BRPI0814220A2 - Purificação de fator viii usando uma resina multimodal ou de modo misto - Google Patents

Purificação de fator viii usando uma resina multimodal ou de modo misto

Info

Publication number
BRPI0814220A2
BRPI0814220A2 BRPI0814220-3A2A BRPI0814220A BRPI0814220A2 BR PI0814220 A2 BRPI0814220 A2 BR PI0814220A2 BR PI0814220 A BRPI0814220 A BR PI0814220A BR PI0814220 A2 BRPI0814220 A2 BR PI0814220A2
Authority
BR
Brazil
Prior art keywords
multimodal
mixture resin
recombinant
viii
factor purification
Prior art date
Application number
BRPI0814220-3A2A
Other languages
English (en)
Inventor
Susanne Bang
Lars Thim
Johan Karlsson
Original Assignee
Novon Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novon Nordisk As filed Critical Novon Nordisk As
Publication of BRPI0814220A2 publication Critical patent/BRPI0814220A2/pt
Publication of BRPI0814220B1 publication Critical patent/BRPI0814220B1/pt
Publication of BRPI0814220B8 publication Critical patent/BRPI0814220B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
BRPI0814220A 2007-07-11 2008-07-11 purificação de fator viii usando uma resina multimodal ou de modo misto BRPI0814220B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07112287 2007-07-11
EP07112287.3 2007-07-11
PCT/EP2008/059094 WO2009007451A1 (en) 2007-07-11 2008-07-11 Purification of factor viii using a mixed-mode or multimodal resin

Publications (3)

Publication Number Publication Date
BRPI0814220A2 true BRPI0814220A2 (pt) 2015-01-06
BRPI0814220B1 BRPI0814220B1 (pt) 2019-09-17
BRPI0814220B8 BRPI0814220B8 (pt) 2021-05-25

Family

ID=38472947

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0814220A BRPI0814220B8 (pt) 2007-07-11 2008-07-11 purificação de fator viii usando uma resina multimodal ou de modo misto

Country Status (15)

Country Link
US (1) US8399620B2 (pt)
EP (1) EP2167526B1 (pt)
JP (1) JP5323072B2 (pt)
KR (1) KR101293504B1 (pt)
CN (1) CN101730707B (pt)
AT (1) ATE503763T1 (pt)
AU (1) AU2008274195B2 (pt)
BR (1) BRPI0814220B8 (pt)
CA (1) CA2692814A1 (pt)
DE (1) DE602008005885D1 (pt)
ES (1) ES2364118T3 (pt)
NL (1) NL300663I2 (pt)
PL (1) PL2167526T3 (pt)
RU (1) RU2493163C2 (pt)
WO (1) WO2009007451A1 (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2300497B1 (en) 2008-06-24 2012-08-08 Octapharma AG A process of purifying coagulation factor viii
MX2011001624A (es) 2008-08-21 2011-03-28 Octapharma Ag Factor viii y ix humano producido en forma recombinante.
US8945895B2 (en) 2009-07-31 2015-02-03 Baxter International Inc. Methods of purifying recombinant ADAMTS13 and other proteins and compositions thereof
US8277649B2 (en) 2009-12-14 2012-10-02 General Electric Company Membranes and associated methods for purification of antibodies
EP2538968B1 (en) 2010-02-24 2017-11-01 Chiesi Farmaceutici S.p.A. Process for production and purification of recombinant lysosomal alpha-mannosidase
RU2590726C2 (ru) 2010-03-30 2016-07-10 Октафарма Аг Способ очистки витамин к-зависимых белков, таких как коагуляционный фактор ix
DK2552948T3 (en) 2010-03-30 2016-10-17 Octapharma Ag A process for the purification of the protein growth factor G-CSF
KR101593766B1 (ko) * 2010-11-05 2016-02-15 에프. 호프만-라 로슈 아게 혼합식 크로마토그래피에 의한 최적화된 항체 포획 방법
AU2011343813B2 (en) 2010-12-15 2015-05-21 Takeda Pharmaceutical Company Limited Eluate collection using conductivity gradient
WO2013075740A1 (en) 2011-11-23 2013-05-30 Sanofi Antibody purification method
DK2911759T3 (da) 2012-10-24 2024-09-16 Genzyme Corp Eluering af biomolekyler fra multimodale harpikser under anvendelse af mes og mops som modifikatorer af den mobile fase
US10188965B2 (en) 2012-12-05 2019-01-29 Csl Behring Gmbh Hydrophobic charge induction chromatographic depletion of a protein from a solution
US20140154233A1 (en) 2012-12-05 2014-06-05 Csl Limited Method of purifying therapeutic proteins
CN103396494B (zh) * 2013-04-27 2015-04-01 江苏省疾病预防控制中心 一种凝血因子ix的单克隆抗体
ES2665645T3 (es) 2013-05-06 2018-04-26 Sanofi Proceso multietapa continuo para purificar anticuerpos
KR20170026521A (ko) * 2014-06-25 2017-03-08 제이에이치엘 바이오테크 인코포레이티드 단백질의 정제를 위한 방법 및 시약
NZ729629A (en) 2014-08-04 2021-12-24 Csl Ltd Factor viii formulation
KR20170125941A (ko) 2015-03-06 2017-11-15 체에스엘 베링 리컴비넌트 퍼실리티 아게 개선된 반감기를 갖는 변형된 폰 빌레브란트 인자
GB201506113D0 (en) * 2015-04-10 2015-05-27 Ge Healthcare Bio Sciences Ab Method for chromatography
GB201506117D0 (en) 2015-04-10 2015-05-27 Ge Healthcare Bio Sciences Ab Method for chromatography
EP3205665A1 (en) * 2016-02-11 2017-08-16 Octapharma AG Method of separating factor viii from blood products
GB201617240D0 (en) * 2016-10-11 2016-11-23 Profactor Pharma Ltd Purification process
US11299533B2 (en) 2017-06-23 2022-04-12 Takeda Pharmaceutical Company Limited Purification of factor VIII subspecies
EP3546475A1 (en) 2018-03-27 2019-10-02 Sanofi Full flow-through process for purifying recombinant proteins
KR20220029733A (ko) 2019-07-04 2022-03-08 체에스엘 베링 렝나우 아게 응고 인자 viii의 시험관내 안정성을 증가시키기 위한 절단된 폰 빌레브란트 인자 (vwf)
WO2021094344A1 (en) 2019-11-11 2021-05-20 CSL Behring Lengnau AG Polypeptides for inducing tolerance to factor viii

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9302006D0 (sv) * 1992-10-02 1993-06-11 Kabi Pharmacia Ab Protein formulation
SE9301581D0 (sv) * 1993-05-07 1993-05-07 Kabi Pharmacia Ab Protein formulation
SE503424C2 (sv) * 1994-11-14 1996-06-10 Pharmacia Ab Process för rening av rekombinant koagulationsfaktor VIII
IL157309A0 (en) * 2003-08-07 2004-02-19 Applied Research Systems Method for the purification of a non-immunoglobulin protein
CN101098883B (zh) * 2004-12-23 2013-01-23 诺和诺德医疗保健公司 减少含有目的维生素k依赖性蛋白质的组合物中的蛋白质污染物的含量
EP1707634A1 (en) * 2005-03-29 2006-10-04 Octapharma AG Method for isolation of recombinantly produced proteins
EP2300497B1 (en) 2008-06-24 2012-08-08 Octapharma AG A process of purifying coagulation factor viii

Also Published As

Publication number Publication date
BRPI0814220B1 (pt) 2019-09-17
DE602008005885D1 (de) 2011-05-12
PL2167526T3 (pl) 2011-09-30
JP2010533150A (ja) 2010-10-21
NL300663I2 (pt) 2016-09-22
AU2008274195B2 (en) 2013-09-05
ES2364118T9 (es) 2014-05-19
CN101730707B (zh) 2014-12-17
WO2009007451A1 (en) 2009-01-15
CN101730707A (zh) 2010-06-09
ATE503763T1 (de) 2011-04-15
EP2167526A1 (en) 2010-03-31
US20100204452A1 (en) 2010-08-12
RU2493163C2 (ru) 2013-09-20
KR101293504B1 (ko) 2013-08-07
KR20100051620A (ko) 2010-05-17
BRPI0814220B8 (pt) 2021-05-25
JP5323072B2 (ja) 2013-10-23
CA2692814A1 (en) 2009-01-15
RU2010103528A (ru) 2011-08-20
US8399620B2 (en) 2013-03-19
AU2008274195A1 (en) 2009-01-15
ES2364118T3 (es) 2011-08-25
EP2167526B1 (en) 2011-03-30

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Legal Events

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

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B09A Decision: intention to grant [chapter 9.1 patent gazette]
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B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

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B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2678 DE 03-05-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.