BRPI0608321A2 - gene sms 12 - Google Patents
gene sms 12Info
- Publication number
- BRPI0608321A2 BRPI0608321A2 BRPI0608321-8A BRPI0608321A BRPI0608321A2 BR PI0608321 A2 BRPI0608321 A2 BR PI0608321A2 BR PI0608321 A BRPI0608321 A BR PI0608321A BR PI0608321 A2 BRPI0608321 A2 BR PI0608321A2
- Authority
- BR
- Brazil
- Prior art keywords
- polynucleotides
- production
- vitamin
- relates
- polypeptides
- Prior art date
Links
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 8
- 102000040430 polynucleotide Human genes 0.000 abstract 7
- 108091033319 polynucleotide Proteins 0.000 abstract 7
- 239000002157 polynucleotide Substances 0.000 abstract 7
- 238000004519 manufacturing process Methods 0.000 abstract 4
- 244000005700 microbiome Species 0.000 abstract 4
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 abstract 3
- 229930003268 Vitamin C Natural products 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 239000011718 vitamin C Substances 0.000 abstract 3
- 235000019154 vitamin C Nutrition 0.000 abstract 3
- 239000012634 fragment Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000002211 L-ascorbic acid Substances 0.000 abstract 1
- 235000000069 L-ascorbic acid Nutrition 0.000 abstract 1
- 229960005070 ascorbic acid Drugs 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
GENE SMS 12. A presente invenção se refere a genes recentemente identificados que codificam proteínas que estão envolvidas na síntese de ácido L-ascárbico (aqui depois também referido como Vitamina C) . A invenção também se caracteriza por polinucleotídeos compreendendo as seqúências de polinucleotídeo de comprimento total dos novos genes e fragmentos das mesmas, a novos polipeptídeos codificados pelos polinucleotídeos e fragmentos dos mesmos, bem como seus equivalentes funcionais. A presente invenção também se refere ao uso dos referidos polinucleotídeos e polipeptídeos como ferramentas biotecnológicas na produção de Vitamina C a partir de microorganismos, pelo que uma modificação dos referidos polinucleotídeos e/ou polipeptídeos codificados tem um impacto direto ou indireto sobre o rendimento, produção e/ou eficácia de produção do produto da fermentação no referido microorganismo. Também incluídos são métodos/processos de uso dos polinucleotídeos e seqúências de polinucleotídeo modificadas para transformar microorganismos hospedeiros. A invenção também se refere a microorganismos geneticamente manipulados e seu uso para a produção direta de Vitamina C.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05405119 | 2005-02-11 | ||
| EP05405066 | 2005-02-11 | ||
| PCT/EP2006/001213 WO2006084718A1 (en) | 2005-02-11 | 2006-02-10 | Gene sms 12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0608321A2 true BRPI0608321A2 (pt) | 2009-12-29 |
Family
ID=36337539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0608321-8A BRPI0608321A2 (pt) | 2005-02-11 | 2006-02-10 | gene sms 12 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20080113417A1 (pt) |
| EP (1) | EP1846553A1 (pt) |
| CN (1) | CN101133155B (pt) |
| BR (1) | BRPI0608321A2 (pt) |
| WO (1) | WO2006084718A1 (pt) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2403934A1 (en) * | 2009-03-05 | 2012-01-11 | DSM IP Assets B.V. | Improved production of 2-keto-l-gulonic acid |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100295038B1 (ko) * | 1993-03-08 | 2001-09-17 | 후지야마 아키라 | 글루코노박터옥시단스t-100으로부터수득된신규한l-소르보스데하이드로게나제및l-소르보손데하이드로게나제 |
| CN1073155C (zh) * | 1994-02-25 | 2001-10-17 | 藤泽药品工业株式会社 | 2－酮－l－古洛糖酸的生产方法 |
-
2006
- 2006-02-10 CN CN200680004775.XA patent/CN101133155B/zh not_active Expired - Fee Related
- 2006-02-10 WO PCT/EP2006/001213 patent/WO2006084718A1/en not_active Ceased
- 2006-02-10 US US11/883,549 patent/US20080113417A1/en not_active Abandoned
- 2006-02-10 EP EP06706840A patent/EP1846553A1/en not_active Withdrawn
- 2006-02-10 BR BRPI0608321-8A patent/BRPI0608321A2/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US20080113417A1 (en) | 2008-05-15 |
| EP1846553A1 (en) | 2007-10-24 |
| CN101133155A (zh) | 2008-02-27 |
| CN101133155B (zh) | 2014-10-08 |
| WO2006084718A1 (en) | 2006-08-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07A | Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |