BRPI0815057A2 - Composto, composição farmacêutica, e, método para tratar infecção. - Google Patents

Composto, composição farmacêutica, e, método para tratar infecção.

Info

Publication number
BRPI0815057A2
BRPI0815057A2 BRPI0815057-5A BRPI0815057A BRPI0815057A2 BR PI0815057 A2 BRPI0815057 A2 BR PI0815057A2 BR PI0815057 A BRPI0815057 A BR PI0815057A BR PI0815057 A2 BRPI0815057 A2 BR PI0815057A2
Authority
BR
Brazil
Prior art keywords
compound
pharmaceutical composition
treating infection
infection
treating
Prior art date
Application number
BRPI0815057-5A
Other languages
English (en)
Inventor
J Edward Semple
Jean-François Rossignol
Original Assignee
Romark Lab Lc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39791394&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0815057(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Romark Lab Lc filed Critical Romark Lab Lc
Publication of BRPI0815057A2 publication Critical patent/BRPI0815057A2/pt
Publication of BRPI0815057B1 publication Critical patent/BRPI0815057B1/pt
Publication of BRPI0815057B8 publication Critical patent/BRPI0815057B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
BRPI0815057A 2007-08-03 2008-08-01 composto, composição farmacêutica, e, uso de um composto BRPI0815057B8 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US95375807P 2007-08-03 2007-08-03
US60/953758 2007-08-03
US4695608P 2008-04-22 2008-04-22
US5636908P 2008-05-27 2008-05-27
US61/056369 2008-05-27
PCT/US2008/071990 WO2009035788A1 (en) 2007-08-03 2008-08-01 Alkylsulfonyl-substituted thiazolide compounds
US61/046956 2009-04-22

Publications (3)

Publication Number Publication Date
BRPI0815057A2 true BRPI0815057A2 (pt) 2015-07-28
BRPI0815057B1 BRPI0815057B1 (pt) 2020-11-10
BRPI0815057B8 BRPI0815057B8 (pt) 2021-05-25

Family

ID=39791394

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0815057A BRPI0815057B8 (pt) 2007-08-03 2008-08-01 composto, composição farmacêutica, e, uso de um composto

Country Status (15)

Country Link
US (2) US8124632B2 (pt)
EP (1) EP2178852B9 (pt)
JP (1) JP5676258B2 (pt)
CN (1) CN101835765B (pt)
AR (1) AR068334A1 (pt)
AU (1) AU2008299781B2 (pt)
BR (1) BRPI0815057B8 (pt)
CA (1) CA2695517C (pt)
CL (1) CL2008002295A1 (pt)
EA (1) EA019357B1 (pt)
ES (1) ES2550755T3 (pt)
MX (1) MX2010001358A (pt)
PT (1) PT2178852E (pt)
TW (1) TWI453018B (pt)
WO (1) WO2009035788A1 (pt)

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BRPI1007945C8 (pt) 2009-02-13 2021-05-25 Romark Laboratories Lc formulação farmacêutica de liberação controlada de nitazoxanida, tizoxanida ou uma combinação dos mesmos, e, comprimido de bicamada para administração oral
EP2408770B1 (en) 2009-03-20 2014-11-05 University Of Virginia Patent Foundation Broad spectrum benzothiophene-nitrothiazolide and other antimicrobials
EP2411007A4 (en) * 2009-03-27 2012-12-05 Uab Research Foundation MODULATION OF IRES-MEDIATED TRANSLATION
EP3078377A3 (en) * 2009-05-12 2017-04-05 Romark Laboratories, L.C. Nitazoxanide and tizoxanide as anti-viral agents
MX341877B (es) 2009-06-26 2016-09-06 Romark Laboratories L C * Compuestos y métodos para tratar influenza.
WO2012040170A2 (en) 2010-09-20 2012-03-29 University Of Virginia Patent Foundation Compositions and methods for treating tuberculosis
MX2013004724A (es) 2010-11-01 2013-08-29 Romark Lab Lc Compuestos de tiazolida alquilsulfinilo-sustituidos.
CN107105660A (zh) * 2014-11-11 2017-08-29 罗马克实验室有限公司 使用替唑尼特、其类似物或盐的前药的治疗组合物和治疗方法
JP6818690B2 (ja) 2014-12-01 2021-01-20 シンジェンタ パーティシペーションズ アーゲー 硫黄含有置換基を有する殺有害生物的に活性なアミド複素環式誘導体
CN105777808B (zh) * 2014-12-23 2018-11-09 中国人民解放军军事医学科学院毒物药物研究所 替唑尼特磷酸酯和烷基磺酸酯及其在药学中的应用
HK1250945A1 (zh) 2016-03-31 2019-01-18 罗马克实验室有限公司 用於治疗病毒性感染的噻唑化物化合物
PT3442580T (pt) 2016-04-11 2020-12-23 Genfit Métodos de tratamento para doenças colestáticas e fibróticas
CN106565626B (zh) * 2016-10-10 2022-06-10 淮海工学院 2-氨基-4-芳基-5-甲硫基噻唑类化合物的合成方法
CN108610301B (zh) * 2016-12-12 2021-08-31 中山大学 一类手性芳杂胺类衍生物及其合成方法和应用
WO2018107332A1 (zh) * 2016-12-12 2018-06-21 中山大学 一类手性芳杂胺类衍生物及其合成方法和应用
WO2018195035A1 (en) 2017-04-18 2018-10-25 Romark Laboratories L.C. Inhibition of protein disulfide-isomerase a3
WO2019241376A1 (en) 2018-06-14 2019-12-19 The Trustees Of Columbia University In The City Of New York Treatment of cognitive disorders using nitazoxanide (ntz), nitazoxanide (ntz) analogs, and metabolites thereof
WO2020221074A1 (zh) * 2019-04-30 2020-11-05 南京海璞医药科技有限公司 一种含稠环的化合物、其应用及含其的药物组合物
CN112480104B (zh) * 2019-09-11 2024-06-18 绍兴君科臻元医药科技有限公司 硝唑尼特衍生物及其医药用途
WO2021151104A1 (en) * 2020-01-26 2021-07-29 The Board Of Regents Of The University Of Texas System Salicylamide derivatives and related methods of making
EP4182304A1 (en) 2020-07-20 2023-05-24 Romark Laboratories, L.C. Crystalline salts of tizoxanide and 2-hydroxy-n-(5-chloro-1,3-thiazol-2-yl)benzamide (rm-4848) with ethanolamine, morpholine, propanolamine, piperazine and n-methylpiperazine
AU2021333566A1 (en) 2020-08-24 2023-03-16 Romark Laboratories L.C. Use of thiazolides against coronaviruses
US12274700B1 (en) 2020-10-30 2025-04-15 Accencio LLC Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors
WO2023111996A1 (en) 2021-12-17 2023-06-22 Reglagene Holding, Inc. Compositions and methods of making and using small molecules in the treatment of cancer
US12215102B2 (en) 2023-02-28 2025-02-04 Reglagene, Inc. Compositions and methods for making and using small molecules for tubulin-targeted therapy in the treatment of cancers and related conditions

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Also Published As

Publication number Publication date
CA2695517A1 (en) 2009-03-19
EA019357B1 (ru) 2014-03-31
EA201070182A1 (ru) 2010-10-29
BRPI0815057B8 (pt) 2021-05-25
BRPI0815057B1 (pt) 2020-11-10
HK1147094A1 (en) 2011-07-29
WO2009035788A1 (en) 2009-03-19
JP2010535712A (ja) 2010-11-25
CN101835765A (zh) 2010-09-15
AU2008299781A1 (en) 2009-03-19
AR068334A1 (es) 2009-11-11
US8124632B2 (en) 2012-02-28
CN101835765B (zh) 2013-05-29
MX2010001358A (es) 2010-04-09
JP5676258B2 (ja) 2015-02-25
EP2178852A1 (en) 2010-04-28
AU2008299781B2 (en) 2013-11-14
PT2178852E (pt) 2015-11-12
TWI453018B (zh) 2014-09-21
TW200911239A (en) 2009-03-16
US20090036467A1 (en) 2009-02-05
EP2178852B1 (en) 2015-07-22
CA2695517C (en) 2016-09-20
CL2008002295A1 (es) 2009-03-27
ES2550755T3 (es) 2015-11-12
US20120122939A1 (en) 2012-05-17
US8895752B2 (en) 2014-11-25
EP2178852B9 (en) 2016-06-22

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
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