BRPI0823084A2 - Método de síntese de uma mistura de oligômeros substancialmente monodispersa - Google Patents

Método de síntese de uma mistura de oligômeros substancialmente monodispersa

Info

Publication number
BRPI0823084A2
BRPI0823084A2 BRPI0823084-6A BRPI0823084A BRPI0823084A2 BR PI0823084 A2 BRPI0823084 A2 BR PI0823084A2 BR PI0823084 A BRPI0823084 A BR PI0823084A BR PI0823084 A2 BRPI0823084 A2 BR PI0823084A2
Authority
BR
Brazil
Prior art keywords
synthesis method
oligomer mixture
substantially monodispersed
monodispersed oligomer
mixture
Prior art date
Application number
BRPI0823084-6A
Other languages
English (en)
Inventor
Vijayaraghavan Reena
Venkata Srinivas Pullela
Aswathanarayanappa Chandrashekar
Original Assignee
Biocon Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocon Ltd filed Critical Biocon Ltd
Publication of BRPI0823084A2 publication Critical patent/BRPI0823084A2/pt
Publication of BRPI0823084B1 publication Critical patent/BRPI0823084B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
    • C08G65/3322—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof acyclic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C08G65/33331—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing imide group
    • C08G65/33337—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing imide group cyclic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Cephalosporin Compounds (AREA)
BRPI0823084-6A 2008-07-14 2008-08-28 Método de síntese de uma mistura de oligômeros substancialmente monodispersa BRPI0823084B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN1694CH2008 2008-07-14
IN01694/CHE/2008 2008-07-14
PCT/IN2008/000545 WO2010007626A1 (en) 2008-07-14 2008-08-28 A method of synthesizing a substantially monodispersed mixture of oligomers

Publications (2)

Publication Number Publication Date
BRPI0823084A2 true BRPI0823084A2 (pt) 2015-06-16
BRPI0823084B1 BRPI0823084B1 (pt) 2019-07-16

Family

ID=41550060

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0823084-6A BRPI0823084B1 (pt) 2008-07-14 2008-08-28 Método de síntese de uma mistura de oligômeros substancialmente monodispersa

Country Status (13)

Country Link
US (1) US9040723B2 (pt)
EP (1) EP2300514B1 (pt)
JP (1) JP5480257B2 (pt)
KR (1) KR101311597B1 (pt)
CN (1) CN102099397B (pt)
BR (1) BRPI0823084B1 (pt)
DK (1) DK2300514T3 (pt)
ES (1) ES2572891T3 (pt)
IL (1) IL210598A (pt)
MY (1) MY155612A (pt)
PL (1) PL2300514T3 (pt)
PT (1) PT2300514E (pt)
WO (1) WO2010007626A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013513622A (ja) 2009-12-14 2013-04-22 ユニバーシティ オブ マサチューセッツ 白内障及び老眼を阻害する方法
US8993614B2 (en) 2012-03-15 2015-03-31 F. Hoffmann-La Roche Ag Substituted pyrrolidine-2-carboxamides
US9353150B2 (en) 2012-12-04 2016-05-31 Massachusetts Institute Of Technology Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment
JP6397477B2 (ja) * 2013-03-14 2018-09-26 ザ ユニバーシティ オブ マサチューセッツＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍａｓｓａｃｈｕｓｅｔｔｓ 白内障及び老眼を阻害する方法
EP3373921B1 (en) * 2015-11-13 2019-08-28 The University of Massachusetts Bifunctional molecules containing peg for use in inhibiting cataracts and presbyopia
US10918627B2 (en) 2016-05-11 2021-02-16 Massachusetts Institute Of Technology Convergent and enantioselective total synthesis of Communesin analogs
US11932650B2 (en) 2017-05-11 2024-03-19 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
CN109179838A (zh) * 2018-10-11 2019-01-11 凯莱英生命科学技术(天津)有限公司 含三乙胺的dmf废水的处理方法
US11535634B2 (en) 2019-06-05 2022-12-27 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
US12030888B2 (en) 2021-02-24 2024-07-09 Massachusetts Institute Of Technology Himastatin derivatives, and processes of preparation thereof, and uses thereof

Family Cites Families (15)

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Publication number Priority date Publication date Assignee Title
AU575038B2 (en) * 1983-01-28 1988-07-21 Fujisawa Pharmaceutical Co., Ltd. Aminoglycoside derivatives, eg 2'n-palmitoyl-kasugamycin
US4980482A (en) * 1988-01-19 1990-12-25 The Dow Chemical Company Process for the preparation of N-maleoyl activated esters of amino acids
ES2247656T3 (es) * 1989-04-19 2006-03-01 Enzon, Inc. Un proceso para formar un polipeptido modificado que comprende un polipeptido y un oxido de polialquileno.
US5672662A (en) * 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
US6703381B1 (en) 1998-08-14 2004-03-09 Nobex Corporation Methods for delivery therapeutic compounds across the blood-brain barrier
US7060675B2 (en) * 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US6828297B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6913903B2 (en) * 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
EP1507755A4 (en) 2001-12-11 2006-05-17 Sun Bio Inc NOVEL MONOFUNCTIONAL POLYETHYLENE GLYCOL ALDEHYDES
KR20050115251A (ko) * 2003-02-28 2005-12-07 알자 코포레이션 리포좀-유도된 보체의 활성화를 감소시키기 위한 리포좀조성물
CA2521648C (en) * 2003-04-17 2012-07-03 Toyama Chemical Co., Ltd. Preventive/remedy for retinal nerve diseases containing alkyl ether derivatives or salts thereof
WO2005025498A2 (en) 2003-09-08 2005-03-24 Corus Pharma Substituted acetanilides and benzamides for the treatment of asthma and pulmonary inflammation
CA2553528C (en) * 2004-01-21 2012-12-04 Nektar Therapeutics Al, Corporation Method of preparing propionic acid-terminated polymers
CA2910494C (en) * 2004-07-19 2018-10-23 Biocon Limited Insulin-oligomer conjugates, formulations and uses thereof

Also Published As

Publication number Publication date
KR20110040916A (ko) 2011-04-20
JP2011528032A (ja) 2011-11-10
US9040723B2 (en) 2015-05-26
HK1156335A1 (zh) 2012-06-08
EP2300514A4 (en) 2012-12-12
DK2300514T3 (en) 2016-06-27
EP2300514A1 (en) 2011-03-30
EP2300514B1 (en) 2016-03-23
CN102099397A (zh) 2011-06-15
WO2010007626A1 (en) 2010-01-21
IL210598A0 (en) 2011-03-31
KR101311597B1 (ko) 2013-09-26
IL210598A (en) 2014-06-30
PT2300514E (pt) 2016-06-20
MY155612A (en) 2015-11-13
US20110118480A1 (en) 2011-05-19
PL2300514T3 (pl) 2016-09-30
ES2572891T3 (es) 2016-06-02
CN102099397B (zh) 2012-12-12
JP5480257B2 (ja) 2014-04-23
BRPI0823084B1 (pt) 2019-07-16

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08H Application fees: decision cancelled [chapter 8.8 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 NA RPI 2336 DE 13/10/2015

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

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B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 16/07/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 16/07/2019, OBSERVADAS AS CONDICOES LEGAIS

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

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B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2737 DE 20-06-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.