BRPI0608076A2 - método de seleção, processo para purificação de oligÈmeros beta-a não difusìveis, anticorpos seletivos contra os ditos oligÈmeros beta-a não difusìveis e um processo para fabricação dos ditos anticorpos - Google Patents

método de seleção, processo para purificação de oligÈmeros beta-a não difusìveis, anticorpos seletivos contra os ditos oligÈmeros beta-a não difusìveis e um processo para fabricação dos ditos anticorpos

Info

Publication number
BRPI0608076A2
BRPI0608076A2 BRPI0608076-6A BRPI0608076A BRPI0608076A2 BR PI0608076 A2 BRPI0608076 A2 BR PI0608076A2 BR PI0608076 A BRPI0608076 A BR PI0608076A BR PI0608076 A2 BRPI0608076 A2 BR PI0608076A2
Authority
BR
Brazil
Prior art keywords
oligomers
diffusible
beta
antibodies
globulomers
Prior art date
Application number
BRPI0608076-6A
Other languages
English (en)
Inventor
Heinz Hillen
Patrick Keller
Stefan Barghorn
Ulrich Ebert
Andreas Striebinger
Original Assignee
Abbott Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36581967&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0608076(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg
Publication of BRPI0608076A2 publication Critical patent/BRPI0608076A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Urology & Nephrology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
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Abstract

MéTODO DE SELEçãO, PROCESSO PARA PURIFICAçãO DE OLIGÈMEROS BETA-A NãO DIFUSìVEIS, ANTICORPOS SELETIVOS CONTRA OS DITOS OLIGÈMEROS BETA-A NãO DIFUSìVEIS E UM PROCESSO PARA FABRICAçãO DOS DITOS ANTICORPOS. A presente invenção diz respeito a oligómeros A<225>(X- 38 ... 43) globulares não difusiveis ("globulómeros") ou derivados destes, métc.dos para enriquecer os ditos globulómeros ou derivados, composições compreendendo os ditos globulómeros ou derivados, anticorpos e aptâmeros tendo especificidade para os ditos globulâmeros ou derivados, métodos para preparar tais an:icorpos e aptâmeros, usos dos ditos globulâmeros ou derivados ou dos ditos anticorpos ou aptâmeros com propósitos diagnósticos, terapêuticos e outros, e métodos correspondentes usando os ditos globulómeros ou derivados, ou os ditos aniticorpos ou aptâmeros.
BRPI0608076-6A 2005-03-05 2006-03-03 método de seleção, processo para purificação de oligÈmeros beta-a não difusìveis, anticorpos seletivos contra os ditos oligÈmeros beta-a não difusìveis e um processo para fabricação dos ditos anticorpos BRPI0608076A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP05004858 2005-03-05
US66447705P 2005-03-23 2005-03-23
EP05006568 2005-03-24
US74086605P 2005-11-30 2005-11-30
PCT/EP2006/001984 WO2006094724A2 (en) 2005-03-05 2006-03-03 Screening method, process for purifying of non-diffusible a-beta oligomers, selective antibodies against said non-diffusible a-beta oligomers and a process for manufacturing of said antibodies

Publications (1)

Publication Number Publication Date
BRPI0608076A2 true BRPI0608076A2 (pt) 2009-11-10

Family

ID=36581967

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0608076-6A BRPI0608076A2 (pt) 2005-03-05 2006-03-03 método de seleção, processo para purificação de oligÈmeros beta-a não difusìveis, anticorpos seletivos contra os ditos oligÈmeros beta-a não difusìveis e um processo para fabricação dos ditos anticorpos

Country Status (14)

Country Link
US (1) US20090035295A1 (pt)
EP (2) EP1861422B1 (pt)
KR (1) KR20080021585A (pt)
CN (1) CN101365717A (pt)
AT (1) ATE458754T1 (pt)
AU (1) AU2006222193B2 (pt)
BR (1) BRPI0608076A2 (pt)
CA (1) CA2599792A1 (pt)
DE (1) DE602006012459D1 (pt)
ES (1) ES2340414T3 (pt)
IL (1) IL185392A0 (pt)
MX (1) MX2007010687A (pt)
WO (1) WO2006094724A2 (pt)
ZA (1) ZA200707234B (pt)

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Publication number Publication date
KR20080021585A (ko) 2008-03-07
ATE458754T1 (de) 2010-03-15
CN101365717A (zh) 2009-02-11
WO2006094724A2 (en) 2006-09-14
WO2006094724A3 (en) 2007-02-15
ES2340414T3 (es) 2010-06-02
MX2007010687A (es) 2008-01-28
US20090035295A1 (en) 2009-02-05
ZA200707234B (en) 2011-02-23
IL185392A0 (en) 2008-02-09
AU2006222193B2 (en) 2011-11-17
EP2204381A1 (en) 2010-07-07
AU2006222193A1 (en) 2006-09-14
EP1861422A2 (en) 2007-12-05
CA2599792A1 (en) 2006-09-14
DE602006012459D1 (de) 2010-04-08
EP1861422B1 (en) 2010-02-24

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