BRPI0807749B8 - composto, composição farmacêutica, e, método para a prevenção, tratamento ou melhora de doenças ou condições dérmicas, ou distúrbios de ferida cutânea agudos ou crônicos - Google Patents

composto, composição farmacêutica, e, método para a prevenção, tratamento ou melhora de doenças ou condições dérmicas, ou distúrbios de ferida cutânea agudos ou crônicos

Info

Publication number
BRPI0807749B8
BRPI0807749B8 BRPI0807749A BRPI0807749A BRPI0807749B8 BR PI0807749 B8 BRPI0807749 B8 BR PI0807749B8 BR PI0807749 A BRPI0807749 A BR PI0807749A BR PI0807749 A BRPI0807749 A BR PI0807749A BR PI0807749 B8 BRPI0807749 B8 BR PI0807749B8
Authority
BR
Brazil
Prior art keywords
prevention
treatment
compound
acute
conditions
Prior art date
Application number
BRPI0807749A
Other languages
English (en)
Inventor
Feldbæk Nielsen Simon
Felding Jakob
Christian Højland Larsen Jens
Ravindra Babu Bollu
Original Assignee
Leo Pharma As
Union Therapeutics As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharma As, Union Therapeutics As filed Critical Leo Pharma As
Publication of BRPI0807749A2 publication Critical patent/BRPI0807749A2/pt
Publication of BRPI0807749B1 publication Critical patent/BRPI0807749B1/pt
Publication of BRPI0807749B8 publication Critical patent/BRPI0807749B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

COMPOSTO,COMPOSIÇÃO FARMACÊUTICA, E MÉTODO PARA A PREVENÇÃO, TRATAMENTO OU MELHORA, E, MÉTODO PARA A PREVENÇÃO, TRATAMENTO OU MELHORA DE DOENÇAS OU CONDIÇÕES DÉRMICAS, OU DISTÚRBIOS DE FERIDA CUTÂNEA AGUDOS OU CRÔNICAS. A presente invenção refere-se a um composto de acordo com a formula I, em que X, A, G, E, R2, R3 são como aqui mostrados; e sais farmaceuticamente aceitáveis dos mesmos, hidratos, N-óxidos e solvatos dos mesmos. A invenção refere-se ainda aos referidos compostos para o uso em terapia, a composições farmacêuticas que compreendem os referidos compostos, e a métodos para o tratamento de doenças, por exemplo, doenças dérmicas, com os referidos compostos, e ao uso dos referidos compostos na manufatura de medicamentos. .
BRPI0807749A 2007-02-28 2008-02-26 composto, composição farmacêutica, e, método para a prevenção, tratamento ou melhora de doenças ou condições dérmicas, ou distúrbios de ferida cutânea agudos ou crônicos BRPI0807749B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US90384907P 2007-02-28 2007-02-28
US60/903849 2007-02-28
US94684907P 2007-06-28 2007-06-28
US60/946849 2007-06-28
PCT/DK2008/000080 WO2008104175A2 (en) 2007-02-28 2008-02-26 Novel phosphodiesterase inhibitors

Publications (3)

Publication Number Publication Date
BRPI0807749A2 BRPI0807749A2 (pt) 2014-06-17
BRPI0807749B1 BRPI0807749B1 (pt) 2021-01-05
BRPI0807749B8 true BRPI0807749B8 (pt) 2022-09-06

Family

ID=39415336

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0807749A BRPI0807749B8 (pt) 2007-02-28 2008-02-26 composto, composição farmacêutica, e, método para a prevenção, tratamento ou melhora de doenças ou condições dérmicas, ou distúrbios de ferida cutânea agudos ou crônicos

Country Status (21)

Country Link
US (1) US8338431B2 (pt)
EP (1) EP2114951B9 (pt)
JP (1) JP5501770B2 (pt)
KR (1) KR101571654B1 (pt)
AU (1) AU2008221121B2 (pt)
BR (1) BRPI0807749B8 (pt)
CA (1) CA2676933C (pt)
CY (1) CY1115227T1 (pt)
DK (1) DK2114951T3 (pt)
ES (1) ES2478670T3 (pt)
HR (1) HRP20140585T1 (pt)
IL (1) IL200153A (pt)
MX (1) MX2009009238A (pt)
MY (1) MY150075A (pt)
NZ (1) NZ578804A (pt)
PL (1) PL2114951T3 (pt)
PT (1) PT2114951E (pt)
RS (1) RS53407B (pt)
RU (1) RU2495043C2 (pt)
SI (1) SI2114951T1 (pt)
WO (1) WO2008104175A2 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120322776A1 (en) 2009-12-22 2012-12-20 Leo Pharma A/S Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants
RU2555339C2 (ru) 2009-12-22 2015-07-10 Лео Фарма А/С Нанокристаллы кальципотриола моногидрита
JP5732471B2 (ja) 2009-12-22 2015-06-10 レオ ファーマ アクティーゼルスカブ 溶媒混合物およびビタミンｄ誘導体から成る医薬品組成物または類似体
KR101864578B1 (ko) * 2010-06-24 2018-06-07 레오 파마 에이/에스 포스포디에스테라제 억제제로서의 벤조디옥솔 또는 벤조디옥세핀 헤테로사이클릭 화합물
WO2013122855A1 (en) * 2012-02-14 2013-08-22 University Of Rochester Methods of increasing lymphatic transport
CN104334542A (zh) * 2012-06-04 2015-02-04 奇斯药制品公司 作为磷酸二酯酶抑制剂的1-苯基-2-吡啶基烷基醇的衍生物
WO2014083099A1 (en) * 2012-11-30 2014-06-05 Leo Pharma A/S A method of inhibiting the expression of il-22 in activated t-cells
AU2015279428B2 (en) * 2014-06-23 2018-02-15 Leo Pharma A/S Methods for the preparation of 1,3-benzodioxole heterocyclic compounds
ES2762987T3 (es) 2015-06-19 2020-05-26 Bristol Myers Squibb Co Macrociclos de diamida como inhibidores del factor XIA
TWI732808B (zh) 2015-12-18 2021-07-11 丹麥商理奧藥品公司 1,3－苯并二氧雜環戊烯雜環化合物之製備方法
JP6850886B2 (ja) * 2016-12-12 2021-03-31 レオ ファーマ アクティーゼルスカブ 置換ピラゾロアゼピン−４−オンおよびそれらのホスホジエステラーゼ阻害剤としての使用
ES2874632T3 (es) * 2016-12-12 2021-11-05 Union Therapeutics As Pirazoloazepin-8-onas sustituidas y su uso como inhibidores de la fosfodiesterasa
EP3551632B1 (en) * 2016-12-12 2024-06-12 UNION therapeutics A/S Substituted pyrazoloazepin-4-ones and their use as phosphodiesterase inhibitors
WO2018234299A1 (en) * 2017-06-20 2018-12-27 Leo Pharma A/S Methods for the preparation of 1,3-benzodioxole heterocyclic compounds
TW201919682A (zh) 2017-08-08 2019-06-01 西班牙商阿爾米雷爾有限公司 活化Ｎｒｆ２路徑的新穎化合物
ES2935615T3 (es) 2017-12-15 2023-03-08 Union Therapeutics As Azetidina dihidrotienopiridinas sustituidas y su uso como inhibidores de la fosfodiesterasa
GB202306662D0 (en) 2023-05-05 2023-06-21 Union Therapeutics As Dosage regimen

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9507297D0 (en) 1995-04-07 1995-05-31 Rh Ne Poulenc Rorer Limited New composition of matter
US6514996B2 (en) * 1995-05-19 2003-02-04 Kyowa Hakko Kogyo Co., Ltd. Derivatives of benzofuran or benzodioxole
DK0771794T3 (da) * 1995-05-19 2006-09-11 Kyowa Hakko Kogyo Kk Oxygenholdige heterocykliske forbindelser
ATE239004T1 (de) * 1996-05-20 2003-05-15 Darwin Discovery Ltd Benzofuran carboxamide und ihre therapeutische anwendung
RU2203274C2 (ru) * 1996-08-28 2003-04-27 Дзе Проктер Энд Гэмбл Компани Спироциклические ингибиторы металлопротеаз
EP0943613A4 (en) * 1996-11-19 2002-07-10 Kyowa Hakko Kogyo Kk Oxygenic heterocyclic compounds
DE69813605T2 (de) * 1997-10-01 2004-02-12 Kyowa Hakko Kogyo Co., Ltd. Benzofuranderivate

Also Published As

Publication number Publication date
MX2009009238A (es) 2009-09-08
EP2114951B9 (en) 2015-09-02
SI2114951T1 (sl) 2014-08-29
KR101571654B1 (ko) 2015-11-25
DK2114951T3 (da) 2014-06-23
PT2114951E (pt) 2014-07-17
EP2114951A2 (en) 2009-11-11
JP5501770B2 (ja) 2014-05-28
HRP20140585T1 (hr) 2014-09-12
BRPI0807749A2 (pt) 2014-06-17
KR20090126252A (ko) 2009-12-08
WO2008104175A2 (en) 2008-09-04
AU2008221121A1 (en) 2008-09-04
US8338431B2 (en) 2012-12-25
CY1115227T1 (el) 2017-01-04
EP2114951B1 (en) 2014-04-09
AU2008221121B2 (en) 2013-10-03
MY150075A (en) 2013-11-29
IL200153A (en) 2016-11-30
IL200153A0 (en) 2010-04-15
NZ578804A (en) 2012-04-27
RU2009135810A (ru) 2011-04-10
RU2495043C2 (ru) 2013-10-10
PL2114951T3 (pl) 2014-10-31
RS53407B (sr) 2014-10-31
JP2010519332A (ja) 2010-06-03
HK1138262A1 (en) 2010-08-20
CA2676933A1 (en) 2008-09-04
ES2478670T3 (es) 2014-07-22
US20100099688A1 (en) 2010-04-22
WO2008104175A3 (en) 2009-01-29
CA2676933C (en) 2015-09-29
BRPI0807749B1 (pt) 2021-01-05

Similar Documents

Publication Publication Date Title
BRPI0807749B8 (pt) composto, composição farmacêutica, e, método para a prevenção, tratamento ou melhora de doenças ou condições dérmicas, ou distúrbios de ferida cutânea agudos ou crônicos
BR112015028879A8 (pt) compostos derivados heterocíclicos, composição farmacêutica compreendendo os referidos compostos e usos dos mesmos
BRPI0714803B8 (pt) compostos peptidomiméticos de smac, seus usos, e composição farmacêutica
BR112013020620A2 (pt) análogos de ácido 4-hidroxibutírico
BRPI0514841A (pt) inibidores de piridila da sinalização de hedgehog, processo de preparação dos mesmos e composição compreendendo os referidos inibidores
BRPI0518846A2 (pt) composto, composiÇço farmacÊutica, mÉtodos de tratar, ou reduzir o risco de doenÇas ou condiÇÕes em que inibiÇço da enzima mpo É benÉfica e de tratar, ou reduzir o risco de distérbios neuroinflamatàrios, uso de um composto, e, processo para a preparaÇço de um composto
BR112014015845A2 (pt) derivados de azetidina, composições farmacêuticas e seu uso
BRPI0717367B8 (pt) di-hidropirazolonas substituídas, seus usos e seu processo de preparação, e medicamento
BR112014007721A2 (pt) processos para preparar compostos úteis como inibidores de atr quinase
BR112013027241A2 (pt) "composto inibidor de rock, composição que o compreende e seus usos"
BR112012010705A2 (pt) composto, composição farmacêutica, produto farmacêutico combinado, uso de um composto, e, métodos para tratar uma doença ou condição, e para inibir um bromodomínio
BRPI0720270B8 (pt) compostos 4-fenil-6-(2,2,2-triflúor-1-fenil etoxi) pirimidina, composição e forma de dosagem sólida
BR112015014458A8 (pt) compostos derivados de manose, seus intermediários, composição, uso e processos de preparação
BR112015012366A2 (pt) antagonistas de cxcr7
BRPI0610850A2 (pt) derivados de Ácido aril alquila, composiÇço farmacÊutica, medicamento, bem como uso dos referidos derivados
BR112013029240A2 (pt) derivados deuterados do ivacaftor
BR112014013661A8 (pt) derivados de nucleosídeos 2’,4’-difluoro-2’-metil substituídos como inibidores de replicação de hcv-rna
BR112012009376A2 (pt) composição farmacêutica, forma de dosagem farmacêutica, processo para a sua preparação, métodos de tratamento e seu uso
BR112014000371A2 (pt) derivados de trifluormetil-oxadiazol e uso dos mesmos no tratamento de doença
BR112012013854A2 (pt) derivados de oxazina.
BR112018067930A2 (pt) composto, sal de ácido trifluoroacético, composição farmacêutica, método para tratamento de uma infecção bacteriana, e, uso de um composto.
BR112012008889A2 (pt) compostos de espiropiperidina e uso farmacêutico dos mesmos para tratar diabetes
BR112012020704A2 (pt) compostos de pirrolopirimidina deuterados como inibidores de cdk4/6
UY33246A (es) Tienopirimidinas que contienen cicloalquilo para composiciones farmacéuticas
BR112013001632A2 (pt) composto, composição farmacêutica, método de inibir uma atividade uma jak quinase in vitro, uso de um composto, ou da composição farmacêutica, e, método de fabricar um composto

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 05/01/2021, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 26/02/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B25A Requested transfer of rights approved

Owner name: UNION THERAPEUTICS A/S (DK)

B25L Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: publication cancelled

Owner name: LEO PHARMA A/S (DK)

Free format text: ANULADA A PUBLICACAO CODIGO 25.1 NA RPI NO 2671 DE 15/03/2022 POR TER SIDO INDEVIDA.

B25A Requested transfer of rights approved

Owner name: UNION THERAPEUTICS A/S (DK)

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 18A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2868 DE 23-12-2025 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.