CR9650A - Derivados de tienopirimidina y tienopiridina como inhibidores de tirosina cinasa 3 tipo fms - Google Patents
Derivados de tienopirimidina y tienopiridina como inhibidores de tirosina cinasa 3 tipo fmsInfo
- Publication number
- CR9650A CR9650A CR9650A CR9650A CR9650A CR 9650 A CR9650 A CR 9650A CR 9650 A CR9650 A CR 9650A CR 9650 A CR9650 A CR 9650A CR 9650 A CR9650 A CR 9650A
- Authority
- CR
- Costa Rica
- Prior art keywords
- compounds
- inhibitors
- tienopirimidine
- tienopiridine
- derivatives
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 101000932478 Homo sapiens Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 abstract 3
- 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 230000002062 proliferating effect Effects 0.000 abstract 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- 229940076155 protein modulator Drugs 0.000 abstract 1
- 229940125670 thienopyridine Drugs 0.000 abstract 1
- 239000002175 thienopyridine Substances 0.000 abstract 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Materials For Medical Uses (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La invencion esta dirigida a tienopirimidinas y tienopiridinas de formula I y formula II en donde R1, R3, B, Z, Q, p, q, y X son como se define en la presente, el uso de dichos compuestos como moduladores de proteina tirosina cinasa, particularmente inhibidores de FLT3, el uso de dichos compuestos para reducir o inhibir la actividad cinasa de FLT3 en una celula o un sujeto, y el uso de dichos compuestos para la prevencion o tratamiento en un sujeto de un trastorno proliferante celular y/o trastornos relacionados a FLT3; la presente invencion se refiere ademas a composiciones farmaceuticas que comprenden los compuestos de la presente invencion y a metodos para el tratamiento de condiciones tales como canceres y otros trastornos proliferantes celulares.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68971005P | 2005-06-10 | 2005-06-10 | |
| US74694106P | 2006-05-10 | 2006-05-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR9650A true CR9650A (es) | 2008-09-09 |
Family
ID=37074647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR9650A CR9650A (es) | 2005-06-10 | 2008-01-09 | Derivados de tienopirimidina y tienopiridina como inhibidores de tirosina cinasa 3 tipo fms |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US20060281768A1 (es) |
| EP (1) | EP1899355A1 (es) |
| JP (1) | JP2008543759A (es) |
| KR (1) | KR20080021126A (es) |
| AR (1) | AR057063A1 (es) |
| AU (1) | AU2006258049A1 (es) |
| BR (1) | BRPI0613644A2 (es) |
| CA (1) | CA2611587A1 (es) |
| CR (1) | CR9650A (es) |
| EA (1) | EA200800011A1 (es) |
| EC (1) | ECSP077992A (es) |
| IL (1) | IL187689A0 (es) |
| MX (1) | MX2007015741A (es) |
| NI (1) | NI200700311A (es) |
| NO (1) | NO20080162L (es) |
| PE (1) | PE20070070A1 (es) |
| TW (1) | TW200716651A (es) |
| UY (1) | UY29590A1 (es) |
| WO (1) | WO2006135639A1 (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
| JP2009534454A (ja) * | 2006-04-25 | 2009-09-24 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
| WO2007125321A2 (en) | 2006-04-25 | 2007-11-08 | Astex Therapeutics Limited | Purine and deazapurine derivatives as pharmaceutical compounds |
| JP2010504362A (ja) * | 2006-09-25 | 2010-02-12 | アレテ セラピューティクス， インコーポレイテッド | 可溶性エポキシドヒドロラーゼ阻害剤 |
| JP5439377B2 (ja) | 2007-09-14 | 2014-03-12 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒスタミンｈ４受容体のチエノ−及びフロ−ピリミジン調節物質 |
| AU2008309383B2 (en) | 2007-10-11 | 2012-04-19 | Astrazeneca Ab | Pyrrolo [2, 3 -D] pyrimidin derivatives as protein kinase B inhibitors |
| BR112013025410A2 (pt) | 2011-04-01 | 2016-12-20 | Astrazeneca Ab | tratamento terapêutico |
| MY173181A (en) | 2011-05-13 | 2020-01-02 | Array Biopharma Inc | Pyrrolidinyl urea, pyrrolidinyl thiourea and pyrrolidinyl guanidine compounds as trka kinase inhibitors |
| AR090037A1 (es) * | 2011-11-15 | 2014-10-15 | Xention Ltd | Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio |
| CA2856646C (en) | 2011-11-30 | 2020-01-14 | Astrazeneca Ab | Combination treatment of cancer |
| AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
| LT3154959T (lt) | 2014-05-15 | 2019-09-25 | Array Biopharma, Inc. | 1-((3s,4r)-4-(3-fluorfenil)-1-(2-metoksietil)pirolidin-3-il)-3-(4-metil-3-(2-metilpirimidin-5-il)-1-fenil-1h-pirazol-5-il)karbamidas kaip trka kinazės inhibitorius |
| WO2018118598A1 (en) * | 2016-12-23 | 2018-06-28 | Arvinas, Inc. | Compounds and methods for the targeted degradation of fetal liver kinase polypeptides |
| KR101954370B1 (ko) | 2018-07-25 | 2019-03-05 | 한미약품 주식회사 | 피리미딘 화합물 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물 |
| TW202039481A (zh) | 2018-12-21 | 2020-11-01 | 美商西建公司 | Ripk2之噻吩并吡啶抑制劑 |
| PH12021551985A1 (en) | 2019-02-22 | 2022-08-22 | Hanmi Pharmaceutical Co Ltd | Pharmaceutical composition comprising flt3 inhibitor and hypomethylating agent for treating acute myeloid leukemia |
| KR20210002015A (ko) | 2019-06-27 | 2021-01-06 | 한미약품 주식회사 | Flt3 저해제 및 화학치료제를 포함하는 급성 골수성 백혈병 치료용 약학적 조성물 |
| WO2024248513A1 (en) * | 2023-05-31 | 2024-12-05 | Hanmi Pharm. Co., Ltd. | Solid dispersion of myeloid kinome inhibitors and pharmaceutical composition comprising the same |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0627940B1 (en) * | 1992-03-05 | 2003-05-07 | Board of Regents, The University of Texas System | Use of immunoconjugates for the diagnosis and/or therapy of vascularized tumors |
| US5474765A (en) * | 1992-03-23 | 1995-12-12 | Ut Sw Medical Ctr At Dallas | Preparation and use of steroid-polyanionic polymer-based conjugates targeted to vascular endothelial cells |
| US5932765A (en) * | 1997-05-23 | 1999-08-03 | Merck Patent Gesellschaft Mit | Nitromethyl ketones, process for preparing them and compositions containing them |
| NZ520093A (en) * | 1997-11-11 | 2004-03-26 | Pfizer Prod Inc | Thienopyrimidine and thienopyridine derivatives useful as anticancer agents |
| WO1999037304A1 (en) * | 1998-01-27 | 1999-07-29 | Aventis Pharmaceuticals Products Inc. | SUBSTITUTED OXOAZAHETEROCYCLYL FACTOR Xa INHIBITORS |
| ES2223705T3 (es) * | 1999-04-28 | 2005-03-01 | Board Of Regents, The University Of Texas System | Composiciones y metodos para el tratamiento de cancer mediante inhibi cion selectiva del vegf. |
| US6776796B2 (en) * | 2000-05-12 | 2004-08-17 | Cordis Corportation | Antiinflammatory drug and delivery device |
| DE10110750A1 (de) * | 2001-03-07 | 2002-09-12 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| TWI238824B (en) * | 2001-05-14 | 2005-09-01 | Novartis Ag | 4-amino-5-phenyl-7-cyclobutyl-pyrrolo[2,3-d]pyrimidine derivatives |
| US7105505B2 (en) * | 2002-04-18 | 2006-09-12 | Schering Corporation | Benzimidazole derivatives useful as histamine H3 antagonists |
| MY141867A (en) * | 2002-06-20 | 2010-07-16 | Vertex Pharma | Substituted pyrimidines useful as protein kinase inhibitors |
| MXPA05001631A (es) * | 2002-08-12 | 2005-08-19 | Takeda Pharmaceutical | Derivado de benceno fusionado y su uso. |
| US20080207617A1 (en) * | 2002-10-29 | 2008-08-28 | Kirin Beer Kabushiki Kaisha | Quinoline Derivatives and Quinazoline Derivatives Inhibiting Autophosphrylation of Flt3 and Medicinal Compositions Containing the Same |
| US20050026944A1 (en) * | 2003-07-24 | 2005-02-03 | Patrick Betschmann | Thienopyridine and furopyridine kinase inhibitors |
| US20060281769A1 (en) * | 2005-06-10 | 2006-12-14 | Baumann Christian A | Synergistic modulation of flt3 kinase using thienopyrimidine and thienopyridine kinase modulators |
-
2006
- 2006-06-06 US US11/422,359 patent/US20060281768A1/en not_active Abandoned
- 2006-06-07 JP JP2008515879A patent/JP2008543759A/ja not_active Withdrawn
- 2006-06-07 MX MX2007015741A patent/MX2007015741A/es unknown
- 2006-06-07 AU AU2006258049A patent/AU2006258049A1/en not_active Abandoned
- 2006-06-07 EP EP06772445A patent/EP1899355A1/en not_active Withdrawn
- 2006-06-07 BR BRPI0613644-3A patent/BRPI0613644A2/pt not_active Application Discontinuation
- 2006-06-07 WO PCT/US2006/022151 patent/WO2006135639A1/en not_active Ceased
- 2006-06-07 KR KR1020087000618A patent/KR20080021126A/ko not_active Withdrawn
- 2006-06-07 NI NI200700311A patent/NI200700311A/es unknown
- 2006-06-07 CA CA002611587A patent/CA2611587A1/en not_active Abandoned
- 2006-06-07 EA EA200800011A patent/EA200800011A1/ru unknown
- 2006-06-08 UY UY29590A patent/UY29590A1/es unknown
- 2006-06-08 PE PE2006000640A patent/PE20070070A1/es not_active Application Discontinuation
- 2006-06-09 AR ARP060102425A patent/AR057063A1/es not_active Application Discontinuation
- 2006-06-09 TW TW095120482A patent/TW200716651A/zh unknown
-
2007
- 2007-11-27 IL IL187689A patent/IL187689A0/en unknown
- 2007-12-10 EC EC2007007992A patent/ECSP077992A/es unknown
-
2008
- 2008-01-09 NO NO20080162A patent/NO20080162L/no not_active Application Discontinuation
- 2008-01-09 CR CR9650A patent/CR9650A/es not_active Application Discontinuation
-
2009
- 2009-01-30 US US12/362,933 patent/US20090143378A1/en not_active Abandoned
- 2009-01-30 US US12/363,043 patent/US20090163710A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1899355A1 (en) | 2008-03-19 |
| NO20080162L (no) | 2008-03-07 |
| WO2006135639A1 (en) | 2006-12-21 |
| IL187689A0 (en) | 2008-08-07 |
| BRPI0613644A2 (pt) | 2011-01-25 |
| NI200700311A (es) | 2009-03-03 |
| CA2611587A1 (en) | 2006-12-21 |
| KR20080021126A (ko) | 2008-03-06 |
| MX2007015741A (es) | 2008-04-29 |
| JP2008543759A (ja) | 2008-12-04 |
| UY29590A1 (es) | 2006-10-02 |
| US20090143378A1 (en) | 2009-06-04 |
| AU2006258049A1 (en) | 2006-12-21 |
| PE20070070A1 (es) | 2007-03-08 |
| TW200716651A (en) | 2007-05-01 |
| ECSP077992A (es) | 2008-01-23 |
| EA200800011A1 (ru) | 2008-06-30 |
| AR057063A1 (es) | 2007-11-14 |
| US20090163710A1 (en) | 2009-06-25 |
| AU2006258049A8 (en) | 2006-12-21 |
| US20060281768A1 (en) | 2006-12-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal (granting procedure) |