BRPI0814220B8 - purificação de fator viii usando uma resina multimodal ou de modo misto - Google Patents
purificação de fator viii usando uma resina multimodal ou de modo mistoInfo
- Publication number
- BRPI0814220B8 BRPI0814220B8 BRPI0814220A BRPI0814220A BRPI0814220B8 BR PI0814220 B8 BRPI0814220 B8 BR PI0814220B8 BR PI0814220 A BRPI0814220 A BR PI0814220A BR PI0814220 A BRPI0814220 A BR PI0814220A BR PI0814220 B8 BRPI0814220 B8 BR PI0814220B8
- Authority
- BR
- Brazil
- Prior art keywords
- multimodal
- mixed
- mode resin
- factor viii
- purification
- Prior art date
Links
- 238000000746 purification Methods 0.000 title abstract 3
- 239000011347 resin Substances 0.000 title abstract 3
- 229920005989 resin Polymers 0.000 title abstract 3
- 102000001690 Factor VIII Human genes 0.000 title abstract 2
- 108010054218 Factor VIII Proteins 0.000 title abstract 2
- 229960000301 factor viii Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 3
- 102000015081 Blood Coagulation Factors Human genes 0.000 abstract 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 abstract 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 239000003114 blood coagulation factor Substances 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
purificação de fator vlll usando uma resina multimodal ou de modo misto. a presente invenção refere-se a um método para purificação de uma proteína recombinante usando uma resina multimodal ou de modo misto contendo iigantes que incluem uma parte hidrofóbica e uma parte negativamente carregada é descrito. a invenção é vantajosa por ser um processo cromatográfico de etapa única que não requer ajuste de ph ou de condutividade durante a etapa de carregamento e resulta em um alto rendimento e potência. o processo é usado para a purificação de composições recombinantes de fator de coagulação, particularmente fator vlll recombinante.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07112287.3 | 2007-07-11 | ||
| EP07112287 | 2007-07-11 | ||
| PCT/EP2008/059094 WO2009007451A1 (en) | 2007-07-11 | 2008-07-11 | Purification of factor viii using a mixed-mode or multimodal resin |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0814220A2 BRPI0814220A2 (pt) | 2015-01-06 |
| BRPI0814220B1 BRPI0814220B1 (pt) | 2019-09-17 |
| BRPI0814220B8 true BRPI0814220B8 (pt) | 2021-05-25 |
Family
ID=38472947
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0814220A BRPI0814220B8 (pt) | 2007-07-11 | 2008-07-11 | purificação de fator viii usando uma resina multimodal ou de modo misto |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8399620B2 (pt) |
| EP (1) | EP2167526B1 (pt) |
| JP (1) | JP5323072B2 (pt) |
| KR (1) | KR101293504B1 (pt) |
| CN (1) | CN101730707B (pt) |
| AT (1) | ATE503763T1 (pt) |
| AU (1) | AU2008274195B2 (pt) |
| BR (1) | BRPI0814220B8 (pt) |
| CA (1) | CA2692814A1 (pt) |
| DE (1) | DE602008005885D1 (pt) |
| ES (1) | ES2364118T3 (pt) |
| NL (1) | NL300663I2 (pt) |
| PL (1) | PL2167526T3 (pt) |
| RU (1) | RU2493163C2 (pt) |
| WO (1) | WO2009007451A1 (pt) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8329871B2 (en) * | 2008-06-24 | 2012-12-11 | Octapharma Ag | Process of purifying coagulation factor VIII |
| WO2010020690A1 (en) | 2008-08-21 | 2010-02-25 | Octapharma Ag | Recombinantly produced human factor viii and ix |
| US8945895B2 (en) | 2009-07-31 | 2015-02-03 | Baxter International Inc. | Methods of purifying recombinant ADAMTS13 and other proteins and compositions thereof |
| US8277649B2 (en) | 2009-12-14 | 2012-10-02 | General Electric Company | Membranes and associated methods for purification of antibodies |
| CA2790786C (en) * | 2010-02-24 | 2019-09-24 | Zymenex A/S | Process for production and purification of recombinant lysosomal alpha-mannosidase |
| EP2552948B1 (en) | 2010-03-30 | 2016-07-13 | Octapharma AG | Process for the purification of growth factor protein g-csf |
| CN102858971B (zh) | 2010-03-30 | 2016-06-01 | 奥克塔法马股份有限公司 | 纯化维生素k依赖性蛋白如凝血因子ix的方法 |
| WO2012059495A1 (en) * | 2010-11-05 | 2012-05-10 | F. Hoffmann-La Roche Ag | Optimized method for antibody capturing by mixed mode chromatography |
| EP2652491B1 (en) | 2010-12-15 | 2017-11-29 | Baxalta GmbH | Eluate collection using conductivity gradient |
| WO2013075740A1 (en) | 2011-11-23 | 2013-05-30 | Sanofi | Antibody purification method |
| MX379269B (es) | 2012-10-24 | 2025-03-11 | Genzyme Corp | Elucion de biomoleculas de resinas multimodales utilizando mes y mops como modificadores de fase movil. |
| US10188965B2 (en) | 2012-12-05 | 2019-01-29 | Csl Behring Gmbh | Hydrophobic charge induction chromatographic depletion of a protein from a solution |
| US20140154233A1 (en) | 2012-12-05 | 2014-06-05 | Csl Limited | Method of purifying therapeutic proteins |
| CN103396494B (zh) * | 2013-04-27 | 2015-04-01 | 江苏省疾病预防控制中心 | 一种凝血因子ix的单克隆抗体 |
| DK2994485T3 (en) | 2013-05-06 | 2018-04-23 | Sanofi Sa | CONTINUOUS MULTIPLE STEP PROCEDURE FOR PURIFICATION OF ANTIBODIES |
| CA2951408A1 (en) * | 2014-06-25 | 2015-12-30 | Jhl Biotech, Inc. | Methods and reagents for purification of proteins |
| JP6516829B2 (ja) | 2014-08-04 | 2019-05-22 | シーエスエル、リミテッド | 第ｖｉｉｉ因子製剤 |
| SG11201706659WA (en) | 2015-03-06 | 2017-09-28 | Csl Behring Recombinant Facility Ag | Modified von willebrand factor having improved half-life |
| GB201506113D0 (en) * | 2015-04-10 | 2015-05-27 | Ge Healthcare Bio Sciences Ab | Method for chromatography |
| GB201506117D0 (en) | 2015-04-10 | 2015-05-27 | Ge Healthcare Bio Sciences Ab | Method for chromatography |
| EP3205665A1 (en) * | 2016-02-11 | 2017-08-16 | Octapharma AG | Method of separating factor viii from blood products |
| GB201617240D0 (en) * | 2016-10-11 | 2016-11-23 | Profactor Pharma Ltd | Purification process |
| EP3642225A1 (en) | 2017-06-23 | 2020-04-29 | Baxalta Incorporated | Purification of factor viii subspecies |
| EP3546475A1 (en) | 2018-03-27 | 2019-10-02 | Sanofi | Full flow-through process for purifying recombinant proteins |
| WO2021001522A1 (en) | 2019-07-04 | 2021-01-07 | CSL Behring Lengnau AG | A truncated von willebrand factor (vwf) for increasing the in vitro stability of coagulation factor viii |
| WO2021094344A1 (en) | 2019-11-11 | 2021-05-20 | CSL Behring Lengnau AG | Polypeptides for inducing tolerance to factor viii |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9302006D0 (sv) * | 1992-10-02 | 1993-06-11 | Kabi Pharmacia Ab | Protein formulation |
| SE9301581D0 (sv) * | 1993-05-07 | 1993-05-07 | Kabi Pharmacia Ab | Protein formulation |
| SE503424C2 (sv) * | 1994-11-14 | 1996-06-10 | Pharmacia Ab | Process för rening av rekombinant koagulationsfaktor VIII |
| IL157309A0 (en) | 2003-08-07 | 2004-02-19 | Applied Research Systems | Method for the purification of a non-immunoglobulin protein |
| EP1831242B1 (en) | 2004-12-23 | 2012-09-26 | Novo Nordisk Health Care AG | Reduction of the content of protein contaminants in compositions comprising a vitamin k-dependent protein of interest |
| EP1707634A1 (en) | 2005-03-29 | 2006-10-04 | Octapharma AG | Method for isolation of recombinantly produced proteins |
| US8329871B2 (en) | 2008-06-24 | 2012-12-11 | Octapharma Ag | Process of purifying coagulation factor VIII |
-
2008
- 2008-07-11 BR BRPI0814220A patent/BRPI0814220B8/pt not_active IP Right Cessation
- 2008-07-11 ES ES08786090T patent/ES2364118T3/es active Active
- 2008-07-11 CA CA 2692814 patent/CA2692814A1/en not_active Abandoned
- 2008-07-11 RU RU2010103528/10A patent/RU2493163C2/ru active
- 2008-07-11 CN CN200880023645.XA patent/CN101730707B/zh active Active
- 2008-07-11 DE DE602008005885T patent/DE602008005885D1/de active Active
- 2008-07-11 AU AU2008274195A patent/AU2008274195B2/en not_active Ceased
- 2008-07-11 PL PL08786090T patent/PL2167526T3/pl unknown
- 2008-07-11 EP EP08786090A patent/EP2167526B1/en active Active
- 2008-07-11 JP JP2010515524A patent/JP5323072B2/ja active Active
- 2008-07-11 WO PCT/EP2008/059094 patent/WO2009007451A1/en not_active Ceased
- 2008-07-11 KR KR1020107001510A patent/KR101293504B1/ko not_active Expired - Fee Related
- 2008-07-11 AT AT08786090T patent/ATE503763T1/de not_active IP Right Cessation
- 2008-07-11 US US12/668,530 patent/US8399620B2/en active Active
-
2014
- 2014-04-15 NL NL300663C patent/NL300663I2/nl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20100051620A (ko) | 2010-05-17 |
| NL300663I2 (pt) | 2016-09-22 |
| RU2010103528A (ru) | 2011-08-20 |
| EP2167526A1 (en) | 2010-03-31 |
| AU2008274195B2 (en) | 2013-09-05 |
| US20100204452A1 (en) | 2010-08-12 |
| BRPI0814220B1 (pt) | 2019-09-17 |
| US8399620B2 (en) | 2013-03-19 |
| PL2167526T3 (pl) | 2011-09-30 |
| RU2493163C2 (ru) | 2013-09-20 |
| KR101293504B1 (ko) | 2013-08-07 |
| CA2692814A1 (en) | 2009-01-15 |
| ES2364118T9 (es) | 2014-05-19 |
| JP2010533150A (ja) | 2010-10-21 |
| JP5323072B2 (ja) | 2013-10-23 |
| BRPI0814220A2 (pt) | 2015-01-06 |
| EP2167526B1 (en) | 2011-03-30 |
| CN101730707B (zh) | 2014-12-17 |
| ATE503763T1 (de) | 2011-04-15 |
| WO2009007451A1 (en) | 2009-01-15 |
| DE602008005885D1 (de) | 2011-05-12 |
| CN101730707A (zh) | 2010-06-09 |
| AU2008274195A1 (en) | 2009-01-15 |
| ES2364118T3 (es) | 2011-08-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
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| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 17/09/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 17/09/2019, OBSERVADAS AS CONDICOES LEGAIS |
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| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 11/07/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
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| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 14A ANUIDADE. |
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| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2678 DE 03-05-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |