes da incubação, e, uso de uma composição
BR112012000862A2 (pt) composição farmaceutica oral, composição farmaceutica oral de baixa dose para administração cronica de tratamento de retardo do inicio ou desenvolvimento de uma condição metodo de tratamento da dor em um individuo que necessita deste medicamento, metodo de tratamento de uma condição em um individuo que necessita deste medicamento
AR049518A1 (es) Composicion farmaceutica que comprende un agente siliconado y dos principios activos solubilizados
BR112013022147A2 (pt) composto, composição farmacêutica, método de inibição da pask, método de tratamento de uma doença, método para alcançar um efeito em um paciente e método de tratamento de uma doença mediada pela pask
BRPI0816952A2 (pt) Composição para tratar ou contralar uma infecção em um indivíduo, e, usos de uma fluoroquinolona e de uma combinação

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM OS ARTIGOS 8O, 11, 13, 15 E 25 DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.

B15K Others concerning applications: alteration of classification

Ipc: A61K 8/34 (2006.01), A61Q 11/00 (2006.01), A61K 8/