BRPI0820770A2 - Sal solúvel em água polimérico de medicamentos, forma de administração sólida, e, método para produzir sais solúveis em água poliméricos de medicamentos. - Google Patents
Sal solúvel em água polimérico de medicamentos, forma de administração sólida, e, método para produzir sais solúveis em água poliméricos de medicamentos.Info
- Publication number
- BRPI0820770A2 BRPI0820770A2 BRPI0820770-4A BRPI0820770A BRPI0820770A2 BR PI0820770 A2 BRPI0820770 A2 BR PI0820770A2 BR PI0820770 A BRPI0820770 A BR PI0820770A BR PI0820770 A2 BRPI0820770 A2 BR PI0820770A2
- Authority
- BR
- Brazil
- Prior art keywords
- soluble polymeric
- polymeric drug
- water
- drug salt
- administration form
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07122995 | 2007-12-12 | ||
| PCT/EP2008/067228 WO2009074609A1 (de) | 2007-12-12 | 2008-12-10 | Salze von wirkstoffen mit polymeren gegenionen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0820770A2 true BRPI0820770A2 (pt) | 2015-06-16 |
Family
ID=40474778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0820770-4A BRPI0820770A2 (pt) | 2007-12-12 | 2008-12-10 | Sal solúvel em água polimérico de medicamentos, forma de administração sólida, e, método para produzir sais solúveis em água poliméricos de medicamentos. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20100280047A1 (pt) |
| EP (1) | EP2229151B1 (pt) |
| JP (1) | JP5646340B2 (pt) |
| KR (1) | KR20100093591A (pt) |
| CN (1) | CN101896169B (pt) |
| AU (1) | AU2008334580A1 (pt) |
| BR (1) | BRPI0820770A2 (pt) |
| CA (1) | CA2707282A1 (pt) |
| ES (1) | ES2388470T3 (pt) |
| MX (1) | MX2010006005A (pt) |
| WO (1) | WO2009074609A1 (pt) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
| DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
| DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
| US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
| DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
| DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| DE102007011485A1 (de) | 2007-03-07 | 2008-09-11 | Grünenthal GmbH | Darreichungsform mit erschwertem Missbrauch |
| EA201000089A1 (ru) * | 2007-07-06 | 2010-06-30 | Басф Се | Применение гомо- и сополимеров для стабилизации составов активных ингредиентов |
| JP5774853B2 (ja) | 2008-01-25 | 2015-09-09 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 医薬投薬形 |
| MX2010012039A (es) | 2008-05-09 | 2010-11-30 | Gruenenthal Gmbh | Proceso para la preparacion de una formulacion de polvo intermedia y una forma de dosificacion solida final bajo el uso de un paso de congelacion por rocio. |
| BRPI1012651A2 (pt) | 2009-03-31 | 2016-04-05 | Basf Se | processo para produzir preparações de substâncias fracamente solúveis em água |
| EP2429492B1 (de) | 2009-05-13 | 2014-06-25 | Basf Se | Feste pharmazeutische Zubereitungen enthaltend Copolymere auf Basis von Polyethern in Kombination mit wasserschwerlöslichen Polymeren |
| ES2428938T3 (es) | 2009-07-22 | 2013-11-12 | Grünenthal GmbH | Forma de dosificación resistente a la manipulación y estabilizada frente a la oxidación |
| BR112012001547A2 (pt) | 2009-07-22 | 2016-03-08 | Gruenenthal Gmbh | forma de dosagem farmacêutica extrusada por fusão a quente |
| CN102573755A (zh) * | 2009-09-18 | 2012-07-11 | 巴斯夫欧洲公司 | 制备具有低水溶性的物质的制剂的方法 |
| CN102821757B (zh) | 2010-02-03 | 2016-01-20 | 格吕伦塔尔有限公司 | 通过挤出机制备粉末状药物组合物 |
| EP2611852B1 (de) | 2010-08-31 | 2014-07-30 | Basf Se | Verzweigte polyester auf basis von zitronensäure sowie deren herstellung und verwendung |
| CN103179954A (zh) | 2010-09-02 | 2013-06-26 | 格吕伦塔尔有限公司 | 包含阴离子聚合物的抗破碎剂型 |
| CA2808219C (en) | 2010-09-02 | 2019-05-14 | Gruenenthal Gmbh | Tamper resistant dosage form comprising inorganic salt |
| CA2839123A1 (en) | 2011-07-29 | 2013-02-07 | Grunenthal Gmbh | Tamper-resistant tablet providing immediate drug release |
| PL2736497T3 (pl) | 2011-07-29 | 2018-01-31 | Gruenenthal Gmbh | Tabletka odporna na ingerencję, zapewniająca natychmiastowe uwalnianie leku |
| MX356421B (es) | 2012-02-28 | 2018-05-29 | Gruenenthal Gmbh | Forma de dosificacion resistente a la manipulacion indebida que comprende un compuesto farmacologicamente activo y un polimero anionico. |
| PL2838512T3 (pl) * | 2012-04-18 | 2018-12-31 | Grünenthal GmbH | Farmaceutyczna postać dawkowania odporna na niewłaściwe użycie i odporna na uderzeniowe uwalnianie dawki |
| US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
| DE102012105512A1 (de) * | 2012-06-25 | 2014-04-24 | Hennig Arzneimittel Gmbh & Co. Kg | Arzneiform zur verlängerten Freisetzung von Wirkstoffen |
| WO2014191396A1 (en) | 2013-05-29 | 2014-12-04 | Grünenthal GmbH | Tamper resistant dosage form with bimodal release profile |
| MX371432B (es) | 2013-05-29 | 2020-01-30 | Gruenenthal Gmbh | Forma de dosificacion resistente al uso indebido que contiene una o mas particulas. |
| US10624862B2 (en) | 2013-07-12 | 2020-04-21 | Grünenthal GmbH | Tamper-resistant dosage form containing ethylene-vinyl acetate polymer |
| WO2015078891A1 (en) | 2013-11-26 | 2015-06-04 | Farmaceutici Formenti S.P.A. | Preparation of a powdery pharmaceutical composition by means of cryo-milling |
| EP3079668A1 (en) | 2013-12-09 | 2016-10-19 | Durect Corporation | Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same |
| US20150320690A1 (en) | 2014-05-12 | 2015-11-12 | Grünenthal GmbH | Tamper resistant immediate release capsule formulation comprising tapentadol |
| EP3148512A1 (en) | 2014-05-26 | 2017-04-05 | Grünenthal GmbH | Multiparticles safeguarded against ethanolic dose-dumping |
| CN104546753A (zh) * | 2014-12-25 | 2015-04-29 | 海南卫康制药(潜山)有限公司 | 一种氟哌啶醇组合物冻干片及其制备方法 |
| BR112017021475A2 (pt) | 2015-04-24 | 2018-07-10 | Gruenenthal Gmbh | forma de dosagem resistente à adulteração (tamper) com liberação imediata e resistência contra extração de solvente |
| TWI735447B (zh) * | 2015-08-06 | 2021-08-11 | 日商日本Ｅｘｌａｎ工業股份有限公司 | 抗病毒用材料、及含有該材料的具有抗病毒性之製品 |
| WO2017032651A1 (de) | 2015-08-21 | 2017-03-02 | Basf Se | Salze von wirkstoffen mit polymeren gegenionen |
| CN107920998B (zh) | 2015-08-21 | 2021-07-27 | 巴斯夫欧洲公司 | 基于n-乙烯基吡咯烷酮和丙烯酸的水溶性聚合物作为药物助剂的用途 |
| AU2016319203A1 (en) | 2015-09-10 | 2018-02-22 | Grünenthal GmbH | Protecting oral overdose with abuse deterrent immediate release formulations |
| EP4021416A1 (en) | 2019-08-28 | 2022-07-06 | Lubrizol Advanced Materials, Inc. | Drug-polymer amorphous solid dispersions using linear poly (acrylic acid) polymers |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5219563A (en) * | 1988-05-11 | 1993-06-15 | Glaxo Group Limited | Drug adsorbates |
| US5736127A (en) * | 1992-04-06 | 1998-04-07 | Hymedix International, Inc. | Polymeric nitrogen-containing drug salt forms for controlled release |
| DE9420259U1 (de) * | 1994-12-17 | 1995-02-09 | Röhm GmbH, 64293 Darmstadt | Entbittertes Ranitidin-Präparat |
| DE19631085A1 (de) * | 1996-08-01 | 1998-02-05 | Basf Ag | Verwendung von (Meth)acrylsäure-Maleinsäure-Copolymeren zur Verbesserung der Permeabilität der Schleimhaut |
| DE19637479A1 (de) * | 1996-09-13 | 1998-03-19 | Basf Ag | Verfahren zur Herstellung fester pharmazeutischer Formen |
| US6126919A (en) * | 1997-02-07 | 2000-10-03 | 3M Innovative Properties Company | Biocompatible compounds for pharmaceutical drug delivery systems |
| DE19913875A1 (de) * | 1999-03-26 | 2000-09-28 | Basf Ag | Wasserlösliche oder wasserdispergierbare polymere Salze |
| PL368587A1 (en) * | 2001-06-22 | 2005-04-04 | Pfizer Products Inc. | Pharmaceutical compositions comprising low-solubility and/or acid-sensitive drugs and neutralized acidic polymers |
| JP2007504239A (ja) * | 2003-09-03 | 2007-03-01 | マリンクロッド・インコーポレイテッド | 顆粒状持続放出製剤およびその製造 |
| JP2007514030A (ja) * | 2003-12-09 | 2007-05-31 | ビーエーエスエフ アクチェンゲゼルシャフト | 両性アニオン性コポリマー |
| DE102004040104A1 (de) * | 2004-08-18 | 2006-02-23 | Basf Ag | Verwendung von amphiphilen Copolymerisaten als Solubilisatoren |
| WO2006061700A2 (en) * | 2004-12-06 | 2006-06-15 | Themis Laboratories Private Limited | Rapid disintegrating taste masked compositions and a process for its preparations |
| DE102005053066A1 (de) * | 2005-11-04 | 2007-05-10 | Basf Ag | Verwendung von Copolymeren als Solubilisatoren für in Wasser schwerlöslichen Verbindungen |
| CN101431985A (zh) * | 2006-04-28 | 2009-05-13 | 巴斯夫欧洲公司 | 在含水介质中加溶疏水活性物质的方法 |
| JP2009540032A (ja) * | 2006-06-07 | 2009-11-19 | ビーエーエスエフ ソシエタス・ヨーロピア | 酢酸ビニル−スルホナート共重合体の、水への溶解度が低い化合物のための可溶化剤としての使用 |
-
2008
- 2008-12-10 MX MX2010006005A patent/MX2010006005A/es not_active Application Discontinuation
- 2008-12-10 AU AU2008334580A patent/AU2008334580A1/en not_active Abandoned
- 2008-12-10 BR BRPI0820770-4A patent/BRPI0820770A2/pt not_active IP Right Cessation
- 2008-12-10 WO PCT/EP2008/067228 patent/WO2009074609A1/de not_active Ceased
- 2008-12-10 CA CA2707282A patent/CA2707282A1/en not_active Abandoned
- 2008-12-10 EP EP08858493A patent/EP2229151B1/de not_active Not-in-force
- 2008-12-10 US US12/747,557 patent/US20100280047A1/en not_active Abandoned
- 2008-12-10 JP JP2010537435A patent/JP5646340B2/ja not_active Expired - Fee Related
- 2008-12-10 CN CN200880120670XA patent/CN101896169B/zh not_active Expired - Fee Related
- 2008-12-10 KR KR1020107015194A patent/KR20100093591A/ko not_active Ceased
- 2008-12-10 ES ES08858493T patent/ES2388470T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2388470T3 (es) | 2012-10-15 |
| AU2008334580A1 (en) | 2009-06-18 |
| KR20100093591A (ko) | 2010-08-25 |
| CA2707282A1 (en) | 2009-06-18 |
| CN101896169A (zh) | 2010-11-24 |
| EP2229151A1 (de) | 2010-09-22 |
| US20100280047A1 (en) | 2010-11-04 |
| JP5646340B2 (ja) | 2014-12-24 |
| CN101896169B (zh) | 2012-11-14 |
| JP2011506395A (ja) | 2011-03-03 |
| MX2010006005A (es) | 2010-06-15 |
| EP2229151B1 (de) | 2012-08-08 |
| WO2009074609A1 (de) | 2009-06-18 |
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