BRPI0707044B8 - comprimido matricial insolúvel em água e processo de fabricação de comprimidos matriciais - Google Patents

comprimido matricial insolúvel em água e processo de fabricação de comprimidos matriciais

Info

Publication number
BRPI0707044B8
BRPI0707044B8 BRPI0707044A BRPI0707044A BRPI0707044B8 BR PI0707044 B8 BRPI0707044 B8 BR PI0707044B8 BR PI0707044 A BRPI0707044 A BR PI0707044A BR PI0707044 A BRPI0707044 A BR PI0707044A BR PI0707044 B8 BRPI0707044 B8 BR PI0707044B8
Authority
BR
Brazil
Prior art keywords
water
insoluble
matrix tablet
manufacturing process
matrix
Prior art date
Application number
BRPI0707044A
Other languages
English (en)
Inventor
Herry Catherine
Bacon Jonathan
Oury Pascal
Cailly - Dufestel Vincent
Original Assignee
Ethypharm Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37460138&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0707044(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ethypharm Sa filed Critical Ethypharm Sa
Publication of BRPI0707044A2 publication Critical patent/BRPI0707044A2/pt
Publication of BRPI0707044B1 publication Critical patent/BRPI0707044B1/pt
Publication of BRPI0707044B8 publication Critical patent/BRPI0707044B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Inorganic Chemistry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

comprimido matricial insolúvel em água, processo de fabricação dos comprimidos matriciais e uso de uma composição farmacêutica na forma de comprimidos. comprimidos matriciais insolúveis em água capazes de liberar de modo prolongado ao longo do tempo princípios ativos suscetíveis de serem usados para fins de toxicomania, princípios ativos esses que estão dispersados em uma matriz de compressão constituída de pelo menos um excipiente escolhido no grupo que compreende os polímeros com liberação prolongada independentes de ph e insolúveis na água, os excipientes minerais e suas misturas e que apresentam uma resistência ao esmagamento de pelo menos 4 mpa.
BRPI0707044A 2006-03-01 2007-03-01 comprimido matricial insolúvel em água e processo de fabricação de comprimidos matriciais BRPI0707044B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0601842 2006-03-01
FR0601842A FR2898056B1 (fr) 2006-03-01 2006-03-01 Comprimes resistant a l'ecrasement destines a eviter le detournement illicite
PCT/EP2007/051967 WO2007099152A1 (fr) 2006-03-01 2007-03-01 Comprimés résistant à l'écrasement destinés à éviter le mésusage involontaire et le détournement illicite

Publications (3)

Publication Number Publication Date
BRPI0707044A2 BRPI0707044A2 (pt) 2011-04-12
BRPI0707044B1 BRPI0707044B1 (pt) 2021-03-02
BRPI0707044B8 true BRPI0707044B8 (pt) 2021-05-25

Family

ID=37460138

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0707044A BRPI0707044B8 (pt) 2006-03-01 2007-03-01 comprimido matricial insolúvel em água e processo de fabricação de comprimidos matriciais
BRPI0707043A BRPI0707043C8 (pt) 2006-03-01 2007-03-01 comprimidos matriciais insolúveis em água a base de oxicodona, seu processo de fabricação e uso de uma composição farmacêutica

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI0707043A BRPI0707043C8 (pt) 2006-03-01 2007-03-01 comprimidos matriciais insolúveis em água a base de oxicodona, seu processo de fabricação e uso de uma composição farmacêutica

Country Status (17)

Country Link
US (3) US20100015223A1 (pt)
EP (4) EP2010157B2 (pt)
JP (3) JP2009528329A (pt)
KR (2) KR101445884B1 (pt)
CN (3) CN102266302B (pt)
AU (2) AU2007220454B2 (pt)
BR (2) BRPI0707044B8 (pt)
CA (2) CA2643330C (pt)
EA (3) EA020550B1 (pt)
ES (3) ES2609469T3 (pt)
FR (1) FR2898056B1 (pt)
IL (2) IL193732A (pt)
MX (2) MX2008011241A (pt)
NZ (3) NZ571519A (pt)
SG (1) SG175666A1 (pt)
WO (2) WO2007099154A1 (pt)
ZA (2) ZA200807571B (pt)

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NZ571518A (en) 2011-11-25
BRPI0707043B1 (pt) 2021-01-26
EP3115042A1 (fr) 2017-01-11
CN101394839A (zh) 2009-03-25
EA200870268A1 (ru) 2009-02-27
KR101445884B1 (ko) 2014-10-02
EA020550B1 (ru) 2014-12-30
EP2010157A1 (fr) 2009-01-07
CN102266302B (zh) 2014-07-09
KR20080110601A (ko) 2008-12-18
ES2609695T5 (es) 2020-05-14
ZA200807571B (en) 2009-08-26
WO2007099152A1 (fr) 2007-09-07
CA2643330A1 (fr) 2007-09-07
ZA200807572B (en) 2009-08-26
EA201170334A1 (ru) 2011-08-30
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EP2010157B2 (fr) 2019-09-18
ES2609469T3 (es) 2017-04-20
HK1165263A1 (en) 2012-10-05
ES2609695T3 (es) 2017-04-21
EA014652B1 (ru) 2010-12-30
AU2007220456B2 (en) 2012-06-14
US20100015223A1 (en) 2010-01-21
WO2007099154A1 (fr) 2007-09-07
CN102266302A (zh) 2011-12-07
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JP2009528328A (ja) 2009-08-06
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BRPI0707043A2 (pt) 2011-04-12
FR2898056B1 (fr) 2012-01-20
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BRPI0707043C8 (pt) 2021-05-25
EP3115041B1 (fr) 2023-10-25
BRPI0707043C1 (pt) 2021-05-11
IL193733A (en) 2014-11-30
FR2898056A1 (fr) 2007-09-07
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BRPI0707044A2 (pt) 2011-04-12
CN101394840A (zh) 2009-03-25
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IL193733A0 (en) 2009-05-04
MX2008011240A (es) 2009-01-27
US8501160B2 (en) 2013-08-06
EA015182B1 (ru) 2011-06-30
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