BRPI0809890A2 - Processo para preparar imatinib ou sal do mesmo e composição farmacêutica - Google Patents
Processo para preparar imatinib ou sal do mesmo e composição farmacêuticaInfo
- Publication number
- BRPI0809890A2 BRPI0809890A2 BRPI0809890-5A2A BRPI0809890A BRPI0809890A2 BR PI0809890 A2 BRPI0809890 A2 BR PI0809890A2 BR PI0809890 A BRPI0809890 A BR PI0809890A BR PI0809890 A2 BRPI0809890 A2 BR PI0809890A2
- Authority
- BR
- Brazil
- Prior art keywords
- salt
- pharmaceutical composition
- preparing imatinib
- imatinib
- preparing
- Prior art date
Links
- 239000005517 L01XE01 - Imatinib Substances 0.000 title 1
- KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 title 1
- 229960002411 imatinib Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/743,520 US7550591B2 (en) | 2007-05-02 | 2007-05-02 | Imatinib production process |
| PCT/IL2008/000591 WO2008135980A1 (en) | 2007-05-02 | 2008-05-01 | Imatinib production process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0809890A2 true BRPI0809890A2 (pt) | 2014-09-30 |
Family
ID=39744792
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0809890-5A2A BRPI0809890A2 (pt) | 2007-05-02 | 2008-05-01 | Processo para preparar imatinib ou sal do mesmo e composição farmacêutica |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7550591B2 (pt) |
| EP (1) | EP2146978A1 (pt) |
| JP (1) | JP2010526056A (pt) |
| BR (1) | BRPI0809890A2 (pt) |
| WO (1) | WO2008135980A1 (pt) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7977348B2 (en) * | 2006-04-27 | 2011-07-12 | Sicor Inc. | Polymorphic forms of imatinib mesylate and processes for preparation of novel crystalline forms as well as amorphous and form α |
| US8067421B2 (en) * | 2006-04-27 | 2011-11-29 | Sicor Inc. | Polymorphic forms of imatinib mesylate and processes for preparation of novel crystalline forms as well as amorphous and form α |
| US20090324718A1 (en) * | 2006-09-01 | 2009-12-31 | Ilan Zalit | Imatinib compositions |
| WO2008051597A1 (en) * | 2006-10-26 | 2008-05-02 | Sicor Inc. | Process for the preparation of imatinib |
| MX2010003200A (es) * | 2007-09-25 | 2010-04-30 | Teva Pharma | Composiciones de imatibnib estables. |
| EP2231161A1 (en) * | 2007-12-22 | 2010-09-29 | Synthon B.V. | A process of making imatinib |
| US20100330130A1 (en) * | 2009-05-22 | 2010-12-30 | Actavis Group Ptc Ehf | Substantially pure imatinib or a pharmaceutically acceptable salt thereof |
| WO2011095835A1 (en) * | 2010-02-02 | 2011-08-11 | Actavis Group Ptc Ehf | Highly pure imatinib or a pharmaceutically acceptable salt thereof |
| CA2792472A1 (en) * | 2010-03-15 | 2011-09-22 | Natco Pharma Limited | Process for the preparation of highly pure crystalline imatinib base |
| CN102250063B (zh) * | 2010-05-19 | 2014-10-22 | 江苏豪森药业股份有限公司 | 甲磺酸伊马替尼的晶型及其制备方法 |
| CN101985442B (zh) * | 2010-09-19 | 2013-04-03 | 南京卡文迪许生物工程技术有限公司 | 一种便捷的制备高纯度的伊马替尼及其甲磺酸盐的方法 |
| CN102070605B (zh) * | 2011-01-30 | 2013-03-13 | 南京卡文迪许生物工程技术有限公司 | 甲磺酸伊马替尼多晶型物和药用组合物 |
| KR101286780B1 (ko) | 2011-02-01 | 2013-07-17 | 에스티팜 주식회사 | 비카보네이트 염 및 이를 이용한 이마티니브 또는 이의 염의 제조방법 |
| JP2014509642A (ja) | 2011-03-31 | 2014-04-21 | アイエヌディー−スイフト ラボラトリーズ リミテッド | イマチニブ及びそのメシル酸塩の生成のための改良方法 |
| CN102796079B (zh) * | 2011-05-27 | 2016-06-29 | 江苏豪森药业集团有限公司 | 一种甲磺酸氟马替尼的制备方法 |
| CN102260242B (zh) * | 2011-05-27 | 2014-08-06 | 南京卡文迪许生物工程技术有限公司 | 甲磺酸伊马替尼多晶型物及其药用组合物 |
| KR101139431B1 (ko) * | 2011-05-30 | 2012-04-27 | (주)비씨월드제약 | 이매티닙 염기의 신규한 제조방법 |
| CN102816145B (zh) * | 2011-06-11 | 2014-09-03 | 南京卡文迪许生物工程技术有限公司 | 甲磺酸伊马替尼多晶型物及其药用组合物 |
| GB2514285B (en) * | 2012-02-13 | 2018-07-18 | Grindeks Jsc | Intermediates for a novel process of preparing imatinib and related tyrosine kinase inhibitors |
| IN2012DE00728A (pt) | 2012-03-13 | 2015-08-21 | Fresenius Kabi Oncology Ltd | |
| CN102659762A (zh) * | 2012-05-24 | 2012-09-12 | 石药集团中奇制药技术（石家庄）有限公司 | 一种甲磺酸伊马替尼晶型及其制备方法 |
| CN104974133B (zh) * | 2014-04-09 | 2018-04-27 | 石药集团中奇制药技术（石家庄）有限公司 | 一种甲磺酸伊马替尼晶型及其制备方法 |
| CN105859683B (zh) * | 2016-04-11 | 2018-09-28 | 连云港恒运药业有限公司 | 伊马替尼的高纯度工业制备工艺 |
| CN112359079B (zh) * | 2020-11-10 | 2022-07-26 | 江苏八巨药业有限公司 | 一种伊马胺的制备方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5521184A (en) | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
| TW225528B (pt) | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
| CO4940418A1 (es) | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
| JP2003073352A (ja) * | 2001-09-05 | 2003-03-12 | Sumitomo Pharmaceut Co Ltd | 新規な環状アミン化合物 |
| GB0201508D0 (en) | 2002-01-23 | 2002-03-13 | Novartis Ag | Organic compounds |
| GB0202873D0 (en) | 2002-02-07 | 2002-03-27 | Novartis Ag | Organic compounds |
| GB0222514D0 (en) * | 2002-09-27 | 2002-11-06 | Novartis Ag | Organic compounds |
| GB2398565A (en) | 2003-02-18 | 2004-08-25 | Cipla Ltd | Imatinib preparation and salts |
| WO2004106326A1 (en) | 2003-06-02 | 2004-12-09 | Hetero Drugs Limited | Novel polymorphs of imatinib mesylate |
| MY144177A (en) | 2004-02-04 | 2011-08-15 | Novartis Ag | Salt forms of 4-(4-methylpiperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide. |
| UA84462C2 (ru) | 2004-04-02 | 2008-10-27 | Институт Фармацевтични | Полиморфные модификации кислотно-аддитивных солей иматиниба с метансульфоновой кислотой |
| TR200701870T1 (tr) | 2004-09-02 | 2007-05-21 | Cipla Limited | İmatinib mesilatın kararlı kristal formu ve bu formun hazırlanması için işlem. |
| EP1802315A2 (en) * | 2004-10-19 | 2007-07-04 | Achillion Pharmaceuticals, Inc. | Combination therapy for treating viral infections |
| WO2006054314A1 (en) | 2004-11-17 | 2006-05-26 | Natco Pharma Limited | Polymorphic forms of imatinib mesylate |
| US7507821B2 (en) | 2004-12-30 | 2009-03-24 | Chemagis Ltd. | Process for preparing Imatinib |
| JP2009506014A (ja) | 2005-08-26 | 2009-02-12 | ノバルティス アクチエンゲゼルシャフト | イマチニブメシレートのデルタおよびイプシロン結晶形 |
| US20060223816A1 (en) | 2006-05-08 | 2006-10-05 | Chemagis Ltd. | Imatinib mesylate alpha form and production process therefor |
| US20060223817A1 (en) | 2006-05-15 | 2006-10-05 | Chemagis Ltd. | Crystalline imatinib base and production process therefor |
| BRPI0808840A2 (pt) * | 2007-03-12 | 2014-09-02 | Reddy S Laborartories Ltd Dr | Mesilato de imatinib |
-
2007
- 2007-05-02 US US11/743,520 patent/US7550591B2/en not_active Expired - Fee Related
-
2008
- 2008-05-01 JP JP2010505010A patent/JP2010526056A/ja active Pending
- 2008-05-01 BR BRPI0809890-5A2A patent/BRPI0809890A2/pt not_active IP Right Cessation
- 2008-05-01 EP EP08738292A patent/EP2146978A1/en not_active Withdrawn
- 2008-05-01 WO PCT/IL2008/000591 patent/WO2008135980A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008135980A1 (en) | 2008-11-13 |
| EP2146978A1 (en) | 2010-01-27 |
| US7550591B2 (en) | 2009-06-23 |
| US20080275055A1 (en) | 2008-11-06 |
| JP2010526056A (ja) | 2010-07-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |