BRPI0519040A2 - tiazolidinonas metassubstituÍdas, sua produÇço e uso como medicamentos - Google Patents

tiazolidinonas metassubstituÍdas, sua produÇço e uso como medicamentos

Info

Publication number
BRPI0519040A2
BRPI0519040A2 BRPI0519040-1A BRPI0519040A BRPI0519040A2 BR PI0519040 A2 BRPI0519040 A2 BR PI0519040A2 BR PI0519040 A BRPI0519040 A BR PI0519040A BR PI0519040 A2 BRPI0519040 A2 BR PI0519040A2
Authority
BR
Brazil
Prior art keywords
thiazolidinones
production
methasubstituted
medicinal
plk
Prior art date
Application number
BRPI0519040-1A
Other languages
English (en)
Inventor
Volker Klaus Schulze
Knut Eis
Lars Wortmann
Dirk Kosemund
Olaf Prien
Gerhard Siemeister
Holger Hess-Stumpp
Uwe Eberspaecher
Dominic E A Brittain
Imadul Islam
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35895206&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0519040(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE102004061503A external-priority patent/DE102004061503A1/de
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of BRPI0519040A2 publication Critical patent/BRPI0519040A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

TIAZOLIDINONAS METASSUBSTITUÍDAS, SUA PRODUÇçO E USO COMO MEDICAMENTOS. A invenção refere-se a tiazolidinonas da fórmula geral (I), bem como sua produção e uso como inibidores da quinase do tipo Polo (Plk) para o tratamento de diversas doenças.
BRPI0519040-1A 2004-12-15 2005-12-12 tiazolidinonas metassubstituÍdas, sua produÇço e uso como medicamentos BRPI0519040A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102004061503A DE102004061503A1 (de) 2004-12-15 2004-12-15 Metasubstituierte Thiazolidinone, deren Herstellung und Verwendung als Arzneimittel
US63777704P 2004-12-22 2004-12-22
PCT/EP2005/013418 WO2006063806A1 (de) 2004-12-15 2005-12-12 Metasubstituierte thiazolidinone, deren herstellung und verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
BRPI0519040A2 true BRPI0519040A2 (pt) 2009-01-13

Family

ID=35895206

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0519040-1A BRPI0519040A2 (pt) 2004-12-15 2005-12-12 tiazolidinonas metassubstituÍdas, sua produÇço e uso como medicamentos

Country Status (18)

Country Link
US (2) US20070015759A1 (pt)
EP (1) EP1824834A1 (pt)
JP (1) JP2008524139A (pt)
KR (1) KR20070092740A (pt)
AR (1) AR055698A1 (pt)
AU (1) AU2005315835A1 (pt)
BR (1) BRPI0519040A2 (pt)
CA (1) CA2590396A1 (pt)
CR (1) CR9183A (pt)
GT (1) GT200500366A (pt)
IL (1) IL183395A0 (pt)
MX (1) MX2007007245A (pt)
NO (1) NO20073631L (pt)
PA (1) PA8656501A1 (pt)
PE (1) PE20061157A1 (pt)
TW (1) TW200628458A (pt)
UY (1) UY29264A1 (pt)
WO (1) WO2006063806A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005005395A1 (de) * 2005-02-03 2006-08-10 Schering Aktiengesellschaft Thiazolidinone, deren Herstellung und Verwendung als Arzneimittel
JP2009525046A (ja) * 2006-01-31 2009-07-09 エラン ファーマシューティカルズ，インコーポレイテッド アルファ−シヌクレインキナーゼ
CA2713753A1 (en) * 2008-02-13 2009-08-20 Elan Pharma International Limited Alpha-synuclein kinase
EP2141163A1 (de) * 2008-07-02 2010-01-06 Bayer Schering Pharma AG Substituierte Thiazolidinone, deren Herstellung und Verwendung als Arzneimittel
JP5578705B2 (ja) * 2010-03-29 2014-08-27 公益財団法人相模中央化学研究所 （アリール）ジフルオロ酢酸エステル誘導体及びその製造方法
WO2014069434A1 (ja) * 2012-10-30 2014-05-08 カルナバイオサイエンス株式会社 新規チアゾリジノン誘導体
US10130633B2 (en) * 2013-03-20 2018-11-20 Bayer Pharma Aktiengesellschaft Compounds
JP2016521259A (ja) * 2013-03-20 2016-07-21 バイエル・ファルマ・アクティエンゲゼルシャフト 置換Ｎ−ビフェニル−３−アセチルアミノ−ベンズアミドおよびＮ−［３−（アセチルアミノ）フェニル］−ビフェニル−カルボキサミドならびにＷｎｔシグナル伝達経路の阻害剤としてのそれらの使用
US9566280B2 (en) 2014-01-28 2017-02-14 Massachusetts Institute Of Technology Combination therapies and methods of use thereof for treating cancer
AU2015276256B2 (en) 2014-06-16 2019-08-15 Centre Hospitalier Regional Et Universitaire De Lille (Chru) Compounds, pharmaceutical composition and their use in treating neurodegenerative diseases
US20230263783A1 (en) 2022-02-18 2023-08-24 Massachusetts Institute Of Technology Cancer treatment by combined inhibition of polo-like kinase and microtubule polymerization

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003093249A1 (de) * 2002-05-03 2003-11-13 Schering Aktiengesellschaft Thiazolidinone und ihre verwendung als polo like kinase inhibitoren
DE10351744A1 (de) * 2003-10-31 2005-06-16 Schering Ag Thiazolidinone, deren Herstellung und Verwendung als Arzneimittel

Also Published As

Publication number Publication date
US20100048891A1 (en) 2010-02-25
WO2006063806A1 (de) 2006-06-22
PA8656501A1 (es) 2006-09-08
MX2007007245A (es) 2008-02-25
TW200628458A (en) 2006-08-16
JP2008524139A (ja) 2008-07-10
US20070015759A1 (en) 2007-01-18
NO20073631L (no) 2007-09-12
CR9183A (es) 2008-01-21
AU2005315835A1 (en) 2006-06-22
UY29264A1 (es) 2006-06-30
AR055698A1 (es) 2007-09-05
CA2590396A1 (en) 2006-06-22
IL183395A0 (en) 2007-09-20
EP1824834A1 (de) 2007-08-29
GT200500366A (es) 2006-12-04
KR20070092740A (ko) 2007-09-13
PE20061157A1 (es) 2006-11-16

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]