BRPI0520016A2 - compostos, enanciÈmeros, composição farmacêutica, uso de compostos, processo para a fabricação de compostos, e, modificação dos processos - Google Patents

compostos, enanciÈmeros, composição farmacêutica, uso de compostos, processo para a fabricação de compostos, e, modificação dos processos

Info

Publication number
BRPI0520016A2
BRPI0520016A2 BRPI0520016-4A BRPI0520016A BRPI0520016A2 BR PI0520016 A2 BRPI0520016 A2 BR PI0520016A2 BR PI0520016 A BRPI0520016 A BR PI0520016A BR PI0520016 A2 BRPI0520016 A2 BR PI0520016A2
Authority
BR
Brazil
Prior art keywords
compounds
processes
modification
pharmaceutical composition
pro
Prior art date
Application number
BRPI0520016-4A
Other languages
English (en)
Inventor
Steven J Demarco
Kerstin Moehle
Heiko Henze
Odile Sellier
Francoise Jung
Frank Gombert
Daniel Obrecht
Christian Ludin
Original Assignee
Polyphor Ltd
Universitaet Zuerich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polyphor Ltd, Universitaet Zuerich filed Critical Polyphor Ltd
Publication of BRPI0520016A2 publication Critical patent/BRPI0520016A2/pt
Publication of BRPI0520016B1 publication Critical patent/BRPI0520016B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

COMPOSTOS, ENANCIÈMEROS, COMPOSIçãO FARMACêUTICA, USO DE COMPOSTOS, PROCESSO PARA A FABRICAçãO DE COMPOSTOS, E, MODIFICAçãO DOS PROCESSOS. Peptidomiméticos de grampo-de-cabelo <225> fixados com modelo das fórmulas gerais (1), em que Z é uma cadeia de 11 radicais de aminoácidos a que, dependendo das posições na cadeia (contadas partindo do aminoácido N-terminal) são Gly, ou Pro, ou Pro(4NHCOPhe), ou de determinados tipos que, como simbolos remanescentes na fórmula acima, são definidos na descrição e nas reivindicações, e sais dos mesmos, apresentam a propriedade de inibir proteases, em particular serina proteases, particularmente Catepsina G ou Elastase ou Triptase. Estes peptidomiméticos de grampo-de-cabelo <225> podem ser fabricados por meio de processos que se baseiam em uma estratégia sintética mista de fase sólida e solução.
BRPI0520016-4A 2005-02-17 2005-02-17 Composto, composiqao farmaceutica, uso de composto e processo para a fabricaqao de composto BRPI0520016B1 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2005/001622 WO2006087001A1 (en) 2005-02-17 2005-02-17 Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity

Publications (2)

Publication Number Publication Date
BRPI0520016A2 true BRPI0520016A2 (pt) 2009-08-18
BRPI0520016B1 BRPI0520016B1 (pt) 2021-11-16

Family

ID=34960696

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0520016-4A BRPI0520016B1 (pt) 2005-02-17 2005-02-17 Composto, composiqao farmaceutica, uso de composto e processo para a fabricaqao de composto

Country Status (20)

Country Link
US (4) US8658604B2 (pt)
EP (1) EP1856140B1 (pt)
JP (1) JP4896892B2 (pt)
KR (3) KR101443171B1 (pt)
CN (1) CN101142228A (pt)
AU (1) AU2005327825B2 (pt)
BR (1) BRPI0520016B1 (pt)
CA (3) CA2598360C (pt)
CY (1) CY1115084T1 (pt)
DK (1) DK1856140T3 (pt)
EA (1) EA013814B1 (pt)
ES (1) ES2453540T3 (pt)
IL (1) IL184804A (pt)
MX (1) MX2007009873A (pt)
NO (1) NO342041B1 (pt)
NZ (1) NZ556747A (pt)
PL (1) PL1856140T3 (pt)
PT (1) PT1856140E (pt)
SI (1) SI1856140T1 (pt)
WO (1) WO2006087001A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8658604B2 (en) * 2005-02-17 2014-02-25 Polyphor Ltd Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity
WO2007079597A1 (en) 2006-01-16 2007-07-19 Polyphor Ltd. Template - fixed peptidomimetics with antimicrobial activity
WO2008092281A1 (en) * 2007-01-29 2008-08-07 Polyphor Ltd. Template-fixed peptidomimetics
PL2132221T3 (pl) 2007-02-28 2011-04-29 Polyphor Ltd Przyłączone do matrycy peptydomimetyki
WO2010015287A2 (en) * 2008-08-08 2010-02-11 Polyphor Ag Template-fixed peptidomimetics
JP6499182B2 (ja) * 2013-12-27 2019-04-10 ポリフォー・アクチェンゲゼルシャフトＰｏｌｙｐｈｏｒ Ａｇ 選択的エラスターゼ阻害剤としてのβ−ヘアピンペプチド模倣体
DK3087094T3 (da) * 2013-12-27 2022-08-29 Polyphor Ag Betahårnål peptidomimetika som selektive elastase inhibitorer
US20170319643A1 (en) 2016-05-05 2017-11-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv Lipoprotein targeting protease inhibitors and uses
CA3024522C (en) * 2016-05-31 2024-06-25 Polyphor Ag Beta-hairpin peptidomimetic with elastase inhibitory activity and aerosol dosage forms thereof
WO2022202816A1 (ja) * 2021-03-22 2022-09-29 ペプチエイド株式会社 ペプチド及びペプチドを含む組成物
WO2024110426A1 (en) 2022-11-23 2024-05-30 F. Hoffmann-La Roche Ag Method for increasing recombinant protein expression

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002247724B2 (en) 2001-02-23 2008-02-07 Polyphor Ltd. Template-fixed peptidomimetics with antimicrobial activity
CN101157924A (zh) * 2001-12-11 2008-04-09 人体基因组科学有限公司 嗜中性白细胞因子α
EP1532164B1 (en) * 2002-08-20 2012-09-26 Polyphor Ltd. Template-fixed peptidomimetics with antibacterial activity
WO2004033489A1 (en) * 2002-10-02 2004-04-22 Polyphor Ltd. Template-fixed peptidomimetics with antimicrobial activity
WO2004096839A1 (en) * 2003-05-02 2004-11-11 Polyphor Ag Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity
EP1622930B9 (en) 2003-05-02 2009-10-14 Polyphor AG Template-fixed peptidomimetics as medicaments against hiv and cancer
US8658604B2 (en) * 2005-02-17 2014-02-25 Polyphor Ltd Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity
US9073973B2 (en) * 2005-05-02 2015-07-07 Polyphor Ltd. Dye conjugates of template-fixed peptidomimetics
WO2007079597A1 (en) * 2006-01-16 2007-07-19 Polyphor Ltd. Template - fixed peptidomimetics with antimicrobial activity

Also Published As

Publication number Publication date
MX2007009873A (es) 2008-02-12
CA3035941C (en) 2021-11-16
US20090054345A1 (en) 2009-02-26
US20190002498A1 (en) 2019-01-03
IL184804A0 (en) 2007-12-03
CA2598360C (en) 2016-12-20
KR101443171B1 (ko) 2014-09-22
NZ556747A (en) 2009-09-25
ES2453540T3 (es) 2014-04-08
CA2598360A1 (en) 2006-08-24
KR20070106775A (ko) 2007-11-05
US20140213531A1 (en) 2014-07-31
EP1856140B1 (en) 2013-12-25
AU2005327825B2 (en) 2012-02-16
KR101420198B1 (ko) 2014-08-13
WO2006087001A1 (en) 2006-08-24
CA2915175C (en) 2019-04-09
CN101142228A (zh) 2008-03-12
DK1856140T3 (en) 2014-03-10
KR20130018449A (ko) 2013-02-22
EP1856140A1 (en) 2007-11-21
JP4896892B2 (ja) 2012-03-14
KR20120127530A (ko) 2012-11-21
PL1856140T3 (pl) 2014-06-30
US8658604B2 (en) 2014-02-25
US20160333051A1 (en) 2016-11-17
CA2915175A1 (en) 2006-08-24
EA013814B1 (ru) 2010-08-30
NO20074674L (no) 2007-11-16
SI1856140T1 (sl) 2014-04-30
HK1213914A1 (zh) 2016-07-15
CY1115084T1 (el) 2016-12-14
BRPI0520016B1 (pt) 2021-11-16
KR101272633B1 (ko) 2013-06-10
US10562933B2 (en) 2020-02-18
JP2008531485A (ja) 2008-08-14
NO342041B1 (no) 2018-03-12
EA200701727A1 (ru) 2008-04-28
US10100084B2 (en) 2018-10-16
IL184804A (en) 2016-05-31
CA3035941A1 (en) 2006-08-24
AU2005327825A1 (en) 2006-08-24
PT1856140E (pt) 2014-03-27

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Legal Events

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B06G Technical and formal requirements: other requirements [chapter 6.7 patent gazette]

Free format text: SOLICITA-SE A REGULARIZACAO DAS PROCURACOES, UMA VEZ QUE BASEADO NO ARTIGO 216 1O DA LPI, O DOCUMENTO DE PROCURACAO DEVE SER APRESENTADO EM SUA FORMA AUTENTICADA; OU SEGUNDO PARECER DA PROCURADORIA NO 074/93, DEVE CONSTAR UMA DECLARACAO DE VERACIDADE, A QUAL DEVE SER ASSINADA POR UMA PESSOA DEVIDAMENTE AUTORIZADA A REPRESENTAR O INTERESSADO, DEVENDO A MESMA CONSTAR NO INSTRUMENTO DE PROCURACAO, OU NO SEU SUBSTABELECIMENTO.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/02/2005, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 20A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

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