BRPI0703655A2 - compostos tetracìclicos, um processo para sua preparação e composições farmacêuticas contendo-os - Google Patents

compostos tetracìclicos, um processo para sua preparação e composições farmacêuticas contendo-os

Info

Publication number
BRPI0703655A2
BRPI0703655A2 BRPI0703655-8A BRPI0703655A BRPI0703655A2 BR PI0703655 A2 BRPI0703655 A2 BR PI0703655A2 BR PI0703655 A BRPI0703655 A BR PI0703655A BR PI0703655 A2 BRPI0703655 A2 BR PI0703655A2
Authority
BR
Brazil
Prior art keywords
pharmaceutical compositions
compositions containing
preparation
tetracyclic compounds
compounds
Prior art date
Application number
BRPI0703655-8A
Other languages
English (en)
Inventor
Jean-Louis Peglion
Christophe Poitevin
Mark Millan
Mauricette Brocco
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of BRPI0703655A2 publication Critical patent/BRPI0703655A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

COMPOSTOS TETRACìCLICOS, UM PROCESSO PARA SUA PREPARAçãO E COMPOSIçõES FARMACêUTICAS CONTENDO-OS. A presente invenção refere-se aos compostos de fórmula I, de configuração relativa trans: em que: X representa um átomo de oxigênio ou um grupo NR~ 2~, Y representa um grupo selecionado de -CH~ 2~-, -(CH~ 2~)~ 2~- e -CH=CH-, R~ 1~ e R~ 2~, os quais podem ser iguais ou diferentes, cada qual representa um átomo de hidrogênio ou um grupo selecionado de alquila, cicloalquila e cicloalquilalquila, em forma racêmica ou na forma de isómeros ópticos, e também sais de adição dos mesmos com um ácido farmaceuticamente aceitável, e hidratos dos mesmos, além disso, medicamentos contendo-os.
BRPI0703655-8A 2006-09-26 2007-09-26 compostos tetracìclicos, um processo para sua preparação e composições farmacêuticas contendo-os BRPI0703655A2 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0608413A FR2906249B1 (fr) 2006-09-26 2006-09-26 Composes tetracycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
BRPI0703655A2 true BRPI0703655A2 (pt) 2009-05-19

Family

ID=37877016

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0703655-8A BRPI0703655A2 (pt) 2006-09-26 2007-09-26 compostos tetracìclicos, um processo para sua preparação e composições farmacêuticas contendo-os

Country Status (31)

Country Link
US (1) US7470683B2 (pt)
EP (1) EP1905775B1 (pt)
JP (1) JP2008100995A (pt)
KR (1) KR100934315B1 (pt)
CN (1) CN101153043B (pt)
AR (1) AR062950A1 (pt)
AT (1) ATE480544T1 (pt)
AU (1) AU2007219281A1 (pt)
BR (1) BRPI0703655A2 (pt)
CA (1) CA2603274C (pt)
CY (1) CY1110799T1 (pt)
DE (1) DE602007009004D1 (pt)
DK (1) DK1905775T3 (pt)
EA (1) EA013406B1 (pt)
ES (1) ES2351945T3 (pt)
FR (1) FR2906249B1 (pt)
GE (1) GEP20104877B (pt)
HR (1) HRP20100605T1 (pt)
MA (1) MA29371B1 (pt)
MX (1) MX2007011524A (pt)
MY (1) MY142517A (pt)
NO (1) NO20074889L (pt)
NZ (1) NZ561905A (pt)
PL (1) PL1905775T3 (pt)
PT (1) PT1905775E (pt)
RS (1) RS51418B (pt)
SG (1) SG141382A1 (pt)
SI (1) SI1905775T1 (pt)
UA (1) UA96125C2 (pt)
WO (1) WO2008037888A2 (pt)
ZA (1) ZA200708215B (pt)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4420480A (en) * 1981-11-20 1983-12-13 Merck & Co., Inc. Hexahydronaphth[1,2-b]-1,4-oxazines
CA1204745A (en) * 1981-11-20 1986-05-20 Merck Co. Hexahydronaphth (1,2-b) -1,4 -oxazines
FR2721027B1 (fr) * 1994-06-08 1996-07-19 Adir Nouveaux dérivés tétracycliques de la 1,4-oxazine, leur procédé de préparation et les compositions pharmaceutiques les contenant.
FR2741074B1 (fr) 1995-11-09 1997-12-19 Adir Nouveaux composes tetracycliques de la 1,4-oxazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2767825A1 (fr) * 1997-09-01 1999-02-26 Adir Nouvelles trans-3,4,4a,5,6,10b-hexahydro-2h-napht°1,2-b!-1, 4-oxazines disubstituees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2845994B1 (fr) * 2002-10-18 2006-05-19 Servier Lab Nouveaux derives de benzo[e][1,4]oxazino[3,2-g]isoindole substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
AR062950A1 (es) 2008-12-17
ZA200708215B (en) 2008-09-25
US20080076765A1 (en) 2008-03-27
MX2007011524A (es) 2009-02-16
CA2603274C (fr) 2010-08-31
MY142517A (en) 2010-12-15
WO2008037888A3 (fr) 2008-06-12
CA2603274A1 (fr) 2008-03-26
FR2906249B1 (fr) 2008-12-19
GEP20104877B (en) 2010-01-11
NO20074889L (no) 2008-03-27
NZ561905A (en) 2009-01-31
US7470683B2 (en) 2008-12-30
PL1905775T3 (pl) 2011-03-31
ATE480544T1 (de) 2010-09-15
EP1905775B1 (fr) 2010-09-08
EA200701807A1 (ru) 2008-04-28
KR100934315B1 (ko) 2009-12-29
CN101153043A (zh) 2008-04-02
EP1905775A1 (fr) 2008-04-02
HRP20100605T1 (hr) 2010-12-31
RS51418B (sr) 2011-02-28
JP2008100995A (ja) 2008-05-01
SG141382A1 (en) 2008-04-28
SI1905775T1 (sl) 2010-10-29
DK1905775T3 (da) 2010-12-06
PT1905775E (pt) 2010-11-17
HK1119163A1 (en) 2009-02-27
WO2008037888A2 (fr) 2008-04-03
FR2906249A1 (fr) 2008-03-28
ES2351945T3 (es) 2011-02-14
DE602007009004D1 (de) 2010-10-21
CN101153043B (zh) 2011-01-19
CY1110799T1 (el) 2015-06-10
UA96125C2 (ru) 2011-10-10
AU2007219281A1 (en) 2008-04-10
KR20080028316A (ko) 2008-03-31
MA29371B1 (fr) 2008-04-01
EA013406B1 (ru) 2010-04-30

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Legal Events

Date Code Title Description
B03A Publication of a patent application or of a certificate of addition of invention [chapter 3.1 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 6A. ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2228 DE 17/09/2013.