BRPI0812942A8 - Composto derivado de 3-amino-6 - (1-amino-etil) - tetra-hidropirano, composição farmacêutica e uso de referido composto. - Google Patents

Composto derivado de 3-amino-6 - (1-amino-etil) - tetra-hidropirano, composição farmacêutica e uso de referido composto.

Info

Publication number
BRPI0812942A8
BRPI0812942A8 BRPI0812942A BRPI0812942A BRPI0812942A8 BR PI0812942 A8 BRPI0812942 A8 BR PI0812942A8 BR PI0812942 A BRPI0812942 A BR PI0812942A BR PI0812942 A BRPI0812942 A BR PI0812942A BR PI0812942 A8 BRPI0812942 A8 BR PI0812942A8
Authority
BR
Brazil
Prior art keywords
amino
compound
ethyl
pharmaceutical composition
tetrahydropyran derivative
Prior art date
Application number
BRPI0812942A
Other languages
English (en)
Inventor
Hubschwerlen Christian
Rueedi Georg
Surivet Jean-Philippe
Zumbrunn-Acklin Cornelia
Original Assignee
Actelion Pharmaceuticals Ltd
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd, Idorsia Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of BRPI0812942A2 publication Critical patent/BRPI0812942A2/pt
Publication of BRPI0812942A8 publication Critical patent/BRPI0812942A8/pt
Publication of BRPI0812942B1 publication Critical patent/BRPI0812942B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

COMPOSTO DERIVADO DE 3-AMINO-6- (1-AMINO-ETIL)-TETRA-HIDROPIRANO, COMPOSIÇÃO FARMACÊUTICA E USO DE REFERIDO COMPOSTO. A presente invenção se refere a compostos antibacterianos da Fórmula TI: R' V U em que Ri representa halogênio ou alcóxi; cada U e W representam N, V representa CH, e Rº representa H ou F, ou cada U e V representa CH, W representa N, e Rº representa H ou EF, ou U representa N, V representa CH, W representa CH ou CRa, e R2 representa H ou também, quando W representar CH, pode representar F; Rº representa CH,0H ou alcóxi-carbonila; A representa o grupo CH=CH-B, um sistema heterocíclico binuclear D, um grupo fenila que é monossubstituído na posição 4 com alquila ou um grupo fenila que é dissubstituído nas posições 3 e 4, em que cada um dos substituintes é selecionado, independentemente, dentre alquila e halogênio, B representa um grupo fenila mono- ou dissubstituído, em que cada substituinte é um átomo de halogênio e D representa o grupo, em que Z representa CH ou N, e Q representa O ou S; e sais desses compostos.
BRPI0812942A 2007-06-15 2008-06-13 composto derivado de 3-amino-6 - (1-amino-etil) - tetra-hidropirano, composição farmacêutica e uso de referido composto. BRPI0812942B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2007052301 2007-06-15
PCT/IB2008/052333 WO2008152603A1 (en) 2007-06-15 2008-06-13 3-amino-6-(1-amino-ethyl)-tetrahydropyran derivatives

Publications (3)

Publication Number Publication Date
BRPI0812942A2 BRPI0812942A2 (pt) 2014-12-16
BRPI0812942A8 true BRPI0812942A8 (pt) 2018-05-02
BRPI0812942B1 BRPI0812942B1 (pt) 2018-11-21

Family

ID=39772866

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0812942A BRPI0812942B1 (pt) 2007-06-15 2008-06-13 composto derivado de 3-amino-6 - (1-amino-etil) - tetra-hidropirano, composição farmacêutica e uso de referido composto.

Country Status (15)

Country Link
US (1) US8193179B2 (pt)
EP (1) EP2167494B1 (pt)
JP (1) JP5274553B2 (pt)
KR (1) KR101538814B1 (pt)
CN (1) CN101711243B (pt)
AR (1) AR067008A1 (pt)
AT (1) ATE520687T1 (pt)
AU (1) AU2008263397B2 (pt)
BR (1) BRPI0812942B1 (pt)
CA (1) CA2689102C (pt)
ES (1) ES2370123T3 (pt)
MX (1) MX2009013254A (pt)
PL (1) PL2167494T3 (pt)
TW (1) TWI414290B (pt)
WO (1) WO2008152603A1 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2411930T3 (es) 2008-02-20 2013-07-09 Actelion Pharmaceuticals Ltd. Compuestos antibióticos azatricíclicos
MX2010012855A (es) 2008-06-03 2010-12-21 Actelion Pharmaceuticals Ltd Derivados de [4-(1-amino-etil)-ciclohexil]-metil-amina y [6-(1-amino-etil)-tetrahidro-piran-3-il]-metil-amina como antibacterianos.
DK2344495T3 (en) 2008-10-07 2015-02-02 Actelion Pharmaceuticals Ltd TRICYCLIC OXAZOLIDINON ANTIBIOTIC COMPOUNDS
AU2009325902B2 (en) * 2008-12-12 2015-01-29 Idorsia Pharmaceuticals Ltd 5-amino-2-(1-hydroxy-ethyl)-tetrahydropyran derivatives
AR086604A1 (es) 2011-05-31 2014-01-08 Actelion Pharmaceuticals Ltd Intermediarios sinteticos para preparar antibioticos y metodo para preparar dichos intermediarios
CA2840060A1 (en) * 2011-06-27 2013-01-03 Kyorin Pharmaceutical Co., Ltd. Bridged bicyclic compounds for the treatment of bacterial infections
CN106083787B (zh) * 2016-06-21 2018-05-04 济南川成医药科技开发有限公司 一种4-(2-氨乙基)四氢吡喃的合成方法
WO2018026877A1 (en) 2016-08-05 2018-02-08 Calitor Sciences, Llc Process for preparing substituted quinolin-4-ol compounds
TW201833120A (zh) 2017-02-17 2018-09-16 瑞士商愛杜西亞製藥有限公司 芳基噁唑啶酮抗生素化合物
CN118239937A (zh) 2017-08-09 2024-06-25 戴纳立制药公司 化合物、组合物及方法
DK3676297T3 (da) * 2017-09-01 2023-08-14 Denali Therapeutics Inc Forbindelser, sammensætninger og fremgangsmåder
US12091392B2 (en) 2019-02-13 2024-09-17 Denali Therapeutics Inc. Compounds, compositions and methods
MA54953A (fr) 2019-02-13 2021-12-22 Denali Therapeutics Inc Composés, compositions et procédés
GB201904469D0 (en) 2019-03-29 2019-05-15 Givaudan Sa Cosmetic composition

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2816618B1 (fr) 2000-11-15 2002-12-27 Aventis Pharma Sa Derives heterocyclylalcoyl piperidine, leur preparation et les compositions qui les contiennent
EP1551829B1 (de) * 2002-10-10 2010-04-07 Morphochem Aktiengesellschaft Für Kombinatorische Chemie Neue verbindungen mit antibakterieller aktivität
US20070270417A1 (en) * 2004-07-22 2007-11-22 Glaxo Group Limited Antibacterial Agents
DE102004041163A1 (de) * 2004-08-25 2006-03-02 Morphochem Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen mit antibakterieller Aktivität
JP4887297B2 (ja) * 2004-09-24 2012-02-29 アクテリオン ファーマシューティカルズ リミテッド 新規二環式抗生物質
JP5314244B2 (ja) 2004-10-27 2013-10-16 富山化学工業株式会社 新規な含窒素複素環化合物およびその塩
MX2007014507A (es) 2005-05-24 2008-02-07 Astrazeneca Ab Aminopiperidin quinolinas y sus analogos azaisostericos con actividad antibacteriana.
ATE536351T1 (de) * 2006-01-26 2011-12-15 Actelion Pharmaceuticals Ltd Tetrahydropyran-antibiotika
CA2643962A1 (en) * 2006-03-10 2007-09-20 Actelion Pharmaceuticals Ltd Antibiotic compounds

Also Published As

Publication number Publication date
RU2010101003A (ru) 2011-07-20
US8193179B2 (en) 2012-06-05
ES2370123T3 (es) 2011-12-12
TWI414290B (zh) 2013-11-11
BRPI0812942B1 (pt) 2018-11-21
AU2008263397A1 (en) 2008-12-18
ATE520687T1 (de) 2011-09-15
KR101538814B1 (ko) 2015-07-22
KR20100023031A (ko) 2010-03-03
CA2689102C (en) 2016-07-26
WO2008152603A1 (en) 2008-12-18
CA2689102A1 (en) 2008-12-18
CN101711243A (zh) 2010-05-19
CN101711243B (zh) 2013-01-09
AR067008A1 (es) 2009-09-30
JP2010529983A (ja) 2010-09-02
MX2009013254A (es) 2010-01-25
BRPI0812942A2 (pt) 2014-12-16
US20100179135A1 (en) 2010-07-15
PL2167494T3 (pl) 2012-01-31
TW200906416A (en) 2009-02-16
JP5274553B2 (ja) 2013-08-28
EP2167494B1 (en) 2011-08-17
AU2008263397B2 (en) 2013-12-05
EP2167494A1 (en) 2010-03-31

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B25A Requested transfer of rights approved

Owner name: IDORSIA PHARMACEUTICALS LTD (CH)

B25L Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: publication cancelled

Owner name: ACTELION PHARMACEUTICALS LTD (CH)

B25C Requirement related to requested transfer of rights

Owner name: ACTELION PHARMACEUTICALS LTD (CH)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B25A Requested transfer of rights approved

Owner name: IDORSIA PHARMACEUTICALS LTD (CH)

B06I Publication of requirement cancelled [chapter 6.9 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 21/11/2018, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 12A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2594 DE 24-09-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.