BRPI0811548A2 - Forma polimórfica de um composto, composição farmacêutica, e, processo para sintetizar uma forma polimórfica de um composto - Google Patents

Forma polimórfica de um composto, composição farmacêutica, e, processo para sintetizar uma forma polimórfica de um composto

Info

Publication number
BRPI0811548A2
BRPI0811548A2 BRPI0811548-6A2A BRPI0811548A BRPI0811548A2 BR PI0811548 A2 BRPI0811548 A2 BR PI0811548A2 BR PI0811548 A BRPI0811548 A BR PI0811548A BR PI0811548 A2 BRPI0811548 A2 BR PI0811548A2
Authority
BR
Brazil
Prior art keywords
compound
polymorphic form
synthesize
pharmaceutical composition
polymorphic
Prior art date
Application number
BRPI0811548-6A2A
Other languages
English (en)
Inventor
Alexander Charles Weymouth-Wilson
Shabana Ahmed
Mark William Hooper
Karen June Etherington
Original Assignee
Summit Corp Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Summit Corp Plc filed Critical Summit Corp Plc
Publication of BRPI0811548A2 publication Critical patent/BRPI0811548A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BRPI0811548-6A2A 2007-08-15 2008-08-14 Forma polimórfica de um composto, composição farmacêutica, e, processo para sintetizar uma forma polimórfica de um composto BRPI0811548A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0715937.9A GB0715937D0 (en) 2007-08-15 2007-08-15 Method of treatment og duchenne muscular dystrophy
PCT/EP2008/006718 WO2009021748A2 (en) 2007-08-15 2008-08-14 Polymorphs of a compound for the treatment of duchenne muscular dystrophy

Publications (1)

Publication Number Publication Date
BRPI0811548A2 true BRPI0811548A2 (pt) 2014-11-18

Family

ID=38566447

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0811548-6A2A BRPI0811548A2 (pt) 2007-08-15 2008-08-14 Forma polimórfica de um composto, composição farmacêutica, e, processo para sintetizar uma forma polimórfica de um composto
BRPI0811315-7A2A BRPI0811315A2 (pt) 2007-08-15 2008-08-14 Processo para a preparação de um composto

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI0811315-7A2A BRPI0811315A2 (pt) 2007-08-15 2008-08-14 Processo para a preparação de um composto

Country Status (17)

Country Link
US (2) US8138351B2 (pt)
EP (2) EP2188270A2 (pt)
JP (2) JP2010535830A (pt)
KR (1) KR20100075777A (pt)
CN (2) CN101679323A (pt)
AR (1) AR068810A1 (pt)
AU (2) AU2008286325A1 (pt)
BR (2) BRPI0811548A2 (pt)
CA (2) CA2685590A1 (pt)
CL (1) CL2008002391A1 (pt)
GB (1) GB0715937D0 (pt)
IL (1) IL201908A0 (pt)
MX (2) MX2009011967A (pt)
PE (1) PE20090604A1 (pt)
RU (1) RU2009141831A (pt)
TW (1) TW200911767A (pt)
WO (2) WO2009021748A2 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2008010187A (es) * 2006-02-10 2008-10-31 Summit Corp Plc Tratamiento de distrofia muscular de duchenne.
GB201208178D0 (en) 2012-05-10 2012-06-20 Summit Corp Plc Pharmaceutical composition for the treatment of duchenne muscular dystrophy
GB201412010D0 (en) 2014-07-04 2014-08-20 Summit Corp Plc Treatment of hypertransaminasemia
MX2018012018A (es) * 2016-03-30 2019-07-04 Summit Oxford Ltd Composicion para el tratamiento de la distrofía muscular de duchenne.
WO2017175842A1 (ja) * 2016-04-07 2017-10-12 国立大学法人京都大学 スプライシングの改変に関する化合物及び医薬組成物
KR102019048B1 (ko) 2017-02-06 2019-09-09 가톨릭대학교 산학협력단 MG53과 Orai1의 결합을 이용한 근육긴장저하 치료제 스크리닝 방법
KR101886788B1 (ko) 2017-02-07 2018-08-09 가톨릭대학교 산학협력단 MG53과 Orai1의 결합을 이용한 뒤시엔느 골격근 위축증 치료제 스크리닝 방법
EP4403171A3 (en) 2017-06-19 2024-09-11 University of Maryland, Baltimore Microtubule polymerization inhibitor prodrugs and methods of using the same

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993659A (en) * 1971-08-10 1976-11-23 Ciba-Geigy Corporation Bis-benzoxazolyl-naphthalenes as optical brighteners
CH617809GA3 (pt) * 1975-10-10 1980-06-30
US4110246A (en) * 1976-05-13 1978-08-29 Hoechst Aktiengesellschaft Mixture of benzoxazole derivatives
DE3027479A1 (de) * 1980-07-19 1982-03-04 Hoechst Ag, 6000 Frankfurt Mischungen von optischen aufhellern und deren verwendung
JPS615071A (ja) * 1984-06-15 1986-01-10 Fuji Photo Film Co Ltd ベンゾオキサゾ−ル誘導体
DE3617451A1 (de) * 1986-05-23 1987-11-26 Hoechst Ag Sulfonat- oder sulfonamidgruppen-haltige bis-benzoxazolylnaphthaline, verfahren zu deren herstellung und deren verwendung
DE3819051A1 (de) * 1988-06-04 1989-12-07 Agfa Gevaert Ag Farbfotografisches aufzeichnungsmaterial
DE59206989D1 (de) * 1991-08-08 1996-10-02 Ciba Geigy Ag Farbstoffe, Verfahren zu deren Herstellung und deren Verwendung
EP0669323B2 (de) * 1994-02-24 2004-04-07 Haarmann & Reimer Gmbh Kosmetische und dermatologische zubereitungen, enthaltend phenylen-1,4-bisbenzimidiazolesulfonsäuren
US6004719A (en) * 1994-04-25 1999-12-21 Polaroid Corporation Imaging medium and process for producing an image
US5583178A (en) * 1994-06-30 1996-12-10 Minnesota Mining And Manufacturing Company Cure-indicating molding and coating composition
AU690302B2 (en) * 1994-06-30 1998-04-23 Dade Behring Inc. Bioactive porous partition members
US6222044B1 (en) * 1995-03-20 2001-04-24 The Dow Chemical Company Process for making 2-aryl benz (ox, thi, imid) azoles and 2-aminoaryl aminobenz (ox, thi, imid) azoles
US5567843A (en) * 1995-03-20 1996-10-22 The Dow Chemical Company Process for making 2-aryl benz (ox, thi, imid)azoles and 2-aminoaryl aminobenz(ox, thi, imid)azoles
US5977101A (en) * 1995-06-29 1999-11-02 Smithkline Beecham Corporation Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity
US5645948A (en) * 1996-08-20 1997-07-08 Eastman Kodak Company Blue organic electroluminescent devices
US5914213A (en) * 1996-11-27 1999-06-22 Polaroid Corporation Process and composition for generation of acid
US6110638A (en) * 1996-11-27 2000-08-29 Polaroid Corporation Process and composition for generation of acid
US6177572B1 (en) * 1997-08-20 2001-01-23 Sepracor, Inc. Solid and liquid-phase synthesis of benzoxazoles and benzothiazoles and their use
US6312822B1 (en) * 1998-05-28 2001-11-06 Eastman Chem Co Dispersion aids for optical brighteners in polyolefins
GB9815880D0 (en) * 1998-07-21 1998-09-16 Pfizer Ltd Heterocycles
US6436558B1 (en) * 1998-08-07 2002-08-20 Fuji Photo Film Co., Ltd. Organic electroluminescence element
FR2789581B1 (fr) * 1999-02-12 2001-05-04 Oreal Compositions photoprotectrices contenant un derive de benzotriazole, un derive de bis-resorcinyl triazine et un compose a groupements benzoazolyle ou benzodiazolyle
FR2789582B1 (fr) * 1999-02-12 2001-05-04 Oreal Compositions photoprotectrices contenant un derive de bis-resorcinyl triazine et un compose a groupements benzoazolyle ou benzodiazolyle
EP1177194B1 (de) * 1999-05-07 2003-09-17 Basf Aktiengesellschaft 4-(3',4'-heterocyclylbenzoyl)pyrazole als herbizide
WO2000068210A1 (de) * 1999-05-07 2000-11-16 Basf Aktiengesellschaft Benzohetero cyclylcyclo hexenone und ihre verwendung als herbizide
FR2794645B1 (fr) * 1999-06-08 2001-08-10 Oreal Compositions photoprotectrices contenant un compose hydrocarbone bis-hydroxyphenylbenzotriazole et un compose a groupements benzoazolyle ou benzodiazolyle
AU7320100A (en) * 1999-09-24 2001-04-24 Ono Pharmaceutical Co. Ltd. Hydroxamic acid derivatives, process for the production thereof and drugs containing the same as the active ingredient
US6565987B2 (en) * 1999-11-12 2003-05-20 Eastman Chemical Company Non-exuding optically brightened polyolefin blends
US6716413B1 (en) * 2000-10-16 2004-04-06 Mallinckrodt, Inc. Indole compounds as tissue-specific exogenous optical agents
CN1285601C (zh) * 2000-11-30 2006-11-22 佳能株式会社 发光器件和显示器
US20050113283A1 (en) * 2002-01-18 2005-05-26 David Solow-Cordero Methods of treating conditions associated with an EDG-4 receptor
US20050261298A1 (en) * 2002-01-18 2005-11-24 David Solow-Cordero Methods of treating conditions associated with an Edg-7 receptor
JP4481011B2 (ja) * 2002-03-05 2010-06-16 トランス テック ファーマ，インコーポレイテッド リガンドのｒａｇｅとの相互作用を阻害する単環式および二環式アゾール誘導体
EP1547996A4 (en) * 2002-08-30 2006-08-02 Bf Res Inst Inc DIAGNOSTIC PROBES AND REMEDIES FOR DISEASES IN WHICH PRION PROTEIN IS ACCUMULATED, AND ANIMAL FEVERING FOR PRION PROTEIN
US20040242673A1 (en) * 2003-05-16 2004-12-02 Ambit Biosciences Corporation Heterocyclic compounds and uses thereof
EP1635823A1 (en) * 2003-05-20 2006-03-22 TransTech Pharma Inc. Rage antagonists as agents to reverse amyloidosis and diseases associated therewith
US7749999B2 (en) * 2003-09-11 2010-07-06 Itherx Pharmaceuticals, Inc. Alpha-ketoamides and derivatives thereof
EP1668417B1 (en) * 2003-09-22 2009-05-13 Agfa Graphics N.V. Photopolymerizable composition.
US7097888B2 (en) * 2003-12-15 2006-08-29 Eastman Kodak Company Aligned liquid crystal layer containing azolium salts and process for increasing the tilt
US7592373B2 (en) * 2003-12-23 2009-09-22 Boehringer Ingelheim International Gmbh Amide compounds with MCH antagonistic activity and medicaments comprising these compounds
AU2005211255A1 (en) * 2004-02-06 2005-08-18 Insight Biopharmaceuticals Ltd Heparanase inhibitors and uses thereof
MY144903A (en) * 2004-06-17 2011-11-30 Novartis Ag Pyrrolopyridine derivatives and their use as crth2 antagonists
JP2008510312A (ja) * 2004-08-19 2008-04-03 エルジー・ケム・リミテッド バッファ層を含む有機発光素子およびその製作方法
US7723340B2 (en) * 2005-01-13 2010-05-25 Signal Pharmaceuticals, Llc Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
ES2400287T3 (es) * 2005-03-14 2013-04-08 High Point Pharmaceuticals, Llc Derivados de benzazol, composiciones y procedimientos de uso como inhibidores de beta-secretasa
JP2007086165A (ja) * 2005-09-20 2007-04-05 Fujifilm Corp 感光性組成物、これを用いた平版印刷版原版及び画像記録方法
US8496835B2 (en) * 2005-12-02 2013-07-30 Sachem, Inc. Anion-exchange displacement chromatography process and anionic organic compounds for use as displacer compounds in anion-exchange displacement chromatography process
KR101213485B1 (ko) * 2006-01-27 2012-12-18 삼성디스플레이 주식회사 유기 금속 착물 및 이를 이용한 유기 전계 발광 소자
KR101213486B1 (ko) * 2006-02-02 2012-12-20 삼성디스플레이 주식회사 유기 금속 착물 및 이를 이용한 유기 전계 발광 소자
MX2008010187A (es) * 2006-02-10 2008-10-31 Summit Corp Plc Tratamiento de distrofia muscular de duchenne.
KR101325062B1 (ko) * 2006-05-19 2013-11-05 삼성디스플레이 주식회사 발광 이종 핵 구리-이리듐 착체 및 이를 이용한 유기 전계발광 소자

Also Published As

Publication number Publication date
US8138351B2 (en) 2012-03-20
AU2008286324A1 (en) 2009-02-19
CN101679323A (zh) 2010-03-24
CN101896475A (zh) 2010-11-24
CA2685939A1 (en) 2009-02-19
TW200911767A (en) 2009-03-16
AU2008286325A1 (en) 2009-02-19
KR20100075777A (ko) 2010-07-05
WO2009021748A3 (en) 2009-04-02
CL2008002391A1 (es) 2009-05-22
GB0715937D0 (en) 2007-09-26
WO2009021749A8 (en) 2009-09-11
MX2009011967A (es) 2009-11-19
EP2176246A2 (en) 2010-04-21
WO2009021749A3 (en) 2009-04-02
CA2685590A1 (en) 2009-02-19
JP2010535830A (ja) 2010-11-25
PE20090604A1 (es) 2009-05-16
MX2009011916A (es) 2009-11-18
RU2009141831A (ru) 2011-05-20
EP2188270A2 (en) 2010-05-26
AR068810A1 (es) 2009-12-09
IL201908A0 (en) 2010-06-16
WO2009021749A2 (en) 2009-02-19
WO2009021748A2 (en) 2009-02-19
US20090048314A1 (en) 2009-02-19
JP2010535829A (ja) 2010-11-25
BRPI0811315A2 (pt) 2015-01-27
US20100267961A1 (en) 2010-10-21

Similar Documents

Publication Publication Date Title
BRPI0814163A2 (pt) Processo para a preparação de compostos, forma cristalina, e, composição farmacêutica
BRPI0810452A2 (pt) Processo para a produção de composições de betume
BRPI0818533A2 (pt) composto, composição farmacêutica, e, processo para a preparação de um composto
PT2242515E (pt) Processo para produzir uma formulação farmacêutica de agentes de contraste
BRPI0905717A2 (pt) Composição farmacêutica, processo para preparar uma composição farmacêutica e forma de dosagem farmacêutica
BRPI0911254A2 (pt) processo para a preparação de um composto
BRPI0810198A2 (pt) Processo para produzir composto de amida
BRPI0814821A2 (pt) Composto, composição farmacêutica, e, processo para preparar um composto
BRPI0916712A2 (pt) processo para preparar uma composição detergente
BRPI0811548A2 (pt) Forma polimórfica de um composto, composição farmacêutica, e, processo para sintetizar uma forma polimórfica de um composto
BRPI0910545A2 (pt) processo contínuo para fazer composições farmacêuticas
BRPI0820911A2 (pt) Método de preparar uma composição de pigmento
BRPI1007161A2 (pt) composição farmacêutica oral, e processo para preparar uma composição
BRPI0814531A2 (pt) Processo de preparo de composições pulverulentas estáveis
BRPI0820976A2 (pt) Processos para produção de ácido succínico
BRPI0815784A2 (pt) Processo para a preparação de 1,2-propanodiol
BRPI0814012A2 (pt) Processo para produção de (met)acrilatos
BRPI1007654A2 (pt) composto, processo para a obtenção de um composto de fórmula geral e composição farmacêutica
BRPI0823084A2 (pt) Método de síntese de uma mistura de oligômeros substancialmente monodispersa
BRPI0815971A2 (pt) Processo para a preparação de 1,2-propanodiol
BRPI0813788A2 (pt) Processo para preparação de metacrilato de alila
BRPI1016109A2 (pt) "composto, composição farmacêutica, e, processo para preparar um composto"
BRPI0914396A2 (pt) " processo de preparação de uma estrutura de folhas "
BR112012003775A2 (pt) processo para a preparação de um composto, composto e composição
BRPI0914400A2 (pt) "processo para a síntese de um composto"

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: BIOMARIN IGA LIMITED (BS)

B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]