BRPI0809079A2 - tratamento de câncer com um combinado de il-18 humana e anticorpo anti-cd20 - Google Patents

tratamento de câncer com um combinado de il-18 humana e anticorpo anti-cd20

Info

Publication number
BRPI0809079A2
BRPI0809079A2 BRPI0809079-3A BRPI0809079A BRPI0809079A2 BR PI0809079 A2 BRPI0809079 A2 BR PI0809079A2 BR PI0809079 A BRPI0809079 A BR PI0809079A BR PI0809079 A2 BRPI0809079 A2 BR PI0809079A2
Authority
BR
Brazil
Prior art keywords
human
antibody
combination
cancer treatment
treatment
Prior art date
Application number
BRPI0809079-3A
Other languages
English (en)
Inventor
Haskova Zdenka
Ludmila Zdenka
H. Trulli Stephen
F. Toso John
N. Whitacre Margaret
Original Assignee
Smithkline Beecham Corparation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39788932&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0809079(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Smithkline Beecham Corparation filed Critical Smithkline Beecham Corparation
Publication of BRPI0809079A2 publication Critical patent/BRPI0809079A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"tratamento de câncer com um combinado de il-18 humana e anticorpo anti-cd20" a presente invenção geralmente se refere ao uso de combinações de il-18 humana no tratamento de cânceres. em particular, a presente invenção se refere a combinação de il-18 humana e um anticorpo anti-cd20.
BRPI0809079-3A 2007-03-23 2008-03-20 tratamento de câncer com um combinado de il-18 humana e anticorpo anti-cd20 BRPI0809079A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US89685507P 2007-03-23 2007-03-23
US60/896.855 2007-03-23
US95200207P 2007-07-26 2007-07-26
US60/952.002 2007-07-26
PCT/US2008/057620 WO2008118736A1 (en) 2007-03-23 2008-03-20 Combined human il- 18 and anti cd20 antibody cancer treatment

Publications (1)

Publication Number Publication Date
BRPI0809079A2 true BRPI0809079A2 (pt) 2019-03-06

Family

ID=39788932

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0808943-4A BRPI0808943A2 (pt) 2007-03-23 2008-03-20 Método de tratamento do câncer por administração de combinações de il-18 humano
BRPI0809079-3A BRPI0809079A2 (pt) 2007-03-23 2008-03-20 tratamento de câncer com um combinado de il-18 humana e anticorpo anti-cd20

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI0808943-4A BRPI0808943A2 (pt) 2007-03-23 2008-03-20 Método de tratamento do câncer por administração de combinações de il-18 humano

Country Status (21)

Country Link
US (4) US20100196310A1 (pt)
EP (3) EP2338514A1 (pt)
JP (2) JP2010522239A (pt)
KR (2) KR20100014530A (pt)
CN (1) CN101678102A (pt)
AR (2) AR065803A1 (pt)
AU (2) AU2008231114A1 (pt)
BR (2) BRPI0808943A2 (pt)
CA (2) CA2681827A1 (pt)
CL (2) CL2008000818A1 (pt)
CR (2) CR10996A (pt)
DO (2) DOP2009000208A (pt)
EA (2) EA200970885A1 (pt)
IL (2) IL200525A0 (pt)
MA (2) MA31264B1 (pt)
MX (2) MX2009010271A (pt)
NZ (1) NZ579179A (pt)
PE (2) PE20090190A1 (pt)
SG (1) SG171674A1 (pt)
TW (2) TW200906436A (pt)
WO (2) WO2008118736A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100951067B1 (ko) * 2000-02-10 2010-04-07 아보트 러보러터리즈 사람 인터류킨-18에 결합하는 항체 및 이를 제조하고사용하는 방법
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
PE20090190A1 (es) * 2007-03-23 2009-03-22 Smithkline Beecham Corp Combinacion de anticuerpos anti-cd20 y polipeptidos de il-18
TW201302793A (zh) 2010-09-03 2013-01-16 Glaxo Group Ltd 新穎之抗原結合蛋白
HRP20192254T1 (hr) 2014-04-25 2020-03-06 Pierre Fabre Medicament Konjugat antitijela i lijeka i njegova upotreba u liječenju karcinoma
PT3134124T (pt) 2014-04-25 2019-06-03 Pf Medicament Conjugado anticorpo-fármaco igf-1r e a sua utilização para o tratamento de cancro
AU2015300006B2 (en) * 2014-08-07 2018-08-30 Haruki Okamura Therapeutic agent for cancer which comprises combination of IL-18 and molecule-targeting antibody
WO2016126615A1 (en) * 2015-02-03 2016-08-11 Armo Biosciences, Inc. Methods of using interleukin-10 for treating diseases and disorders
US20240368247A1 (en) * 2020-12-02 2024-11-07 The Royal Institution For The Advancement Of Learning/Mcgill University Therapeutic applications of type 1 insulin-like growth factor (igf-1) receptor antagonists
WO2025033330A1 (ja) * 2023-08-04 2025-02-13 医療革新国際連携株式会社 キマーゼ阻害剤と免疫療法の併用による抗腫瘍療法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69519454T2 (de) 1994-07-14 2001-05-03 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo, Okayama Protein, das Interferon-Gamma Herstellung induziert und monoklonaler Antikörper dagegen
JP4004088B2 (ja) 1995-09-26 2007-11-07 株式会社林原生物化学研究所 免疫担当細胞においてインターフェロン−γの産生を誘導する蛋白質
TW581771B (en) 1994-11-15 2004-04-01 Hayashibara Biochem Lab Recombinant production of a polypeptide for inducing interferon-gamma production, and monoclonal antibody against the polypeptide
US7135458B1 (en) * 1995-11-15 2006-11-14 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interferon-γ inducing polypeptide, pharmaceutical composition thereof, monoclonal antibody thereto, and methods of use
US5680795A (en) 1995-07-05 1997-10-28 Norco Inc. Mechanical drive assembly incorporating counter-spring biassed radially-adjustable rollers
JP4024366B2 (ja) * 1996-11-29 2007-12-19 株式会社林原生物化学研究所 ポリペプチド
US6787132B1 (en) * 1997-12-04 2004-09-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Combined chemo-immunotherapy with liposomal drugs and cytokines
TWI227136B (en) * 1998-05-21 2005-02-01 Smithkline Beecham Corp Novel pharmaceutical composition for the prevention and/or treatment of cancer
IL153422A0 (en) * 2000-06-15 2003-07-06 Smithkline Beecham Corp Method for preparing a physiologically active il-18 polypeptide
US20020094323A1 (en) * 2000-10-12 2002-07-18 Kristoffer Hellstrand Methods and compositions for promoting the maturation of monocytes
WO2003068821A2 (en) * 2002-02-14 2003-08-21 Immunomedics, Inc. Anti-cd20 antibodies and fusion proteins thereof and methods of use
WO2003072736A2 (en) * 2002-02-21 2003-09-04 Duke University Reagents and treatment methods for autoimmune diseases
EP1545587B1 (en) * 2002-09-16 2011-02-09 Agennix Incorporated Lactoferrin compositions and methods of diabetic ulcer treatment
WO2004032962A1 (en) * 2002-10-08 2004-04-22 Immunomedics, Inc. Combination therapy with class iii anti-cea monoclonal antibodies and therapeutic agents
KR101348472B1 (ko) * 2002-10-17 2014-01-07 젠맵 에이/에스 Ｃｄ20에 대한 인간 모노클로날 항체
US7534427B2 (en) * 2002-12-31 2009-05-19 Immunomedics, Inc. Immunotherapy of B cell malignancies and autoimmune diseases using unconjugated antibodies and conjugated antibodies and antibody combinations and fusion proteins
ATE459647T1 (de) * 2003-04-15 2010-03-15 Glaxosmithkline Llc Humane il-18 substitutionsmutanten und deren konjugate
WO2005018542A2 (en) * 2003-07-10 2005-03-03 Agennix Incorporated Use of lactoferrin in prophylaxis against infection and/or inflammation in immunosuppressed subjects
EP2216342B1 (en) * 2003-07-31 2015-04-22 Immunomedics, Inc. Anti-CD19 antibodies
ATE497975T1 (de) * 2005-04-18 2011-02-15 Novo Nordisk As Il-21-varianten
JP2009501913A (ja) * 2005-07-21 2009-01-22 ゲンマブ エー／エス Ｆｃ受容体と結合する抗体原薬に関する効力アッセイ
AU2007272330A1 (en) * 2006-07-13 2008-01-17 Zymogenetics, Inc. Interleukin 21 and tyrosine kinase inhibitor combination therapy
JP2010503680A (ja) * 2006-09-14 2010-02-04 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア ヒトｉｌ−１８による調節ｔ細胞のモジュレーション
PE20090190A1 (es) * 2007-03-23 2009-03-22 Smithkline Beecham Corp Combinacion de anticuerpos anti-cd20 y polipeptidos de il-18

Also Published As

Publication number Publication date
AU2008231114A1 (en) 2008-10-02
DOP2009000208A (es) 2010-03-31
CL2008000842A1 (es) 2008-10-17
WO2008118733A3 (en) 2008-11-27
DOP2009000220A (es) 2009-10-31
EP2338514A1 (en) 2011-06-29
CA2681827A1 (en) 2008-10-02
AR065818A1 (es) 2009-07-01
EA200970884A1 (ru) 2010-04-30
WO2008118736A1 (en) 2008-10-02
IL200863A0 (en) 2010-05-17
US20090035258A1 (en) 2009-02-05
CL2008000818A1 (es) 2008-09-26
EP2136841A4 (en) 2010-07-07
MA31265B1 (fr) 2010-03-01
WO2008118733A2 (en) 2008-10-02
CR10996A (es) 2009-11-12
PE20090190A1 (es) 2009-03-22
JP2010522239A (ja) 2010-07-01
TW200906436A (en) 2009-02-16
JP2010522200A (ja) 2010-07-01
SG171674A1 (en) 2011-06-29
MX2009010269A (es) 2009-10-12
KR20100015798A (ko) 2010-02-12
BRPI0808943A2 (pt) 2014-08-26
MA31264B1 (fr) 2010-03-01
EP2129398A4 (en) 2010-04-21
CA2681851A1 (en) 2008-10-02
MX2009010271A (es) 2009-10-12
US20100196310A1 (en) 2010-08-05
AU2008231025A1 (en) 2008-10-02
AR065803A1 (es) 2009-07-01
IL200525A0 (en) 2010-04-29
NZ579179A (en) 2011-12-22
EP2129398A1 (en) 2009-12-09
EP2136841A2 (en) 2009-12-30
KR20100014530A (ko) 2010-02-10
CN101678102A (zh) 2010-03-24
CR11075A (es) 2010-03-22
TW200904469A (en) 2009-02-01
EA200970885A1 (ru) 2010-02-26
PE20090184A1 (es) 2009-03-22
US20080274078A1 (en) 2008-11-06
US20100111945A1 (en) 2010-05-06

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2514 DE 12-03-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B350 Update of information on the portal [chapter 15.35 patent gazette]