MA54953A - Composés, compositions et procédés - Google Patents

Composés, compositions et procédés

Info

Publication number
MA54953A
MA54953A MA054953A MA54953A MA54953A MA 54953 A MA54953 A MA 54953A MA 054953 A MA054953 A MA 054953A MA 54953 A MA54953 A MA 54953A MA 54953 A MA54953 A MA 54953A
Authority
MA
Morocco
Prior art keywords
compositions
compounds
methods
Prior art date
Application number
MA054953A
Other languages
English (en)
Inventor
Robert A Ii Craig
Vicente Fidalgo Javier De
Anthony A Estrada
Jianwen A Feng
Brian M Fox
Maksim Osipov
Arun Thottumkara
Original Assignee
Denali Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Denali Therapeutics Inc filed Critical Denali Therapeutics Inc
Publication of MA54953A publication Critical patent/MA54953A/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433Thidiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D271/00Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/101,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • C07D271/1131,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
MA054953A 2019-02-13 2020-02-12 Composés, compositions et procédés MA54953A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962805263P 2019-02-13 2019-02-13
US201962877232P 2019-07-22 2019-07-22

Publications (1)

Publication Number Publication Date
MA54953A true MA54953A (fr) 2021-12-22

Family

ID=72043948

Family Applications (1)

Application Number Title Priority Date Filing Date
MA054953A MA54953A (fr) 2019-02-13 2020-02-12 Composés, compositions et procédés

Country Status (21)

Country Link
US (2) US11306077B2 (fr)
EP (1) EP3923935A4 (fr)
JP (2) JP2022520236A (fr)
KR (1) KR20210126036A (fr)
CN (1) CN113518618A (fr)
AU (1) AU2020223228A1 (fr)
BR (1) BR112021015639A2 (fr)
CA (1) CA3129609A1 (fr)
CL (1) CL2021002104A1 (fr)
CO (1) CO2021010490A2 (fr)
CR (1) CR20210426A (fr)
IL (1) IL285302A (fr)
MA (1) MA54953A (fr)
MX (1) MX2021009669A (fr)
PE (1) PE20212023A1 (fr)
PH (1) PH12021551923A1 (fr)
SA (1) SA521430021B1 (fr)
SG (1) SG11202108552QA (fr)
TW (1) TWI877136B (fr)
WO (1) WO2020168011A1 (fr)
ZA (1) ZA202105930B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CR20200054A (es) 2017-08-09 2020-03-21 Denali Therapeutics Inc Compuestos, composiciones y métodos
HUE062446T2 (hu) 2017-09-01 2023-11-28 Denali Therapeutics Inc Vegyületek, készítmények és eljárások
AU2018383675A1 (en) 2017-12-13 2020-07-09 Altos Labs, Inc. Inhibitors of integrated stress response pathway
MX2020013269A (es) 2018-06-05 2021-02-18 Praxis Biotech LLC Inhibidores de la vía de respuesta al estrés integrada.
EP3923935A4 (fr) 2019-02-13 2022-10-26 Denali Therapeutics Inc. Composés, compositions et procédés
MX2021009667A (es) 2019-02-13 2021-12-10 Ptc Therapeutics Inc Compuestos de tioeno[3,2-b] piridin-7-amina para tratar la disautonomía familiar.
MA54959A (fr) 2019-02-13 2021-12-22 Denali Therapeutics Inc Composés, compositions et procédés
WO2020167624A1 (fr) 2019-02-13 2020-08-20 Ptc Therapeutics, Inc. Composés de pyrrolo[2,3-d] pyrimidine pour le traitement de la dysautonomie familiale
CN114466654A (zh) 2019-06-12 2022-05-10 普拉西斯生物技术有限责任公司 整合应激反应通路调节剂
CA3165813A1 (fr) 2020-03-11 2021-09-16 Holly Victoria Atton Modulateurs de la voie de reponse au stress integree
CN116761803A (zh) * 2020-10-22 2023-09-15 埃沃特克国际有限责任公司 整合应激反应途径的调节剂
MX2023004626A (es) 2020-10-22 2023-05-23 Evotec Int Gmbh Moduladores de la via de respuesta integrada al estres.
KR20230110509A (ko) 2020-10-22 2023-07-24 에보텍 인터내셔널 게엠베하 통합 스트레스 반응 경로의 조절제
AU2021363616B2 (en) * 2020-10-22 2026-03-26 Evotec International Gmbh Modulators of the integrated stress response pathway
US20240059662A1 (en) * 2020-12-18 2024-02-22 Denali Therapeutics Inc. Solid forms of a compound
LU102921B1 (en) 2022-03-25 2023-09-26 Stratec Se Consumable for sample processing in automated analyser
JP2025526814A (ja) * 2022-08-08 2025-08-15 シェンチェン チョンゲ バイオロジカル テクノロジー カンパニー リミテッド 化合物、それを含む医薬組成物及びその用途
WO2024185688A1 (fr) 2023-03-03 2024-09-12 ダイキン工業株式会社 Polymère fluoré
EP4516773A4 (fr) 2023-03-03 2025-10-29 Daikin Ind Ltd Composé contenant du fluor
CN120835908A (zh) 2023-03-03 2025-10-24 大金工业株式会社 含氟化合物
WO2025019827A1 (fr) * 2023-07-20 2025-01-23 Denali Therapeutics Inc. Formulation, forme posologique solide et méthodes

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6429207B1 (en) 1997-11-21 2002-08-06 Nps Pharmaceuticals, Inc. Metabotropic glutamate receptor antagonists and their use for treating central nervous system diseases
AU762345B2 (en) 1998-10-16 2003-06-26 Asubio Pharma Co., Ltd. Aminophenoxyacetic acid derivatives as neuroprotectants
AR024077A1 (es) 1999-05-25 2002-09-04 Smithkline Beecham Corp Compuestos antibacterianos
US20010047100A1 (en) * 2000-04-26 2001-11-29 Kjaersgaard Hans Joergen Chiral imidazoyl intermediates for the synthesis of 2-(4-imidazoyl)-cyclopropyl derivatives
US7259157B2 (en) * 2001-04-03 2007-08-21 Merck & Co., Inc. N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists
JO2397B1 (en) 2002-12-20 2007-06-17 ميرك شارب اند دوم كوربوريشن Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors
WO2006028904A1 (fr) 2004-09-02 2006-03-16 Vertex Pharmaceuticals Incorporated Quinazolines utiles en tant que modulateurs de canaux ioniques
WO2006125974A1 (fr) 2005-05-24 2006-11-30 Astrazeneca Ab Quinoleines d’aminopiperidine et leurs analogues azaisosteriques presentant une activite antibacterienne
DK1966130T3 (da) * 2005-12-23 2014-02-10 Zealand Pharma As Modificerede lysin-mimetiske forbindelser
MX2009004089A (es) 2006-10-20 2009-07-10 Arete Therapeutics Inc Inhibidores de epoxido hidrolasa soluble.
CN101711243B (zh) 2007-06-15 2013-01-09 埃科特莱茵药品有限公司 3-氨基-6-(1-氨基-乙基)-四氢吡喃衍生物
CN102232078B (zh) 2008-12-12 2014-07-16 埃科特莱茵药品有限公司 5-氨基-2-(1-羟基-乙基)-四氢吡喃衍生物
US9421211B2 (en) 2009-05-28 2016-08-23 President And Fellows Of Harvard College N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation
DK2442809T3 (en) 2009-06-17 2016-12-19 Vertex Pharma Inhibitors of the replication of influenza virus
AR084457A1 (es) 2010-12-22 2013-05-15 Lundbeck & Co As H Derivados de biciclo[3,2,1]octilamida
WO2012113774A1 (fr) 2011-02-24 2012-08-30 Nerviano Medical Sciences S.R.L. Dérivés de thiazolylphényl-benzènesulfonamido en tant qu'inhibiteurs de la kinase
DK2684880T3 (en) 2011-03-10 2018-05-22 Daiichi Sankyo Co Ltd DISPIROPYRROLIDINE DERIVATIVES
HRP20240097T1 (hr) 2011-04-22 2024-03-29 Signal Pharmaceuticals, Llc Supstituirani diaminokarboksamid i diaminokarbonitril pirimidini, njihovi pripravci i postupci liječenja s njima
WO2013120940A2 (fr) * 2012-02-14 2013-08-22 Syngenta Participations Ag Nouveaux composés
JPWO2014054635A1 (ja) 2012-10-02 2016-08-25 大日本住友製薬株式会社 イミダゾール誘導体
US9447025B2 (en) 2013-03-14 2016-09-20 Kalyra Pharmaceuticals, Inc. Bicyclic analgesic compounds
JP6806562B2 (ja) 2013-03-15 2021-01-06 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア eIF2α経路の調節因子
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US20160318856A1 (en) 2013-09-11 2016-11-03 The Brigham And Women's Hospital, Inc. Substituted Urea eIF2alpha Kinase Activators
RU2016141934A (ru) 2014-04-04 2018-05-07 Сирос Фармасьютикалз, Инк. Ингибиторы циклин-зависимой киназы 7 (cdk7)
CN106999451B (zh) 2014-09-17 2021-04-02 里科瑞尔姆Ip控股有限责任公司 双环化合物
ES2772133T3 (es) 2014-11-20 2020-07-07 Merck Patent Gmbh Compuestos heteroarilo como inhibidores de IRAK y sus usos
EP3623371A1 (fr) 2014-12-16 2020-03-18 Axovant Sciences GmbH Composés amide de quinuclidine à substituants géminal en tant qu'agonistes des récepteurs nicotiniques de l'acétylcholine 7
EA201791896A1 (ru) 2015-02-25 2018-02-28 Уильям Марш Райс Юниверсити Дезацетокситубулизин н и его аналоги
GB201506894D0 (en) * 2015-04-23 2015-06-10 Galapagos Nv Novel dihydropyridoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders
MX2017014222A (es) 2015-05-05 2018-08-15 Bayer Pharma AG Derivados de ciclohexano sustituido con amido.
TW201718557A (zh) 2015-10-08 2017-06-01 歌林達有限公司 經吡唑基取代之四氫吡喃基碸
TW201808888A (zh) 2016-05-05 2018-03-16 嘉來克生命科學有限責任公司 整合應激途徑之調節劑
TW201808903A (zh) 2016-05-05 2018-03-16 嘉來克生命科學有限責任公司 整合應激途徑之調節劑
TW201808914A (zh) 2016-05-05 2018-03-16 嘉來克生命科學有限責任公司 整合應激途徑之調節劑
TWI763668B (zh) * 2016-05-05 2022-05-11 美商嘉來克生命科學有限責任公司 整合應激途徑之調節劑
KR20190015492A (ko) * 2016-06-08 2019-02-13 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 화학적 화합물
KR20190015748A (ko) 2016-06-08 2019-02-14 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 Atf4 경로 억제제로서의 화학적 화합물
BR112019000201A2 (pt) 2016-07-06 2019-07-09 Acquist Llc compostos e seu uso na redução dos níveis de ácido úrico
JOP20190072A1 (ar) 2016-10-13 2019-04-07 Glaxosmithkline Ip Dev Ltd مشتقات 1، 3 سيكلوبوتان ثنائي الاستبدال أو آزيتيدين كمثبطات للإنزيم المخلق للبروستاجلاندين d المكون للدم
BR112019011801A2 (pt) 2016-12-08 2019-10-29 Univ Texas composto, composição farmacêutica e método de inibição de dlk, método de tratamento de uma doença mediada por dlk, método de tratamento de câncer e redução do desenvolvimento de um distúrbio neurológico induzido por quimioterapia e método para alcançar um efeito em um paciente
WO2018225093A1 (fr) 2017-06-07 2018-12-13 Glaxosmithkline Intellectual Property Development Limited Composés chimiques utilisés comme inhibiteurs de la voie atf4
EP3634958B1 (fr) * 2017-06-09 2021-07-21 Bristol-Myers Squibb Company Agonistes du récepteur 2 du peptide formylé et agonistes du récepteur 1 du peptide formylé à base de cyclopropyle d'urée
CA3068395A1 (fr) 2017-07-03 2019-01-10 Glaxosmithkline Intellectual Property Development Limited Derives de 2-(4-chlorophenoxy)-n-((1-(2-(4-chlorophenoxy)ethynazetidine-3-yl)methyl)acetamide et composes apparentes servant d'inhibiteurs d'atf4 pour le traitement du cancer et d'autres maladies
CA3068753A1 (fr) * 2017-07-03 2019-01-10 Glaxosmithkline Intellectual Property Development Limited Derives de n-(3-(2-(4-chlorophenoxy)acetamido)bicyclo[1.1.1]pentan-1-yl)-2-cyclobutane-1-carboxamide et composes apparentes en tant qu'inhibiteurs atf4 pour le traitement du canceret d'autres maladies
CR20200054A (es) * 2017-08-09 2020-03-21 Denali Therapeutics Inc Compuestos, composiciones y métodos
HUE062446T2 (hu) 2017-09-01 2023-11-28 Denali Therapeutics Inc Vegyületek, készítmények és eljárások
WO2019054430A1 (fr) 2017-09-14 2019-03-21 第一三共株式会社 Composé amide ayant un hétérocycle aromatique
UY37956A (es) 2017-11-02 2019-05-31 Abbvie Inc Moduladores de la vía de estrés integrada
EP3704089B1 (fr) 2017-11-02 2023-07-19 Calico Life Sciences LLC Modulateurs de la voie de réponse intégrée au stress
AU2018358157B2 (en) 2017-11-02 2023-03-09 Abbvie Inc. Modulators of the integrated stress pathway
JP2021501785A (ja) 2017-11-02 2021-01-21 カリコ ライフ サイエンシーズ エルエルシー 統合的ストレス経路の調節剤
UY37958A (es) 2017-11-02 2019-05-31 Abbvie Inc Moduladores de la vía de estrés integrada
SG11202004009TA (en) 2017-11-02 2020-05-28 Calico Life Sciences Llc Modulators of the integrated stress pathway
UY37957A (es) 2017-11-02 2019-05-31 Abbvie Inc Moduladores de la vía de estrés integrada
WO2019090078A1 (fr) 2017-11-02 2019-05-09 Calico Life Sciences Llc Modulateurs de la voie de réponse intégrée au stress
CA3080948A1 (fr) 2017-11-02 2019-05-09 Calico Life Sciences Llc Modulateurs de la voie de reponse integree au stress
AU2018383675A1 (en) 2017-12-13 2020-07-09 Altos Labs, Inc. Inhibitors of integrated stress response pathway
EP3768660A1 (fr) 2018-03-23 2021-01-27 Denali Therapeutics Inc. Modulateurs du facteur 2 d'initiation eucaryote
WO2019193541A1 (fr) 2018-04-06 2019-10-10 Glaxosmithkline Intellectual Property Development Limited Dérivés de cycle aromatiques bicycliques de formule (i) utilisés en tant qu'inhibiteurs d'atf4
WO2019193540A1 (fr) 2018-04-06 2019-10-10 Glaxosmithkline Intellectual Property Development Limited Dérivés hétéroaryles de formule (i) utilisés en tant qu'inhibiteurs d'atf4
EP3820843A1 (fr) 2018-07-09 2021-05-19 GlaxoSmithKline Intellectual Property Development Limited Composés chimiques
WO2020031107A1 (fr) 2018-08-08 2020-02-13 Glaxosmithkline Intellectual Property Development Limited Composés chimiques
TWI771621B (zh) 2018-10-11 2022-07-21 美商嘉來克生命科學有限責任公司 整合應激路徑之前藥調節劑
EP3923935A4 (fr) * 2019-02-13 2022-10-26 Denali Therapeutics Inc. Composés, compositions et procédés
MA54959A (fr) 2019-02-13 2021-12-22 Denali Therapeutics Inc Composés, compositions et procédés
WO2020181247A1 (fr) 2019-03-06 2020-09-10 Denali Therapeutics Inc. Composés, compositions et procédés
IL287379B2 (en) * 2019-04-23 2025-11-01 Evotec Int Gmbh Modulators of the integrated stress response pathway
EP3962899A1 (fr) 2019-04-30 2022-03-09 Calico Life Sciences LLC Cyclolalkyles substitués en tant que modulateurs de la voie de stress intégrée
PE20220572A1 (es) 2019-04-30 2022-04-20 Calico Life Sciences Llc Moduladores de la via integrada del estres
EP4096665A1 (fr) * 2020-01-28 2022-12-07 Evotec International GmbH Modulateurs de la voie de réponse au stress intégrée
US20240059662A1 (en) 2020-12-18 2024-02-22 Denali Therapeutics Inc. Solid forms of a compound

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JP2024166311A (ja) 2024-11-28
CA3129609A1 (fr) 2020-08-20
US11958840B2 (en) 2024-04-16
PE20212023A1 (es) 2021-10-18
CO2021010490A2 (es) 2021-08-30
US20210292311A1 (en) 2021-09-23
TWI877136B (zh) 2025-03-21
US11306077B2 (en) 2022-04-19
US20230114472A1 (en) 2023-04-13
AU2020223228A1 (en) 2021-08-26
JP2022520236A (ja) 2022-03-29
CL2021002104A1 (es) 2022-04-08
ZA202105930B (en) 2025-03-26
CR20210426A (es) 2021-09-30
EP3923935A1 (fr) 2021-12-22
PH12021551923A1 (en) 2022-08-01
IL285302A (en) 2021-09-30
SA521430021B1 (ar) 2024-08-11
SG11202108552QA (en) 2021-09-29
MX2021009669A (es) 2021-10-13
CN113518618A (zh) 2021-10-19
EP3923935A4 (fr) 2022-10-26
BR112021015639A2 (pt) 2021-10-05

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