BRPI0808524A2 - Composto macrocíclico - Google Patents

Composto macrocíclico

Info

Publication number: BRPI0808524A2
Authority: BR; Brazil
Prior art keywords: macrocyclic compound; macrocyclic; compound
Prior art date: 2007-03-01

Application number

BRPI0808524-2A2A

Other languages

English (en)

Inventor

Nobuo Shimma

Takuo Tsukuda

Hiroshi Koyano

Atsushi Suda

Tadakatsu Hayase

Kihito Hada

Ken-Ichi Kawasaki

Susumu Komiyama

Naomi Ono

Toshikazu Yamazaki

Ryoichi Saitoh

Masami Kohchi

Kiyoshi Hasegawa

Original Assignee

Chugai Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-03-01

Filing date

2008-02-29

Publication date

2014-11-11

2008-02-29 Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd

2014-11-11 Publication of BRPI0808524A2 publication Critical patent/BRPI0808524A2/pt

Links

150000002678 macrocyclic compounds Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D515/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/529—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/18—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/20—Spiro-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Physical Education & Sports Medicine (AREA)
Oncology (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Vascular Medicine (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Communicable Diseases (AREA)
Transplantation (AREA)
Hematology (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

BRPI0808524-2A2A 2007-03-01 2008-02-29 Composto macrocíclico BRPI0808524A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2007052072		2007-03-01
PCT/JP2008/053599 WO2008105526A1 (ja)	2007-03-01	2008-02-29	マクロ環状化合物

Publications (1)

Publication Number	Publication Date
BRPI0808524A2 true BRPI0808524A2 (pt)	2014-11-11

Family

ID=39721348

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0808524-2A2A BRPI0808524A2 (pt)	2007-03-01	2008-02-29	Composto macrocíclico

Country Status (18)

Country	Link
US (1)	US8362236B2 (pt)
EP (1)	EP2119718B1 (pt)
JP (1)	JP5235859B2 (pt)
KR (1)	KR20090125155A (pt)
CN (1)	CN101675059A (pt)
AR (1)	AR065583A1 (pt)
AT (1)	ATE553107T1 (pt)
AU (1)	AU2008220009A1 (pt)
BR (1)	BRPI0808524A2 (pt)
CA (1)	CA2679126A1 (pt)
CL (1)	CL2008000629A1 (pt)
IL (1)	IL200009A0 (pt)
MX (1)	MX2009008756A (pt)
PE (1)	PE20090110A1 (pt)
RU (1)	RU2009136343A (pt)
TW (1)	TW200904435A (pt)
WO (1)	WO2008105526A1 (pt)
ZA (1)	ZA200905116B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
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AR061185A1 (es) *	2006-05-26	2008-08-13	Chugai Pharmaceutical Co Ltd	Compuestos heterociclicos como inhibidores de hsp90. composiciones farmaceuticas.
PE20090110A1 (es)	2007-03-01	2009-04-04	Chugai Pharmaceutical Co Ltd	Compuestos macrociclicos derivados de amina como agentes inhibidores de hsp90
AR077405A1 (es)	2009-07-10	2011-08-24	Sanofi Aventis	Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr)	2009-09-03	2011-11-25	Sanofi Aventis	Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
CA2863892C (en)	2012-03-06	2016-08-30	Pfizer Inc.	Macrocyclic derivatives for the treatment of proliferative diseases
EP2836485B1 (en) *	2012-03-17	2018-01-10	Polyphor Ag	Conformationally constrained, fully synthetic macrocyclic compounds
US9617282B2 (en)	2013-03-15	2017-04-11	Biogen Ma Inc.	Macrocyclic compounds as IRAK4 inhibitors for the treatment of inflammatory diseases
PL3053578T3 (pl)	2013-09-30	2021-06-14	Taiho Pharmaceutical Co., Ltd.	Skojarzona terapia przeciwnowotworowa z zastosowaniem związku azabicyklicznego
TWI780152B (zh)	2017-05-12	2022-10-11	日商中外製藥股份有限公司	環狀有機化合物的製造方法
CN115124550B (zh) *	2020-10-26	2024-04-02	山东大学	一种特异性热休克蛋白90α亚型抑制剂制备及其应用
WO2022089449A1 (zh) *	2020-10-26	2022-05-05	山东大学	一种特异性热休克蛋白90α亚型抑制剂制备及其应用
WO2024107783A2 (en) *	2022-11-15	2024-05-23	Enanta Pharmaceuticals, Inc.	Novel macrocyclic chalcone-amide derived antiviral agents

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JPS60208968A (ja)	1984-03-07	1985-10-21	イー・アイ・デユポン・デ・ニモアス・アンド・カンパニー	除草剤性フルオロエトキシピリミジン類及びトリアジン類
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JP2004512381A (ja)	2000-11-02	2004-04-22	スローン−ケッタリング・インスティテュート・フォー・キャンサー・リサーチ	Ｈｓｐ９０インヒビターの使用により細胞毒性剤の効力を増強させる方法
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GB0228417D0 (en)	2002-12-05	2003-01-08	Cancer Rec Tech Ltd	Pyrazole compounds
ES2559779T3 (es)	2003-08-29	2016-02-15	Vernalis (R&D) Limited	Compuestos de pirimidotiofeno
JP2005225787A (ja) *	2004-02-12	2005-08-25	Nippon Kayaku Co Ltd	Ｈｓｐ９０阻害剤
GB0416168D0 (en)	2004-07-20	2004-08-18	Vernalis Cambridge Ltd	Pyrmidothiophene compounds
WO2006123165A2 (en)	2005-05-19	2006-11-23	Astex Therapeutics Limited	Pyrimidine derivatives as hsp90 inhibitors
DE102005022977A1 (de)	2005-05-19	2006-12-07	Merck Patent Gmbh	Phenylchinazolinderivate
CN101360751B (zh) *	2005-11-16	2011-09-14	S*Bio私人有限公司	氧连接的嘧啶衍生物
AR061185A1 (es) *	2006-05-26	2008-08-13	Chugai Pharmaceutical Co Ltd	Compuestos heterociclicos como inhibidores de hsp90. composiciones farmaceuticas.
PE20090110A1 (es)	2007-03-01	2009-04-04	Chugai Pharmaceutical Co Ltd	Compuestos macrociclicos derivados de amina como agentes inhibidores de hsp90
JP2009067729A (ja)	2007-09-14	2009-04-02	Kyowa Hakko Kirin Co Ltd	Ｈｓｐ９０ファミリー蛋白質阻害剤
WO2009097578A1 (en)	2008-02-01	2009-08-06	Takeda Pharmaceutical Company Limited	Oxim derivatives as hsp90 inhibitors

2008
- 2008-02-29 PE PE2008000409A patent/PE20090110A1/es not_active Application Discontinuation
- 2008-02-29 US US12/529,222 patent/US8362236B2/en not_active Expired - Fee Related
- 2008-02-29 AU AU2008220009A patent/AU2008220009A1/en not_active Abandoned
- 2008-02-29 AT AT08721047T patent/ATE553107T1/de active
- 2008-02-29 CA CA002679126A patent/CA2679126A1/en not_active Abandoned
- 2008-02-29 CN CN200880014171A patent/CN101675059A/zh not_active Withdrawn
- 2008-02-29 TW TW097107103A patent/TW200904435A/zh unknown
- 2008-02-29 WO PCT/JP2008/053599 patent/WO2008105526A1/ja not_active Ceased
- 2008-02-29 CL CL200800629A patent/CL2008000629A1/es unknown
- 2008-02-29 BR BRPI0808524-2A2A patent/BRPI0808524A2/pt not_active IP Right Cessation
- 2008-02-29 KR KR1020097020448A patent/KR20090125155A/ko not_active Withdrawn
- 2008-02-29 EP EP08721047A patent/EP2119718B1/en not_active Not-in-force
- 2008-02-29 JP JP2009501315A patent/JP5235859B2/ja not_active Expired - Fee Related
- 2008-02-29 AR ARP080100884A patent/AR065583A1/es unknown
- 2008-02-29 RU RU2009136343/04A patent/RU2009136343A/ru unknown
- 2008-02-29 MX MX2009008756A patent/MX2009008756A/es not_active Application Discontinuation
2009
- 2009-07-22 ZA ZA200905116A patent/ZA200905116B/xx unknown
- 2009-07-22 IL IL200009A patent/IL200009A0/en unknown

Also Published As

Publication number	Publication date
TW200904435A (en)	2009-02-01
KR20090125155A (ko)	2009-12-03
RU2009136343A (ru)	2011-04-10
EP2119718A4 (en)	2010-12-15
US20100056510A1 (en)	2010-03-04
MX2009008756A (es)	2009-08-27
AU2008220009A1 (en)	2008-09-04
JPWO2008105526A1 (ja)	2010-06-03
EP2119718B1 (en)	2012-04-11
IL200009A0 (en)	2010-04-15
ZA200905116B (en)	2010-07-28
CA2679126A1 (en)	2008-09-04
US8362236B2 (en)	2013-01-29
WO2008105526A1 (ja)	2008-09-04
ATE553107T1 (de)	2012-04-15
AR065583A1 (es)	2009-06-17
CN101675059A (zh)	2010-03-17
CL2008000629A1 (es)	2008-08-29
EP2119718A1 (en)	2009-11-18
JP5235859B2 (ja)	2013-07-10
PE20090110A1 (es)	2009-04-04

Legal Events

Date	Code	Title	Description
2015-08-25	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES.
2016-05-10	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2329 DE 25-08-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.
2022-07-12	B350	Update of information on the portal [chapter 15.35 patent gazette]

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ATE524477T1 (de)	2011-09-15	Aziridinylepothilonverbindungen
BRPI0811264A2 (pt)	2014-11-04	Compostos
ATE514696T1 (de)	2011-07-15	Diphenyl-dihydro-imidazopyridinone
BRPI0811451A2 (pt)	2014-11-04	Exopolissacarídeo
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