BRPI0717441B8 - composto, medicamento, e, uso do derivado de metastina - Google Patents

composto, medicamento, e, uso do derivado de metastina

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Publication number
BRPI0717441B8
BRPI0717441B8 BRPI0717441A BRPI0717441A BRPI0717441B8 BR PI0717441 B8 BRPI0717441 B8 BR PI0717441B8 BR PI0717441 A BRPI0717441 A BR PI0717441A BR PI0717441 A BRPI0717441 A BR PI0717441A BR PI0717441 B8 BRPI0717441 B8 BR PI0717441B8
Authority
BR
Brazil
Prior art keywords
suppressing activity
metastin
activity
hormone secretion
present
Prior art date
Application number
BRPI0717441A
Other languages
English (en)
Inventor
Nishizawa Naoki
Asami Taiji
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of BRPI0717441A2 publication Critical patent/BRPI0717441A2/pt
Publication of BRPI0717441B1 publication Critical patent/BRPI0717441B1/pt
Publication of BRPI0717441B8 publication Critical patent/BRPI0717441B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C07K14/4703—Inhibitors; Suppressors
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    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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Abstract

composto, medicamento, e, uso do derivado de metastina. a presente invenção fornece derivados de metastina estáveis tendo atividades biológicas excelentes (uma atividade de suprimir a metástase do câncer, uma atividade de suprimir o crescimento de câncer, uma atividade estimuladora da secreção do hormônio gonadotrópico, atividade estimuladora da secreção do hormônio sexual, etc). pela substituição dos aminoácidos constituintes de metastina com aminoácidos específicos, os derivados de metastina da presente invenção alcançam estabilidade, solubilidade, etc. no sangue mais melhoradas tendência reduzida para a formação de gel, farmacocinéticas melhoradas, assim como exibem uma excelente atividade de suprimir a metástase do câncer ou uma atividade de suprimir o crescimento de câncer. os derivados de metastina da presente invenção também têm uma atividade de suprimir a secreção do hormônio gonadotrópico, atividade de suprimir a secreção do hormônio sexual, etc.
BRPI0717441A 2006-10-25 2007-10-24 composto, medicamento, e, uso do derivado de metastina BRPI0717441B8 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP2006-290536 2006-10-25
JP2006290536 2006-10-25
JP2007-021387 2007-01-31
JP2007021387 2007-01-31
JP2007221911 2007-08-28
JP2007-221911 2007-08-28
PCT/JP2007/071169 WO2008050897A1 (en) 2006-10-25 2007-10-24 Metastin derivatives and use thereof

Publications (3)

Publication Number Publication Date
BRPI0717441A2 BRPI0717441A2 (pt) 2013-11-19
BRPI0717441B1 BRPI0717441B1 (pt) 2019-07-02
BRPI0717441B8 true BRPI0717441B8 (pt) 2021-05-25

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ID=38925530

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0717441A BRPI0717441B8 (pt) 2006-10-25 2007-10-24 composto, medicamento, e, uso do derivado de metastina

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US (2) US7786083B2 (pt)
EP (1) EP2081955B1 (pt)
JP (2) JP2010507565A (pt)
KR (1) KR101424306B1 (pt)
AR (1) AR063367A1 (pt)
AU (1) AU2007309969B2 (pt)
BR (1) BRPI0717441B8 (pt)
CA (1) CA2667537C (pt)
CL (1) CL2007003053A1 (pt)
CR (1) CR10799A (pt)
CY (1) CY1116627T1 (pt)
DK (1) DK2081955T3 (pt)
EC (1) ECSP099279A (pt)
ES (1) ES2539430T3 (pt)
GE (1) GEP20125568B (pt)
HR (1) HRP20150819T1 (pt)
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IL (1) IL198046A (pt)
JO (1) JO3048B1 (pt)
MA (1) MA30887B1 (pt)
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MX (1) MX2009004148A (pt)
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NO (1) NO341584B1 (pt)
NZ (1) NZ576375A (pt)
PE (1) PE20081469A1 (pt)
PL (1) PL2081955T3 (pt)
PT (1) PT2081955E (pt)
RS (1) RS54083B1 (pt)
SI (1) SI2081955T1 (pt)
TN (1) TN2009000140A1 (pt)
TW (1) TWI404726B (pt)
WO (1) WO2008050897A1 (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004063221A1 (ja) 2002-12-26 2004-07-29 Takeda Pharmaceutical Company Limited メタスチン誘導体およびその用途
WO2006001499A2 (en) * 2004-06-25 2006-01-05 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
AR058584A1 (es) 2005-12-22 2008-02-13 Takeda Pharmaceutical Derivados de metastina y uso de los mismos
US8404643B2 (en) 2005-12-22 2013-03-26 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
US20090099334A1 (en) * 2005-12-22 2009-04-16 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
US20090093615A1 (en) * 2005-12-22 2009-04-09 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
JP5279021B2 (ja) * 2006-04-26 2013-09-04 国立大学法人京都大学 Ｇｐｒ５４アゴニスト活性を有する新規化合物
JO3048B1 (ar) 2006-10-25 2016-09-05 Takeda Pharmaceuticals Co مشتقات متاستين واستخدامها
US8110639B2 (en) * 2006-11-17 2012-02-07 Solvay Advanced Polymers, L.L.C. Transparent and flame retardant polysulfone compositions
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