BRPI0817850A2 - Cis-imidazolinas quirais - Google Patents
Cis-imidazolinas quiraisInfo
- Publication number
- BRPI0817850A2 BRPI0817850A2 BRPI0817850A BRPI0817850A2 BR PI0817850 A2 BRPI0817850 A2 BR PI0817850A2 BR PI0817850 A BRPI0817850 A BR PI0817850A BR PI0817850 A2 BRPI0817850 A2 BR PI0817850A2
- Authority
- BR
- Brazil
- Prior art keywords
- immedazolines
- cis
- cis immedazolines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97850607P | 2007-10-09 | 2007-10-09 | |
| US9275908P | 2008-08-29 | 2008-08-29 | |
| PCT/EP2008/063053 WO2009047161A1 (en) | 2007-10-09 | 2008-09-30 | Chiral cis-imidazolines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0817850A2 true BRPI0817850A2 (pt) | 2015-04-07 |
Family
ID=40149549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0817850 BRPI0817850A2 (pt) | 2007-10-09 | 2008-09-30 | Cis-imidazolinas quirais |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8513239B2 (pt) |
| EP (2) | EP2325180A1 (pt) |
| JP (1) | JP5324586B2 (pt) |
| KR (1) | KR101203020B1 (pt) |
| CN (2) | CN104710408A (pt) |
| AR (1) | AR068742A1 (pt) |
| AU (1) | AU2008309759A1 (pt) |
| BR (1) | BRPI0817850A2 (pt) |
| CA (1) | CA2701932C (pt) |
| CL (1) | CL2008002982A1 (pt) |
| CO (1) | CO6280486A2 (pt) |
| CR (1) | CR11333A (pt) |
| ES (1) | ES2395210T3 (pt) |
| IL (1) | IL204653A0 (pt) |
| MA (1) | MA31754B1 (pt) |
| MX (1) | MX2010003868A (pt) |
| PE (1) | PE20090814A1 (pt) |
| RU (1) | RU2487127C2 (pt) |
| TW (1) | TW200916446A (pt) |
| WO (1) | WO2009047161A1 (pt) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8809538B2 (en) * | 2009-01-12 | 2014-08-19 | Array Biopharma Inc. | Piperidine-containing compounds and use thereof |
| US8389731B2 (en) * | 2009-05-15 | 2013-03-05 | Northwestern University | Chiral pyrrolidine core compounds en route to inhibitors of nitric oxide synthase |
| AU2010332969B2 (en) | 2009-12-17 | 2015-02-12 | Centrexion Therapeutics Corporation | New CCR2 receptor antagonists and uses thereof |
| US20130143905A1 (en) | 2009-12-17 | 2013-06-06 | Boehringer Ingelheim International Gmbh | Novel antagonists for ccr2 and uses thereof |
| WO2011141474A1 (en) | 2010-05-12 | 2011-11-17 | Boehringer Ingelheim International Gmbh | Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| WO2011147772A1 (en) | 2010-05-25 | 2011-12-01 | Boehringer Ingelheim International Gmbh | Ccr2 receptor antagonists |
| US8962656B2 (en) | 2010-06-01 | 2015-02-24 | Boehringer Ingelheim International Gmbh | CCR2 antagonists |
| JO2998B1 (ar) | 2010-06-04 | 2016-09-05 | Amgen Inc | مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان |
| EP2621275B1 (en) * | 2010-09-30 | 2018-03-28 | St. Jude Children's Research Hospital | Aryl-substituted imidazoles |
| RU2013131444A (ru) * | 2010-12-16 | 2015-01-27 | Рош Гликарт Аг | Сочетанная терапия афукозилированным антителом к cd20 и ингибитором mdm2 |
| WO2013049250A1 (en) | 2011-09-27 | 2013-04-04 | Amgen Inc. | Heterocyclic compounds as mdm2 inhibitors for the treatment of cancer |
| WO2014082889A1 (en) * | 2012-11-28 | 2014-06-05 | F. Hoffmann-La Roche Ag | Novel imidazolines as dual inhibitors of mdm2 and mdmx |
| ES2707305T3 (es) | 2012-12-20 | 2019-04-03 | Merck Sharp & Dohme | Imidazopiridinas sustituidas como inhibidores de HDM2 |
| US11407721B2 (en) | 2013-02-19 | 2022-08-09 | Amgen Inc. | CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer |
| CN105121407B (zh) | 2013-02-28 | 2017-07-18 | 美国安进公司 | 用于治疗癌症的苯甲酸衍生物mdm2抑制剂 |
| PH12015502097B1 (en) | 2013-03-13 | 2023-02-03 | Forma Therapeutics Inc | Novel compounds and compositions for inhibition of fasn |
| MX374513B (es) | 2013-03-14 | 2025-03-06 | Amgen Inc | Compuestos de morfolinona de ácido heteroarilo como inhibidores mdm2 para el tratamiento de cáncer. |
| PE20160113A1 (es) | 2013-06-10 | 2016-03-03 | Amgen Inc | Procesos de fabricacion y formas cristalinas de un inhibidor de mdm2 |
| US10758525B2 (en) | 2015-01-22 | 2020-09-01 | MyoKardia, Inc. | 4-methylsulfonyl-substituted piperidine urea compounds |
| EP3458101B1 (en) | 2016-05-20 | 2020-12-30 | H. Hoffnabb-La Roche Ag | Protac antibody conjugates and methods of use |
| CN105906610B (zh) * | 2016-05-24 | 2018-10-23 | 绍兴文理学院 | 一种3-（4-苯基-1h-咪唑-5-基）-1h-吲哚衍生物及其制备方法和应用 |
| PL3415802T3 (pl) | 2017-06-14 | 2020-03-31 | Borealis Ag | Dylatacja |
| EP3774808A1 (en) * | 2018-03-26 | 2021-02-17 | Novartis AG | 3-hydroxy-n-(3-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)pyrrolidine-1-carboxamide derivatives |
| US10793554B2 (en) | 2018-10-29 | 2020-10-06 | Forma Therapeutics, Inc. | Solid forms of 4-(2-fluoro-4-(1-methyl-1H-benzo[d]imidazol-5-yl)benzoyl)piperazin-1-yl)(1-hydroxycyclopropyl)methanone |
| EP3999504A1 (en) | 2019-07-16 | 2022-05-25 | MyoKardia, Inc. | Polymorphic forms of (r)-4-(1-((3-(difluoromethyl)-1-methyl-1h-pyrazol-4-yl)sulfonyl)-1-fluoroethyl)-n-(isoxazol-3-yl)piperidine-1-carboxamide |
| CN115461338B (zh) * | 2020-05-07 | 2024-02-20 | 小野药品工业株式会社 | 具有kdm5抑制活性的3-氮杂二环(3.1.0)己烷衍生物及其用途 |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
| JP7743829B2 (ja) * | 2021-11-05 | 2025-09-25 | 小野薬品工業株式会社 | Ｋｄｍ５阻害作用を有する化合物を含有する医薬組成物 |
| WO2024240858A1 (en) | 2023-05-23 | 2024-11-28 | Valerio Therapeutics | Protac molecules directed against dna damage repair system and uses thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02101065A (ja) | 1988-10-06 | 1990-04-12 | Tanabe Seiyaku Co Ltd | イミダゾリン誘導体及びその製法 |
| GB2351082A (en) | 1999-06-18 | 2000-12-20 | Lilly Forschung Gmbh | Synthesis of Cyclic Substituted Amidines |
| AU2002366278B2 (en) | 2001-12-18 | 2007-07-19 | F. Hoffmann-La Roche Ag | CIS-2,4,5- triphenyl-imidazolines and their use in the treatment of tumors |
| JP4361798B2 (ja) * | 2001-12-18 | 2009-11-11 | エフ．ホフマン−ラ ロシュ アーゲー | Ｍｄｍ２インヒビターとしてのシス−イミダゾリン |
| WO2005110996A1 (en) | 2004-05-18 | 2005-11-24 | F.Hoffmann-La Roche Ag | Novel cis-imidazolines |
| US8147202B2 (en) | 2005-07-08 | 2012-04-03 | Vestas Wind Systems A/S | Wind turbine, a hub for a wind turbine and use hereof |
| KR20100129331A (ko) * | 2005-12-01 | 2010-12-08 | 에프. 호프만-라 로슈 아게 | 항암제로서 사용하기 위한 ｐ53 및 ｍｄｍ2 단백질 간 상호작용의 저해제로서의 2,4,5-트리페닐 이미다졸린 유도체 |
| AU2007207052B2 (en) * | 2006-01-18 | 2012-07-12 | F. Hoffmann-La Roche Ag | CIS-4, 5-biaryl-2-heterocyclic-imidazolines as MDM2 inhibitors |
-
2008
- 2008-09-30 BR BRPI0817850 patent/BRPI0817850A2/pt not_active Application Discontinuation
- 2008-09-30 CN CN201510024021.1A patent/CN104710408A/zh active Pending
- 2008-09-30 EP EP10175975A patent/EP2325180A1/en not_active Withdrawn
- 2008-09-30 KR KR1020107007374A patent/KR101203020B1/ko not_active Expired - Fee Related
- 2008-09-30 ES ES08837881T patent/ES2395210T3/es active Active
- 2008-09-30 EP EP08837881A patent/EP2203437B1/en active Active
- 2008-09-30 AU AU2008309759A patent/AU2008309759A1/en not_active Abandoned
- 2008-09-30 WO PCT/EP2008/063053 patent/WO2009047161A1/en not_active Ceased
- 2008-09-30 MX MX2010003868A patent/MX2010003868A/es active IP Right Grant
- 2008-09-30 CN CN200880110704A patent/CN101821251A/zh active Pending
- 2008-09-30 JP JP2010528361A patent/JP5324586B2/ja not_active Expired - Fee Related
- 2008-09-30 RU RU2010118018/04A patent/RU2487127C2/ru active
- 2008-09-30 CA CA2701932A patent/CA2701932C/en not_active Expired - Fee Related
- 2008-10-07 PE PE2008001740A patent/PE20090814A1/es not_active Application Discontinuation
- 2008-10-07 CL CL2008002982A patent/CL2008002982A1/es unknown
- 2008-10-07 AR ARP080104381A patent/AR068742A1/es not_active Application Discontinuation
- 2008-10-08 TW TW097138773A patent/TW200916446A/zh unknown
- 2008-10-09 US US12/248,095 patent/US8513239B2/en not_active Expired - Fee Related
-
2010
- 2010-03-22 IL IL204653A patent/IL204653A0/en unknown
- 2010-03-24 CR CR11333A patent/CR11333A/es not_active Application Discontinuation
- 2010-03-26 CO CO10036293A patent/CO6280486A2/es not_active Application Discontinuation
- 2010-04-05 MA MA32739A patent/MA31754B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP5324586B2 (ja) | 2013-10-23 |
| WO2009047161A1 (en) | 2009-04-16 |
| CN104710408A (zh) | 2015-06-17 |
| EP2203437B1 (en) | 2012-11-07 |
| CA2701932A1 (en) | 2009-04-16 |
| JP2010540675A (ja) | 2010-12-24 |
| ES2395210T3 (es) | 2013-02-11 |
| RU2010118018A (ru) | 2011-11-20 |
| US8513239B2 (en) | 2013-08-20 |
| MX2010003868A (es) | 2010-04-27 |
| EP2325180A1 (en) | 2011-05-25 |
| CL2008002982A1 (es) | 2009-10-16 |
| CR11333A (es) | 2010-06-21 |
| US20090111789A1 (en) | 2009-04-30 |
| KR101203020B1 (ko) | 2012-11-20 |
| IL204653A0 (en) | 2010-11-30 |
| CO6280486A2 (es) | 2011-05-20 |
| CA2701932C (en) | 2015-10-20 |
| CN101821251A (zh) | 2010-09-01 |
| KR20100051742A (ko) | 2010-05-17 |
| TW200916446A (en) | 2009-04-16 |
| RU2487127C2 (ru) | 2013-07-10 |
| AR068742A1 (es) | 2009-12-02 |
| PE20090814A1 (es) | 2009-06-27 |
| MA31754B1 (fr) | 2010-10-01 |
| EP2203437A1 (en) | 2010-07-07 |
| AU2008309759A1 (en) | 2009-04-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO2024050I1 (no) | capivasertib | |
| NO2023012I1 (no) | Evolocumab | |
| NL301207I2 (nl) | tezepelumab | |
| BRPI0817850A2 (pt) | Cis-imidazolinas quirais | |
| NO2016018I1 (no) | Fluralaner | |
| NL300788I2 (nl) | Pembrolizumab | |
| NO2014015I1 (no) | Dimetylfumarat | |
| NO2014002I1 (no) | Lipegfilgrastim | |
| DK2205737T3 (da) | Mikromirer | |
| EP2157090A4 (en) | PYRAZINAMIDE COMPOUND | |
| DE602008006301D1 (de) | Koaxialnadelanordnung | |
| EP2188984A4 (en) | PREPARATION OF TRANSPORT FLOW PACKAGE (TS) | |
| FI20075610A0 (fi) | Rikastepoltin | |
| FI20075873A0 (fi) | Suotokuristinjärjestely | |
| EP2149500A4 (en) | Electron beam sterilizer | |
| EP2216932A4 (en) | BITS IDENTIFICATION CIRCUIT | |
| EP2237903A4 (en) | METAL BENDING APPARATUS | |
| DE112008001216A5 (de) | Magnetronplasmaanlage | |
| FI20070655A0 (fi) | Imuhihnakuljetin | |
| DE502008003063D1 (de) | Magnetventilinjektor | |
| EP2128006A4 (en) | DRIVING TYPE VEHICLE IN CALIFOURCHON | |
| DE602007008359D1 (de) | Hemdendbearbeitungsmaschine | |
| ES1066408Y (es) | Biberon monouso | |
| ES1065848Y (es) | Cubitera | |
| AT9563U3 (de) | Wirbelsäulenzuggurtung |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL |