BRPI0905707A2 - Método para aumentar a solubilidade aquosa de um composto ativo e composição compreendendo um composto ativo - Google Patents

Método para aumentar a solubilidade aquosa de um composto ativo e composição compreendendo um composto ativo

Info

Publication number
BRPI0905707A2
BRPI0905707A2 BRPI0905707-2A BRPI0905707A BRPI0905707A2 BR PI0905707 A2 BRPI0905707 A2 BR PI0905707A2 BR PI0905707 A BRPI0905707 A BR PI0905707A BR PI0905707 A2 BRPI0905707 A2 BR PI0905707A2
Authority
BR
Brazil
Prior art keywords
active compound
increasing
composition
aqueous solubility
solubility
Prior art date
Application number
BRPI0905707-2A
Other languages
English (en)
Inventor
David Bradley Wurm
David A Wilson
Bruce A Barner
Cynthia L Rand
Matthew D Miller
Michael J Johnson
Original Assignee
Dow Global Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Global Technologies Inc filed Critical Dow Global Technologies Inc
Publication of BRPI0905707A2 publication Critical patent/BRPI0905707A2/pt
Publication of BRPI0905707B1 publication Critical patent/BRPI0905707B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
BRPI0905707-2A 2008-01-18 2009-01-05 Método para aumentar a solubilidade aquosa de um composto ativo e composição compreendendo um composto ativo BRPI0905707B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2193508P 2008-01-18 2008-01-18
US61/021,935 2008-01-18
PCT/US2009/030071 WO2009091622A1 (en) 2008-01-18 2009-01-05 Method to enhance aqueous solubility of poorly soluble actives using methoxypolyethylene glycol

Publications (2)

Publication Number Publication Date
BRPI0905707A2 true BRPI0905707A2 (pt) 2015-07-14
BRPI0905707B1 BRPI0905707B1 (pt) 2024-02-27

Family

ID=40545939

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0905707-2A BRPI0905707B1 (pt) 2008-01-18 2009-01-05 Método para aumentar a solubilidade aquosa de um composto ativo e composição compreendendo um composto ativo

Country Status (6)

Country Link
US (1) US8497303B2 (pt)
EP (1) EP2252262B1 (pt)
JP (1) JP2011510005A (pt)
CN (1) CN101909601B (pt)
BR (1) BRPI0905707B1 (pt)
WO (1) WO2009091622A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200932107A (en) * 2008-01-18 2009-08-01 Dow Global Technologies Inc Stable, low VOC, low viscous biocidal formulations and method of making such formulations
CN102805080B (zh) * 2012-08-24 2014-10-15 广西田园生化股份有限公司 一种可用于防治农业病虫害的可溶性粒剂
CA3042642A1 (en) 2013-08-12 2015-02-19 Pharmaceutical Manufacturing Research Services, Inc. Extruded immediate release abuse deterrent pill
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US10172797B2 (en) 2013-12-17 2019-01-08 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
CA2955229C (en) 2014-07-17 2020-03-10 Pharmaceutical Manufacturing Research Services, Inc. Immediate release abuse deterrent liquid fill dosage form
AU2015336065A1 (en) 2014-10-20 2017-05-04 Pharmaceutical Manufacturing Research Services, Inc. Extended release abuse deterrent liquid fill dosage form
CN107184565B (zh) * 2017-06-01 2018-04-03 海南妙音春制药有限公司 一种布洛芬缓释胶囊的制备方法
CN106983734B (zh) * 2017-06-01 2018-09-14 海南妙音春制药有限公司 一种布洛芬缓释胶囊及其制备方法

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU432703A3 (pt) 1971-08-24 1974-06-15 Фридрих Боссерт, Вульф Фатер, Курт Бауер
GB2004747B (en) 1977-09-30 1982-02-17 Ici Ltd Compositions of matter
ZA784934B (en) 1977-09-30 1979-10-31 Ici Ltd Solutions of benzisothiazolinones
EP0173729B1 (fr) 1984-03-14 1990-10-17 Jérôme CORBIERE Ppocede de solubilisation de principes actifs et compositions pharmaceutiques ainsi obtenues
DE3437599C2 (de) 1984-10-13 1987-04-16 Dolorgiet GmbH & Co KG, 5205 St Augustin Ibuprofen enthaltende Weichgelatinekapseln
JP2524586B2 (ja) * 1985-06-26 1996-08-14 シタス コーポレイション ポリマ−接合を利用する医薬組成物用蛋白質の可溶化
US5071643A (en) 1986-10-17 1991-12-10 R. P. Scherer Corporation Solvent system enhancing the solubility of pharmaceuticals for encapsulation
GB8630273D0 (en) 1986-12-18 1987-01-28 Til Medical Ltd Pharmaceutical delivery systems
US4859704A (en) 1987-10-15 1989-08-22 Oratech Pharmaceutical Development Corporation Water soluble ibuprofen compositions and methods of making them
US4861797A (en) 1987-10-15 1989-08-29 Oratech Pharmaceutical Development Corporation Liquid ibuprofen compositions and methods of making them
DE3738236A1 (de) 1987-11-11 1989-05-24 Euro Celtique Sa Beisskapsel
US5004749A (en) 1989-04-20 1991-04-02 Imperial Chemical Industries Plc Concentrated aqueous solution of glutaraldehyde and 1,2-benzisothiazolin-3-one
US5910489A (en) * 1990-09-18 1999-06-08 Hyal Pharmaceutical Corporation Topical composition containing hyaluronic acid and NSAIDS
US5141961A (en) 1991-06-27 1992-08-25 Richrdson-Vicks Inc. Process for solubilizing difficulty soluble pharmaceutical actives
US5431916A (en) 1993-04-29 1995-07-11 The Procter & Gamble Company Pharmaceutical compositions and process of manufacture thereof
US5505961A (en) 1993-08-05 1996-04-09 R. P. Scherer Corporation Gelatin capsules containing a highly concentrated acetaminophen solution
US5484606A (en) 1994-01-24 1996-01-16 The Procter & Gamble Company Process for reducing the precipitation of difficulty soluble pharmaceutical actives
ZA961522B (en) 1995-03-23 1996-11-06 Zeneca Inc Fungicidal composition
US5897880A (en) * 1995-09-29 1999-04-27 Lam Pharmaceuticals, Llc. Topical drug preparations
GB9600661D0 (en) 1996-01-12 1996-03-13 Woolard Trevor Bactericidal compostions and articles containing them
DE19612085A1 (de) 1996-03-27 1997-10-02 Henkel Kgaa Verwendung von Polyalkylenglycolethern
DE69910709T2 (de) 1998-09-24 2004-06-17 Rohm And Haas Co. Mikrobizide Formulierung mit verringerter Rostfrasskorrosion
US6221391B1 (en) 1998-11-23 2001-04-24 Accucaps Industries Limited Self-emulsifying ibuprofen solution and soft gelatin capsule for use therewith
US6861397B2 (en) 1999-06-23 2005-03-01 The Dial Corporation Compositions having enhanced deposition of a topically active compound on a surface
KR100360827B1 (ko) * 1999-08-14 2002-11-18 주식회사 삼양사 난용성 약물을 가용화하기 위한 고분자 조성물 및 그의 제조방법
US6251426B1 (en) 1999-09-02 2001-06-26 Banner Pharmacaps, Inc. Ibuprofen-containing softgels
AU4504201A (en) 1999-11-08 2001-06-12 L.A.M. Pharmaceutical Corp Drug preparations
KR100416242B1 (ko) * 1999-12-22 2004-01-31 주식회사 삼양사 약물전달체용 생분해성 블록 공중합체의 액체 조성물 및이의 제조방법
AU2458501A (en) * 2000-01-05 2001-07-16 Imarx Therapeutics, Inc. Pharmaceutical formulations for the delivery of drugs having low aqueous solubility
US7135437B2 (en) 2000-05-19 2006-11-14 Monsanto Technology Llc Stable liquid pesticide compositions
KR100446101B1 (ko) 2000-12-07 2004-08-30 주식회사 삼양사 수난용성 약물의 서방성 제형 조성물
US6551615B1 (en) 2001-10-18 2003-04-22 M/S. Strides Arcolab Limited Dexibuprofen-containing soft gelatin capsules and process for preparing the same
US6569439B1 (en) * 2001-11-13 2003-05-27 Noville Inc. Process for making personal care compositions comprising titanium dioxide and personal care compositions made by the process
WO2003045357A1 (en) 2001-11-27 2003-06-05 Transform Pharmaceuticals, Inc. Oral pharmaceutical formulations comprising paclitaxel, derivatives and methods of administration thereof
WO2004103342A2 (en) 2003-05-16 2004-12-02 Alkermes Controlled Therapeutics, Inc. Injectable sustained release compositions
US7311901B2 (en) 2003-10-10 2007-12-25 Samyang Corporation Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery
US7105555B2 (en) 2004-04-06 2006-09-12 Isp Investments Inc. Stable, neutral pH VOC-free biocidal compositions of 1,2-benzisothiazolin-3-one
DE602005013244D1 (de) 2004-08-12 2009-04-23 Quest Pharmaceutical Services Pharmazeutische zusammensetzungen für die kontroll
ES2785999T3 (es) 2005-05-16 2020-10-08 Novapharm Res Australia Pty Limited Composición para su uso en la preparación de un paciente para cirugía
EP1948103A2 (en) * 2005-09-15 2008-07-30 UMD, Inc. A method of intraepithelial and systemic exposure of therapeutic agents following vaginal and oral cavity administration
DE102005045002A1 (de) 2005-09-21 2007-03-29 Clariant Produkte (Deutschland) Gmbh Biozide Zusammensetzungen
ZA200900482B (en) 2006-07-25 2010-05-26 Down Global Technologies Inc Stable, low voc, low viscous biocidal formulations and methods of making such formulations
TW200932107A (en) 2008-01-18 2009-08-01 Dow Global Technologies Inc Stable, low VOC, low viscous biocidal formulations and method of making such formulations

Also Published As

Publication number Publication date
JP2011510005A (ja) 2011-03-31
EP2252262B1 (en) 2020-03-18
EP2252262A1 (en) 2010-11-24
WO2009091622A1 (en) 2009-07-23
CN101909601A (zh) 2010-12-08
US8497303B2 (en) 2013-07-30
CN101909601B (zh) 2013-06-26
BRPI0905707B1 (pt) 2024-02-27
US20100286277A1 (en) 2010-11-11

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 05/01/2009, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.