BRPI0606975A2 - gene de sms 03 - Google Patents
gene de sms 03Info
- Publication number
- BRPI0606975A2 BRPI0606975A2 BRPI0606975-4A BRPI0606975A BRPI0606975A2 BR PI0606975 A2 BRPI0606975 A2 BR PI0606975A2 BR PI0606975 A BRPI0606975 A BR PI0606975A BR PI0606975 A2 BRPI0606975 A2 BR PI0606975A2
- Authority
- BR
- Brazil
- Prior art keywords
- polynucleotides
- production
- vitamin
- relates
- polypeptides
- Prior art date
Links
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 8
- 102000040430 polynucleotide Human genes 0.000 abstract 7
- 108091033319 polynucleotide Proteins 0.000 abstract 7
- 239000002157 polynucleotide Substances 0.000 abstract 7
- 238000004519 manufacturing process Methods 0.000 abstract 4
- 244000005700 microbiome Species 0.000 abstract 4
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 abstract 3
- 229930003268 Vitamin C Natural products 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 239000011718 vitamin C Substances 0.000 abstract 3
- 235000019154 vitamin C Nutrition 0.000 abstract 3
- 239000012634 fragment Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000002211 L-ascorbic acid Substances 0.000 abstract 1
- 235000000069 L-ascorbic acid Nutrition 0.000 abstract 1
- 229960005070 ascorbic acid Drugs 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
GENE DE SMS 03. A presente invenção se refere a genes recentemente identificados que codificam proteínas que estão envolvidas na síntese de ácido L-ascórbico (aqui depois também referido como Vitamina C) . A invenção também se caracteriza por polinucleotídeos compreendendo as seqúências de polinucleotídeo de comprimento total dos novos genes e fragmentos das mesmas, a novos polipeptídeos codificados pelos polinucleotídeos e fragmentos dos mesmos, bem como seus equivalentes funcionais. A presente invenção também se refere ao uso dos referidos polinucleotídeos e polipeptídeos como ferramentas biotecnológicas na produção de Vitamina C a partir de microorganismos, pelo que uma modificação dos referidos polinucleotídeos e/ou polipeptídeos codificados tem um impacto direto ou indireto sobre o rendimento, produção e/ou eficácia de produção do produto da fermentação no referido microorganismo. Também incluídos são métodos/processos de uso dos polinucleotídeos e seqúências de polinucleotídeo modificadas para transformar microorganismos hospedeiros. A invenção também se refere a microorganismos geneticamente manipulados e seu uso para a produção direta de Vitamina C.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05405110 | 2005-02-11 | ||
| EP05405066 | 2005-02-11 | ||
| PCT/EP2006/001216 WO2006084721A1 (en) | 2005-02-11 | 2006-02-10 | Alcohol dehydrogenase gene from gluconobacter oxydans |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0606975A2 true BRPI0606975A2 (pt) | 2009-07-28 |
Family
ID=36143262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0606975-4A BRPI0606975A2 (pt) | 2005-02-11 | 2006-02-10 | gene de sms 03 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20080160588A1 (pt) |
| EP (1) | EP1846555A1 (pt) |
| BR (1) | BRPI0606975A2 (pt) |
| WO (1) | WO2006084721A1 (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105002131A (zh) * | 2015-08-03 | 2015-10-28 | 浙江大学 | 一种不含外源dna片段的氧化葡萄糖酸杆菌基因工程菌及其制备方法和应用 |
| CN105002204B (zh) * | 2015-08-03 | 2018-07-24 | 浙江大学 | 一株高产5-kga的氧化葡萄糖酸杆菌基因工程菌及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6730503B1 (en) * | 1996-09-19 | 2004-05-04 | Roche Vitamins Inc. | Alcohol/aldehyde dehydrogenase |
| DE69937086T2 (de) * | 1998-03-13 | 2008-06-12 | Dsm Ip Assets B.V. | Genetisch veränderte, L-Sorbose Reduktase defiziente Mutanten |
| EP0955358B1 (en) * | 1998-03-13 | 2007-09-12 | DSM IP Assets B.V. | Genetically engineered L-sorbose reductase-deficient mutants |
| CN100357446C (zh) * | 2002-09-27 | 2007-12-26 | 帝斯曼知识产权资产管理有限公司 | 维生素c的微生物生产方法 |
| JP4566000B2 (ja) * | 2002-09-27 | 2010-10-20 | ディーエスエム アイピー アセッツ ビー．ブイ． | ビタミンｃを産生する方法 |
| EP1716240B1 (en) * | 2004-01-30 | 2010-06-02 | DSM IP Assets B.V. | Microbial production of vitamin c |
-
2006
- 2006-02-10 BR BRPI0606975-4A patent/BRPI0606975A2/pt not_active Application Discontinuation
- 2006-02-10 US US11/883,553 patent/US20080160588A1/en not_active Abandoned
- 2006-02-10 EP EP06706842A patent/EP1846555A1/en not_active Withdrawn
- 2006-02-10 WO PCT/EP2006/001216 patent/WO2006084721A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US20080160588A1 (en) | 2008-07-03 |
| EP1846555A1 (en) | 2007-10-24 |
| WO2006084721A1 (en) | 2006-08-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: AS CLASSIFICACOES ANTERIORES ERAM: C12N 9/04 , C12P 17/04 Ipc: C12N 15/53 (2006.01), C12N 15/63 (2006.01), C12N 1 |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
| B11T | Dismissal: dismissal of application maintained |