BRPI0619213B8 - composto precursor de composto orgânico marcado com haloênio radioativo - Google Patents

composto precursor de composto orgânico marcado com haloênio radioativo

Info

Publication number
BRPI0619213B8
BRPI0619213B8 BRPI0619213A BRPI0619213A BRPI0619213B8 BR PI0619213 B8 BRPI0619213 B8 BR PI0619213B8 BR PI0619213 A BRPI0619213 A BR PI0619213A BR PI0619213 A BRPI0619213 A BR PI0619213A BR PI0619213 B8 BRPI0619213 B8 BR PI0619213B8
Authority
BR
Brazil
Prior art keywords
substituent
compound
radioactive
amino acid
halogen
Prior art date
Application number
BRPI0619213A
Other languages
English (en)
Inventor
Hayashi Akio
Harano Arinori
Kurosaki Fumie
Toyama Masahito
Ito Osamu
Shinmura Toshiyuki
Original Assignee
Nihon Mediphysics Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nihon Mediphysics Co Ltd filed Critical Nihon Mediphysics Co Ltd
Publication of BRPI0619213A2 publication Critical patent/BRPI0619213A2/pt
Publication of BRPI0619213B1 publication Critical patent/BRPI0619213B1/pt
Publication of BRPI0619213B8 publication Critical patent/BRPI0619213B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/307—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

composto precursor de composto orgânico marcado com halogênio radioativo. a presente invenção tem por objetivo oferecer um novo composto orgânico de aminoácidos que possa ser utilizado como composto precursor para marcação para compostos de aminoácidos marcados com halogênio radioativo incluindo [18f]facbc, e que impeça o metanol de remanescer nos compostos de aminoácidos marcados com halogênio radioativo produzidos a partir dos mesmos. o novo composto orgânico de aminoácidos é um composto representado pela seguinte fórmula: (1) em que n é um número inteiro igual 0 ou de 1 a 4; r1 é um substituinte etila, 1-propila ou isopropila; x é um substituinte halogênio ou um grupo representado por -or2; r2 é um substituinte ácido haloalquilsulfônico de cadeia linear ou cadeia ramificada com um a 10 átomos de carbono, substituinte trialquilestanil com 3 a 12 átomos de carbono, substituinte ácido fluorsulfônico ou substituinte ácido sulfônico aromático; e r3 é um grupo protetor.
BRPI0619213A 2005-11-29 2006-11-28 composto precursor de composto orgânico marcado com haloênio radioativo BRPI0619213B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2005343653 2005-11-29
JP2005-343653 2005-11-29
PCT/JP2006/323659 WO2007063824A1 (ja) 2005-11-29 2006-11-28 放射性ハロゲン標識有機化合物の前駆体化合物

Publications (3)

Publication Number Publication Date
BRPI0619213A2 BRPI0619213A2 (pt) 2011-09-20
BRPI0619213B1 BRPI0619213B1 (pt) 2018-12-26
BRPI0619213B8 true BRPI0619213B8 (pt) 2021-07-27

Family

ID=38092157

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0619213A BRPI0619213B8 (pt) 2005-11-29 2006-11-28 composto precursor de composto orgânico marcado com haloênio radioativo

Country Status (17)

Country Link
US (7) US8758724B2 (pt)
EP (2) EP1978015B1 (pt)
JP (2) JP5635225B2 (pt)
KR (3) KR20080071146A (pt)
CN (1) CN101316812A (pt)
AU (1) AU2006319987B2 (pt)
BR (1) BRPI0619213B8 (pt)
CA (1) CA2629227C (pt)
ES (1) ES2663496T3 (pt)
IL (2) IL191184A (pt)
NO (3) NO341981B1 (pt)
NZ (1) NZ568179A (pt)
PL (1) PL1978015T3 (pt)
PT (1) PT1978015T (pt)
RU (1) RU2428415C2 (pt)
TW (1) TW200800869A (pt)
WO (1) WO2007063824A1 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8758773B2 (en) 2005-12-09 2014-06-24 Wisconsin Alumni Research Foundation Vaccine candidates against Johne's disease
CA2672914C (en) * 2006-12-27 2014-02-04 Nihon Medi-Physics Co., Ltd. Process for production of precursor compound for radioactive halogen-labeled organic compound
US20130217908A1 (en) 2010-10-28 2013-08-22 Ge Healthcare Limited Stabilisation of radiopharmaceutical precursors
US9278916B2 (en) * 2010-11-29 2016-03-08 Ge Healthcare Limited Preparation of pet precursor
US9061977B2 (en) 2010-12-20 2015-06-23 Ge Healthcare Limited Purification of precursor compound by crystallisation
GB201021523D0 (en) * 2010-12-20 2011-02-02 Ge Healthcare Ltd Process simplification for precursor compound
GB201021530D0 (en) * 2010-12-20 2011-02-02 Ge Healthcare Ltd Purification of precursor compound by crystallisation
EP2683684B1 (en) * 2011-03-08 2018-01-03 GE Healthcare Limited Preparation of a 1-amino-3-hydroxy-cyclobutane-1-carboxylic acid derivative
DK2758368T3 (da) 2011-06-14 2015-08-31 Ge Healthcare Uk Ltd Fremstilling af pet-prækursor
JP6118318B2 (ja) 2011-07-21 2017-04-19 ジーイー・ヘルスケア・リミテッド 前駆体化合物及びその製造方法
GB201411569D0 (en) 2014-06-30 2014-08-13 Ge Healthcare Ltd Novel formulation and method of synthesis
US11534494B2 (en) 2011-12-21 2022-12-27 Ge Healthcare Limited Formulation and method of synthesis
GB2509476B (en) * 2011-12-21 2018-08-08 Ge Healthcare Ltd Ip 18F - Fluciclovine compositions in citrate buffers
EP3302581B1 (en) * 2015-06-04 2021-04-28 Nihon Medi-Physics Co., Ltd. Diagnostic imaging agent for early bone metastasis from cancer
AU2017218125B2 (en) * 2016-02-12 2019-10-10 Graphic Packaging International, Llc Carton with handle
WO2018164043A1 (ja) * 2017-03-07 2018-09-13 日本メジフィジックス株式会社 放射性フッ素標識前駆体化合物及びそれを用いた放射性フッ素標識化合物の製造方法

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US5360928A (en) * 1989-10-23 1994-11-01 Research Corporation Technologies, Inc. Synthesis and use of amino acid fluorides as peptide coupling reagents
NZ262562A (en) 1993-02-23 1996-04-26 Warner Lambert Co Preparation of solvent free pharmaceutical compositions
US5808146A (en) 1995-11-09 1998-09-15 Emory University Amino acid analogs for tumor imaging
HUP0102154A3 (en) * 1998-05-15 2009-01-28 Ge Healthcare Ltd Labelled glutamine and lysine analogues
KR100852362B1 (ko) 2000-08-08 2008-08-14 오르토-맥네일 파마슈티칼, 인코퍼레이티드 비-이미다졸 아릴옥시피페리딘
WO2002030943A1 (fr) 2000-10-12 2002-04-18 Chugai Seiyaku Kabushiki Kaisha Derive d'erythromycine possedant des nouvelles structures cristallines et procedes associes de production
GB0115927D0 (en) * 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase nucleophilic fluorination
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GB0229695D0 (en) 2002-12-20 2003-01-29 Amersham Plc Solid-phase preparation of 18F-labelled amino acids
EP1660137A4 (en) 2003-07-31 2008-11-12 Univ St Louis SIGMA 2 RECEPTOR RADIOTRACER FOR IMAGING THE PROLIFERATION STATUS OF SOLID TUMORS
JP4979945B2 (ja) * 2003-09-30 2012-07-18 日本メジフィジックス株式会社 放射性フッ素化合物の製造方法
EP1768951A4 (en) * 2004-06-17 2011-06-15 Musc Found For Res Dev NON-NATURAL AMINO ACIDS
WO2006126410A1 (ja) * 2005-05-23 2006-11-30 Nihon Medi-Physics Co., Ltd. 新規有機化合物及び該化合物を利用した放射性ハロゲン標識有機化合物の製造方法
AU2006262425C1 (en) 2005-06-23 2012-06-21 Emory University Stereoselective synthesis of amino acid analogs for tumor imaging
JP2009505947A (ja) * 2005-06-23 2009-02-12 エモリー・ユニバーシティ 画像化剤
AU2007251015B2 (en) 2006-05-11 2011-09-01 Nihon Medi-Physics Co., Ltd. Process for production of radioactive fluorine-labeled organic compound
AU2007335633A1 (en) 2006-12-21 2008-06-26 Nihon Medi-Physics Co., Ltd. Radioactive diagnostic imaging agent
CA2672914C (en) 2006-12-27 2014-02-04 Nihon Medi-Physics Co., Ltd. Process for production of precursor compound for radioactive halogen-labeled organic compound
EP2119458B9 (en) 2007-02-13 2013-08-21 Nihon Medi-Physics Co., Ltd. Method for production of radiation diagnostic imaging agent
RU2476423C2 (ru) 2007-12-19 2013-02-27 Нихон Меди-Физикс Ко., Лтд. Способ получения радиоактивного, меченного фтором органического соединения

Also Published As

Publication number Publication date
US20200282082A1 (en) 2020-09-10
ES2663496T3 (es) 2018-04-13
CA2629227C (en) 2014-02-25
US20180256760A1 (en) 2018-09-13
WO2007063824A1 (ja) 2007-06-07
EP1978015B1 (en) 2018-03-07
TW200800869A (en) 2008-01-01
KR20130101158A (ko) 2013-09-12
RU2428415C2 (ru) 2011-09-10
PL1978015T3 (pl) 2018-07-31
US8758724B2 (en) 2014-06-24
JP5684333B2 (ja) 2015-03-11
KR101643991B1 (ko) 2016-07-29
KR20140108350A (ko) 2014-09-05
KR20080071146A (ko) 2008-08-01
US10010632B2 (en) 2018-07-03
EP3354639A1 (en) 2018-08-01
US10953112B2 (en) 2021-03-23
NZ568179A (en) 2010-06-25
JP5635225B2 (ja) 2014-12-03
US9387266B2 (en) 2016-07-12
BRPI0619213A2 (pt) 2011-09-20
TWI371439B (pt) 2012-09-01
JPWO2007063824A1 (ja) 2009-05-07
JP2013177468A (ja) 2013-09-09
NO20180010A1 (no) 2008-08-25
US20140213817A1 (en) 2014-07-31
NO2018027I2 (no) 2018-08-27
PT1978015T (pt) 2018-03-26
KR101608755B1 (ko) 2016-04-04
US20080281121A1 (en) 2008-11-13
EP1978015A1 (en) 2008-10-08
AU2006319987A1 (en) 2007-06-07
IL235029A (en) 2016-02-29
CA2629227A1 (en) 2007-06-07
US9381259B2 (en) 2016-07-05
RU2008126277A (ru) 2010-01-10
BRPI0619213B1 (pt) 2018-12-26
US20210386873A1 (en) 2021-12-16
AU2006319987B2 (en) 2012-09-06
NO2018027I1 (no) 2018-08-27
NO341981B1 (no) 2018-03-05
NO20082877L (no) 2008-08-25
EP3354639B1 (en) 2024-02-21
US11083804B2 (en) 2021-08-10
EP1978015A4 (en) 2010-08-11
US20160082135A1 (en) 2016-03-24
CN101316812A (zh) 2008-12-03
US20160000944A1 (en) 2016-01-07
IL191184A (en) 2015-07-30

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 26/12/2018, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/11/2006, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO