BRPI0612778A2 - anticorpos humanizados anti-alfavbeta6, mólecula de ácido nucléico e peptìdeo isolados, vetor recombinante e composição - Google Patents

anticorpos humanizados anti-alfavbeta6, mólecula de ácido nucléico e peptìdeo isolados, vetor recombinante e composição

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Publication number
BRPI0612778A2
BRPI0612778A2 BRPI0612778-9A BRPI0612778A BRPI0612778A2 BR PI0612778 A2 BRPI0612778 A2 BR PI0612778A2 BR PI0612778 A BRPI0612778 A BR PI0612778A BR PI0612778 A2 BRPI0612778 A2 BR PI0612778A2
Authority
BR
Brazil
Prior art keywords
antibodies
humanized anti
nucleic acid
composition
isolated nucleic
Prior art date
Application number
BRPI0612778-9A
Other languages
English (en)
Inventor
Shelia M Violette
Louise A Koopman
Kenneth J Simon
Paul H Weinreb
Herman Van Vlijmen
Jose Saldanha
Alexey A Lugovskoy
Original Assignee
Biogen Idec Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Idec Inc filed Critical Biogen Idec Inc
Publication of BRPI0612778A2 publication Critical patent/BRPI0612778A2/pt
Publication of BRPI0612778A8 publication Critical patent/BRPI0612778A8/pt
Publication of BRPI0612778B1 publication Critical patent/BRPI0612778B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C12P21/00—Preparation of peptides or proteins
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70546—Integrin superfamily, e.g. VLAs, leuCAM, GPIIb/GPIIIa, LPAM
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Abstract

ANTICORPOS HUMANIZADOS ANTI-ALFA~ v~BETA~ 6~, MOLéCULA DE áCIDO NUCLéICO E PEPTìDEO ISOLADOS, VETOR RECOMBINANTE E COMPOSIçãO. A presente invenção está inserida nos campos da biologia celular, imunologia e oncologia. A invenção proporciona anticorpos humanizados que reconhecem as integrinas <244>~ v~<225>~ 6~, cujos anticorpos compreendem uma região variável de origem não humana e pelo menos uma porção de uma imunoglobulina de origem humana. A invenção proporciona também métodos compreendendo os mesmos, e métodos para tratar, diagnosticar e/ou prevenir várias doenças e distúrbios por administração dos anticorpos anti<244>~ v~<225>~ 6~ humanizados da invenção. A invenção ainda refere-se à identificação de expressão diferencial da integrina <244>~ v~<225>~ 6~ sobre as superfícies das células tumorais e tecidos, o uso desta expressão diferencial na determinação do potencial metastático de células tumorais e métodos de diagnóstico e tratamento/prevenção de metástase de tumor e para eliminação de células tumorais metastáticas residuais usando ligantes, particularmente anticorpos, que se ligam à integrina <244>~ v~<225>~ 6~.
BRPI0612778-9A 2005-07-08 2006-07-10 Anticorpo humanizado que se liga especificamente a ?lfav?eta6, seu método de preparação, composição e método in vitro de diagnóstico de um carcinoma que tem maior probabilidade de progredir para um carcinoma invasivo BRPI0612778B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US69744205P 2005-07-08 2005-07-08
US60/697,442 2005-07-08
US77331006P 2006-02-15 2006-02-15
US60/773,310 2006-02-15
PCT/US2006/026598 WO2007008712A2 (en) 2005-07-08 2006-07-10 Anti-alpha v beta 6 antibodies and uses thereof

Publications (3)

Publication Number Publication Date
BRPI0612778A2 true BRPI0612778A2 (pt) 2009-05-05
BRPI0612778A8 BRPI0612778A8 (pt) 2018-01-30
BRPI0612778B1 BRPI0612778B1 (pt) 2022-04-05

Family

ID=37637797

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Application Number Title Priority Date Filing Date
BRPI0612778-9A BRPI0612778B1 (pt) 2005-07-08 2006-07-10 Anticorpo humanizado que se liga especificamente a ?lfav?eta6, seu método de preparação, composição e método in vitro de diagnóstico de um carcinoma que tem maior probabilidade de progredir para um carcinoma invasivo

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US (3) US7943742B2 (pt)
EP (4) EP1920065B1 (pt)
JP (2) JP5116671B2 (pt)
KR (3) KR101531317B1 (pt)
CN (3) CN104072614B (pt)
AU (1) AU2006269266B2 (pt)
BR (1) BRPI0612778B1 (pt)
CA (1) CA2614183C (pt)
CY (1) CY1120924T1 (pt)
DK (1) DK1920065T3 (pt)
EA (1) EA016342B1 (pt)
ES (1) ES2700025T3 (pt)
HU (1) HUE039034T2 (pt)
LT (1) LT1920065T (pt)
PL (1) PL1920065T3 (pt)
PT (1) PT1920065T (pt)
SI (1) SI1920065T1 (pt)
WO (1) WO2007008712A2 (pt)

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NZ535425A (en) 2002-03-13 2008-05-30 Biogen Idec Inc Anti-alphavbeta6 antibodies
CN104072614B (zh) 2005-07-08 2017-04-26 生物基因Ma公司 抗-αvβ6 抗体及其用途
CN101563105B (zh) 2006-07-10 2013-01-23 拜奥根Idec马萨诸塞公司 用于抑制smad4-缺陷癌症的组合物和方法
EP2064244B1 (en) 2006-08-03 2019-06-05 MedImmune Limited ANTIBODIES DIRECTED TO alphaVbeta6 AND USES THEREOF
JP2010506944A (ja) 2006-10-19 2010-03-04 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア インテグリンαＶβ６のアンタゴニストを用いる慢性喘息の処置および予防
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BRPI0813645A2 (pt) 2007-06-25 2014-12-30 Esbatech Alcon Biomed Res Unit Métodos para modificar anticorpos, e anticorpos modificados com propriedades funcionais aperfeiçoadas
EP2031064A1 (de) * 2007-08-29 2009-03-04 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Steigerung von Proteintitern
GB0718843D0 (en) 2007-09-26 2007-11-07 Cancer Rec Tech Ltd Materials and methods relating to modifying the binding of antibodies
WO2009059115A1 (en) * 2007-10-31 2009-05-07 Trustees Of The University Of Pennsylvania Culture based screening assay and methods of use thereof to identify agents which modulate tumor development, invasion and differentiation
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CA2787783A1 (en) * 2010-01-20 2011-07-28 Tolerx, Inc. Anti-ilt5 antibodies and ilt5-binding antibody fragments
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Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 10/06/2006, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

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B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2726 DE 04-04-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.