MA31754B1 - Cis-imidazolines chirales - Google Patents

Cis-imidazolines chirales

Info

Publication number
MA31754B1
MA31754B1 MA32739A MA32739A MA31754B1 MA 31754 B1 MA31754 B1 MA 31754B1 MA 32739 A MA32739 A MA 32739A MA 32739 A MA32739 A MA 32739A MA 31754 B1 MA31754 B1 MA 31754B1
Authority
MA
Morocco
Prior art keywords
chirales
imidazolines
cis
compounds
agents
Prior art date
Application number
MA32739A
Other languages
English (en)
Inventor
David Joseph Bartkovitz
Jianping Cai
Xin-Jie Chu
Hongju Li
Allen John Lovey
Binh Thanh Vu
Chunlin Zhao
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40149549&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA31754(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA31754B1 publication Critical patent/MA31754B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'INVENTION PORTE SUR DES COMPOSÉS REPRÉSENTÉS PAR LA FORMULE (I), OU SUR LEURS SELS PHARMACEUTIQUEMENT ACCEPTABLES, FORMULE DANS LAQUELLE X, Y, Z, V1, V2, R1, R2, R3, R4 ET R5 SONT TELS QUE PRÉSENTEMENT DÉCRITS, SUR DES PROCÉDÉS D'OBTENTION DESDITS COMPOSÉS, ET SUR DES PRÉPARATIONS PHARMACEUTIQUES LES CONTENANT. CES COMPOSÉS SONT UTILES COMME AGENTS ANTI-CANCER, EN PARTICULIER COMME AGENTS DANS LE TRAITEMENT DE TUMEURS SOLIDES.
MA32739A 2007-10-09 2010-04-05 Cis-imidazolines chirales MA31754B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97850607P 2007-10-09 2007-10-09
US9275908P 2008-08-29 2008-08-29

Publications (1)

Publication Number Publication Date
MA31754B1 true MA31754B1 (fr) 2010-10-01

Family

ID=40149549

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32739A MA31754B1 (fr) 2007-10-09 2010-04-05 Cis-imidazolines chirales

Country Status (20)

Country Link
US (1) US8513239B2 (fr)
EP (2) EP2203437B1 (fr)
JP (1) JP5324586B2 (fr)
KR (1) KR101203020B1 (fr)
CN (2) CN104710408A (fr)
AR (1) AR068742A1 (fr)
AU (1) AU2008309759A1 (fr)
BR (1) BRPI0817850A2 (fr)
CA (1) CA2701932C (fr)
CL (1) CL2008002982A1 (fr)
CO (1) CO6280486A2 (fr)
CR (1) CR11333A (fr)
ES (1) ES2395210T3 (fr)
IL (1) IL204653A0 (fr)
MA (1) MA31754B1 (fr)
MX (1) MX2010003868A (fr)
PE (1) PE20090814A1 (fr)
RU (1) RU2487127C2 (fr)
TW (1) TW200916446A (fr)
WO (1) WO2009047161A1 (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2375899B1 (fr) * 2009-01-12 2015-02-25 Array Biopharma Inc. Composés contenant de la pipéridine et leur utilisation dans le traitement du diabète
WO2010132873A2 (fr) 2009-05-15 2010-11-18 Northwestern University Composés à noyau pyrrolidine chiraux utilisés pour la préparation d'inhibiteurs d'oxyde nitrique synthase
EP2513086B1 (fr) 2009-12-17 2015-04-29 Boehringer Ingelheim International GmbH Nouveaux antagonistes pour CCR2 et utilisations associées
ES2674275T3 (es) 2009-12-17 2018-06-28 Centrexion Therapeutics Corporation Antagonistas del receptor CCR2 y usos de los mismos
WO2011141474A1 (fr) 2010-05-12 2011-11-17 Boehringer Ingelheim International Gmbh Nouveaux antagonistes des récepteurs ccr2, procédé de production associé et application comme médicaments
WO2011147772A1 (fr) 2010-05-25 2011-12-01 Boehringer Ingelheim International Gmbh Antagonistes du récepteur ccr2
US8962656B2 (en) 2010-06-01 2015-02-24 Boehringer Ingelheim International Gmbh CCR2 antagonists
JO2998B1 (ar) 2010-06-04 2016-09-05 Amgen Inc مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان
WO2012045018A1 (fr) 2010-09-30 2012-04-05 St. Jude Children's Research Hospital Imidazoles substitués par aryle
WO2012080389A1 (fr) 2010-12-16 2012-06-21 Roche Glycart Ag Thérapie d'association d'un anticorps cd20 afucosylé avec un inhibiteur mdm2
US9376425B2 (en) 2011-09-27 2016-06-28 Amgen, Inc. Heterocyclic compounds as MDM2 inhibitors for the treatment of cancer
WO2014082889A1 (fr) * 2012-11-28 2014-06-05 F. Hoffmann-La Roche Ag Nouvelles imidazolines utilisées en tant que doubles inhibiteurs de mdm2 et mdmx
KR102196882B1 (ko) 2012-12-20 2020-12-30 머크 샤프 앤드 돔 코포레이션 Hdm2 억제제로서의 치환된 이미다조피리딘
US11407721B2 (en) 2013-02-19 2022-08-09 Amgen Inc. CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
WO2014134201A1 (fr) 2013-02-28 2014-09-04 Amgen Inc. Inhibiteur mdm2 dérivé de l'acide benzoïque pour le traitement du cancer
ES2753386T3 (es) 2013-03-13 2020-04-08 Forma Therapeutics Inc Derivados de 2-hidroxi-1-{4-[(4-fenil)fenil]carbonil}piperazin-1-il}etano-1-ona y compuestos relacionados como inhibidores de sintasa de ácido graso (FASN) para el tratamiento del cáncer
MX374513B (es) 2013-03-14 2025-03-06 Amgen Inc Compuestos de morfolinona de ácido heteroarilo como inhibidores mdm2 para el tratamiento de cáncer.
CN105358530A (zh) 2013-06-10 2016-02-24 美国安进公司 制备mdm2抑制剂的方法及其结晶形式
US10758525B2 (en) 2015-01-22 2020-09-01 MyoKardia, Inc. 4-methylsulfonyl-substituted piperidine urea compounds
CN118436801A (zh) 2016-05-20 2024-08-06 豪夫迈·罗氏有限公司 Protac抗体缀合物及其使用方法
CN105906610B (zh) * 2016-05-24 2018-10-23 绍兴文理学院 一种3-（4-苯基-1h-咪唑-5-基）-1h-吲哚衍生物及其制备方法和应用
EP3415802B1 (fr) 2017-06-14 2019-08-28 Borealis AG Raccord de dilatation
EP3774808A1 (fr) * 2018-03-26 2021-02-17 Novartis AG Dérivés de 3-hydroxy-n-(3-(7h-pyrrolo[2,3-d]pyrimidin-4-yl) phényl)pyrrolidine-1-carboxamide
US10793554B2 (en) 2018-10-29 2020-10-06 Forma Therapeutics, Inc. Solid forms of 4-(2-fluoro-4-(1-methyl-1H-benzo[d]imidazol-5-yl)benzoyl)piperazin-1-yl)(1-hydroxycyclopropyl)methanone
CN114127061A (zh) 2019-07-16 2022-03-01 迈奥卡迪亚公司 (r)-4-(1-((3-(二氟甲基)-1-甲基-1h-吡唑-4-基)磺酰基)-1-氟乙基)-n-(异噁唑-3-基)哌啶-1-甲酰胺的多晶型物形式
ES3037418T3 (en) * 2020-05-07 2025-10-01 Ono Pharmaceutical Co 3-azabicyclo(3.1.0)hexane derivatives having kdm5 inhibitory activity and use thereof
WO2023056069A1 (fr) 2021-09-30 2023-04-06 Angiex, Inc. Conjugués agent de dégradation-anticorps et leurs procédés d'utilisation
JP7743829B2 (ja) * 2021-11-05 2025-09-25 小野薬品工業株式会社 Ｋｄｍ５阻害作用を有する化合物を含有する医薬組成物
WO2024240858A1 (fr) 2023-05-23 2024-11-28 Valerio Therapeutics Molécules protac dirigées contre un système de réparation de dommages à l'adn et leurs utilisations

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02101065A (ja) 1988-10-06 1990-04-12 Tanabe Seiyaku Co Ltd イミダゾリン誘導体及びその製法
GB2351082A (en) 1999-06-18 2000-12-20 Lilly Forschung Gmbh Synthesis of Cyclic Substituted Amidines
PL370823A1 (en) 2001-12-18 2005-05-30 F.Hoffmann-La Roche Ag Cis-2,4,5- triphenyl-imidazolines and their use in the treatment of tumors
ATE397925T1 (de) * 2001-12-18 2008-07-15 Hoffmann La Roche Cis-imidazoline als mdm2-hemmer
JP4814228B2 (ja) 2004-05-18 2011-11-16 エフ．ホフマン−ラ ロシュ アーゲー 新規ｃｉｓ−イミダゾリン
EP1907694B2 (fr) 2005-07-08 2016-01-20 Vestas Wind Systems A/S Eolienne, moyeu d'eolienne et utilisation
JP4870778B2 (ja) 2005-12-01 2012-02-08 エフ．ホフマン−ラ ロシュ アーゲー 抗ガン剤として使用されるｐ５３およびｍｄｍ２タンパク質間の相互作用の阻害剤としての２，４，５−トリフェニルイミダゾリン誘導体
KR101015073B1 (ko) * 2006-01-18 2011-02-16 에프. 호프만-라 로슈 아게 Ｍｄｍ2 억제제로서의시스-4,5-비아릴-2-헤테로시클릭-이미다졸린

Also Published As

Publication number Publication date
WO2009047161A1 (fr) 2009-04-16
US20090111789A1 (en) 2009-04-30
TW200916446A (en) 2009-04-16
MX2010003868A (es) 2010-04-27
JP5324586B2 (ja) 2013-10-23
PE20090814A1 (es) 2009-06-27
EP2203437B1 (fr) 2012-11-07
CO6280486A2 (es) 2011-05-20
BRPI0817850A2 (pt) 2015-04-07
AU2008309759A1 (en) 2009-04-16
CA2701932C (fr) 2015-10-20
CL2008002982A1 (es) 2009-10-16
IL204653A0 (en) 2010-11-30
CA2701932A1 (fr) 2009-04-16
CR11333A (es) 2010-06-21
JP2010540675A (ja) 2010-12-24
AR068742A1 (es) 2009-12-02
ES2395210T3 (es) 2013-02-11
EP2325180A1 (fr) 2011-05-25
CN101821251A (zh) 2010-09-01
CN104710408A (zh) 2015-06-17
KR101203020B1 (ko) 2012-11-20
KR20100051742A (ko) 2010-05-17
EP2203437A1 (fr) 2010-07-07
US8513239B2 (en) 2013-08-20
RU2010118018A (ru) 2011-11-20
RU2487127C2 (ru) 2013-07-10

Similar Documents

Publication Publication Date Title
MA31754B1 (fr) Cis-imidazolines chirales
MA54653B1 (fr) Modulateurs du récepteur de cxcr7 pipéridine
MA28747B1 (fr) Dérivés de pyridine
MA32711B1 (fr) Pyrrolidine-2-carboxamides substitues
MA29926B1 (fr) Derives de pyrazine
TN2009000450A1 (fr) Derives de pyridine
MA32965B1 (fr) Derives de sulfonamides
TNSN08445A1 (fr) Derives de triazolopyrazine utiles comme agent anticancereux
MA27568A1 (fr) Derives de pyrrolopyrimidine
MA31142B1 (fr) Derives heteroaryles de pyrrolidinyl et piperdinyl cetones.
TN2010000175A1 (fr) Piperidino-dihydrothienopyrimidines substituees
MA28270A1 (fr) Pyrido [2, 3-D] pyrimidine-2, 4-diamines servant d'inhibiteurs de PDE 2
MA30352B1 (fr) Pyridine [3,4-b] pyrazinones
MA27774A1 (fr) Inhibiteurs de phosphatidylinositol 3-kinase
MA56883B1 (fr) Dérivés de 2-hydroxycycloalcane-1-carbamoyle
MA31766B1 (fr) Composés organiques
MA31894B1 (fr) Composes organiques
MA31683B1 (fr) Composes et procedes pour moduler fxr
TN2009000483A1 (fr) Derives de 7-alkynyl-1-8-naphthyridones, leur preparation et leur application en therapeutique
MA30291B1 (fr) Derives de l'azolopyridin-3-one en tant qu'inhibiteurs de la lipase endotheliale
MA29856B1 (fr) Derives de diacylindazole en tant qu'inhibiteurs de lipases et de phospholipases
MA28007A1 (fr) Composes organiques
MA43639B1 (fr) Nouveaux dérivés d'ammonium, procédé de préparation de ceux-ci et compositions pharmaceutiques les contenant
TN2009000471A1 (fr) Composes amino-heterocycliques
MA31952B1 (fr) Pyrrolopyrimidines et pyrrolopyridines