BRPI0607095A2 - método e aparelho para classificação de células - Google Patents

método e aparelho para classificação de células

Info

Publication number
BRPI0607095A2
BRPI0607095A2 BRPI0607095-7A BRPI0607095A BRPI0607095A2 BR PI0607095 A2 BRPI0607095 A2 BR PI0607095A2 BR PI0607095 A BRPI0607095 A BR PI0607095A BR PI0607095 A2 BRPI0607095 A2 BR PI0607095A2
Authority
BR
Brazil
Prior art keywords
stream
cells
inlet
forming
detector
Prior art date
Application number
BRPI0607095-7A
Other languages
English (en)
Inventor
Daniel Mueth
Amy L Anderson
Christopher R Knutson
Joseph Plewa
Original Assignee
Arryx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36756165&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0607095(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Arryx Inc filed Critical Arryx Inc
Priority to BR122017014567-3A priority Critical patent/BR122017014567B1/pt
Publication of BRPI0607095A2 publication Critical patent/BRPI0607095A2/pt
Publication of BRPI0607095B1 publication Critical patent/BRPI0607095B1/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/02—Electrical or electromagnetic means, e.g. for electroporation or for cell fusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/04—Cell isolation or sorting
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/06—Hydrolysis; Cell lysis; Extraction of intracellular or cell wall material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G01N15/1409—Handling samples, e.g. injecting samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G01N15/1409—Handling samples, e.g. injecting samples
    • G01N2015/1411—Features of sheath fluids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Sustainable Development (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Electromagnetism (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

MéTODO E APARELHO PARA CLASSIFICAçãO DE CéLULAS. Um aparelho para classificação e orientação de células de esperma inclui um par de paredes em arranjo confrontante e formando uma câmara de fluxo que tem uma entrada, uma saída a jusante e uma região de detector intermediária. A entrada recebe uma primeira e uma segunda corrente espaçada de fluido de entrada e uma terceira corrente de fluido de amostra contendo as células a serem classificadas. As primeira e segunda correntes têm respectivas vazões em relação à terceira corrente, de modo que a terceira corrente seja restrita, formando uma corrente de amostra relativamente estreita, de modo que as células sejam orientadas paralelas às paredes. Um detector detecta as células desejadas e um classificador a jusante do detector classifica as células desejadas a partir da corrente.
BRPI0607095-7A 2005-02-01 2006-02-01 "flow device apparatus for cell classification and orientation" BRPI0607095B1 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122017014567-3A BR122017014567B1 (pt) 2005-02-01 2006-02-01 Aparelho sensor para a formação de imagem e sistema que compreende o aparelho sensor

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/046,896 2005-02-01
US11/046,896 US7355696B2 (en) 2005-02-01 2005-02-01 Method and apparatus for sorting cells
PCT/US2006/003462 WO2006083907A2 (en) 2005-02-01 2006-02-01 Method and apparatus for sorting cells

Publications (2)

Publication Number Publication Date
BRPI0607095A2 true BRPI0607095A2 (pt) 2009-08-04
BRPI0607095B1 BRPI0607095B1 (pt) 2017-11-21

Family

ID=36756165

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0607095-7A BRPI0607095B1 (pt) 2005-02-01 2006-02-01 "flow device apparatus for cell classification and orientation"
BR122017014567-3A BR122017014567B1 (pt) 2005-02-01 2006-02-01 Aparelho sensor para a formação de imagem e sistema que compreende o aparelho sensor

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR122017014567-3A BR122017014567B1 (pt) 2005-02-01 2006-02-01 Aparelho sensor para a formação de imagem e sistema que compreende o aparelho sensor

Country Status (9)

Country Link
US (3) US7355696B2 (pt)
EP (5) EP2801813A1 (pt)
JP (2) JP5086101B2 (pt)
CN (3) CN102128778B (pt)
BR (2) BRPI0607095B1 (pt)
DK (1) DK2166340T3 (pt)
ES (2) ES2639306T3 (pt)
HK (1) HK1203626A1 (pt)
WO (1) WO2006083907A2 (pt)

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EP1846748A2 (en) 2007-10-24
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USRE46992E1 (en) 2018-08-14
CN101189504B (zh) 2012-05-30
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US20060170912A1 (en) 2006-08-03
CN102128778A (zh) 2011-07-20
CN101189504A (zh) 2008-05-28
CN102128778B (zh) 2013-12-18
BRPI0607095B1 (pt) 2017-11-21
WO2006083907A3 (en) 2006-12-21
JP5086101B2 (ja) 2012-11-28
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