BRPI0613644A2 - moduladores de tieno pirimidina e tieno pirimidina cinase - Google Patents

moduladores de tieno pirimidina e tieno pirimidina cinase Download PDF

Info

Publication number: BRPI0613644A2
Authority: BR; Brazil
Prior art keywords: formula; compound; alkyl; original document; see original
Prior art date: 2005-06-10

Application number

BRPI0613644-3A

Other languages

English (en)

Portuguese (pt)

Inventor

Michael David Gaul

Kevin Douglas Kreutter

Christian Andrew Baumann

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-06-10

Filing date

2006-06-07

Publication date

2011-01-25

2006-06-07 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2011-01-25 Publication of BRPI0613644A2 publication Critical patent/BRPI0613644A2/pt

Links

108091000080 Phosphotransferase Proteins 0.000 title abstract description 16
102000020233 phosphotransferase Human genes 0.000 title abstract description 16
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title abstract description 10
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238000000034 method Methods 0.000 claims abstract description 89
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-1 pyrrolidinonyl Chemical group 0.000 claims description 173
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125000001072 heteroaryl group Chemical group 0.000 claims description 43
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125000001424 substituent group Chemical group 0.000 claims description 31
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229910052757 nitrogen Inorganic materials 0.000 claims description 26
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GARSDLRPRBEKQE-UHFFFAOYSA-N tert-butyl(pyrrolidin-3-yl)carbamic acid Chemical compound CC(C)(C)N(C(O)=O)C1CCNC1 GARSDLRPRBEKQE-UHFFFAOYSA-N 0.000 description 1
YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 description 1
CIHOLLKRGTVIJN-UHFFFAOYSA-N tert‐butyl hydroperoxide Chemical compound CC(C)(C)OO CIHOLLKRGTVIJN-UHFFFAOYSA-N 0.000 description 1
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JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Oncology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Materials For Medical Uses (AREA)

BRPI0613644-3A 2005-06-10 2006-06-07 moduladores de tieno pirimidina e tieno pirimidina cinase BRPI0613644A2 (pt)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US68971005P	2005-06-10	2005-06-10
US60/689,710		2005-06-10
US74694106P	2006-05-10	2006-05-10
US60/746,941		2006-05-10
PCT/US2006/022151 WO2006135639A1 (en)	2005-06-10	2006-06-07	Thiξnopyrimidine and thienopyridine derivatives as flt-3 kinase inhibitors

Publications (1)

Publication Number	Publication Date
BRPI0613644A2 true BRPI0613644A2 (pt)	2011-01-25

Family

ID=37074647

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0613644-3A BRPI0613644A2 (pt)	2005-06-10	2006-06-07	moduladores de tieno pirimidina e tieno pirimidina cinase

Country Status (19)

Country	Link
US (3)	US20060281768A1 (es)
EP (1)	EP1899355A1 (es)
JP (1)	JP2008543759A (es)
KR (1)	KR20080021126A (es)
AR (1)	AR057063A1 (es)
AU (1)	AU2006258049A1 (es)
BR (1)	BRPI0613644A2 (es)
CA (1)	CA2611587A1 (es)
CR (1)	CR9650A (es)
EA (1)	EA200800011A1 (es)
EC (1)	ECSP077992A (es)
IL (1)	IL187689A0 (es)
MX (1)	MX2007015741A (es)
NI (1)	NI200700311A (es)
NO (1)	NO20080162L (es)
PE (1)	PE20070070A1 (es)
TW (1)	TW200716651A (es)
UY (1)	UY29590A1 (es)
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- 2006-06-07 KR KR1020087000618A patent/KR20080021126A/ko not_active Withdrawn
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- 2006-06-07 EA EA200800011A patent/EA200800011A1/ru unknown
- 2006-06-07 WO PCT/US2006/022151 patent/WO2006135639A1/en not_active Ceased
- 2006-06-08 PE PE2006000640A patent/PE20070070A1/es not_active Application Discontinuation
- 2006-06-08 UY UY29590A patent/UY29590A1/es unknown
- 2006-06-09 AR ARP060102425A patent/AR057063A1/es not_active Application Discontinuation
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2007
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2008
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- 2008-01-09 NO NO20080162A patent/NO20080162L/no not_active Application Discontinuation
2009
- 2009-01-30 US US12/363,043 patent/US20090163710A1/en not_active Abandoned
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Publication number	Publication date
CR9650A (es)	2008-09-09
EP1899355A1 (en)	2008-03-19
US20090163710A1 (en)	2009-06-25
ECSP077992A (es)	2008-01-23
AR057063A1 (es)	2007-11-14
MX2007015741A (es)	2008-04-29
TW200716651A (en)	2007-05-01
KR20080021126A (ko)	2008-03-06
AU2006258049A8 (en)	2006-12-21
CA2611587A1 (en)	2006-12-21
AU2006258049A1 (en)	2006-12-21
NI200700311A (es)	2009-03-03
US20090143378A1 (en)	2009-06-04
NO20080162L (no)	2008-03-07
JP2008543759A (ja)	2008-12-04
WO2006135639A1 (en)	2006-12-21
IL187689A0 (en)	2008-08-07
US20060281768A1 (en)	2006-12-14
UY29590A1 (es)	2006-10-02
EA200800011A1 (ru)	2008-06-30
PE20070070A1 (es)	2007-03-08

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2011-07-26

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