MA31754B1 - Cis-imidazolines chirales - Google Patents

Cis-imidazolines chirales

Info

Publication number
MA31754B1
MA31754B1 MA32739A MA32739A MA31754B1 MA 31754 B1 MA31754 B1 MA 31754B1 MA 32739 A MA32739 A MA 32739A MA 32739 A MA32739 A MA 32739A MA 31754 B1 MA31754 B1 MA 31754B1
Authority
MA
Morocco
Prior art keywords
chirales
imidazolines
cis
compounds
agents
Prior art date
Application number
MA32739A
Other languages
English (en)
Inventor
David Joseph Bartkovitz
Jianping Cai
Xin-Jie Chu
Hongju Li
Allen John Lovey
Binh Thanh Vu
Chunlin Zhao
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40149549&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA31754(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA31754B1 publication Critical patent/MA31754B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'INVENTION PORTE SUR DES COMPOSÉS REPRÉSENTÉS PAR LA FORMULE (I), OU SUR LEURS SELS PHARMACEUTIQUEMENT ACCEPTABLES, FORMULE DANS LAQUELLE X, Y, Z, V1, V2, R1, R2, R3, R4 ET R5 SONT TELS QUE PRÉSENTEMENT DÉCRITS, SUR DES PROCÉDÉS D'OBTENTION DESDITS COMPOSÉS, ET SUR DES PRÉPARATIONS PHARMACEUTIQUES LES CONTENANT. CES COMPOSÉS SONT UTILES COMME AGENTS ANTI-CANCER, EN PARTICULIER COMME AGENTS DANS LE TRAITEMENT DE TUMEURS SOLIDES.
MA32739A 2007-10-09 2010-04-05 Cis-imidazolines chirales MA31754B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97850607P 2007-10-09 2007-10-09
US9275908P 2008-08-29 2008-08-29

Publications (1)

Publication Number Publication Date
MA31754B1 true MA31754B1 (fr) 2010-10-01

Family

ID=40149549

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32739A MA31754B1 (fr) 2007-10-09 2010-04-05 Cis-imidazolines chirales

Country Status (20)

Country Link
US (1) US8513239B2 (fr)
EP (2) EP2203437B1 (fr)
JP (1) JP5324586B2 (fr)
KR (1) KR101203020B1 (fr)
CN (2) CN101821251A (fr)
AR (1) AR068742A1 (fr)
AU (1) AU2008309759A1 (fr)
BR (1) BRPI0817850A2 (fr)
CA (1) CA2701932C (fr)
CL (1) CL2008002982A1 (fr)
CO (1) CO6280486A2 (fr)
CR (1) CR11333A (fr)
ES (1) ES2395210T3 (fr)
IL (1) IL204653A0 (fr)
MA (1) MA31754B1 (fr)
MX (1) MX2010003868A (fr)
PE (1) PE20090814A1 (fr)
RU (1) RU2487127C2 (fr)
TW (1) TW200916446A (fr)
WO (1) WO2009047161A1 (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2375899B1 (fr) * 2009-01-12 2015-02-25 Array Biopharma Inc. Composés contenant de la pipéridine et leur utilisation dans le traitement du diabète
WO2010132873A2 (fr) 2009-05-15 2010-11-18 Northwestern University Composés à noyau pyrrolidine chiraux utilisés pour la préparation d'inhibiteurs d'oxyde nitrique synthase
WO2011073154A1 (fr) 2009-12-17 2011-06-23 Boehringer Ingelheim International Gmbh Nouveaux antagonistes du récepteur ccr2 et leurs utilisations
WO2011073155A1 (fr) 2009-12-17 2011-06-23 Boehringer Ingelheim International Gmbh Nouveaux antagonistes du récepteur ccr2 et leurs utilisations
US8877745B2 (en) 2010-05-12 2014-11-04 Boehringer Ingelheim International Gmbh CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments
US9018212B2 (en) 2010-05-25 2015-04-28 Boehringer Ingelheim International Gmbh Pyridazine carboxamides as CCR2 receptor antagonists
EP2576538B1 (fr) 2010-06-01 2015-10-28 Boehringer Ingelheim International GmbH Nouveaux antagonistes de CCR2
JO2998B1 (ar) 2010-06-04 2016-09-05 Amgen Inc مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان
US9266860B2 (en) 2010-09-30 2016-02-23 St. Jude Children's Research Hospital Aryl-substituted imidazoles
JP2014507384A (ja) * 2010-12-16 2014-03-27 ロシュ グリクアート アーゲー Ｍｄｍ２阻害剤とのアフコシル化ｃｄ２０抗体の併用療法
AU2012316055B2 (en) 2011-09-27 2016-05-12 Amgen Inc. Heterocyclic compounds as MDM2 inhibitors for the treatment of cancer
WO2014082889A1 (fr) * 2012-11-28 2014-06-05 F. Hoffmann-La Roche Ag Nouvelles imidazolines utilisées en tant que doubles inhibiteurs de mdm2 et mdmx
EP2935263B1 (fr) 2012-12-20 2018-12-05 Merck Sharp & Dohme Corp. Imidazopyridines substituées en tant qu'inhibiteurs d'hdm2
US11407721B2 (en) 2013-02-19 2022-08-09 Amgen Inc. CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
CA2902856C (fr) 2013-02-28 2021-02-16 Amgen Inc. Inhibiteur mdm2 derive de l'acide benzoique pour le traitement du cancer
HRP20191860T1 (hr) 2013-03-13 2019-12-27 Forma Therapeutics, Inc. Derivati 2-hidroksi-1-{4-[(4-fenilfenil)karbonil]piperazin-1-il}etan-1-ona i srodni spojevi kao inhibitori sintaze masnih kiselina (fasn) za liječenje raka
WO2014151863A1 (fr) 2013-03-14 2014-09-25 Amgen Inc. Composés morpholinone d'acide hétéroaryle utilisés comme inhibiteurs de mdm2 pour le traitement du cancer
MA53572A1 (fr) 2013-06-10 2021-10-29 Amgen Inc Procédés de production et formes cristallines d'un inhibiteur mdm2
US10758525B2 (en) 2015-01-22 2020-09-01 MyoKardia, Inc. 4-methylsulfonyl-substituted piperidine urea compounds
CN118436801A (zh) 2016-05-20 2024-08-06 豪夫迈·罗氏有限公司 Protac抗体缀合物及其使用方法
CN105906610B (zh) * 2016-05-24 2018-10-23 绍兴文理学院 一种3-（4-苯基-1h-咪唑-5-基）-1h-吲哚衍生物及其制备方法和应用
EP3415802B1 (fr) 2017-06-14 2019-08-28 Borealis AG Raccord de dilatation
CN117186108B (zh) * 2018-03-26 2025-08-19 诺华股份有限公司 布鲁顿酪氨酸激酶降解剂
WO2020092395A1 (fr) 2018-10-29 2020-05-07 Forma Therapeutics, Inc. Formes solides de (4-(2-fluoro-4-(1-méthyl-1h-benzo[d]imidazol-5-yl)benzoyl)pipérazin-1-yl)(1-hydroxycyclopropyl)méthanone
AU2020315605A1 (en) 2019-07-16 2022-03-03 MyoKardia, Inc. Polymorphic forms of (R)-4-(1-((3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)sulfonyl)-1-fluoroethyl)-N-(isoxazol-3-yl)piperidine-1-carboxamide
EP4146645B1 (fr) * 2020-05-07 2025-06-25 ONO Pharmaceutical Co., Ltd. Dérivés de 3-azabicyclo(3.1.0)hexane ayant une activité inhibitrice de kdm5 et leur utilisation
WO2023056069A1 (fr) 2021-09-30 2023-04-06 Angiex, Inc. Conjugués agent de dégradation-anticorps et leurs procédés d'utilisation
JP7743829B2 (ja) * 2021-11-05 2025-09-25 小野薬品工業株式会社 Ｋｄｍ５阻害作用を有する化合物を含有する医薬組成物
WO2024240858A1 (fr) 2023-05-23 2024-11-28 Valerio Therapeutics Molécules protac dirigées contre un système de réparation de dommages à l'adn et leurs utilisations

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02101065A (ja) 1988-10-06 1990-04-12 Tanabe Seiyaku Co Ltd イミダゾリン誘導体及びその製法
GB2351082A (en) 1999-06-18 2000-12-20 Lilly Forschung Gmbh Synthesis of Cyclic Substituted Amidines
CN100486969C (zh) 2001-12-18 2009-05-13 霍夫曼-拉罗奇有限公司 顺式-2,4,5-三苯基-咪唑啉及其在肿瘤治疗中的应用
PL370909A1 (en) * 2001-12-18 2005-05-30 F.Hoffmann-La Roche Ag Cis-imidazolines as mdm2 inhibitors
EP1753727B1 (fr) 2004-05-18 2008-11-19 F.Hoffmann-La Roche Ag Nouvelles cis-imidazolines
WO2007006301A1 (fr) 2005-07-08 2007-01-18 Vestas Wind Systems A/S Eolienne, moyeu d'eolienne et utilisation
KR20100129331A (ko) * 2005-12-01 2010-12-08 에프. 호프만-라 로슈 아게 항암제로서 사용하기 위한 ｐ53 및 ｍｄｍ2 단백질 간 상호작용의 저해제로서의 2,4,5-트리페닐 이미다졸린 유도체
WO2007082805A1 (fr) * 2006-01-18 2007-07-26 F. Hoffmann-La Roche Ag Imidazolines cis-4,5-biaryl-2-hétérocycliques utilisées comme inhibiteurs de mdm2

Also Published As

Publication number Publication date
US20090111789A1 (en) 2009-04-30
EP2325180A1 (fr) 2011-05-25
MX2010003868A (es) 2010-04-27
CO6280486A2 (es) 2011-05-20
CL2008002982A1 (es) 2009-10-16
KR20100051742A (ko) 2010-05-17
CN104710408A (zh) 2015-06-17
RU2487127C2 (ru) 2013-07-10
WO2009047161A1 (fr) 2009-04-16
EP2203437B1 (fr) 2012-11-07
CR11333A (es) 2010-06-21
PE20090814A1 (es) 2009-06-27
CN101821251A (zh) 2010-09-01
KR101203020B1 (ko) 2012-11-20
AR068742A1 (es) 2009-12-02
ES2395210T3 (es) 2013-02-11
JP5324586B2 (ja) 2013-10-23
IL204653A0 (en) 2010-11-30
CA2701932A1 (fr) 2009-04-16
AU2008309759A1 (en) 2009-04-16
JP2010540675A (ja) 2010-12-24
US8513239B2 (en) 2013-08-20
EP2203437A1 (fr) 2010-07-07
TW200916446A (en) 2009-04-16
BRPI0817850A2 (pt) 2015-04-07
CA2701932C (fr) 2015-10-20
RU2010118018A (ru) 2011-11-20

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