DK2114951T3 - Hidtil ukendte phosphodiesterase-inhibitorer - Google Patents
Hidtil ukendte phosphodiesterase-inhibitorerInfo
- Publication number
- DK2114951T3 DK2114951T3 DK08706922.5T DK08706922T DK2114951T3 DK 2114951 T3 DK2114951 T3 DK 2114951T3 DK 08706922 T DK08706922 T DK 08706922T DK 2114951 T3 DK2114951 T3 DK 2114951T3
- Authority
- DK
- Denmark
- Prior art keywords
- unknown
- phosphodiesterase inhibitors
- phosphodiesterase
- inhibitors
- unknown phosphodiesterase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90384907P | 2007-02-28 | 2007-02-28 | |
| US94684907P | 2007-06-28 | 2007-06-28 | |
| PCT/DK2008/000080 WO2008104175A2 (en) | 2007-02-28 | 2008-02-26 | Novel phosphodiesterase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2114951T3 true DK2114951T3 (da) | 2014-06-23 |
Family
ID=39415336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08706922.5T DK2114951T3 (da) | 2007-02-28 | 2008-02-26 | Hidtil ukendte phosphodiesterase-inhibitorer |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8338431B2 (da) |
| EP (1) | EP2114951B9 (da) |
| JP (1) | JP5501770B2 (da) |
| KR (1) | KR101571654B1 (da) |
| AU (1) | AU2008221121B2 (da) |
| BR (1) | BRPI0807749B8 (da) |
| CA (1) | CA2676933C (da) |
| CY (1) | CY1115227T1 (da) |
| DK (1) | DK2114951T3 (da) |
| ES (1) | ES2478670T3 (da) |
| HR (1) | HRP20140585T1 (da) |
| IL (1) | IL200153A (da) |
| MX (1) | MX2009009238A (da) |
| MY (1) | MY150075A (da) |
| NZ (1) | NZ578804A (da) |
| PL (1) | PL2114951T3 (da) |
| PT (1) | PT2114951E (da) |
| RS (1) | RS53407B (da) |
| RU (1) | RU2495043C2 (da) |
| SI (1) | SI2114951T1 (da) |
| WO (1) | WO2008104175A2 (da) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112012015449B1 (pt) | 2009-12-22 | 2021-09-28 | Leo Pharma A/S | Suspensão de monoidrato de calcipotriol, e, processo para preparar nanocristais de monoidrato de calcipotriol |
| US20120322776A1 (en) | 2009-12-22 | 2012-12-20 | Leo Pharma A/S | Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants |
| CN102770121B (zh) | 2009-12-22 | 2014-10-15 | 利奥制药有限公司 | 包含溶剂混合物和维生素d衍生物或类似物的药物组合物 |
| NZ603895A (en) | 2010-06-24 | 2014-10-31 | Leo Pharma As | Novel phosphodiesterase inhibitors |
| WO2013122855A1 (en) * | 2012-02-14 | 2013-08-22 | University Of Rochester | Methods of increasing lymphatic transport |
| CA2875421A1 (en) * | 2012-06-04 | 2013-12-12 | Chiesi Farmaceutici S.P.A. | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors |
| US9855285B2 (en) | 2012-11-30 | 2018-01-02 | Leo Pharma A/S | Method of inhibiting the expression of IL-22 in activated T-cells |
| RU2697251C2 (ru) * | 2014-06-23 | 2019-08-13 | Лео Фарма А/С | Способы получения 1, 3-бензодиоксольных гетероциклических соединений |
| JP6742348B2 (ja) | 2015-06-19 | 2020-08-19 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 第ｘｉａ因子阻害剤としてのジアミド大員環 |
| CN114085234B (zh) | 2015-12-18 | 2024-12-17 | 联合疗法公司 | 用于制备1,3-苯并间二氧杂环戊烯杂环化合物的方法 |
| ES2875128T3 (es) * | 2016-12-12 | 2021-11-08 | Union Therapeutics As | Pirazoloazepin-8-onas sustituidas y su uso como inhibidores de la fosfodiesterasa |
| CN110167944B (zh) * | 2016-12-12 | 2024-08-23 | 联合疗法公司 | 取代的吡唑并氮杂䓬-4-酮类及其作为磷酸二酯酶抑制剂的用途 |
| EP3551634B1 (en) * | 2016-12-12 | 2021-03-31 | Leo Pharma A/S | Substituted pyrazoloazepin-8-ones and their use as phosphodiesterase inhibitors |
| KR102676384B1 (ko) * | 2017-06-20 | 2024-06-20 | 유니온 테라퓨틱스 에이/에스 | 1,3-벤조디옥솔 헤테로시클릭 화합물의 제조방법 |
| TW201919682A (zh) | 2017-08-08 | 2019-06-01 | 西班牙商阿爾米雷爾有限公司 | 活化Ｎｒｆ２路徑的新穎化合物 |
| DK3724196T3 (da) | 2017-12-15 | 2023-01-16 | Union Therapeutics As | Substituerede azetidindihydrothienopyridiner og anvendelse deraf som phosphodiesterasehæmmere |
| GB202306662D0 (en) | 2023-05-05 | 2023-06-21 | Union Therapeutics As | Dosage regimen |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9507297D0 (en) | 1995-04-07 | 1995-05-31 | Rh Ne Poulenc Rorer Limited | New composition of matter |
| US6514996B2 (en) | 1995-05-19 | 2003-02-04 | Kyowa Hakko Kogyo Co., Ltd. | Derivatives of benzofuran or benzodioxole |
| AU705690B2 (en) * | 1995-05-19 | 1999-05-27 | Kyowa Hakko Kogyo Co. Ltd. | Oxygen-containing heterocyclic compounds |
| TR199802386T2 (xx) * | 1996-05-20 | 1999-02-22 | Darwin Discovery Limited | Benzofuran karboksamidler ve bunlar�n terap�tik kullan�m�. |
| WO1998008850A1 (en) * | 1996-08-28 | 1998-03-05 | The Procter & Gamble Company | Spirocyclic metalloprotease inhibitors |
| WO1998022455A1 (en) | 1996-11-19 | 1998-05-28 | Kyowa Hakko Kogyo Co., Ltd. | Oxygenic heterocyclic compounds |
| JP4219554B2 (ja) * | 1997-10-01 | 2009-02-04 | 協和発酵キリン株式会社 | ベンゾフラン誘導体 |
-
2008
- 2008-02-26 KR KR1020097018073A patent/KR101571654B1/ko active Active
- 2008-02-26 RS RS20140365A patent/RS53407B/sr unknown
- 2008-02-26 RU RU2009135810/04A patent/RU2495043C2/ru active
- 2008-02-26 MY MYPI20093168A patent/MY150075A/en unknown
- 2008-02-26 ES ES08706922.5T patent/ES2478670T3/es active Active
- 2008-02-26 WO PCT/DK2008/000080 patent/WO2008104175A2/en not_active Ceased
- 2008-02-26 NZ NZ578804A patent/NZ578804A/en not_active IP Right Cessation
- 2008-02-26 HR HRP20140585AT patent/HRP20140585T1/hr unknown
- 2008-02-26 BR BRPI0807749A patent/BRPI0807749B8/pt not_active IP Right Cessation
- 2008-02-26 JP JP2009551915A patent/JP5501770B2/ja not_active Expired - Fee Related
- 2008-02-26 US US12/528,649 patent/US8338431B2/en active Active
- 2008-02-26 PT PT87069225T patent/PT2114951E/pt unknown
- 2008-02-26 SI SI200831224T patent/SI2114951T1/sl unknown
- 2008-02-26 DK DK08706922.5T patent/DK2114951T3/da active
- 2008-02-26 CA CA2676933A patent/CA2676933C/en active Active
- 2008-02-26 MX MX2009009238A patent/MX2009009238A/es active IP Right Grant
- 2008-02-26 PL PL08706922T patent/PL2114951T3/pl unknown
- 2008-02-26 AU AU2008221121A patent/AU2008221121B2/en not_active Ceased
- 2008-02-26 EP EP08706922.5A patent/EP2114951B9/en active Active
-
2009
- 2009-07-30 IL IL200153A patent/IL200153A/en active IP Right Grant
-
2014
- 2014-06-17 CY CY20141100437T patent/CY1115227T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2114951B1 (en) | 2014-04-09 |
| HK1138262A1 (en) | 2010-08-20 |
| RU2009135810A (ru) | 2011-04-10 |
| NZ578804A (en) | 2012-04-27 |
| CA2676933C (en) | 2015-09-29 |
| US20100099688A1 (en) | 2010-04-22 |
| JP5501770B2 (ja) | 2014-05-28 |
| HRP20140585T1 (hr) | 2014-09-12 |
| CY1115227T1 (el) | 2017-01-04 |
| KR101571654B1 (ko) | 2015-11-25 |
| JP2010519332A (ja) | 2010-06-03 |
| PT2114951E (pt) | 2014-07-17 |
| RS53407B (sr) | 2014-10-31 |
| BRPI0807749A2 (pt) | 2014-06-17 |
| WO2008104175A2 (en) | 2008-09-04 |
| AU2008221121A1 (en) | 2008-09-04 |
| CA2676933A1 (en) | 2008-09-04 |
| ES2478670T3 (es) | 2014-07-22 |
| AU2008221121B2 (en) | 2013-10-03 |
| BRPI0807749B1 (pt) | 2021-01-05 |
| IL200153A0 (en) | 2010-04-15 |
| US8338431B2 (en) | 2012-12-25 |
| IL200153A (en) | 2016-11-30 |
| MX2009009238A (es) | 2009-09-08 |
| EP2114951B9 (en) | 2015-09-02 |
| RU2495043C2 (ru) | 2013-10-10 |
| MY150075A (en) | 2013-11-29 |
| EP2114951A2 (en) | 2009-11-11 |
| SI2114951T1 (sl) | 2014-08-29 |
| PL2114951T3 (pl) | 2014-10-31 |
| KR20090126252A (ko) | 2009-12-08 |
| WO2008104175A3 (en) | 2009-01-29 |
| BRPI0807749B8 (pt) | 2022-09-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL280173A (en) | Inhibitors of brutons tyrosine kinase | |
| CY2020024I2 (el) | Αναστολεiς βητα-λακταμασων | |
| CY2019009I1 (el) | Αναστολεις πρωτεϊνικων κινασων | |
| CY2017016I1 (el) | Αναστολεις πρωτεασωματος | |
| BRPI0814797A2 (pt) | Inibidores dna-pk | |
| BRPI0811212A2 (pt) | Inibidores de p70 quinase | |
| ATE522535T1 (de) | Pyrrolotriazin-kinasehemmer | |
| BRPI0910668A2 (pt) | inibidores de proteína quinases | |
| DK2041138T3 (da) | Pyrroltriazinkinase-inhibitorer | |
| DK2024375T3 (da) | Cyclopropyl-kondenserede indolobenzazepin-HCV-NS5B-hæmmere | |
| BRPI0810365A2 (pt) | Inibidores de mlc-1 de indol 7-substituído | |
| DK2015754T3 (da) | Anvendelse af dpp-iv-inhibitorer | |
| CR10831A (es) | INHIBIDORES ESPIRO CETONA DE ACETIL-CoA CARBOXILASA | |
| ATE519763T1 (de) | Pyrrolopyrazin-kinasehemmer | |
| BRPI0918846A2 (pt) | inibidores de cinase heterocíclica | |
| BRPI0806898A2 (pt) | Inibidores de mek | |
| ATE506358T1 (de) | 2-benzylpyridazinonderivate als met-kinasehemmer | |
| BRPI0918564A2 (pt) | inibidores | |
| IL200153A0 (en) | Novel phosphodiesterase inhibitors | |
| ATE545417T1 (de) | Pyrazoloä3,4-büpyridin-derivate als phosphodiesterasehemmer | |
| DK2066662T3 (da) | Serinhydrolaseinhibitorer | |
| EP2162436A4 (en) | NEW CASE OF RENININHIBITORS | |
| BRPI0716198A2 (pt) | Pirrolo-isoquinolinas como inibidores de cinase | |
| EP2195521A4 (en) | Fuel vapor separator | |
| ZA200905371B (en) | Novel phosphodiesterase Inhibitors |