BRPI0708865A8 - métodos para produzir uma resposta imune à tuberculose - Google Patents

métodos para produzir uma resposta imune à tuberculose

Info

Publication number
BRPI0708865A8
BRPI0708865A8 BRPI0708865A BRPI0708865A BRPI0708865A8 BR PI0708865 A8 BRPI0708865 A8 BR PI0708865A8 BR PI0708865 A BRPI0708865 A BR PI0708865A BR PI0708865 A BRPI0708865 A BR PI0708865A BR PI0708865 A8 BRPI0708865 A8 BR PI0708865A8
Authority
BR
Brazil
Prior art keywords
immune response
methods
tuberculosis
produce
mtb
Prior art date
Application number
BRPI0708865A
Other languages
English (en)
Inventor
Lewinsohn David
Lewinsohn Deborah
Original Assignee
Univ Oregon Health & Science
The Government Of The United States Of America D B A The Dept Of Veterans Affairs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Oregon Health & Science, The Government Of The United States Of America D B A The Dept Of Veterans Affairs filed Critical Univ Oregon Health & Science
Publication of BRPI0708865A2 publication Critical patent/BRPI0708865A2/pt
Publication of BRPI0708865A8 publication Critical patent/BRPI0708865A8/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/5695—Mycobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/35—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Mycobacteriaceae (F)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/26—Infectious diseases, e.g. generalised sepsis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)

Abstract

métodos para produzir uma resposta imune à tuberculose. a presente invenção refere-se a métodos para produzir uma resposta imune ao mycobacterium tuberculosis (mtb), que são descritos aqui. em vários exemplos, a resposta imune é uma resposta imune protetora. em modalidades adicionais, são descritos métodos para prevenir uma infecção com mtb, ou tratar uma infecção com mtb. composições farmacêuticas para a prevenção e/ou tratamento de tuberculose também são descritos.
BRPI0708865A 2006-03-14 2007-03-14 métodos para produzir uma resposta imune à tuberculose BRPI0708865A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78236406P 2006-03-14 2006-03-14
US60/782,364 2006-03-14
PCT/US2007/006472 WO2007106536A2 (en) 2006-03-14 2007-03-14 Methods for producing an immune response to tuberculosis

Publications (2)

Publication Number Publication Date
BRPI0708865A2 BRPI0708865A2 (pt) 2011-06-14
BRPI0708865A8 true BRPI0708865A8 (pt) 2019-01-22

Family

ID=38208601

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0708912A BRPI0708912B8 (pt) 2006-03-14 2007-03-14 métodos in vitro para detecção de mycobacterium tuberculosis e de células t expressando cd8 que especificamente reconhecem seq id no: 11 em um indivíduo
BRPI0708865A BRPI0708865A8 (pt) 2006-03-14 2007-03-14 métodos para produzir uma resposta imune à tuberculose

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI0708912A BRPI0708912B8 (pt) 2006-03-14 2007-03-14 métodos in vitro para detecção de mycobacterium tuberculosis e de células t expressando cd8 que especificamente reconhecem seq id no: 11 em um indivíduo

Country Status (7)

Country Link
US (7) US7842299B2 (pt)
EP (13) EP2441469A1 (pt)
CN (1) CN101438166A (pt)
BR (2) BRPI0708912B8 (pt)
CA (1) CA2649688A1 (pt)
WO (2) WO2007106560A2 (pt)
ZA (2) ZA200808644B (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60117164T2 (de) * 2000-11-07 2006-08-03 Immuno Vaccine Technologies Inc., Halifax Impfstoffe mit erhöhter immunantwort und verfahren zur deren herstellung
EP2441469A1 (en) * 2006-03-14 2012-04-18 Oregon Health and Science University Methods for producing an immune response to tuberculosis
DE602007013620D1 (de) * 2006-09-05 2011-05-12 Hvidovre Hospital Auf IP-10 basierende immunologische Überwachung
BRPI0604958B1 (pt) * 2006-11-23 2022-05-17 Fundação Oswaldo Cruz Kit para distinção de mycobacterium tuberculosis, m. bovis, m. bovis bcg em uma amostra, e, método para distinguir mycobacterium tuberculosis, m. bovis, m. bovis bcg
CN106310293A (zh) 2007-09-27 2017-01-11 免疫疫苗技术有限公司 在包括连续疏水相的载体中的脂质体在体内输送多核苷酸中的应用
US20100209452A1 (en) * 2007-10-03 2010-08-19 Immunovaccine Technologies, Inc Compositions comprising an antigen, an amphipathic compound and a hydrophobic carrier, and uses thereof
WO2009146523A1 (en) * 2008-06-05 2009-12-10 Immunovaccine Technologies Inc. Compositions comprising liposomes, an antigen, a polynucleotide and a carrier comprising a continuous phase of a hydrophobic substance
AT506819B1 (de) * 2008-06-12 2011-06-15 Affiris Forschungs Und Entwicklungs Gmbh Vakzin zur behandlung von alzheimer-krankheit
JP2012503206A (ja) 2008-09-22 2012-02-02 オレゴン ヘルス アンド サイエンス ユニバーシティ Ｍｙｃｏｂａｃｔｅｒｉｕｍｔｕｂｅｒｃｕｌｏｓｉｓ感染を検出するための方法
BR112012003539A2 (pt) 2009-08-28 2017-05-23 Dow Global Technologies Llc artigo rotomoldado e processo para fabricar um artigo
CN102713629B (zh) 2009-11-20 2016-02-24 俄勒冈健康科学大学 用于检测结核分枝杆菌感染的方法
CN113876945A (zh) 2011-10-06 2022-01-04 免疫疫苗技术有限公司 包括激活或增加tlr2活性的佐剂的脂质体组合物及其应用
WO2013090897A1 (en) * 2011-12-15 2013-06-20 The Trustees Of The University Of Pennsylvania Using adaptive immunity to detect drug resistance
CN103864907B (zh) * 2012-12-18 2016-12-28 中国医学科学院病原生物学研究所 用于结核病诊断的蛋白以及试剂盒
CN104151411B (zh) * 2013-05-14 2018-03-20 中国医学科学院病原生物学研究所 用于结核病诊断的蛋白以及药物组合物
US10226522B2 (en) 2013-08-30 2019-03-12 Globeimmune, Inc. Compositions and methods for the treatment or prevention of tuberculosis
US9970062B2 (en) * 2015-08-06 2018-05-15 Roche Molecular Systems, Inc. Compositions and methods for detection of mycobacterium tuberculosis
CN107304231B (zh) * 2016-04-18 2021-01-01 华中农业大学 一种结核分枝杆菌融合蛋白及应用
CN110073215B (zh) * 2016-09-22 2024-04-30 佩斯诊断公司 结核分枝杆菌蛋白诊断测定和结核病检测和诊断装置
US10684275B2 (en) 2016-12-14 2020-06-16 Becton, Dickinson And Company Methods and compositions for obtaining a tuberculosis assessment in a subject
CA3098015A1 (en) 2018-04-26 2019-10-31 Children's National Medical Center Mycobacterial antigen compositions and methods of use
US10973908B1 (en) 2020-05-14 2021-04-13 David Gordon Bermudes Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine
US12537071B1 (en) 2020-07-22 2026-01-27 David Gordon Bermudes Bacteria having boolean control pathways expressing therapeutic proteins including immunotherapeutic cytotoxins
CN112322566A (zh) * 2020-11-17 2021-02-05 中国农业科学院北京畜牧兽医研究所 牛分枝杆菌弱毒株及其应用
CN116262794B (zh) * 2021-12-13 2024-09-13 江苏瑞科生物技术股份有限公司 重组结核分枝杆菌抗原、其制备方法和应用
WO2025106997A1 (en) * 2023-11-17 2025-05-22 The General Hospital Corporation Mycobacterium tuberculosis vaccines and methods of use thereof

Family Cites Families (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4444487A (en) 1979-07-02 1984-04-24 Xerox Corporation Multiple-flash fuser
US4603112A (en) 1981-12-24 1986-07-29 Health Research, Incorporated Modified vaccinia virus
US4722848A (en) 1982-12-08 1988-02-02 Health Research, Incorporated Method for immunizing animals with synthetically modified vaccinia virus
US7045313B1 (en) 1982-11-30 2006-05-16 The United States Of America As Represented By The Department Of Health And Human Services Recombinant vaccinia virus containing a chimeric gene having foreign DNA flanked by vaccinia regulatory DNA
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4957735A (en) 1984-06-12 1990-09-18 The University Of Tennessee Research Corporation Target-sensitive immunoliposomes- preparation and characterization
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4745055A (en) 1985-05-07 1988-05-17 California Biotechnology Inc. Fused protein for enzyme immunoassay system
US4895800A (en) 1985-11-26 1990-01-23 Phillips Petroleum Company Yeast production of hepatitis B surface antigen
US4811254A (en) 1985-12-17 1989-03-07 Nippon Gakki Seizo Kabushiki Kaisha Displacement detector for an encoder
US5091309A (en) 1986-01-16 1992-02-25 Washington University Sindbis virus vectors
CA1340456C (en) 1986-07-07 1999-03-23 Hubert J.P. Schoemaker Chimeric rodent/human immunoglobulins specific for tumor-associated antigens
US4902505A (en) 1986-07-30 1990-02-20 Alkermes Chimeric peptides for neuropeptide delivery through the blood-brain barrier
GB8626412D0 (en) 1986-11-05 1986-12-03 Clark M R Antibodies
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
AP56A (en) 1987-01-30 1989-09-26 Smithkline Biologicals S A Hepatitis B virus surface antigens and hybrid antigehs containing them.
DE3789866T2 (de) 1987-07-17 1994-09-22 Rhein Biotech Gesellschaft Fuer Neue Biotechnologische Prozesse Und Produkte Mbh, 40595 Duesseldorf DNA-Moleküle, die für FMDH-Kontrollabschnitte und Strukturgene für ein Protein mit FMDH-Aktivität kodieren, sowie deren Anwendung.
US5004697A (en) 1987-08-17 1991-04-02 Univ. Of Ca Cationized antibodies for delivery through the blood-brain barrier
DE10399032I1 (de) 1987-08-28 2004-01-29 Health Research Inc Rekombinante Viren.
CA1340203C (en) 1987-09-16 1998-12-15 Noboru Yanagida Recombinant apivoxvirus
CA1323293C (en) 1987-12-11 1993-10-19 Keith C. Backman Assay using template-dependent nucleic acid probe reorganization
JPH0630628B2 (ja) 1987-12-16 1994-04-27 キング醸造株式会社 生細胞数及び活力の測定方法
US4957795A (en) 1988-05-13 1990-09-18 Minnesota Mining And Manufacturing Company Absorbent elastomeric wound dressing
ATE138106T1 (de) 1988-07-20 1996-06-15 David Segev Verfahren zur amplifizierung und zum nachweis von nukleinsäuresequenzen
US5093258A (en) 1988-08-26 1992-03-03 Therion Biologics Corporation Recombinant fowlpox virus and recombination vector
US5217879A (en) 1989-01-12 1993-06-08 Washington University Infectious Sindbis virus vectors
US5055303A (en) 1989-01-31 1991-10-08 Kv Pharmaceutical Company Solid controlled release bioadherent emulsions
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5188937A (en) 1989-04-06 1993-02-23 Becton, Dickinson And Company Layered sandwich assay method for chlamydia and materials therefor
US5270202A (en) 1989-11-03 1993-12-14 Syamal Raychaudhuri Anti-idiotypic antibodies to human melanoma-associated proteoglycan antigen
US5271961A (en) 1989-11-06 1993-12-21 Alkermes Controlled Therapeutics, Inc. Method for producing protein microspheres
US5188837A (en) 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances
US5427930A (en) 1990-01-26 1995-06-27 Abbott Laboratories Amplification of target nucleic acids using gap filling ligase chain reaction
GB9007024D0 (en) 1990-03-29 1990-05-30 Imperial College Novel vaccine
US5268164A (en) 1990-04-23 1993-12-07 Alkermes, Inc. Increasing blood-brain barrier permeability with permeabilizer peptides
WO1991019803A1 (en) 1990-06-19 1991-12-26 Applied Biotechnology, Incorporated Self assembled, defective, nonself-propagating viral particles
US5709860A (en) 1991-07-25 1998-01-20 Idec Pharmaceuticals Corporation Induction of cytotoxic T-lymphocyte responses
RO116459B1 (ro) 1991-07-25 2001-02-28 Idec Pharma Corp Compozitie imunogena
US5254342A (en) 1991-09-30 1993-10-19 University Of Southern California Compositions and methods for enhanced transepithelial and transendothelial transport or active agents
US5643578A (en) 1992-03-23 1997-07-01 University Of Massachusetts Medical Center Immunization by inoculation of DNA transcription unit
DE69311538D1 (de) 1992-03-12 1997-07-17 Alkermes Inc Acth enthaltende mikrokugeln mit gesteuerter abgabe
US5534496A (en) 1992-07-07 1996-07-09 University Of Southern California Methods and compositions to enhance epithelial drug transport
US5662907A (en) 1992-08-07 1997-09-02 Cytel Corporation Induction of anti-tumor cytotoxic T lymphocytes in humans using synthetic peptide epitopes
EP0671926B1 (en) 1992-08-11 2002-11-13 President And Fellows Of Harvard College Immunomodulatory peptides
FR2698877B1 (fr) 1992-12-04 1995-04-07 Atochem Elf Sa Composition adhésives thermofusibles réticulables à l'humidité.
US5593972A (en) 1993-01-26 1997-01-14 The Wistar Institute Genetic immunization
US6991797B2 (en) * 1993-07-02 2006-01-31 Statens Serum Institut M. tuberculosis antigens
US5514670A (en) 1993-08-13 1996-05-07 Pharmos Corporation Submicron emulsions for delivery of peptides
US5648211A (en) 1994-04-18 1997-07-15 Becton, Dickinson And Company Strand displacement amplification using thermophilic enzymes
EP1167379A3 (en) 1994-07-15 2004-09-08 University Of Iowa Research Foundation Immunomodulatory oligonucleotides
US6239116B1 (en) 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6429199B1 (en) 1994-07-15 2002-08-06 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules for activating dendritic cells
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
ES2168380T3 (es) 1994-07-15 2002-06-16 Organon Teknika Bv Utilizacion de arn polimerasa para mejorar un procedimiento de amplificacion de acido nucleico.
DE69519521T2 (de) 1994-10-03 2001-06-28 The Government Of The United States Of America, As Represented By The Secretary National Institute Of Health Zusammensetzung enthaltend ein antigen exprimierendes rekombinantes virus und ein immunstimulierendes molekül exprimierendes rekombinantes virus
US6045802A (en) 1994-10-03 2000-04-04 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Enhanced immune response to an antigen by a composition of a recombinant virus expressing the antigen with a recombinant virus expressing an immunostimulatory molecule
US5736524A (en) * 1994-11-14 1998-04-07 Merck & Co.,. Inc. Polynucleotide tuberculosis vaccine
AT402203B (de) 1995-06-13 1997-03-25 Himmler Gottfried Dipl Ing Dr Verfahren zur transkriptionsfreien amplifizierung von nucleinsäuren
US6165460A (en) 1995-07-10 2000-12-26 Therion Biologics Corporation Generation of immune responses to prostate-specific antigen (PSA)
WO1998037919A1 (en) 1997-02-28 1998-09-03 University Of Iowa Research Foundation USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS
US6406705B1 (en) 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
ATE370236T1 (de) * 1997-04-02 2007-09-15 Statens Seruminstitut Nukleinsäure- und polypeptidfragmente von m. tuberculosis
US7037510B2 (en) * 1997-04-18 2006-05-02 Statens Serum Institut Hybrids of M. tuberculosis antigens
EP1003531B1 (en) 1997-05-20 2007-08-22 Ottawa Health Research Institute Processes for preparing nucleic acid constructs
US6555653B2 (en) * 1997-05-20 2003-04-29 Corixa Corporation Compounds for diagnosis of tuberculosis and methods for their use
US6613881B1 (en) * 1997-05-20 2003-09-02 Corixa Corporation Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use
CA2319380A1 (en) 1997-11-10 1999-05-20 Statens Serum Institut Nucleic acid fragments and polypeptide fragments derived from m. tuberculosis
EP1484405A1 (en) * 1997-11-10 2004-12-08 Statens Serum Institut Nucleic acid fragments and polypeptide fragments derived from M. Tuberculosis
AU760549B2 (en) 1998-04-03 2003-05-15 University Of Iowa Research Foundation, The Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines
US6294328B1 (en) * 1998-06-24 2001-09-25 The Institute For Genomic Research DNA sequences for strain analysis in Mycobacterium tuberculosis
US20020131976A1 (en) * 1998-12-23 2002-09-19 Ajit Lalvani Tuberculosis vaccine
EP2087906A1 (en) * 1999-05-04 2009-08-12 The University of Medicine and Dentistry of New Jersey Proteins expressed by Mycobacterium tuberculosis and not by BCG and their use as diagnostic reagents and vaccines
CA2383213A1 (en) 1999-09-10 2001-03-15 Fordham University Methods and compositions for the treatment and prevention of graft rejection using heat shock proteins
US6861513B2 (en) * 2000-01-12 2005-03-01 Schering Corporation Everninomicin biosynthetic genes
AU2001241738A1 (en) * 2000-02-25 2001-09-03 Corixa Corporation Compounds and methods for diagnosis and immunotherapy of tuberculosis
CA2404260A1 (en) 2000-03-21 2001-09-27 Elitra Pharmaceuticals, Inc. Identification of essential genes in prokaryotes
US7657378B1 (en) * 2000-03-30 2010-02-02 Council Of Scientific & Industrial Research Computer based method for identifying peptides useful as drug targets
AU2001253508A1 (en) * 2000-04-14 2001-10-30 Phytera, Inc. Mdr efflux pumps
KR100464485B1 (ko) 2000-11-09 2004-12-31 엘지전자 주식회사 고속무선 패킷 데이터의 전송 장치 및 그 방법
CA2430896A1 (en) * 2000-12-13 2002-06-20 Argonex Pharmaceuticals, Inc. Mhc class i associated peptides for prevention and treatment of tuberculosis
AU2002306849A1 (en) * 2001-03-21 2002-10-08 Elitra Pharmaceuticals, Inc. Identification of essential genes in microorganisms
FI116851B (fi) * 2001-05-03 2006-03-15 Fit Biotech Oyj Plc Ilmentämisvektori, sen käyttöjä ja menetelmä sen valmistamiseksi sekä sitä sisältäviä tuotteita
US7067492B2 (en) * 2001-09-06 2006-06-27 Omnio Ab Method of promoting healing of a tympanic membrane perforation
GB0124593D0 (en) * 2001-10-12 2001-12-05 Microbiological Res Authority Mycobacterial antigens expressed under high oxygen tension
US20040029129A1 (en) * 2001-10-25 2004-02-12 Liangsu Wang Identification of essential genes in microorganisms
US20050123511A1 (en) * 2001-12-07 2005-06-09 Mccreavy David T. Dna vaccine
GB2398302B (en) * 2002-02-08 2005-10-19 All India Inst Med A process for identifying a novel target for use for the development of therapeutic modalities and drugs effective against tuberculosis
US7074559B2 (en) * 2002-03-06 2006-07-11 Refents of the University of Minnesota Mycobacterial diagnostics
US20030236393A1 (en) * 2002-03-22 2003-12-25 United States Of America Dept Of Vetrans Affairs Virulence genes of M. marinum and M. tuberculosis
WO2004006952A2 (en) * 2002-07-13 2004-01-22 Statens Serum Institut Therapeutic tuberculosis vaccines
US7364869B2 (en) * 2003-07-29 2008-04-29 The J. David Gladstone Institutes Method of detecting antigen-specific T lymphocytes
ITRM20030411A1 (it) * 2003-08-29 2005-02-28 Consiglio Nazionale Ricerche Uso di sequenze geniche specifiche di mycobacterium tubercolosis ecorrispondenti proteine per la diagnosi e la prevenzione di infezione tubercolare.
EP1518932A1 (en) * 2003-09-29 2005-03-30 GSF-Forschungszentrum für Umwelt und Gesundheit GmbH Modified vaccinia virus Ankara (MVA) mutant and use thereof
US7424370B2 (en) * 2004-02-06 2008-09-09 Council Of Scientific And Industrial Research Computational method for identifying adhesin and adhesin-like proteins of therapeutic potential
GB0406271D0 (en) * 2004-03-19 2004-04-21 Isis Innovation Diagnostic test
US20090070897A1 (en) * 2006-01-12 2009-03-12 Goldman Barry S Genes and uses for plant improvement
US7566459B2 (en) * 2005-02-28 2009-07-28 New York University Modified mycobacterium tuberculosis strains and uses thereof
DK2457926T3 (da) * 2005-04-29 2015-01-05 Glaxosmithkline Biolog Sa Ny fremgangsmåde til forebyggelse eller behandling af M. tuberkulose-infektion
EP1910410B1 (en) 2005-07-01 2011-10-26 Forsyth Dental Infirmary for Children Tuberculosis antigen detection assays and vaccines
EP2441469A1 (en) * 2006-03-14 2012-04-18 Oregon Health and Science University Methods for producing an immune response to tuberculosis
KR100756676B1 (ko) * 2006-11-23 2007-09-07 제일모직주식회사 실리콘계 미립자, 그 제조 방법, 및 그 미립자가 함유된열가소성 수지 조성물
BRPI0809926B8 (pt) * 2007-04-04 2021-05-25 Infectious Disease Res Inst composição que compreende antígenos de mycobacterium tuberculosis, polipeptídeo de fusão isolado, polinucleotídeo isolado que codifica o dito polipeptídeo e uso da dita composição para estimular uma resposta imune protetora
US10611818B2 (en) * 2007-09-27 2020-04-07 Agilent Technologies, Inc. MHC multimers in tuberculosis diagnostics, vaccine and therapeutics
BRPI0904621A2 (pt) * 2008-07-25 2015-06-30 Dept Of Biotechnology India Quimera recombinante de construção de dna
AU2009273132B2 (en) * 2008-07-25 2015-09-03 Glaxo Group Limited The tuberculosis Rv2386c protein, compositions and uses thereof
JP2012503206A (ja) * 2008-09-22 2012-02-02 オレゴン ヘルス アンド サイエンス ユニバーシティ Ｍｙｃｏｂａｃｔｅｒｉｕｍｔｕｂｅｒｃｕｌｏｓｉｓ感染を検出するための方法
WO2010037402A1 (en) * 2008-10-02 2010-04-08 Dako Denmark A/S Molecular vaccines for infectious disease
US8691502B2 (en) * 2008-10-31 2014-04-08 Tremrx, Inc. T-cell vaccination with viral vectors via mechanical epidermal disruption
CN102713629B (zh) * 2009-11-20 2016-02-24 俄勒冈健康科学大学 用于检测结核分枝杆菌感染的方法
US10703784B2 (en) * 2011-09-30 2020-07-07 La Jolla Institute For Allergy And Immunology Antigens and epitopes derived from Mycobacterium tuberculosis

Also Published As

Publication number Publication date
US8101192B2 (en) 2012-01-24
WO2007106560A3 (en) 2007-12-13
US9040233B2 (en) 2015-05-26
EP2441469A1 (en) 2012-04-18
US8440206B2 (en) 2013-05-14
US20120107341A1 (en) 2012-05-03
EP2397853B1 (en) 2014-01-15
EP2397854A3 (en) 2012-03-14
EP2397852B1 (en) 2013-12-04
US20110014224A1 (en) 2011-01-20
US8361707B2 (en) 2013-01-29
EP2005184A2 (en) 2008-12-24
WO2007106560A2 (en) 2007-09-20
EP2441470B1 (en) 2014-05-07
EP2428801B1 (en) 2014-05-07
US20150219645A1 (en) 2015-08-06
US20130101523A1 (en) 2013-04-25
CN101438166A (zh) 2009-05-20
EP2397854B1 (en) 2014-06-04
EP2397853A3 (en) 2012-03-14
EP1994409A2 (en) 2008-11-26
US7842299B2 (en) 2010-11-30
EP2397853A2 (en) 2011-12-21
ZA200808644B (en) 2017-08-30
EP2207035A2 (en) 2010-07-14
EP2428801A1 (en) 2012-03-14
EP2397856B1 (en) 2013-11-13
US20090324503A1 (en) 2009-12-31
EP2207035B1 (en) 2013-10-16
EP2397856A2 (en) 2011-12-21
US20120014881A1 (en) 2012-01-19
US20090124549A1 (en) 2009-05-14
BRPI0708865A2 (pt) 2011-06-14
EP2207035A3 (en) 2010-11-17
CA2649688A1 (en) 2007-09-20
WO2007106536A2 (en) 2007-09-20
US8053181B2 (en) 2011-11-08
EP2397852A2 (en) 2011-12-21
EP2441470A1 (en) 2012-04-18
EP2397856A3 (en) 2012-03-14
EP2253957B1 (en) 2013-05-15
EP2397855A3 (en) 2012-03-14
EP2397854A2 (en) 2011-12-21
EP2441493A1 (en) 2012-04-18
ZA200808643B (en) 2014-03-26
BRPI0708912B1 (pt) 2018-03-20
EP2397852A3 (en) 2012-03-14
EP2253957A1 (en) 2010-11-24
WO2007106536A3 (en) 2008-01-10
EP2397855A2 (en) 2011-12-21
BRPI0708912B8 (pt) 2021-07-27
BRPI0708912A2 (pt) 2011-06-14
EP2441493B1 (en) 2014-05-07

Similar Documents

Publication Publication Date Title
BRPI0708865A8 (pt) métodos para produzir uma resposta imune à tuberculose
WO2011063263A3 (en) Methods for producing an immune response to tuberculosis
MY153228A (en) Composition to treat and/ or prevent gastrointestinal infection
BRPI0819323B8 (pt) composição à base de bactéria probiótica em associação com uma prebiótica e uso da mesma na prevenção e/ou tratamento de patologias respiratórias e/ou infecções e no aperfeiçoamento de funcionalidade intestinal
SV2009002899A (es) Diarilureas para el tratamiento de la hipertension pulmonar
MY147247A (en) Organic compounds and their uses
WO2007109172A3 (en) Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
BRPI0618451A2 (pt) derivados de piridopirazina, seu uso, composição farmacêutica e estojo
MX2009007345A (es) Compuestos con (fenil sustituido), con restos de propenal, sus derivados, actividad biologica y uso del mismo.
BRPI0516059A (pt) pelìcula proterora de piso, método para aplicar uma pelìcula ao piso, e, piso
WO2007109160A3 (en) Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
FR2925522B1 (fr) Procede de traitement superficiel d'un alliage de zirconium ou de hafnium, et piece ainsi traitee
CY1118835T1 (el) Αντισωμα anti-fgf23 και φαρμακευτικη συνθεση που το περιλαμβανει
MX390386B (es) Carotenoides microbianos que afectan la composicion de la microbiota intestinal
WO2009017902A3 (en) Compositions and methods for identification of subspecies characteristics of mycobacterium tuberculosis
BR112014019399A2 (pt) métodos de tratamento da fibrose
WO2007150008A3 (en) Polypeptides from african swine virus as vaccines for preventive and therapeutic use
BRPI0622083A2 (pt) Método e aparelho destinados à fabricação de substratos purificados ou substratos puros que são adicionalmente processados.
BR112022000873A2 (pt) Cepas de pseudomonas e métodos relacionados
WO2008057158A3 (en) Novel neutralizing immunogen (nimiv) of rhinovirus and its use for vaccine applications
BR112023026164A2 (pt) Bacteriófagos contra enterococci resistentes à vancomicina
BRPI0808823A2 (pt) composição e método para tratar, reduzir, melhorar ou prevenir uma infecção.
BR112017021166A2 (pt) componente e dispositivo eletrônico
BR112014014805A2 (pt) processos para tratamento e prevenção de constipação induzida por opióide que utilizam composições orais de metilnaltrexona
BRPI0819195A2 (pt) métodos para tratar escleroderma em um paciente em necessidade de tal tratamento e para aliviar um ou mais dos sintomas associados com escleroderma em um paciente em necessidade de tal tratamento.

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06H Technical and formal requirements: requirement cancelled [chapter 6.8 patent gazette]

Free format text: REF. A RPI NO 2155 DE 24/04/2012. ANULACAO DA EXIGENCIA 6.6 POR TER SIDO INDEVIDA. REQUERENTE NAO APRESENTOU RESPOSTA A EXIGENCIA CONFORME DISPOE A RESOLUCAO 207 DE 24/04/2009, ENTRETANTO, A RESPOSTA CONSTA NO FORMULARIO DE DEPOSITO.

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette]
B06A Notification to applicant to reply to the report for non-patentability or inadequacy of the application [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements